PubMed

Arrestin development: emerging roles for beta-arrestins in developmental signaling pathways.

Kovacs JJ, Hara MR, Davenport CL, Kim J, Lefkowitz RJ.

Dev Cell. 2009 Oct;17(4):443-58. Review.PMID: 19853559 [PubMed - indexed for MEDLINE]Related articles

G protein-coupled receptor kinases phosphorylate LRP6 in the Wnt pathway.

Chen M, Philipp M, Wang J, Premont RT, Garrison TR, Caron MG, Lefkowitz RJ, Chen W.

J Biol Chem. 2009 Oct 2. [Epub ahead of print]PMID: 19801552 [PubMed - as supplied by publisher]Related articlesFree article

Oxygen-regulated beta(2)-adrenergic receptor hydroxylation by EGLN3 and ubiquitylation by pVHL.

Xie L, Xiao K, Whalen EJ, Forrester MT, Freeman RS, Fong G, Gygi SP, Lefkowitz RJ, Stamler JS.

Sci Signal. 2009 Jul 7;2(78):ra33.PMID: 19584355 [PubMed - indexed for MEDLINE]Related articles

Selective engagement of G protein coupled receptor kinases (GRKs) encodes distinct functions of biased ligands.

Zidar DA, Violin JD, Whalen EJ, Lefkowitz RJ.

Proc Natl Acad Sci U S A. 2009 Jun 16;106(24):9649-54. Epub 2009 Jun 2.PMID: 19497875 [PubMed - indexed for MEDLINE]Related articlesFree article

Beta-arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2.

Shenoy SK, Modi AS, Shukla AK, Xiao K, Berthouze M, Ahn S, Wilkinson KD, Miller WE, Lefkowitz RJ.

Proc Natl Acad Sci U S A. 2009 Apr 21;106(16):6650-5. Epub 2009 Apr 10.PMID: 19363159 [PubMed - indexed for MEDLINE]Related articlesFree article

beta-Arrestin1 mediates nicotinic acid-induced flushing, but not its antilipolytic effect, in mice.

Walters RW, Shukla AK, Kovacs JJ, Violin JD, DeWire SM, Lam CM, Chen JR, Muehlbauer MJ, Whalen EJ, Lefkowitz RJ.

J Clin Invest. 2009 May;119(5):1312-21. doi: 10.1172/JCI36806. Epub 2009 Apr 6.PMID: 19349687 [PubMed - indexed for MEDLINE]Related articlesFree article

Independent beta-arrestin2 and Gq/protein kinase Czeta pathways for ERK stimulated by angiotensin type 1A receptors in vascular smooth muscle cells converge on transactivation of the epidermal growth factor receptor.

Kim J, Ahn S, Rajagopal K, Lefkowitz RJ.

J Biol Chem. 2009 May 1;284(18):11953-62. Epub 2009 Mar 2.PMID: 19254952 [PubMed - indexed for MEDLINE]Related articlesFree article

{beta}-Arrestin-2 Mediates Anti-apoptotic Signaling through Regulation of BAD Phosphorylation.

Ahn S, Kim J, Hara MR, Ren XR, Lefkowitz RJ.

J Biol Chem. 2009 Mar 27;284(13):8855-65. Epub 2009 Jan 26.PMID: 19171933 [PubMed - indexed for MEDLINE]Related articlesFree article

S-nitrosylation of beta-arrestin regulates beta-adrenergic receptor trafficking.

Ozawa K, Whalen EJ, Nelson CD, Mu Y, Hess DT, Lefkowitz RJ, Stamler JS.

Mol Cell. 2008 Aug 8;31(3):395-405.PMID: 18691971 [PubMed - indexed for MEDLINE]Related articlesFree article

Granulocyte chemotaxis and disease expression are differentially regulated by GRK subtype in an acute inflammatory arthritis model (K/BxN).

Tarrant TK, Rampersad RR, Esserman D, Rothlein LR, Liu P, Premont RT, Lefkowitz RJ, Lee DM, Patel DD.

Clin Immunol. 2008 Oct;129(1):115-22. Epub 2008 Jul 26.PMID: 18662895 [PubMed - indexed for MEDLINE]Related articlesFree article

Distinct conformational changes in beta-arrestin report biased agonism at seven-transmembrane receptors.

Shukla AK, Violin JD, Whalen EJ, Gesty-Palmer D, Shenoy SK, Lefkowitz RJ.

Proc Natl Acad Sci U S A. 2008 Jul 22;105(29):9988-93. Epub 2008 Jul 11.PMID: 18621717 [PubMed - indexed for MEDLINE]Related articlesFree article

Beta-arrestin scaffolding of phosphatidylinositol 4-phosphate 5-kinase Ialpha promotes agonist-stimulated sequestration of the beta2-adrenergic receptor.

Nelson CD, Kovacs JJ, Nobles KN, Whalen EJ, Lefkowitz RJ.

J Biol Chem. 2008 Jul 25;283(30):21093-101. Epub 2008 Jun 5.PMID: 18534983 [PubMed - indexed for MEDLINE]Related articlesFree article

Pharmacological characterization of membrane-expressed human trace amine-associated receptor 1 (TAAR1) by a bioluminescence resonance energy transfer cAMP biosensor.

Barak LS, Salahpour A, Zhang X, Masri B, Sotnikova TD, Ramsey AJ, Violin JD, Lefkowitz RJ, Caron MG, Gainetdinov RR.

Mol Pharmacol. 2008 Sep;74(3):585-94. Epub 2008 Jun 4.PMID: 18524885 [PubMed - indexed for MEDLINE]Related articlesFree article

Beta-arrestins regulate atherosclerosis and neointimal hyperplasia by controlling smooth muscle cell proliferation and migration.

Kim J, Zhang L, Peppel K, Wu JH, Zidar DA, Brian L, DeWire SM, Exum ST, Lefkowitz RJ, Freedman NJ.

Circ Res. 2008 Jul 3;103(1):70-9. Epub 2008 Jun 2.PMID: 18519945 [PubMed - indexed for MEDLINE]Related articlesFree article

Beta-arrestin-mediated localization of smoothened to the primary cilium.

Kovacs JJ, Whalen EJ, Liu R, Xiao K, Kim J, Chen M, Wang J, Chen W, Lefkowitz RJ.

Science. 2008 Jun 27;320(5884):1777-81. Epub 2008 May 22.PMID: 18497258 [PubMed - indexed for MEDLINE]Related articlesFree article

The annual ASCI meeting: does nostalgia have a future?

Lefkowitz RJ.

J Clin Invest. 2008 Apr;118(4):1231-3.PMID: 18382732 [PubMed - indexed for MEDLINE]Related articlesFree article

Beta-arrestin-mediated signaling regulates protein synthesis.

DeWire SM, Kim J, Whalen EJ, Ahn S, Chen M, Lefkowitz RJ.

J Biol Chem. 2008 Apr 18;283(16):10611-20. Epub 2008 Feb 14.PMID: 18276584 [PubMed - indexed for MEDLINE]Related articlesFree article

A crystal clear view of the beta2-adrenergic receptor.

Lefkowitz RJ, Sun JP, Shukla AK.

Nat Biotechnol. 2008 Feb;26(2):189-91. No abstract available. PMID: 18259173 [PubMed - indexed for MEDLINE]Related articles

Crystallizing thinking about the beta2-adrenergic receptor.

Shukla AK, Sun JP, Lefkowitz RJ.

Mol Pharmacol. 2008 May;73(5):1333-8. Epub 2008 Jan 31.PMID: 18239031 [PubMed - indexed for MEDLINE]Related articlesFree article

A beta-arrestin 2 signaling complex mediates lithium action on behavior.

Beaulieu JM, Marion S, Rodriguiz RM, Medvedev IO, Sotnikova TD, Ghisi V, Wetsel WC, Lefkowitz RJ, Gainetdinov RR, Caron MG.

Cell. 2008 Jan 11;132(1):125-36.PMID: 18191226 [PubMed - indexed for MEDLINE]Related articles

beta-arrestin-biased agonism at the beta2-adrenergic receptor.

Drake MT, Violin JD, Whalen EJ, Wisler JW, Shenoy SK, Lefkowitz RJ.

J Biol Chem. 2008 Feb 29;283(9):5669-76. Epub 2007 Dec 17.PMID: 18086673 [PubMed - indexed for MEDLINE]Related articlesFree article

beta2-adrenergic receptor signaling and desensitization elucidated by quantitative modeling of real time cAMP dynamics.

Violin JD, DiPilato LM, Yildirim N, Elston TC, Zhang J, Lefkowitz RJ.

J Biol Chem. 2008 Feb 1;283(5):2949-61. Epub 2007 Nov 28.PMID: 18045878 [PubMed - indexed for MEDLINE]Related articlesFree article

A unique mechanism of beta-blocker action: carvedilol stimulates beta-arrestin signaling.

Wisler JW, DeWire SM, Whalen EJ, Violin JD, Drake MT, Ahn S, Shenoy SK, Lefkowitz RJ.

Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16657-62. Epub 2007 Oct 9.PMID: 17925438 [PubMed - indexed for MEDLINE]Related articlesFree article

Beta-arrestin-mediated beta1-adrenergic receptor transactivation of the EGFR confers cardioprotection.

Noma T, Lemaire A, Naga Prasad SV, Barki-Harrington L, Tilley DG, Chen J, Le Corvoisier P, Violin JD, Wei H, Lefkowitz RJ, Rockman HA.

J Clin Invest. 2007 Sep;117(9):2445-58.PMID: 17786238 [PubMed - indexed for MEDLINE]Related articlesFree article

Ubiquitination of beta-arrestin links seven-transmembrane receptor endocytosis and ERK activation.

Shenoy SK, Barak LS, Xiao K, Ahn S, Berthouze M, Shukla AK, Luttrell LM, Lefkowitz RJ.

J Biol Chem. 2007 Oct 5;282(40):29549-62. Epub 2007 Jul 31.PMID: 17666399 [PubMed - indexed for MEDLINE]Related articlesFree article

Beta-arrestin-biased ligands at seven-transmembrane receptors.

Violin JD, Lefkowitz RJ.

Trends Pharmacol Sci. 2007 Aug;28(8):416-22. Epub 2007 Jul 20. Review.PMID: 17644195 [PubMed - indexed for MEDLINE]Related articles

Functional specialization of beta-arrestin interactions revealed by proteomic analysis.

Xiao K, McClatchy DB, Shukla AK, Zhao Y, Chen M, Shenoy SK, Yates JR 3rd, Lefkowitz RJ.

Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):12011-6. Epub 2007 Jul 9.PMID: 17620599 [PubMed - indexed for MEDLINE]Related articlesFree article

The active conformation of beta-arrestin1: direct evidence for the phosphate sensor in the N-domain and conformational differences in the active states of beta-arrestins1 and -2.

Nobles KN, Guan Z, Xiao K, Oas TG, Lefkowitz RJ.

J Biol Chem. 2007 Jul 20;282(29):21370-81. Epub 2007 May 18.PMID: 17513300 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of beta-adrenergic receptor signaling by S-nitrosylation of G-protein-coupled receptor kinase 2.

Whalen EJ, Foster MW, Matsumoto A, Ozawa K, Violin JD, Que LG, Nelson CD, Benhar M, Keys JR, Rockman HA, Koch WJ, Daaka Y, Lefkowitz RJ, Stamler JS.

Cell. 2007 May 4;129(3):511-22.PMID: 17482545 [PubMed - indexed for MEDLINE]Related articles

Seven transmembrane receptors: something old, something new.

Lefkowitz RJ.

Acta Physiol (Oxf). 2007 May;190(1):9-19. Review.PMID: 17428228 [PubMed - indexed for MEDLINE]Related articles

Beta-arrestins and cell signaling.

DeWire SM, Ahn S, Lefkowitz RJ, Shenoy SK.

Annu Rev Physiol. 2007;69:483-510. Review.PMID: 17305471 [PubMed - indexed for MEDLINE]Related articles

Beta-arrestin and Mdm2 mediate IGF-1 receptor-stimulated ERK activation and cell cycle progression.

Girnita L, Shenoy SK, Sehat B, Vasilcanu R, Vasilcanu D, Girnita A, Lefkowitz RJ, Larsson O.

J Biol Chem. 2007 Apr 13;282(15):11329-38. Epub 2007 Feb 15.PMID: 17303558 [PubMed - indexed for MEDLINE]Related articlesFree article

Targeting of diacylglycerol degradation to M1 muscarinic receptors by beta-arrestins.

Nelson CD, Perry SJ, Regier DS, Prescott SM, Topham MK, Lefkowitz RJ.

Science. 2007 Feb 2;315(5812):663-6.PMID: 17272726 [PubMed - indexed for MEDLINE]Related articlesFree article

Seven transmembrane receptors: a brief personal retrospective.

Lefkowitz RJ.

Biochim Biophys Acta. 2007 Apr;1768(4):748-55. Epub 2006 Nov 10.PMID: 17173855 [PubMed - indexed for MEDLINE]Related articles

New roles for beta-arrestins in cell signaling: not just for seven-transmembrane receptors.

Lefkowitz RJ, Rajagopal K, Whalen EJ.

Mol Cell. 2006 Dec 8;24(5):643-52. Review.PMID: 17157248 [PubMed - indexed for MEDLINE]Related articles

Beta-arrestin2-mediated inotropic effects of the angiotensin II type 1A receptor in isolated cardiac myocytes.

Rajagopal K, Whalen EJ, Violin JD, Stiber JA, Rosenberg PB, Premont RT, Coffman TM, Rockman HA, Lefkowitz RJ.

Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16284-9. Epub 2006 Oct 23.PMID: 17060617 [PubMed - indexed for MEDLINE]Related articlesFree article

G protein-coupled receptor kinase and beta-arrestin-mediated desensitization of the angiotensin II type 1A receptor elucidated by diacylglycerol dynamics.

Violin JD, Dewire SM, Barnes WG, Lefkowitz RJ.

J Biol Chem. 2006 Nov 24;281(47):36411-9. Epub 2006 Sep 28.PMID: 17008309 [PubMed - indexed for MEDLINE]Related articlesFree article

Trafficking of G protein-coupled receptors.

Drake MT, Shenoy SK, Lefkowitz RJ.

Circ Res. 2006 Sep 15;99(6):570-82.PMID: 16973913 [PubMed - indexed for MEDLINE]Related articlesFree article

Smoothened signal transduction is promoted by G protein-coupled receptor kinase 2.

Meloni AR, Fralish GB, Kelly P, Salahpour A, Chen JK, Wechsler-Reya RJ, Lefkowitz RJ, Caron MG.

Mol Cell Biol. 2006 Oct;26(20):7550-60. Epub 2006 Aug 14.PMID: 16908539 [PubMed - indexed for MEDLINE]Related articlesFree article

G-protein-coupled receptor kinase specificity for beta-arrestin recruitment to the beta2-adrenergic receptor revealed by fluorescence resonance energy transfer.

Violin JD, Ren XR, Lefkowitz RJ.

J Biol Chem. 2006 Jul 21;281(29):20577-88. Epub 2006 May 10.PMID: 16687412 [PubMed - indexed for MEDLINE]Related articlesFree article

GRKs and beta-arrestins: roles in receptor silencing, trafficking and signaling.

Reiter E, Lefkowitz RJ.

Trends Endocrinol Metab. 2006 May-Jun;17(4):159-65. Epub 2006 Apr 3. Review.PMID: 16595179 [PubMed - indexed for MEDLINE]Related articles

Distinct beta-arrestin- and G protein-dependent pathways for parathyroid hormone receptor-stimulated ERK1/2 activation.

Gesty-Palmer D, Chen M, Reiter E, Ahn S, Nelson CD, Wang S, Eckhardt AE, Cowan CL, Spurney RF, Luttrell LM, Lefkowitz RJ.

J Biol Chem. 2006 Apr 21;281(16):10856-64. Epub 2006 Feb 21.PMID: 16492667 [PubMed - indexed for MEDLINE]Related articlesFree article

Receptor regulation: beta-arrestin moves up a notch.

Shenoy SK, Lefkowitz RJ.

Nat Cell Biol. 2005 Dec;7(12):1159-61. No abstract available. Erratum in: Nat Cell Biol. 2006 Jan;8(1):100. PMID: 16319967 [PubMed - indexed for MEDLINE]Related articles

Angiotensin II-stimulated signaling through G proteins and beta-arrestin.

Shenoy SK, Lefkowitz RJ.

Sci STKE. 2005 Nov 22;2005(311):cm14.PMID: 16304060 [PubMed - indexed for MEDLINE]Related articles

beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor.

Shenoy SK, Drake MT, Nelson CD, Houtz DA, Xiao K, Madabushi S, Reiter E, Premont RT, Lichtarge O, Lefkowitz RJ.

J Biol Chem. 2006 Jan 13;281(2):1261-73. Epub 2005 Nov 9.PMID: 16280323 [PubMed - indexed for MEDLINE]Related articlesFree article

When 7 transmembrane receptors are not G protein-coupled receptors.

Rajagopal K, Lefkowitz RJ, Rockman HA.

J Clin Invest. 2005 Nov;115(11):2971-4. Review.PMID: 16276410 [PubMed - indexed for MEDLINE]Related articlesFree article

Seven-transmembrane receptor signaling through beta-arrestin.

Shenoy SK, Lefkowitz RJ.

Sci STKE. 2005 Nov 1;2005(308):cm10. Review.PMID: 16267056 [PubMed - indexed for MEDLINE]Related articles

An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior.

Beaulieu JM, Sotnikova TD, Marion S, Lefkowitz RJ, Gainetdinov RR, Caron MG.

Cell. 2005 Jul 29;122(2):261-73.PMID: 16051150 [PubMed - indexed for MEDLINE]Related articles

Summary of Wenner-Gren international symposium receptor-receptor interactions among heptaspanning membrane receptors: from structure to function.

Lefkowitz RJ.

J Mol Neurosci. 2005;26(2-3):293-4.PMID: 16012202 [PubMed - indexed for MEDLINE]Related articles

{beta}-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase.

Girnita L, Shenoy SK, Sehat B, Vasilcanu R, Girnita A, Lefkowitz RJ, Larsson O.

J Biol Chem. 2005 Jul 1;280(26):24412-9. Epub 2005 May 3.PMID: 15878855 [PubMed - indexed for MEDLINE]Related articlesFree article