PubMed

Orexins/hypocretins and orexin receptors in apoptosis: a mini-review.

Laburthe M, Voisin T, El Firar A.

Acta Physiol (Oxf). 2009 Aug 28. [Epub ahead of print]PMID: 19719798 [PubMed - as supplied by publisher]Related articles

Discovery of a functional immunoreceptor tyrosine-based switch motif in a 7-transmembrane-spanning receptor: role in the orexin receptor OX1R-driven apoptosis.

El Firar A, Voisin T, Rouyer-Fessard C, Ostuni MA, Couvineau A, Laburthe M.

FASEB J. 2009 Dec;23(12):4069-80. Epub 2009 Aug 6.PMID: 19661287 [PubMed - in process]Related articles

Molecular and conformational determinants of pituitary adenylate cyclase-activating polypeptide (PACAP) for activation of the PAC1 receptor.

Bourgault S, Vaudry D, Ségalas-Milazzo I, Guilhaudis L, Couvineau A, Laburthe M, Vaudry H, Fournier A.

J Med Chem. 2009 May 28;52(10):3308-16.PMID: 19413310 [PubMed - indexed for MEDLINE]Related articles

Aberrant expression of proteinase-activated receptor 4 promotes colon cancer cell proliferation through a persistent signaling that involves Src and ErbB-2 kinase.

Gratio V, Walker F, Lehy T, Laburthe M, Darmoul D.

Int J Cancer. 2009 Apr 1;124(7):1517-25.PMID: 19058300 [PubMed - indexed for MEDLINE]Related articles

PACAP prevents toxicity induced by cisplatin in rat and primate neurons but not in proliferating ovary cells: involvement of the mitochondrial apoptotic pathway.

Aubert N, Vaudry D, Falluel-Morel A, Desfeux A, Fisch C, Ancian P, de Jouffrey S, Le Bigot JF, Couvineau A, Laburthe M, Fournier A, Laudenbach V, Vaudry H, Gonzalez BJ.

Neurobiol Dis. 2008 Oct;32(1):66-80. Epub 2008 Jul 3.PMID: 18652895 [PubMed - indexed for MEDLINE]Related articles

The N-terminal parts of VIP and antagonist PG97-269 physically interact with different regions of the human VPAC1 receptor.

Ceraudo E, Tan YV, Nicole P, Couvineau A, Laburthe M.

J Mol Neurosci. 2008 Nov;36(1-3):245-8. Epub 2008 Jul 3.PMID: 18597186 [PubMed - indexed for MEDLINE]Related articles

Production and purification of large quantities of the functional N-terminal ectodomain of human VPAC1 receptor.

Couvineau A, Robert JC, Ramdani T, Lacapère JJ, Rouyer-Fessard C, Laburthe M.

J Mol Neurosci. 2008 Nov;36(1-3):249-53. Epub 2008 Jul 1.PMID: 18592417 [PubMed - indexed for MEDLINE]Related articles

Class-B GPCR activation: is ligand helix-capping the key?

Neumann JM, Couvineau A, Murail S, Lacapère JJ, Jamin N, Laburthe M.

Trends Biochem Sci. 2008 Jul;33(7):314-9. Epub 2008 Jun 12.PMID: 18555686 [PubMed - indexed for MEDLINE]Related articles

Biological and structural analysis of truncated analogs of PACAP27.

Bourgault S, Vaudry D, Guilhaudis L, Raoult E, Couvineau A, Laburthe M, Ségalas-Milazzo I, Vaudry H, Fournier A.

J Mol Neurosci. 2008 Nov;36(1-3):260-9. Epub 2008 May 13.PMID: 18473187 [PubMed - indexed for MEDLINE]Related articles

Novel stable PACAP analogs with potent activity towards the PAC1 receptor.

Bourgault S, Vaudry D, Botia B, Couvineau A, Laburthe M, Vaudry H, Fournier A.

Peptides. 2008 Jun;29(6):919-32. Epub 2008 Feb 13.PMID: 18353507 [PubMed - indexed for MEDLINE]Related articles

A hallmark of immunoreceptor, the tyrosine-based inhibitory motif ITIM, is present in the G protein-coupled receptor OX1R for orexins and drives apoptosis: a novel mechanism.

Voisin T, El Firar A, Rouyer-Fessard C, Gratio V, Laburthe M.

FASEB J. 2008 Jun;22(6):1993-2002. Epub 2008 Jan 15.PMID: 18198212 [PubMed - indexed for MEDLINE]Related articlesFree article

PAR-2 activation increases human intestinal mucin secretion through EGFR transactivation.

Jarry A, Dorso L, Gratio V, Forgue-Lafitte ME, Laburthe M, Laboisse CL, Darmoul D.

Biochem Biophys Res Commun. 2007 Dec 21;364(3):689-94. Epub 2007 Oct 22.PMID: 18028876 [PubMed - indexed for MEDLINE]Related articles

The vasoactive intestinal peptide (VIP) alpha-Helix up to C terminus interacts with the N-terminal ectodomain of the human VIP/Pituitary adenylate cyclase-activating peptide 1 receptor: photoaffinity, molecular modeling, and dynamics.

Ceraudo E, Murail S, Tan YV, Lacapère JJ, Neumann JM, Couvineau A, Laburthe M.

Mol Endocrinol. 2008 Jan;22(1):147-55. Epub 2007 Sep 20.PMID: 17885205 [PubMed - indexed for MEDLINE]Related articlesFree article

Involvement of VIP and PACAP in neonatal brain lesions generated by a combined excitotoxic/inflammatory challenge.

Favrais G, Couvineau A, Laburthe M, Gressens P, Lelievre V.

Peptides. 2007 Sep;28(9):1727-37. Epub 2007 Jun 28.PMID: 17683829 [PubMed - indexed for MEDLINE]Related articles

Orexins control intestinal glucose transport by distinct neuronal, endocrine, and direct epithelial pathways.

Ducroc R, Voisin T, El Firar A, Laburthe M.

Diabetes. 2007 Oct;56(10):2494-500. Epub 2007 Jul 12.PMID: 17626888 [PubMed - indexed for MEDLINE]Related articlesFree article

Class II G protein-coupled receptors for VIP and PACAP: structure, models of activation and pharmacology.

Laburthe M, Couvineau A, Tan V.

Peptides. 2007 Sep;28(9):1631-9. Epub 2007 May 22. Review.PMID: 17574305 [PubMed - indexed for MEDLINE]Related articles

[MicroRNAs and intestinal pathophysiology]

Ogier-Denis E, Fasseu M, Vandewalle A, Laburthe M.

Med Sci (Paris). 2007 May;23(5):509-14. Review. French. PMID: 17502067 [PubMed - indexed for MEDLINE]Related articles

Characterization of the new photoaffinity probe (Bz2-K24)-VIP.

Tan YV, Couvineau A, Lacapere JJ, Laburthe M.

Ann N Y Acad Sci. 2006 Jul;1070:575-80.PMID: 16888228 [PubMed - indexed for MEDLINE]Related articles

Expression and GTP sensitivity of peptide histidine isoleucine high-affinity-binding sites in rat.

Debaigt C, Meunier AC, Goursaud S, Montoni A, Pineau N, Couvineau A, Laburthe M, Muller JM, Janet T.

Ann N Y Acad Sci. 2006 Jul;1070:215-9.PMID: 16888169 [PubMed - indexed for MEDLINE]Related articles

The human VPAC1 receptor: identification of the N-terminal ectodomain as a major VIP-binding site by photoaffinity labeling and 3D modeling.

Couvineau A, Tan YV, Ceraudo E, Lacapère JJ, Murail S, Neumann JM, Laburthe M.

Ann N Y Acad Sci. 2006 Jul;1070:205-9.PMID: 16888167 [PubMed - indexed for MEDLINE]Related articles

Spatial approximation between the C-terminus of VIP and the N-terminal ectodomain of the VPAC1 receptor.

Ceraudo E, Tan YV, Couvineau A, Lacapere JJ, Laburthe M.

Ann N Y Acad Sci. 2006 Jul;1070:180-4.PMID: 16888162 [PubMed - indexed for MEDLINE]Related articles

Orexin-induced apoptosis: the key role of the seven-transmembrane domain orexin type 2 receptor.

Voisin T, Firar AE, Avondo V, Laburthe M.

Endocrinology. 2006 Oct;147(10):4977-84. Epub 2006 Jul 20.PMID: 16857748 [PubMed - indexed for MEDLINE]Related articlesFree article

Peptide agonist docking in the N-terminal ectodomain of a class II G protein-coupled receptor, the VPAC1 receptor. Photoaffinity, NMR, and molecular modeling.

Tan YV, Couvineau A, Murail S, Ceraudo E, Neumann JM, Lacapère JJ, Laburthe M.

J Biol Chem. 2006 May 5;281(18):12792-8. Epub 2006 Mar 6.PMID: 16520374 [PubMed - indexed for MEDLINE]Related articlesFree article

Presence of a N-terminal signal peptide in class II G protein-coupled receptors: crucial role for expression of the human VPAC1 receptor.

Couvineau A, Rouyer-Fessard C, Laburthe M.

Regul Pept. 2004 Dec 15;123(1-3):181-5.PMID: 15518910 [PubMed - indexed for MEDLINE]Related articles

Activation of proteinase-activated receptor 1 promotes human colon cancer cell proliferation through epidermal growth factor receptor transactivation.

Darmoul D, Gratio V, Devaud H, Peiretti F, Laburthe M.

Mol Cancer Res. 2004 Sep;2(9):514-22.PMID: 15383630 [PubMed - indexed for MEDLINE]Related articlesFree article

Orexins acting at native OX(1) receptor in colon cancer and neuroblastoma cells or at recombinant OX(1) receptor suppress cell growth by inducing apoptosis.

Rouet-Benzineb P, Rouyer-Fessard C, Jarry A, Avondo V, Pouzet C, Yanagisawa M, Laboisse C, Laburthe M, Voisin T.

J Biol Chem. 2004 Oct 29;279(44):45875-86. Epub 2004 Aug 13.PMID: 15310763 [PubMed - indexed for MEDLINE]Related articlesFree article

Diffuse pharmacophoric domains of vasoactive intestinal peptide (VIP) and further insights into the interaction of VIP with the N-terminal ectodomain of human VPAC1 receptor by photoaffinity labeling with [Bpa6]-VIP.

Tan YV, Couvineau A, Laburthe M.

J Biol Chem. 2004 Sep 10;279(37):38889-94. Epub 2004 Jul 6.PMID: 15247290 [PubMed - indexed for MEDLINE]Related articlesFree article

Protease-activated receptor 2 in colon cancer: trypsin-induced MAPK phosphorylation and cell proliferation are mediated by epidermal growth factor receptor transactivation.

Darmoul D, Gratio V, Devaud H, Laburthe M.

J Biol Chem. 2004 May 14;279(20):20927-34. Epub 2004 Mar 9.PMID: 15010475 [PubMed - indexed for MEDLINE]Related articlesFree article

Serine 447 in the carboxyl tail of human VPAC1 receptor is crucial for agonist-induced desensitization but not internalization of the receptor.

Marie JC, Rouyer-Fessard C, Couvineau A, Nicole P, Devaud H, El Benna J, Laburthe M.

Mol Pharmacol. 2003 Dec;64(6):1565-74.PMID: 14645688 [PubMed - indexed for MEDLINE]Related articlesFree article

Photoaffinity labeling demonstrates physical contact between vasoactive intestinal peptide and the N-terminal ectodomain of the human VPAC1 receptor.

Tan YV, Couvineau A, Van Rampelbergh J, Laburthe M.

J Biol Chem. 2003 Sep 19;278(38):36531-6. Epub 2003 Jun 13.PMID: 12807902 [PubMed - indexed for MEDLINE]Related articlesFree article

Aberrant expression and activation of the thrombin receptor protease-activated receptor-1 induces cell proliferation and motility in human colon cancer cells.

Darmoul D, Gratio V, Devaud H, Lehy T, Laburthe M.

Am J Pathol. 2003 May;162(5):1503-13.PMID: 12707033 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of cytoplasmic domains of hVPAC1 receptor required for activation of adenylyl cyclase. Crucial role of two charged amino acids strictly conserved in class II G protein-coupled receptors.

Couvineau A, Lacapere JJ, Tan YV, Rouyer-Fessard C, Nicole P, Laburthe M.

J Biol Chem. 2003 Jul 4;278(27):24759-66. Epub 2003 Apr 10.PMID: 12690118 [PubMed - indexed for MEDLINE]Related articlesFree article

Orexins and their receptors: structural aspects and role in peripheral tissues.

Voisin T, Rouet-Benzineb P, Reuter N, Laburthe M.

Cell Mol Life Sci. 2003 Jan;60(1):72-87. Review.PMID: 12613659 [PubMed - indexed for MEDLINE]Related articles

VPAC receptors for VIP and PACAP.

Laburthe M, Couvineau A, Marie JC.

Receptors Channels. 2002;8(3-4):137-53. Review.PMID: 12529932 [PubMed - indexed for MEDLINE]Related articles

Novel receptor partners and function of receptor activity-modifying proteins.

Christopoulos A, Christopoulos G, Morfis M, Udawela M, Laburthe M, Couvineau A, Kuwasako K, Tilakaratne N, Sexton PM.

J Biol Chem. 2003 Jan 31;278(5):3293-7. Epub 2002 Nov 21.PMID: 12446722 [PubMed - indexed for MEDLINE]Related articlesFree article

Molecular pharmacology and structure of VPAC Receptors for VIP and PACAP.

Laburthe M, Couvineau A.

Regul Pept. 2002 Oct 15;108(2-3):165-73. Review.PMID: 12220741 [PubMed - indexed for MEDLINE]Related articles

Human VPAC1 receptor selectivity filter. Identification of a critical domain for restricting secretin binding.

Du K, Couvineau A, Rouyer-Fessard C, Nicole P, Laburthe M.

J Biol Chem. 2002 Oct 4;277(40):37016-22. Epub 2002 Jul 19.PMID: 12133828 [PubMed - indexed for MEDLINE]Related articlesFree article

Trypsin is produced by and activates protease-activated receptor-2 in human cancer colon cells: evidence for new autocrine loop.

Ducroc R, Bontemps C, Marazova K, Devaud H, Darmoul D, Laburthe M.

Life Sci. 2002 Feb 8;70(12):1359-67.PMID: 11883712 [PubMed - indexed for MEDLINE]Related articles

PepT1-mediated epithelial transport of dipeptides and cephalexin is enhanced by luminal leptin in the small intestine.

Buyse M, Berlioz F, Guilmeau S, Tsocas A, Voisin T, Péranzi G, Merlin D, Laburthe M, Lewin MJ, Rozé C, Bado A.

J Clin Invest. 2001 Nov;108(10):1483-94.PMID: 11714740 [PubMed - indexed for MEDLINE]Related articlesFree article

Initiation of human colon cancer cell proliferation by trypsin acting at protease-activated receptor-2.

Darmoul D, Marie JC, Devaud H, Gratio V, Laburthe M.

Br J Cancer. 2001 Sep 1;85(5):772-9.PMID: 11531266 [PubMed - indexed for MEDLINE]Related articlesFree article

The peptide YY-preferring receptor mediating inhibition of small intestinal secretion is a peripheral Y(2) receptor: pharmacological evidence and molecular cloning.

Goumain M, Voisin T, Lorinet AM, Ducroc R, Tsocas A, Rozé C, Rouet-Benzineb P, Herzog H, Balasubramaniam A, Laburthe M.

Mol Pharmacol. 2001 Jul;60(1):124-34.PMID: 11408607 [PubMed - indexed for MEDLINE]Related articlesFree article

Alanine scanning of VIP. Structure-function relationship for binding to human recombinant VPAC1 receptor.

Nicole P, Rouyer-Fessard C, Couvineau A, Drouot C, Fulcrand P, Martinez J, Laburthe M.

Ann N Y Acad Sci. 2000;921:352-6. No abstract available. PMID: 11193851 [PubMed - indexed for MEDLINE]Related articles

The human VPAC1 receptor: three-dimensional model and mutagenesis of the N-terminal domain.

Lins L, Couvineau A, Rouyer-Fessard C, Nicole P, Maoret JJ, Benhamed M, Brasseur R, Thomas A, Laburthe M.

J Biol Chem. 2001 Mar 30;276(13):10153-60. Epub 2000 Dec 21.PMID: 11124960 [PubMed - indexed for MEDLINE]Related articlesFree article

Tryptophan 67 in the human VPAC(1) receptor: crucial role for VIP binding.

Nicole P, Maoret JJ, Couvineau A, Momany FA, Laburthe M.

Biochem Biophys Res Commun. 2000 Sep 24;276(2):654-9.PMID: 11027527 [PubMed - indexed for MEDLINE]Related articles

Structure-activity studies including a Psi(CH(2)-NH) scan of peptide YY (PYY) active site, PYY(22-36), for interaction with rat intestinal PYY receptors: development of analogues with potent in vivo activity in the intestine.

Balasubramaniam A, Tao Z, Zhai W, Stein M, Sheriff S, Chance WT, Fischer JE, Eden PE, Taylor JE, Liu CD, McFadden DW, Voisin T, Roze C, Laburthe M.

J Med Chem. 2000 Sep 7;43(18):3420-7.PMID: 10978189 [PubMed - indexed for MEDLINE]Related articles

Y receptors characterized by RT-PCR. Distribution in rat intestine.

Goumain M, Voisin T, Laburthe M.

Methods Mol Biol. 2000;153:209-17. No abstract available. PMID: 10957995 [PubMed - indexed for MEDLINE]Related articles

A G alpha i RNA-antisense expression strategy to investigate coupling of peptide YY/neuropeptide Y receptor to G alpha i.

Voisin T, Lorinet AM, Goumain M, Laburthe M.

Methods Mol Biol. 2000;153:115-28. No abstract available. PMID: 10957989 [PubMed - indexed for MEDLINE]Related articles

alpha(2)-adrenergic receptors stimulate oligopeptide transport in a human intestinal cell line.

Berlioz F, Maoret JJ, Paris H, Laburthe M, Farinotti R, Rozé C.

J Pharmacol Exp Ther. 2000 Aug;294(2):466-72.PMID: 10900220 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of key residues for interaction of vasoactive intestinal peptide with human VPAC1 and VPAC2 receptors and development of a highly selective VPAC1 receptor agonist. Alanine scanning and molecular modeling of the peptide.

Nicole P, Lins L, Rouyer-Fessard C, Drouot C, Fulcrand P, Thomas A, Couvineau A, Martinez J, Brasseur R, Laburthe M.

J Biol Chem. 2000 Aug 4;275(31):24003-12.PMID: 10801840 [PubMed - indexed for MEDLINE]Related articlesFree article

The human vasoactive intestinal peptide/pituitary adenylate cyclase-activating peptide receptor 1 (VPAC1) promoter: characterization and role in receptor expression during enterocytic differentiation of the colon cancer cell line Caco-2Cl.20.

Couvineau A, Maoret JJ, Rouyer-Fessard C, Carrero I, Laburthe M.

Biochem J. 2000 May 1;347 Pt 3:623-32.PMID: 10769164 [PubMed - indexed for MEDLINE]Related articlesFree article