PubMed

Interleukin-2 therapy in patients with HIV infection.

INSIGHT-ESPRIT Study Group; SILCAAT Scientific Committee, Abrams D, Lévy Y, Losso MH, Babiker A, Collins G, Cooper DA, Darbyshire J, Emery S, Fox L, Gordin F, Lane HC, Lundgren JD, Mitsuyasu R, Neaton JD, Phillips A, Routy JP, Tambussi G, Wentworth D.

N Engl J Med. 2009 Oct 15;361(16):1548-59.PMID: 19828532 [PubMed - indexed for MEDLINE]Related articles

Interleukin-2 cycling causes transient increases in high-sensitivity C-reactive protein and D-dimer that are not associated with plasma HIV-RNA levels.

Porter BO, Shen J, Kovacs JA, Davey RT, Rehm C, Lozier J, Csako G, Nghiem K, Costello R, Lane HC, Sereti I.

AIDS. 2009 Sep 24;23(15):2015-9.PMID: 19617815 [PubMed - in process]Related articles

Safety and immunogenicity of multiple and higher doses of an inactivated influenza A/H5N1 vaccine.

Beigel JH, Voell J, Huang CY, Burbelo PD, Lane HC.

J Infect Dis. 2009 Aug 15;200(4):501-9.PMID: 19569973 [PubMed - indexed for MEDLINE]Related articles

Noninvasive in vivo imaging of CD4 cells in simian-human immunodeficiency virus (SHIV)-infected nonhuman primates.

Di Mascio M, Paik CH, Carrasquillo JA, Maeng JS, Jang BS, Shin IS, Srinivasula S, Byrum R, Neria A, Kopp W, Catalfamo M, Nishimura Y, Reimann K, Martin M, Lane HC.

Blood. 2009 Jul 9;114(2):328-37. Epub 2009 May 5.PMID: 19417212 [PubMed - indexed for MEDLINE]Related articles

Identification and characterization of CRF02_AG, CRF06_cpx, and CRF09_cpx recombinant subtypes in Mali, West Africa.

Imamichi H, Koita O, Dabitao D, Dao S, Ibrah M, Sogoba D, Dewar RL, Berg SC, Jiang MK, Parta M, Washington JA, Polis MA, Lane HC, Tounkara A.

AIDS Res Hum Retroviruses. 2009 Jan;25(1):45-55.PMID: 19182920 [PubMed - indexed for MEDLINE]Related articles

Inferiority of IL-2 alone versus IL-2 with HAART in maintaining CD4 T cell counts during HAART interruption: a randomized controlled trial.

Porter BO, Anthony KB, Shen J, Hahn B, Keh CE, Maldarelli F, Blackwelder WC, Lane HC, Kovacs JA, Davey RT, Sereti I.

AIDS. 2009 Jan 14;23(2):203-12.PMID: 19098490 [PubMed - indexed for MEDLINE]Related articles

HIV infection-associated immune activation occurs by two distinct pathways that differentially affect CD4 and CD8 T cells.

Catalfamo M, Di Mascio M, Hu Z, Srinivasula S, Thaker V, Adelsberger J, Rupert A, Baseler M, Tagaya Y, Roby G, Rehm C, Follmann D, Lane HC.

Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19851-6. Epub 2008 Dec 5.PMID: 19060209 [PubMed - indexed for MEDLINE]Related articlesFree article

Inflammatory and coagulation biomarkers and mortality in patients with HIV infection.

Kuller LH, Tracy R, Belloso W, De Wit S, Drummond F, Lane HC, Ledergerber B, Lundgren J, Neuhaus J, Nixon D, Paton NI, Neaton JD; INSIGHT SMART Study Group.

PLoS Med. 2008 Oct 21;5(10):e203.PMID: 18942885 [PubMed - indexed for MEDLINE]Related articlesFree article

DAVID gene ID conversion tool.

Huang da W, Sherman BT, Stephens R, Baseler MW, Lane HC, Lempicki RA.

Bioinformation. 2008 Jul 30;2(10):428-30.PMID: 18841237 [PubMed - in process]Related articlesFree article

CD4 T cell survival after intermittent interleukin-2 therapy is predictive of an increase in the CD4 T cell count of HIV-infected patients.

Read SW, Lempicki RA, Di Mascio M, Srinivasula S, Burke R, Sachau W, Bosche M, Adelsberger JW, Sereti I, Davey RT Jr, Tavel JA, Huang CY, Issaq HJ, Fox SD, Lane HC, Kovacs JA.

J Infect Dis. 2008 Sep 15;198(6):843-50.PMID: 18684102 [PubMed - indexed for MEDLINE]Related articlesFree article

IL-15 acts as a potent inducer of CD4(+)CD25(hi) cells expressing FOXP3.

Imamichi H, Sereti I, Lane HC.

Eur J Immunol. 2008 Jun;38(6):1621-30.PMID: 18493981 [PubMed - indexed for MEDLINE]Related articlesFree article

Idiopathic CD4+ lymphocytopenia: natural history and prognostic factors.

Zonios DI, Falloon J, Bennett JE, Shaw PA, Chaitt D, Baseler MW, Adelsberger JW, Metcalf JA, Polis MA, Kovacs SJ, Kovacs JA, Davey RT, Lane HC, Masur H, Sereti I.

Blood. 2008 Jul 15;112(2):287-94. Epub 2008 May 2.PMID: 18456875 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of delays in peripheral blood processing, including cryopreservation, on detection of CD31 expression on naive CD4 T cells.

Higgins J, Metcalf JA, Stevens RA, Baseler M, Proschan M, Lane HC, Sereti I.

Clin Vaccine Immunol. 2008 Jul;15(7):1141-3. Epub 2008 Apr 30.PMID: 18448620 [PubMed - indexed for MEDLINE]Related articlesFree article

Getting personal about treating HIV.

Neaton JD, Lane HC.

Nat Med. 2008 Apr;14(4):369-70. No abstract available. PMID: 18391933 [PubMed - indexed for MEDLINE]Related articles

IL-27, a novel anti-HIV cytokine, activates multiple interferon-inducible genes in macrophages.

Imamichi T, Yang J, Huang DW, Brann TW, Fullmer BA, Adelsberger JW, Lempicki RA, Baseler MW, Lane HC.

AIDS. 2008 Jan 2;22(1):39-45.PMID: 18090390 [PubMed - indexed for MEDLINE]Related articles

DAVID Knowledgebase: a gene-centered database integrating heterogeneous gene annotation resources to facilitate high-throughput gene functional analysis.

Sherman BT, Huang da W, Tan Q, Guo Y, Bour S, Liu D, Stephens R, Baseler MW, Lane HC, Lempicki RA.

BMC Bioinformatics. 2007 Nov 2;8:426.PMID: 17980028 [PubMed - indexed for MEDLINE]Related articlesFree article

The DAVID Gene Functional Classification Tool: a novel biological module-centric algorithm to functionally analyze large gene lists.

Huang da W, Sherman BT, Tan Q, Collins JR, Alvord WG, Roayaei J, Stephens R, Baseler MW, Lane HC, Lempicki RA.

Genome Biol. 2007;8(9):R183.PMID: 17784955 [PubMed - indexed for MEDLINE]Related articlesFree article

CD4+ T cell responses to interleukin-2 administration in HIV-infected patients are directly related to the baseline level of immune activation.

Sereti I, Sklar P, Ramchandani MS, Read SW, Aggarwal V, Imamichi H, Natarajan V, Metcalf JA, Kovacs JA, Tavel J, Davey RT, Dersimonian R, Lane HC.

J Infect Dis. 2007 Sep 1;196(5):677-83. Epub 2007 Jul 16.PMID: 17674308 [PubMed - indexed for MEDLINE]Related articles

Human immunodeficiency virus type 1 derivative with 7% simian immunodeficiency virus genetic content is able to establish infections in pig-tailed macaques.

Igarashi T, Iyengar R, Byrum RA, Buckler-White A, Dewar RL, Buckler CE, Lane HC, Kamada K, Adachi A, Martin MA.

J Virol. 2007 Oct;81(20):11549-52. Epub 2007 Aug 1.PMID: 17670817 [PubMed - indexed for MEDLINE]Related articlesFree article

Comparison of the abbott 7000 and bayer 340 systems for measurement of hepatitis C virus load.

Highbarger HC, Hu Z, Kottilil S, Metcalf JA, Polis MA, Vasudevachari MB, Lane HC, Dewar RL.

J Clin Microbiol. 2007 Sep;45(9):2808-12. Epub 2007 Jun 27.PMID: 17596352 [PubMed - indexed for MEDLINE]Related articlesFree article

DAVID Bioinformatics Resources: expanded annotation database and novel algorithms to better extract biology from large gene lists.

Huang da W, Sherman BT, Tan Q, Kir J, Liu D, Bryant D, Guo Y, Stephens R, Baseler MW, Lane HC, Lempicki RA.

Nucleic Acids Res. 2007 Jul;35(Web Server issue):W169-75. Epub 2007 Jun 18.PMID: 17576678 [PubMed - indexed for MEDLINE]Related articlesFree article

Bovine apolipoprotein B-100 is a dominant immunogen in therapeutic cell populations cultured in fetal calf serum in mice and humans.

Sakamoto N, Tsuji K, Muul LM, Lawler AM, Petricoin EF, Candotti F, Metcalf JA, Tavel JA, Lane HC, Urba WJ, Fox BA, Varki A, Lunney JK, Rosenberg AS.

Blood. 2007 Jul 15;110(2):501-8. Epub 2007 Mar 29.PMID: 17395779 [PubMed - indexed for MEDLINE]Related articlesFree article

Project Phidisa: development of clinical research capacity within the South African National Defence Force.

Motumi N, Emery S, Lane HC.

Curr Opin HIV AIDS. 2007 Jan;2(1):69-76.PMID: 19372868 [PubMed - as supplied by publisher]Related articles

Loss of naïve cells accompanies memory CD4+ T-cell depletion during long-term progression to AIDS in Simian immunodeficiency virus-infected macaques.

Nishimura Y, Igarashi T, Buckler-White A, Buckler C, Imamichi H, Goeken RM, Lee WR, Lafont BA, Byrum R, Lane HC, Hirsch VM, Martin MA.

J Virol. 2007 Jan;81(2):893-902. Epub 2006 Nov 8.PMID: 17093193 [PubMed - indexed for MEDLINE]Related articlesFree article

Noninfectious papilloma virus-like particles inhibit HIV-1 replication: implications for immune control of HIV-1 infection by IL-27.

Fakruddin JM, Lempicki RA, Gorelick RJ, Yang J, Adelsberger JW, Garcia-Pineres AJ, Pinto LA, Lane HC, Imamichi T.

Blood. 2007 Mar 1;109(5):1841-9. Epub 2006 Oct 26.PMID: 17068156 [PubMed - indexed for MEDLINE]Related articlesFree article

Explaining, predicting, and treating HIV-associated CD4 cell loss: after 25 years still a puzzle.

Henry WK, Tebas P, Lane HC.

JAMA. 2006 Sep 27;296(12):1523-5. No abstract available. PMID: 17003402 [PubMed - indexed for MEDLINE]Related articles

A randomised trial of subcutaneous intermittent interleukin-2 without antiretroviral therapy in HIV-infected patients: the UK-Vanguard Study.

Youle M, Emery S, Fisher M, Nelson M, Fosdick L, Janossy G, Loveday C, Sullivan A, Herzmann C, Wand H, Davey RT Jr, Johnson MA, Tavel JA, Lane HC.

PLoS Clin Trials. 2006 May;1(1):e3. Epub 2006 May 19. Erratum in: PLoS Clin Trials. 2007 May;2(5):e23. PMID: 16871325 [PubMed]Related articlesFree article

Decreased CD127 expression on T Cells in HIV-1-infected adults receiving antiretroviral therapy with or without intermittent IL-2 therapy.

Read SW, Higgins J, Metcalf JA, Stevens RA, Rupert A, Nason MC, Lane HC, Sereti I.

J Acquir Immune Defic Syndr. 2006 Aug 15;42(5):537-44.PMID: 16837861 [PubMed - indexed for MEDLINE]Related articles

Cbl and Akt regulate CXCL8-induced and CXCR1- and CXCR2-mediated chemotaxis.

Lane HC, Anand AR, Ganju RK.

Int Immunol. 2006 Aug;18(8):1315-25. Epub 2006 Jun 23.PMID: 16798838 [PubMed - indexed for MEDLINE]Related articlesFree article

Functional correlation between a novel amino acid insertion at codon 19 in the protease of human immunodeficiency virus type 1 and polymorphism in the p1/p6 Gag cleavage site in drug resistance and replication fitness.

Brann TW, Dewar RL, Jiang MK, Shah A, Nagashima K, Metcalf JA, Falloon J, Lane HC, Imamichi T.

J Virol. 2006 Jun;80(12):6136-45.PMID: 16731952 [PubMed - indexed for MEDLINE]Related articlesFree article

Gene expression profiles in hepatitis C virus (HCV) and HIV coinfection: class prediction analyses before treatment predict the outcome of anti-HCV therapy among HIV-coinfected persons.

Lempicki RA, Polis MA, Yang J, McLaughlin M, Koratich C, Huang DW, Fullmer B, Wu L, Rehm CA, Masur H, Lane HC, Sherman KE, Fauci AS, Kottilil S.

J Infect Dis. 2006 Apr 15;193(8):1172-7. Epub 2006 Mar 13.PMID: 16544259 [PubMed - indexed for MEDLINE]Related articles

Interruption of antiretroviral therapy blunts but does not abrogate CD4 T-cell responses to interleukin-2 administration in HIV infected patients.

Keh CE, Shen JM, Hahn B, Hallahan CW, Rehm CA, Thaker V, Wynne SM, Davey RT, Lane HC, Sereti I.

AIDS. 2006 Feb 14;20(3):361-9.PMID: 16439869 [PubMed - indexed for MEDLINE]Related articles

A transcription inhibitor, actinomycin D, enhances HIV-1 replication through an interleukin-6-dependent pathway.

Imamichi T, Conrads TP, Zhou M, Liu Y, Adelsberger JW, Veenstra TD, Lane HC.

J Acquir Immune Defic Syndr. 2005 Dec 1;40(4):388-97.PMID: 16280692 [PubMed - indexed for MEDLINE]Related articles

Preferential survival of CD4+ T lymphocytes engineered with anti-human immunodeficiency virus (HIV) genes in HIV-infected individuals.

Morgan RA, Walker R, Carter CS, Natarajan V, Tavel JA, Bechtel C, Herpin B, Muul L, Zheng Z, Jagannatha S, Bunnell BA, Fellowes V, Metcalf JA, Stevens R, Baseler M, Leitman SF, Read EJ, Blaese RM, Lane HC.

Hum Gene Ther. 2005 Sep;16(9):1065-74.PMID: 16149905 [PubMed - indexed for MEDLINE]Related articles

Treatment of intestinal helminths does not reduce plasma concentrations of HIV-1 RNA in coinfected Zambian adults.

Modjarrad K, Zulu I, Redden DT, Njobvu L, Lane HC, Bentwich Z, Vermund SH.

J Infect Dis. 2005 Oct 1;192(7):1277-83. Epub 2005 Aug 25.PMID: 16136473 [PubMed - indexed for MEDLINE]Related articlesFree article

Induction of prolonged survival of CD4+ T lymphocytes by intermittent IL-2 therapy in HIV-infected patients.

Kovacs JA, Lempicki RA, Sidorov IA, Adelsberger JW, Sereti I, Sachau W, Kelly G, Metcalf JA, Davey RT Jr, Falloon J, Polis MA, Tavel J, Stevens R, Lambert L, Hosack DA, Bosche M, Issaq HJ, Fox SD, Leitman S, Baseler MW, Masur H, Di Mascio M, Dimitrov DS, Lane HC.

J Clin Invest. 2005 Aug;115(8):2139-48. Epub 2005 Jul 14.PMID: 16025158 [PubMed - indexed for MEDLINE]Related articlesFree article

In vivo expansion of CD4CD45RO-CD25 T cells expressing foxP3 in IL-2-treated HIV-infected patients.

Sereti I, Imamichi H, Natarajan V, Imamichi T, Ramchandani MS, Badralmaa Y, Berg SC, Metcalf JA, Hahn BK, Shen JM, Powers A, Davey RT, Kovacs JA, Shevach EM, Lane HC.

J Clin Invest. 2005 Jul;115(7):1839-47. Epub 2005 Jun 2.PMID: 15937547 [PubMed - indexed for MEDLINE]Related articlesFree article

Reports on nevirapine threaten public health.

Lane HC, Folkers GK, Fauci AS.

Nat Med. 2005 Mar;11(3):245. No abstract available. PMID: 15746930 [PubMed - indexed for MEDLINE]Related articles

Effects of lymphocyte isolation and timing of processing on detection of CD127 expression on T cells in human immunodeficiency virus-infected patients.

Higgins J, Metcalf JA, Stevens RA, Baseler M, Nason MC, Lane HC, Sereti I.

Clin Diagn Lab Immunol. 2005 Jan;12(1):228-30.PMID: 15643013 [PubMed - indexed for MEDLINE]Related articlesFree article

BAY 50-4798, a novel, high-affinity receptor-specific recombinant interleukin-2 analog, induces dose-dependent increases in CD25 expression and proliferation among unstimulated, human peripheral blood mononuclear cells in vitro.

Matthews L, Chapman S, Ramchandani MS, Lane HC, Davey RT Jr, Sereti I.

Clin Immunol. 2004 Dec;113(3):248-55.PMID: 15507389 [PubMed - indexed for MEDLINE]Related articles

CD4 cell response to 3 doses of subcutaneous interleukin 2: meta-analysis of 3 Vanguard studies.

Arduino RC, Nannini EC, Rodriguez-Barradas M, Schrader S, Losso M, Ruxrungtham K, Allende MC, Emery S, Fosdick L, Neaton J, Tavel JA, Davey RT, Lane HC; Evaluation of Subcutaneous Proleukin in a Randomized International Trial (ESPRIT) Vanguard Group; ESPRIT Executive Committee.

Clin Infect Dis. 2004 Jul 1;39(1):115-22. Epub 2004 Jun 14.PMID: 15206062 [PubMed - indexed for MEDLINE]Related articles

IL-2-induced CD4+ T-cell expansion in HIV-infected patients is associated with long-term decreases in T-cell proliferation.

Sereti I, Anthony KB, Martinez-Wilson H, Lempicki R, Adelsberger J, Metcalf JA, Hallahan CW, Follmann D, Davey RT, Kovacs JA, Lane HC.

Blood. 2004 Aug 1;104(3):775-80. Epub 2004 Apr 13.PMID: 15090457 [PubMed - indexed for MEDLINE]Related articlesFree article

Induction and maintenance therapy with intermittent interleukin-2 in HIV-1 infection.

Farel CE, Chaitt DG, Hahn BK, Tavel JA, Kovacs JA, Polis MA, Masur H, Follmann DA, Lane HC, Davey RT Jr.

Blood. 2004 May 1;103(9):3282-6. Epub 2004 Jan 15.PMID: 14726376 [PubMed - indexed for MEDLINE]Related articlesFree article

Macrophage-tropic simian/human immunodeficiency virus chimeras use CXCR4, not CCR5, for infections of rhesus macaque peripheral blood mononuclear cells and alveolar macrophages.

Igarashi T, Donau OK, Imamichi H, Dumaurier MJ, Sadjadpour R, Plishka RJ, Buckler-White A, Buckler C, Suffredini AF, Lane HC, Moore JP, Martin MA.

J Virol. 2003 Dec;77(24):13042-52.PMID: 14645561 [PubMed - indexed for MEDLINE]Related articlesFree article

A comparison of microLC/electrospray ionization-MS and GC/MS for the measurement of stable isotope enrichment from a [2H2]-glucose metabolic probe in T-cell genomic DNA.

Fox SD, Lempicki RA, Hosack DA, Baseler MW, Kovacs JA, Lane HC, Veenstra TD, Issaq HJ.

Anal Chem. 2003 Dec 1;75(23):6517-22.PMID: 14640722 [PubMed - indexed for MEDLINE]Related articles

Increases in CD4+ T lymphocytes occur without increases in thymic size in HIV-infected subjects receiving interleukin-2 therapy.

Lu AC, Jones EC, Chow C, Miller KD, Herpin B, Rock-Kress D, Metcalf JA, Lane HC, Kovacs JA.

J Acquir Immune Defic Syndr. 2003 Nov 1;34(3):299-303.PMID: 14600575 [PubMed - indexed for MEDLINE]Related articles

Identifying biological themes within lists of genes with EASE.

Hosack DA, Dennis G Jr, Sherman BT, Lane HC, Lempicki RA.

Genome Biol. 2003;4(10):R70. Epub 2003 Sep 11.PMID: 14519205 [PubMed - indexed for MEDLINE]Related articlesFree article

A randomized, double-blinded, placebo-controlled trial of intermittent administration of interleukin-2 and prednisone in subjects infected with human immunodeficiency virus.

Tavel JA, Sereti I, Walker RE, Hahn B, Kovacs JA, Jagannatha S, Davey RT Jr, Falloon J, Polis MA, Masur H, Metcalf JA, Stevens R, Rupert A, Baseler M, Lane HC.

J Infect Dis. 2003 Aug 15;188(4):531-6. Epub 2003 Jul 31.PMID: 12898439 [PubMed - indexed for MEDLINE]Related articles

Incomplete CD4 T cell recovery in HIV-1 infection after 12 months of highly active antiretroviral therapy is associated with ongoing increased CD4 T cell activation and turnover.

Anthony KB, Yoder C, Metcalf JA, DerSimonian R, Orenstein JM, Stevens RA, Falloon J, Polis MA, Lane HC, Sereti I.

J Acquir Immune Defic Syndr. 2003 Jun 1;33(2):125-33.PMID: 12794543 [PubMed - indexed for MEDLINE]Related articles

Severe acute respiratory syndrome: providing care in the face of uncertainty.

Masur H, Emanuel E, Lane HC.

JAMA. 2003 Jun 4;289(21):2861-3. Epub 2003 May 6. No abstract available. PMID: 12734146 [PubMed - indexed for MEDLINE]Related articles