PubMed

Reassessing the role of HLA-DRB3 T-cell responses: Evidence for significant expression and complementary antigen presentation.

Faner R, James E, Huston L, Pujol-Borrel R, Kwok WW, Juan M.

Eur J Immunol. 2009 Oct 14. [Epub ahead of print]PMID: 19830726 [PubMed - as supplied by publisher]Related articles

Tumor antigen-specific FOXP3+ CD4 T cells identified in human metastatic melanoma: peptide vaccination results in selective expansion of Th1-like counterparts.

Jandus C, Bioley G, Dojcinovic D, Derré L, Baitsch L, Wieckowski S, Rufer N, Kwok WW, Tiercy JM, Luescher IF, Speiser DE, Romero P.

Cancer Res. 2009 Oct 15;69(20):8085-93. Epub 2009 Oct 6.PMID: 19808957 [PubMed - in process]Related articles

The binding of antigenic peptides to HLA-DR is influenced by interactions between pocket 6 and pocket 9.

James EA, Moustakas AK, Bui J, Nouv R, Papadopoulos GK, Kwok WW.

J Immunol. 2009 Sep 1;183(5):3249-58. Epub 2009 Jul 31.PMID: 19648278 [PubMed - indexed for MEDLINE]Related articles

Lineages of human T-cell clones, including T helper 17/T helper 1 cells, isolated at different stages of anti-factor VIII immune responses.

Ettinger RA, James EA, Kwok WW, Thompson AR, Pratt KP.

Blood. 2009 Aug 13;114(7):1423-8. Epub 2009 Jun 23.PMID: 19549986 [PubMed - indexed for MEDLINE]Related articles

H5N1 strain-specific hemagglutinin CD4+ T cell epitopes restricted by HLA DR4.

Yang J, Gebe JA, Huston L, James E, Tan V, Yue BB, Nepom GT, Kwok WW.

Vaccine. 2009 Jun 12;27(29):3862-9. Epub 2009 May 3.PMID: 19446935 [PubMed - indexed for MEDLINE]Related articles

Functional islet-specific Treg can be generated from CD4+CD25- T cells of healthy and type 1 diabetic subjects.

Long SA, Walker MR, Rieck M, James E, Kwok WW, Sanda S, Pihoker C, Greenbaum C, Nepom GT, Buckner JH.

Eur J Immunol. 2009 Feb;39(2):612-20.PMID: 19180473 [PubMed - indexed for MEDLINE]Related articlesFree article

Searching immunodominant epitopes prior to epidemic: HLA class II-restricted SARS-CoV spike protein epitopes in unexposed individuals.

Yang J, James E, Roti M, Huston L, Gebe JA, Kwok WW.

Int Immunol. 2009 Jan;21(1):63-71. Epub 2008 Dec 2.PMID: 19050106 [PubMed - indexed for MEDLINE]Related articles

The anthrax vaccine adsorbed vaccine generates protective antigen (PA)-Specific CD4+ T cells with a phenotype distinct from that of naive PA T cells.

Kwok WW, Yang J, James E, Bui J, Huston L, Wiesen AR, Roti M.

Infect Immun. 2008 Oct;76(10):4538-45. Epub 2008 Aug 4.PMID: 18678674 [PubMed - indexed for MEDLINE]Related articlesFree article

Low-affinity major histocompatibility complex-binding peptides in type 1 diabetes.

James EA, Kwok WW.

Diabetes. 2008 Jul;57(7):1788-9. No abstract available. PMID: 18586912 [PubMed - indexed for MEDLINE]Related articlesFree article

CD4+ T cells from type 1 diabetic and healthy subjects exhibit different thresholds of activation to a naturally processed proinsulin epitope.

Yang J, Danke N, Roti M, Huston L, Greenbaum C, Pihoker C, James E, Kwok WW.

J Autoimmun. 2008 Aug;31(1):30-41. Epub 2008 Apr 2.PMID: 18385016 [PubMed - indexed for MEDLINE]Related articles

Identification and in vitro expansion of functional antigen-specific CD25+ FoxP3+ regulatory T cells in hepatitis C virus infection.

Ebinuma H, Nakamoto N, Li Y, Price DA, Gostick E, Levine BL, Tobias J, Kwok WW, Chang KM.

J Virol. 2008 May;82(10):5043-53. Epub 2008 Mar 12.PMID: 18337568 [PubMed - indexed for MEDLINE]Related articlesFree article

Definition of the peptide binding motif within DRB1*1401 restricted epitopes by peptide competition and structural modeling.

James EA, Moustakas AK, Berger D, Huston L, Papadopoulos GK, Kwok WW.

Mol Immunol. 2008 May;45(9):2651-9. Epub 2008 Feb 13.PMID: 18276010 [PubMed - indexed for MEDLINE]Related articles

Healthy human subjects have CD4+ T cells directed against H5N1 influenza virus.

Roti M, Yang J, Berger D, Huston L, James EA, Kwok WW.

J Immunol. 2008 Feb 1;180(3):1758-68.PMID: 18209073 [PubMed - indexed for MEDLINE]Related articlesFree article

Searching for borrelial T cell epitopes associated with antibiotic-refractory Lyme arthritis.

Drouin EE, Glickstein L, Kwok WW, Nepom GT, Steere AC.

Mol Immunol. 2008 Apr;45(8):2323-32. Epub 2008 Jan 11. Erratum in: Mol Immunol. 2008 Jul;45(12):3508. PMID: 18191206 [PubMed - indexed for MEDLINE]Related articlesFree article

High level of PD-1 expression on hepatitis C virus (HCV)-specific CD8+ and CD4+ T cells during acute HCV infection, irrespective of clinical outcome.

Kasprowicz V, Schulze Zur Wiesch J, Kuntzen T, Nolan BE, Longworth S, Berical A, Blum J, McMahon C, Reyor LL, Elias N, Kwok WW, McGovern BG, Freeman G, Chung RT, Klenerman P, Lewis-Ximenez L, Walker BD, Allen TM, Kim AY, Lauer GM.

J Virol. 2008 Mar;82(6):3154-60. Epub 2007 Dec 26.PMID: 18160439 [PubMed - indexed for MEDLINE]Related articlesFree article

T-cell responses over time in a mild hemophilia A inhibitor subject: epitope identification and transient immunogenicity of the corresponding self-peptide.

James EA, Kwok WW, Ettinger RA, Thompson AR, Pratt KP.

J Thromb Haemost. 2007 Dec;5(12):2399-407.PMID: 18034765 [PubMed - indexed for MEDLINE]Related articles

Tracking antigen specific CD4+ T-cells with soluble MHC molecules.

Gebe JA, Kwok WW.

Methods Mol Med. 2007;136:39-50.PMID: 17983139 [PubMed - indexed for MEDLINE]Related articles

Decline in the frequencies of Borrelia burgdorferi OspA161 175-specific T cells after antibiotic therapy in HLA-DRB1*0401-positive patients with antibiotic-responsive or antibiotic-refractory lyme arthritis.

Kannian P, Drouin EE, Glickstein L, Kwok WW, Nepom GT, Steere AC.

J Immunol. 2007 Nov 1;179(9):6336-42.PMID: 17947711 [PubMed - indexed for MEDLINE]Related articlesFree article

Tetramer-guided epitope mapping reveals broad, individualized repertoires of tetanus toxin-specific CD4+ T cells and suggests HLA-based differences in epitope recognition.

James EA, Bui J, Berger D, Huston L, Roti M, Kwok WW.

Int Immunol. 2007 Nov;19(11):1291-301. Epub 2007 Sep 30.PMID: 17906339 [PubMed - indexed for MEDLINE]Related articlesFree article

Human homologues of a Borrelia T cell epitope associated with antibiotic-refractory Lyme arthritis.

Drouin EE, Glickstein L, Kwok WW, Nepom GT, Steere AC.

Mol Immunol. 2008 Jan;45(1):180-9. Epub 2007 Jun 6.PMID: 17555819 [PubMed - indexed for MEDLINE]Related articlesFree article

Dominance and diversity in the primary human CD4 T cell response to replication-competent vaccinia virus.

Jing L, Chong TM, Byrd B, McClurkan CL, Huang J, Story BT, Dunkley KM, Aldaz-Carroll L, Eisenberg RJ, Cohen GH, Kwok WW, Sette A, Koelle DM.

J Immunol. 2007 May 15;178(10):6374-86.PMID: 17475867 [PubMed - indexed for MEDLINE]Related articlesFree article

Potential of an altered peptide ligand of lipocalin allergen Bos d 2 for peptide immunotherapy.

Kinnunen T, Jutila K, Kwok WW, Rytkönen-Nissinen M, Immonen A, Saarelainen S, Närvänen A, Taivainen A, Virtanen T.

J Allergy Clin Immunol. 2007 Apr;119(4):965-72. Epub 2007 Mar 1.PMID: 17335888 [PubMed - indexed for MEDLINE]Related articles

CD8+ suppressor-mediated regulation of human CD4+ T cell responses to glutamic acid decarboxylase 65.

James EA, Kwok WW.

Eur J Immunol. 2007 Jan;37(1):78-86.PMID: 17163450 [PubMed - indexed for MEDLINE]Related articles

Detection of low avidity desmoglein 3-reactive T cells in pemphigus vulgaris using HLA-DR beta 1*0402 tetramers.

Veldman C, Eming R, Wolff-Franke S, Sonderstrup G, Kwok WW, Hertl M.

Clin Immunol. 2007 Mar;122(3):330-7. Epub 2006 Nov 17.PMID: 17113829 [PubMed - indexed for MEDLINE]Related articles

Melan-A/MART-1-specific CD4 T cells in melanoma patients: identification of new epitopes and ex vivo visualization of specific T cells by MHC class II tetramers.

Bioley G, Jandus C, Tuyaerts S, Rimoldi D, Kwok WW, Speiser DE, Tiercy JM, Thielemans K, Cerottini JC, Romero P.

J Immunol. 2006 Nov 15;177(10):6769-79.PMID: 17082590 [PubMed - indexed for MEDLINE]Related articlesFree article

HLA-DQ2 and -DQ8 signatures of gluten T cell epitopes in celiac disease.

Tollefsen S, Arentz-Hansen H, Fleckenstein B, Molberg O, Ráki M, Kwok WW, Jung G, Lundin KE, Sollid LM.

J Clin Invest. 2006 Aug;116(8):2226-36. Epub 2006 Jul 27.PMID: 16878175 [PubMed - indexed for MEDLINE]Related articlesFree article

Multiplex mapping of CD4 T cell epitopes using class II tetramers.

Yang J, James EA, Huston L, Danke NA, Liu AW, Kwok WW.

Clin Immunol. 2006 Jul;120(1):21-32. Epub 2006 May 4.PMID: 16677863 [PubMed - indexed for MEDLINE]Related articles

Allergen-specific MHC class II tetramer+ cells are detectable in allergic, but not in nonallergic, individuals.

Macaubas C, Wahlstrom J, Galvão da Silva AP, Forsthuber TG, Sønderstrup G, Kwok WW, DeKruyff RH, Umetsu DT.

J Immunol. 2006 Apr 15;176(8):5069-77.PMID: 16585604 [PubMed - indexed for MEDLINE]Related articlesFree article

Antibiotic-refractory Lyme arthritis is associated with HLA-DR molecules that bind a Borrelia burgdorferi peptide.

Steere AC, Klitz W, Drouin EE, Falk BA, Kwok WW, Nepom GT, Baxter-Lowe LA.

J Exp Med. 2006 Apr 17;203(4):961-71. Epub 2006 Apr 3.PMID: 16585267 [PubMed - indexed for MEDLINE]Related articlesFree article

Islet-specific glucose-6-phosphatase catalytic subunit-related protein-reactive CD4+ T cells in human subjects.

Yang J, Danke NA, Berger D, Reichstetter S, Reijonen H, Greenbaum C, Pihoker C, James EA, Kwok WW.

J Immunol. 2006 Mar 1;176(5):2781-9.PMID: 16493034 [PubMed - indexed for MEDLINE]Related articlesFree article

Cytotoxic herpes simplex type 2-specific, DQ0602-restricted CD4 T+-cell clones show alloreactivity to DQ0601.

Reichstetter S, Standifer NE, Geubtner KA, Liu AW, Agar SL, Kwok WW.

Immunology. 2006 Mar;117(3):350-7.PMID: 16476054 [PubMed - indexed for MEDLINE]Related articlesFree article

Allelic variation in key peptide-binding pockets discriminates between closely related diabetes-protective and diabetes-susceptible HLA-DQB1*06 alleles.

Ettinger RA, Papadopoulos GK, Moustakas AK, Nepom GT, Kwok WW.

J Immunol. 2006 Feb 1;176(3):1988-98.PMID: 16424231 [PubMed - indexed for MEDLINE]Related articlesFree article

GAD65- and proinsulin-specific CD4+ T-cells detected by MHC class II tetramers in peripheral blood of type 1 diabetes patients and at-risk subjects.

Oling V, Marttila J, Ilonen J, Kwok WW, Nepom G, Knip M, Simell O, Reijonen H.

J Autoimmun. 2005 Nov;25(3):235-43. Epub 2005 Nov 2. Erratum in: J Autoimmun. 2006 Aug;27(1):69. PMID: 16263242 [PubMed - indexed for MEDLINE]Related articles

Comparative study of GAD65-specific CD4+ T cells in healthy and type 1 diabetic subjects.

Danke NA, Yang J, Greenbaum C, Kwok WW.

J Autoimmun. 2005 Dec;25(4):303-11. Epub 2005 Oct 24.PMID: 16249070 [PubMed - indexed for MEDLINE]Related articles

The heat shock protein Hsp70 enhances antigen-specific proliferation of human CD4+ memory T cells.

Haug M, Dannecker L, Schepp CP, Kwok WW, Wernet D, Buckner JH, Kalbacher H, Dannecker GE, Holzer U.

Eur J Immunol. 2005 Nov;35(11):3163-72.PMID: 16245362 [PubMed - indexed for MEDLINE]Related articles

Immunomodulatory potential of heteroclitic analogs of the dominant T-cell epitope of lipocalin allergen Bos d 2 on specific T cells.

Kinnunen T, Kwok WW, Närvänen A, Rytkönen-Nissinen M, Immonen A, Saarelainen S, Taivainen A, Virtanen T.

Int Immunol. 2005 Dec;17(12):1573-81. Epub 2005 Oct 12.PMID: 16221722 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression of HLA-DP0401 molecules for identification of DP0401 restricted antigen specific T cells.

Yang J, Huston L, Berger D, Danke NA, Liu AW, Disis ML, Kwok WW.

J Clin Immunol. 2005 Sep;25(5):428-36.PMID: 16160911 [PubMed - indexed for MEDLINE]Related articles

Persistence of herpes simplex virus type 2 VP16-specific CD4+ T cells.

Danke NA, Koelle DM, Kwok WW.

Hum Immunol. 2005 Jul;66(7):777-87.PMID: 16112025 [PubMed - indexed for MEDLINE]Related articles

Functional avidity directs T-cell fate in autoreactive CD4+ T cells.

Mallone R, Kochik SA, Reijonen H, Carson B, Ziegler SF, Kwok WW, Nepom GT.

Blood. 2005 Oct 15;106(8):2798-805. Epub 2005 Jul 19.PMID: 16030184 [PubMed - indexed for MEDLINE]Related articlesFree article

Clustering of T cell ligands on artificial APC membranes influences T cell activation and protein kinase C theta translocation to the T cell plasma membrane.

Giannoni F, Barnett J, Bi K, Samodal R, Lanza P, Marchese P, Billetta R, Vita R, Klein MR, Prakken B, Kwok WW, Sercarz E, Altman A, Albani S.

J Immunol. 2005 Mar 15;174(6):3204-11.PMID: 15749850 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression of cutaneous lymphocyte-associated antigen and E-selectin ligand by circulating human memory CD4+ T lymphocytes specific for herpes simplex virus type 2.

González JC, Kwok WW, Wald A, McClurkan CL, Huang J, Koelle DM.

J Infect Dis. 2005 Jan 15;191(2):243-54. Epub 2004 Dec 15.PMID: 15609235 [PubMed - indexed for MEDLINE]Related articlesFree article

In vivo biotinylation of the major histocompatibility complex (MHC) class II/peptide complex by coexpression of BirA enzyme for the generation of MHC class II/tetramers.

Yang J, Jaramillo A, Shi R, Kwok WW, Mohanakumar T.

Hum Immunol. 2004 Jul;65(7):692-9.PMID: 15301857 [PubMed - indexed for MEDLINE]Related articles

GAD65-specific CD4+ T-cells with high antigen avidity are prevalent in peripheral blood of patients with type 1 diabetes.

Reijonen H, Mallone R, Heninger AK, Laughlin EM, Kochik SA, Falk B, Kwok WW, Greenbaum C, Nepom GT.

Diabetes. 2004 Aug;53(8):1987-94.PMID: 15277377 [PubMed - indexed for MEDLINE]Related articlesFree article

Extensive replicative capacity of human central memory T cells.

Maus MV, Kovacs B, Kwok WW, Nepom GT, Schlienger K, Riley JL, Allman D, Finkel TH, June CH.

J Immunol. 2004 Jun 1;172(11):6675-83.PMID: 15153483 [PubMed - indexed for MEDLINE]Related articlesFree article

Autoreactive T cells in healthy individuals.

Danke NA, Koelle DM, Yee C, Beheray S, Kwok WW.

J Immunol. 2004 May 15;172(10):5967-72.PMID: 15128778 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential recognition and activation thresholds in human autoreactive GAD-specific T-cells.

Mallone R, Kochik SA, Laughlin EM, Gersuk VH, Reijonen H, Kwok WW, Nepom GT.

Diabetes. 2004 Apr;53(4):971-7.PMID: 15047612 [PubMed - indexed for MEDLINE]Related articlesFree article

HLA class II polymorphisms determine responses to bacterial superantigens.

Llewelyn M, Sriskandan S, Peakman M, Ambrozak DR, Douek DC, Kwok WW, Cohen J, Altmann DM.

J Immunol. 2004 Feb 1;172(3):1719-26.PMID: 14734754 [PubMed - indexed for MEDLINE]Related articlesFree article

Detection of CD4+ autoreactive T cells in T1D using HLA class II tetramers.

Reijonen H, Kwok WW, Nepom GT.

Ann N Y Acad Sci. 2003 Nov;1005:82-7.PMID: 14679042 [PubMed - indexed for MEDLINE]Related articles

Direct killing of Epstein-Barr virus (EBV)-infected B cells by CD4 T cells directed against the EBV lytic protein BHRF1.

Landais E, Saulquin X, Scotet E, Trautmann L, Peyrat MA, Yates JL, Kwok WW, Bonneville M, Houssaint E.

Blood. 2004 Feb 15;103(4):1408-16. Epub 2003 Oct 16.PMID: 14563644 [PubMed - indexed for MEDLINE]Related articlesFree article

Diminished proliferation of human immunodeficiency virus-specific CD4+ T cells is associated with diminished interleukin-2 (IL-2) production and is recovered by exogenous IL-2.

Iyasere C, Tilton JC, Johnson AJ, Younes S, Yassine-Diab B, Sekaly RP, Kwok WW, Migueles SA, Laborico AC, Shupert WL, Hallahan CW, Davey RT Jr, Dybul M, Vogel S, Metcalf J, Connors M.

J Virol. 2003 Oct;77(20):10900-9.PMID: 14512540 [PubMed - indexed for MEDLINE]Related articlesFree article