PubMed

The Liver X-Receptor (LXR) gene promoter is hypermethylated in a mouse model of prenatal protein restriction.

van Straten EM, Bloks VW, Huijkman NC, Baller JF, van Meer H, Lutjohann D, Kuipers F, Plosch T.

Am J Physiol Regul Integr Comp Physiol. 2009 Nov 4. [Epub ahead of print]PMID: 19889862 [PubMed - as supplied by publisher]Related articles

Metabolic responses to long-term pharmacological inhibition of CB(1)-receptor activity in mice in relation to dietary fat composition.

Koolman AH, Bloks VW, Oosterveer MH, Jonas I, Kuipers F, Sauer PJ, van Dijk G.

Int J Obes (Lond). 2009 Oct 20. [Epub ahead of print]PMID: 19844210 [PubMed - as supplied by publisher]Related articles

Fenofibrate simultaneously induces hepatic fatty acid oxidation, synthesis and elongation in mice.

Oosterveer MH, Grefhorst A, van Dijk TH, Havinga R, Staels B, Kuipers F, Groen AK, Reijngoud DJ.

J Biol Chem. 2009 Oct 2. [Epub ahead of print]PMID: 19801551 [PubMed - as supplied by publisher]Related articlesFree article

Alterations in Brain Cholesterol Metabolism in the APPSLxPS1mut mouse, a Model for Alzheimer's Disease.

Vanmierlo T, Bloks VW, van Vark-van der Zee LC, Rutten K, Kerksiek A, Friedrichs S, Sijbrands E, Steinbusch HW, Kuipers F, Lütjohann D, Mulder M.

J Alzheimers Dis. 2009 Sep 11. [Epub ahead of print]PMID: 19749424 [PubMed - as supplied by publisher]Related articles

Fetal Liver X Receptor activation acutely induces lipogenesis, but does not affect plasma lipid response to a high-fat diet in adult mice.

van Straten E, van Meer H, Huijkman N, van Dijk TH, Baller JF, Verkade HJ, Kuipers F, Plosch T.

Am J Physiol Endocrinol Metab. 2009 Sep 1. [Epub ahead of print]PMID: 19724022 [PubMed - as supplied by publisher]Related articles

Scavenger receptor BI (SR-BI) facilitates hepatic very low density lipoprotein (VLDL) production in mice.

Wiersma H, Nijstad N, Gautier T, Iqbal J, Kuipers F, Hussain MM, Tietge UJ.

J Lipid Res. 2009 Sep 1. [Epub ahead of print]PMID: 19723664 [PubMed - as supplied by publisher]Related articlesFree article

Regulatory enzymes of mitochondrial beta-oxidation as targets for treatment of the metabolic syndrome.

Schreurs M, Kuipers F, van der Leij FR.

Obes Rev. 2009 Aug 20. [Epub ahead of print]PMID: 19694967 [PubMed - as supplied by publisher]Related articles

Liver X receptor activation restores memory in aged AD mice without reducing amyloid.

Vanmierlo T, Rutten K, Dederen J, Bloks VW, van Vark-van der Zee LC, Kuipers F, Kiliaan A, Blokland A, Sijbrands EJ, Steinbusch H, Prickaerts J, Lütjohann D, Mulder M.

Neurobiol Aging. 2009 Aug 10. [Epub ahead of print]PMID: 19674815 [PubMed - as supplied by publisher]Related articles

Scavenger receptor class B type I mediates biliary cholesterol secretion independent of ATP-binding cassette transporter g5/g8 in mice.

Wiersma H, Gatti A, Nijstad N, Oude Elferink RP, Kuipers F, Tietge UJ.

Hepatology. 2009 Oct;50(4):1263-72.PMID: 19637290 [PubMed - indexed for MEDLINE]Related articles

Reduced fecal sterol excretion in subjects with familial hypoalphalipoproteinemia.

Harchaoui KE, Franssen R, Hovingh GK, Bisoendial RJ, Stellaard F, Kuipers F, Kastelein JJ, Kuivenhoven JA, Stroes ES, Groen AK.

Atherosclerosis. 2009 Jun 18. [Epub ahead of print]PMID: 19616211 [PubMed - as supplied by publisher]Related articles

High fat feeding induces hepatic fatty acid elongation in mice.

Oosterveer MH, van Dijk TH, Tietge UJ, Boer T, Havinga R, Stellaard F, Groen AK, Kuipers F, Reijngoud DJ.

PLoS One. 2009 Jun 26;4(6):e6066.PMID: 19557132 [PubMed - indexed for MEDLINE]Related articlesFree article

Soraphen, an inhibitor of the acetyl-CoA carboxylase system, improves peripheral insulin sensitivity in mice fed a high-fat diet.

Schreurs M, van Dijk TH, Gerding A, Havinga R, Reijngoud DJ, Kuipers F.

Diabetes Obes Metab. 2009 Oct;11(10):987-91. Epub 2009 Jun 10.PMID: 19519866 [PubMed - in process]Related articles

PPARd activation leads to increased trans intestinal cholesterol efflux.

Vrins CL, Van der Velde AE, Van den Oever K, Levels JH, Huet S, Oude Elferink RP, Kuipers F, Groen AK.

J Lipid Res. 2009 May 13. [Epub ahead of print]PMID: 19439761 [PubMed - as supplied by publisher]Related articlesFree article

Activation of the liver X receptor stimulates trans-intestinal excretion of plasma cholesterol.

van der Veen JN, van Dijk TH, Vrins CL, van Meer H, Havinga R, Bijsterveld K, Tietge UJ, Groen AK, Kuipers F.

J Biol Chem. 2009 Jul 17;284(29):19211-9. Epub 2009 May 5.PMID: 19416968 [PubMed - indexed for MEDLINE]Related articles

Non-alcoholic fatty liver disease is associated with cardiovascular disease risk markers.

Edens MA, Kuipers F, Stolk RP.

Obes Rev. 2009 Jul;10(4):412-9. Epub 2009 Apr 21. Review.PMID: 19413701 [PubMed - indexed for MEDLINE]Related articles

Combining simvastatin with the farnesyltransferase inhibitor tipifarnib results in an enhanced cytotoxic effect in a subset of primary CD34+ acute myeloid leukemia samples.

van der Weide K, de Jonge-Peeters SD, Kuipers F, de Vries EG, Vellenga E.

Clin Cancer Res. 2009 May 1;15(9):3076-83. Epub 2009 Apr 21.PMID: 19383813 [PubMed - indexed for MEDLINE]Related articles

Lack of Abcg1 results in decreased plasma HDL cholesterol levels and increased biliary cholesterol secretion in mice fed a high cholesterol diet.

Wiersma H, Nijstad N, de Boer JF, Out R, Hogewerf W, Van Berkel TJ, Kuipers F, Tietge UJ.

Atherosclerosis. 2009 Sep;206(1):141-7. Epub 2009 Mar 11.PMID: 19339012 [PubMed - in process]Related articles

Nuclear receptors: mediators and modifiers of inflammation-induced cholestasis.

Mulder J, Karpen SJ, Tietge UJ, Kuipers F.

Front Biosci. 2009 Jan 1;14:2599-630. Review.PMID: 19273222 [PubMed - indexed for MEDLINE]Related articles

Adiponectin levels correlate with the severity of hypertriglyceridaemia in glycogen storage disease Ia.

Bandsma RH, Smit GP, Reijngoud DJ, Kuipers F.

J Inherit Metab Dis. 2009 Mar 11. [Epub ahead of print]PMID: 19267215 [PubMed - as supplied by publisher]Related articles

Proprotein convertase subtilisin kexin type 9 null mice are protected from postprandial triglyceridemia.

Le May C, Kourimate S, Langhi C, Chétiveaux M, Jarry A, Comera C, Collet X, Kuipers F, Krempf M, Cariou B, Costet P.

Arterioscler Thromb Vasc Biol. 2009 May;29(5):684-90. Epub 2009 Mar 5.PMID: 19265033 [PubMed - indexed for MEDLINE]Related articles

Hepatic SR-BI, not endothelial lipase, expression determines biliary cholesterol secretion in mice.

Wiersma H, Gatti A, Nijstad N, Kuipers F, Tietge UJ.

J Lipid Res. 2009 Aug;50(8):1571-80. Epub 2009 Feb 28.PMID: 19252221 [PubMed - indexed for MEDLINE]Related articles

An increased flux through the glucose 6-phosphate pool in enterocytes delays glucose absorption in Fxr-/- mice.

van Dijk TH, Grefhorst A, Oosterveer MH, Bloks VW, Staels B, Reijngoud DJ, Kuipers F.

J Biol Chem. 2009 Apr 17;284(16):10315-23. Epub 2009 Feb 9.PMID: 19204003 [PubMed - indexed for MEDLINE]Related articles

Role of bile acids and bile acid receptors in metabolic regulation.

Lefebvre P, Cariou B, Lien F, Kuipers F, Staels B.

Physiol Rev. 2009 Jan;89(1):147-91. Review.PMID: 19126757 [PubMed - indexed for MEDLINE]Related articles

Low retinol levels differentially modulate bile salt-induced expression of human and mouse hepatic bile salt transporters.

Hoeke MO, Plass JR, Heegsma J, Geuken M, van Rijsbergen D, Baller JF, Kuipers F, Moshage H, Jansen PL, Faber KN.

Hepatology. 2009 Jan;49(1):151-9.PMID: 19111018 [PubMed - indexed for MEDLINE]Related articles

Altered bile composition after liver transplantation is associated with the development of nonanastomotic biliary strictures.

Buis CI, Geuken E, Visser DS, Kuipers F, Haagsma EB, Verkade HJ, Porte RJ.

J Hepatol. 2009 Jan;50(1):69-79. Epub 2008 Oct 7.PMID: 19012987 [PubMed - indexed for MEDLINE]Related articles

Variability in responsiveness to lovastatin of the primitive CD34+ AML subfraction compared to normal CD34+ cells.

de Jonge-Peeters SD, van der Weide K, Kuipers F, Sluiter WJ, de Vries EG, Vellenga E.

Ann Hematol. 2009 Jun;88(6):573-80. Epub 2008 Nov 11.PMID: 19002460 [PubMed - indexed for MEDLINE]Related articles

Exclusive MRI-based tandem and colpostats reconstruction in gynaecological brachytherapy treatment planning.

Perez-Calatayud J, Kuipers F, Ballester F, Granero D, Richart J, Rodriguez S, Tormo A, Santos M.

Radiother Oncol. 2009 May;91(2):181-6. Epub 2008 Oct 22.PMID: 18947893 [PubMed - indexed for MEDLINE]Related articles

Pharmacological activation of LXR in utero directly influences ABC transporter expression and function in mice but does not affect adult cholesterol metabolism.

van Straten EM, Huijkman NC, Baller JF, Kuipers F, Plösch T.

Am J Physiol Endocrinol Metab. 2008 Dec;295(6):E1341-8. Epub 2008 Oct 7.PMID: 18840761 [PubMed - indexed for MEDLINE]Related articles

Association of plasma phytosterol concentrations with incident coronary heart disease Data from the CORA study, a case-control study of coronary artery disease in women.

Windler E, Zyriax BC, Kuipers F, Linseisen J, Boeing H.

Atherosclerosis. 2009 Mar;203(1):284-90. Epub 2008 Jun 26.PMID: 18656878 [PubMed - indexed for MEDLINE]Related articles

Lxralpha deficiency hampers the hepatic adaptive response to fasting in mice.

Oosterveer MH, van Dijk TH, Grefhorst A, Bloks VW, Havinga R, Kuipers F, Reijngoud DJ.

J Biol Chem. 2008 Sep 12;283(37):25437-45. Epub 2008 Jul 8.PMID: 18611859 [PubMed - indexed for MEDLINE]Related articlesFree article

Chipping away at gallstones.

Kuipers F, Groen AK.

Nat Med. 2008 Jul;14(7):715-6. No abstract available. PMID: 18607368 [PubMed - indexed for MEDLINE]Related articles

Regulation of bile acid synthesis by the nuclear receptor Rev-erbalpha.

Duez H, van der Veen JN, Duhem C, Pourcet B, Touvier T, Fontaine C, Derudas B, Baugé E, Havinga R, Bloks VW, Wolters H, van der Sluijs FH, Vennström B, Kuipers F, Staels B.

Gastroenterology. 2008 Aug;135(2):689-98. Epub 2008 May 15.PMID: 18565334 [PubMed - indexed for MEDLINE]Related articles

Increased de novo lipogenesis and delayed conversion of large VLDL into intermediate density lipoprotein particles contribute to hyperlipidemia in glycogen storage disease type 1a.

Bandsma RH, Prinsen BH, van Der Velden Mde S, Rake JP, Boer T, Smit GP, Reijngoud DJ, Kuipers F.

Pediatr Res. 2008 Jun;63(6):702-7.PMID: 18520334 [PubMed - indexed for MEDLINE]Related articles

Regulation of direct transintestinal cholesterol excretion in mice.

van der Velde AE, Vrins CL, van den Oever K, Seemann I, Oude Elferink RP, van Eck M, Kuipers F, Groen AK.

Am J Physiol Gastrointest Liver Physiol. 2008 Jul;295(1):G203-G208. Epub 2008 May 29.PMID: 18511744 [PubMed - indexed for MEDLINE]Related articlesFree article

Disturbed hepatic carbohydrate management during high metabolic demand in medium-chain acyl-CoA dehydrogenase (MCAD)-deficient mice.

Herrema H, Derks TG, van Dijk TH, Bloks VW, Gerding A, Havinga R, Tietge UJ, Müller M, Smit GP, Kuipers F, Reijngoud DJ.

Hepatology. 2008 Jun;47(6):1894-904.PMID: 18459129 [PubMed - indexed for MEDLINE]Related articles

Dexamethasone exposure of neonatal rats modulates biliary lipid secretion and hepatic expression of genes controlling bile acid metabolism in adulthood without interfering with primary bile acid kinetics.

Liu Y, Havinga R, VAN DER Leij FR, Boverhof R, Sauer PJ, Kuipers F, Stellaard F.

Pediatr Res. 2008 Apr;63(4):375-81.PMID: 18356742 [PubMed - indexed for MEDLINE]Related articles

A cholesterol-free, high-fat diet suppresses gene expression of cholesterol transporters in murine small intestine.

de Vogel-van den Bosch HM, de Wit NJ, Hooiveld GJ, Vermeulen H, van der Veen JN, Houten SM, Kuipers F, Müller M, van der Meer R.

Am J Physiol Gastrointest Liver Physiol. 2008 May;294(5):G1171-80. Epub 2008 Mar 20.PMID: 18356535 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of mitochondrial fatty acid oxidation in vivo only slightly suppresses gluconeogenesis but enhances clearance of glucose in mice.

Derks TG, van Dijk TH, Grefhorst A, Rake JP, Smit GP, Kuipers F, Reijngoud DJ.

Hepatology. 2008 Mar;47(3):1032-42.PMID: 18302288 [PubMed - indexed for MEDLINE]Related articles

Increased de novo lipogenesis and delayed conversion of large VLDL into IDL particles contribute to hyperlipidemia in Glycogen Storage Disease type 1a.

Bandsma RH, Prinsen BH, van der Velden MD, Rake JP, Boer T, Smit GP, Reijngoud DJ, Kuipers F.

Pediatr Res. 2008 Feb 13. [Epub ahead of print]PMID: 18277936 [PubMed - as supplied by publisher]Related articles

Stearoyl-CoA desaturase deficiency, hypercholesterolaemia, cholestasis and diabetes.

Attie AD, Flowers MT, Flowers JB, Groen AK, Kuipers F, Ntambi JM.

Novartis Found Symp. 2007;286:47-53; discussion 54-7, 162-3, 196-203.PMID: 18269173 [PubMed - indexed for MEDLINE]Related articles

European Lipoprotein Club: Report of the 30th ELC annual conference, Tutzing, 3-6 September 2007.

Hofker M, Bernini F, von Eckardstein A, Freeman D, Heeren J, Karpe F, Kalopissis A, Kronenberg F, Kuipers F, Lindstedt K, Parini P, Schuster G, van Dijk KW.

Atherosclerosis. 2008 Mar;197(1):471-9. No abstract available. PMID: 18243210 [PubMed - indexed for MEDLINE]Related articles

Neonatal dexamethasone administration causes progressive renal damage due to induction of an early inflammatory response.

Liu Y, van Goor H, Havinga R, Baller JF, Bloks VW, van der Leij FR, Sauer PJ, Kuipers F, Navis G, de Borst MH.

Am J Physiol Renal Physiol. 2008 Apr;294(4):F768-76. Epub 2008 Jan 30.PMID: 18234956 [PubMed - indexed for MEDLINE]Related articlesFree article

Human apolipoprotein C-I expression in mice impairs learning and memory functions.

Abildayeva K, Berbée JF, Blokland A, Jansen PJ, Hoek FJ, Meijer O, Lütjohann D, Gautier T, Pillot T, De Vente J, Havekes LM, Ramaekers FC, Kuipers F, Rensen PC, Mulder M.

J Lipid Res. 2008 Apr;49(4):856-69. Epub 2007 Dec 26.PMID: 18160739 [PubMed - indexed for MEDLINE]Related articlesFree article

Plant sterols cause macrothrombocytopenia in a mouse model of sitosterolemia.

Kruit JK, Drayer AL, Bloks VW, Blom N, Olthof SG, Sauer PJ, de Haan G, Kema IP, Vellenga E, Kuipers F.

J Biol Chem. 2008 Mar 7;283(10):6281-7. Epub 2007 Dec 21.PMID: 18156627 [PubMed - indexed for MEDLINE]Related articlesFree article

Secretory phospholipase A2 increases SR-BI-mediated selective uptake from HDL but not biliary cholesterol secretion.

Tietge UJ, Nijstad N, Havinga R, Baller JF, van der Sluijs FH, Bloks VW, Gautier T, Kuipers F.

J Lipid Res. 2008 Mar;49(3):563-71. Epub 2007 Nov 25.PMID: 18037706 [PubMed - indexed for MEDLINE]Related articlesFree article

FXR-deficiency confers increased susceptibility to torpor.

Cariou B, Bouchaert E, Abdelkarim M, Dumont J, Caron S, Fruchart JC, Burcelin R, Kuipers F, Staels B.

FEBS Lett. 2007 Nov 13;581(27):5191-8. Epub 2007 Oct 12.PMID: 17950284 [PubMed - indexed for MEDLINE]Related articles

Gene expression profiling in livers of mice after acute inhibition of beta-oxidation.

van der Leij FR, Bloks VW, Grefhorst A, Hoekstra J, Gerding A, Kooi K, Gerbens F, te Meerman G, Kuipers F.

Genomics. 2007 Dec;90(6):680-9. Epub 2007 Oct 22.PMID: 17933490 [PubMed - indexed for MEDLINE]Related articles

Direct intestinal cholesterol secretion contributes significantly to total fecal neutral sterol excretion in mice.

van der Velde AE, Vrins CL, van den Oever K, Kunne C, Oude Elferink RP, Kuipers F, Groen AK.

Gastroenterology. 2007 Sep;133(3):967-75. Epub 2007 Jun 20.PMID: 17854600 [PubMed - indexed for MEDLINE]Related articles

European Lipoprotein Club: Report of the 29th ELC Annual Conference, Tutzing, 4-7 September 2006.

Hofker M, Calabresi L, von Eckardstein A, Heeren J, Karpe F, Kalopissis A, Kronenberg F, Kuipers F, Lindstedt K, Parini P, Schuster G, van Dijk KW.

Atherosclerosis. 2007 Aug;193(2):461-8. Epub 2007 Jan 3. No abstract available. PMID: 17640533 [PubMed - indexed for MEDLINE]Related articles

Intestinal capacity to digest and absorb carbohydrates is maintained in a rat model of cholestasis.

Los EL, Wolters H, Stellaard F, Kuipers F, Verkade HJ, Rings EH.

Am J Physiol Gastrointest Liver Physiol. 2007 Sep;293(3):G615-22. Epub 2007 Jul 12.PMID: 17627970 [PubMed - indexed for MEDLINE]Related articlesFree article