PubMed

Increases in cytoplasmic dopamine compromise the normal resistance of the nucleus accumbens to methamphetamine neurotoxicity.

Thomas DM, Francescutti-Verbeem DM, Kuhn DM.

J Neurochem. 2009 Jun;109(6):1745-55. Epub 2009 Apr 28.PMID: 19457119 [PubMed - indexed for MEDLINE]Related articles

Dopamine disposition in the presynaptic process regulates the severity of methamphetamine-induced neurotoxicity.

Kuhn DM, Francescutti-Verbeem DM, Thomas DM.

Ann N Y Acad Sci. 2008 Oct;1139:118-26.PMID: 18991856 [PubMed - indexed for MEDLINE]Related articlesFree article

The existence of a local 5-hydroxytryptaminergic system in peripheral arteries.

Ni W, Geddes TJ, Priestley JR, Szasz T, Kuhn DM, Watts SW.

Br J Pharmacol. 2008 Jun;154(3):663-74. Epub 2008 Apr 14.PMID: 18414394 [PubMed - indexed for MEDLINE]Related articlesFree article

Methamphetamine-induced neurotoxicity and microglial activation are not mediated by fractalkine receptor signaling.

Thomas DM, Francescutti-Verbeem DM, Kuhn DM.

J Neurochem. 2008 Jul;106(2):696-705. Epub 2008 Apr 12.PMID: 18410508 [PubMed - indexed for MEDLINE]Related articlesFree article

A serotonergic system in veins: serotonin transporter-independent uptake.

Linder AE, Ni W, Szasz T, Burnett R, Diaz J, Geddes TJ, Kuhn DM, Watts SW.

J Pharmacol Exp Ther. 2008 Jun;325(3):714-22. Epub 2008 Mar 5.PMID: 18322152 [PubMed - indexed for MEDLINE]Related articlesFree article

The newly synthesized pool of dopamine determines the severity of methamphetamine-induced neurotoxicity.

Thomas DM, Francescutti-Verbeem DM, Kuhn DM.

J Neurochem. 2008 May;105(3):605-16. Epub 2007 Dec 6.PMID: 18088364 [PubMed - indexed for MEDLINE]Related articlesFree article

Phosphorylation and activation of tryptophan hydroxylase 2: identification of serine-19 as the substrate site for calcium, calmodulin-dependent protein kinase II.

Kuhn DM, Sakowski SA, Geddes TJ, Wilkerson C, Haycock JW.

J Neurochem. 2007 Nov;103(4):1567-73. Epub 2007 Aug 28.PMID: 17727633 [PubMed - indexed for MEDLINE]Related articles

Dopamine quinones activate microglia and induce a neurotoxic gene expression profile: relationship to methamphetamine-induced nerve ending damage.

Kuhn DM, Francescutti-Verbeem DM, Thomas DM.

Ann N Y Acad Sci. 2006 Aug;1074:31-41.PMID: 17105901 [PubMed - indexed for MEDLINE]Related articles

MDMA and fenfluramine reduce L-DOPA-induced dyskinesia via indirect 5-HT1A receptor stimulation.

Bishop C, Taylor JL, Kuhn DM, Eskow KL, Park JY, Walker PD.

Eur J Neurosci. 2006 May;23(10):2669-76.PMID: 16817869 [PubMed - indexed for MEDLINE]Related articles

Problem doctors: is there a system-level solution?

Kuhn DM.

Ann Intern Med. 2006 Jun 6;144(11):861; author reply 863. No abstract available. PMID: 16754931 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential tissue distribution of tryptophan hydroxylase isoforms 1 and 2 as revealed with monospecific antibodies.

Sakowski SA, Geddes TJ, Thomas DM, Levi E, Hatfield JS, Kuhn DM.

Brain Res. 2006 Apr 26;1085(1):11-8. Epub 2006 Apr 11.PMID: 16581041 [PubMed - indexed for MEDLINE]Related articles

Mouse tryptophan hydroxylase isoform 2 and the role of proline 447 in enzyme function.

Sakowski SA, Geddes TJ, Kuhn DM.

J Neurochem. 2006 Feb;96(3):758-65. Epub 2006 Jan 9.PMID: 16405505 [PubMed - indexed for MEDLINE]Related articles

Gene expression profile of activated microglia under conditions associated with dopamine neuronal damage.

Thomas DM, Francescutti-Verbeem DM, Kuhn DM.

FASEB J. 2006 Mar;20(3):515-7. Epub 2005 Dec 29.PMID: 16384912 [PubMed - indexed for MEDLINE]Related articlesFree article

S-thiolation of tyrosine hydroxylase by reactive nitrogen species in the presence of cysteine or glutathione.

Sadidi M, Geddes TJ, Kuhn DM.

Antioxid Redox Signal. 2005 Jul-Aug;7(7-8):863-9.PMID: 15998241 [PubMed - indexed for MEDLINE]Related articles

MK-801 and dextromethorphan block microglial activation and protect against methamphetamine-induced neurotoxicity.

Thomas DM, Kuhn DM.

Brain Res. 2005 Jul 19;1050(1-2):190-8.PMID: 15987631 [PubMed - indexed for MEDLINE]Related articles

Influence of intravenous drug abuse on vascular access placement and survival in HIV-seropositive patients.

Eustace JA, Gregory PC, Krishnan M, Ni W, Kuhn DM, Astor BC, Scheel PJ Jr.

Nephron Clin Pract. 2005;100(2):c38-45. Epub 2005 Apr 7.PMID: 15818057 [PubMed - indexed for MEDLINE]Related articles

Cyclooxygenase-2 is an obligatory factor in methamphetamine-induced neurotoxicity.

Thomas DM, Kuhn DM.

J Pharmacol Exp Ther. 2005 May;313(2):870-6. Epub 2005 Feb 17.PMID: 15718289 [PubMed - indexed for MEDLINE]Related articlesFree article

Attenuated microglial activation mediates tolerance to the neurotoxic effects of methamphetamine.

Thomas DM, Kuhn DM.

J Neurochem. 2005 Feb;92(4):790-7.PMID: 15686480 [PubMed - indexed for MEDLINE]Related articles

Microglial activation is a pharmacologically specific marker for the neurotoxic amphetamines.

Thomas DM, Dowgiert J, Geddes TJ, Francescutti-Verbeem D, Liu X, Kuhn DM.

Neurosci Lett. 2004 Sep 9;367(3):349-54.PMID: 15337264 [PubMed - indexed for MEDLINE]Related articles

Candida parapsilosis characterization in an outbreak setting.

Kuhn DM, Mikherjee PK, Clark TA, Pujol C, Chandra J, Hajjeh RA, Warnock DW, Soil DR, Ghannoum MA.

Emerg Infect Dis. 2004 Jun;10(6):1074-81.PMID: 15207060 [PubMed - indexed for MEDLINE]Related articlesFree article

Methamphetamine neurotoxicity in dopamine nerve endings of the striatum is associated with microglial activation.

Thomas DM, Walker PD, Benjamins JA, Geddes TJ, Kuhn DM.

J Pharmacol Exp Ther. 2004 Oct;311(1):1-7. Epub 2004 May 26.PMID: 15163680 [PubMed - indexed for MEDLINE]Related articlesFree article

Nitrotyrosine as a marker for peroxynitrite-induced neurotoxicity: the beginning or the end of the end of dopamine neurons?

Kuhn DM, Sakowski SA, Sadidi M, Geddes TJ.

J Neurochem. 2004 May;89(3):529-36. Review.PMID: 15086510 [PubMed - indexed for MEDLINE]Related articles

Candida biofilms: antifungal resistance and emerging therapeutic options.

Kuhn DM, Ghannoum MA.

Curr Opin Investig Drugs. 2004 Feb;5(2):186-97. Review.PMID: 15043393 [PubMed - indexed for MEDLINE]Related articles

Gene expression profile of the nucleus accumbens of human cocaine abusers: evidence for dysregulation of myelin.

Albertson DN, Pruetz B, Schmidt CJ, Kuhn DM, Kapatos G, Bannon MJ.

J Neurochem. 2004 Mar;88(5):1211-9.PMID: 15009677 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of differentially regulated transcripts in mouse striatum following methamphetamine treatment--an oligonucleotide microarray approach.

Thomas DM, Francescutti-Verbeem DM, Liu X, Kuhn DM.

J Neurochem. 2004 Jan;88(2):380-93.PMID: 14690526 [PubMed - indexed for MEDLINE]Related articles

Tetrahydrobiopterin prevents nitration of tyrosine hydroxylase by peroxynitrite and nitrogen dioxide.

Kuhn DM, Geddes TJ.

Mol Pharmacol. 2003 Oct;64(4):946-53.PMID: 14500751 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanism of fluconazole resistance in Candida albicans biofilms: phase-specific role of efflux pumps and membrane sterols.

Mukherjee PK, Chandra J, Kuhn DM, Ghannoum MA.

Infect Immun. 2003 Aug;71(8):4333-40.PMID: 12874310 [PubMed - indexed for MEDLINE]Related articlesFree article

Dopamine prevents nitration of tyrosine hydroxylase by peroxynitrite and nitrogen dioxide: is nitrotyrosine formation an early step in dopamine neuronal damage?

Park S, Geddes TJ, Javitch JA, Kuhn DM.

J Biol Chem. 2003 Aug 1;278(31):28736-42. Epub 2003 May 27.PMID: 12771134 [PubMed - indexed for MEDLINE]Related articlesFree article

Mass mapping sites of nitration in tyrosine hydroxylase: random vs selective nitration of three tyrosine residues.

Borges CR, Kuhn DM, Watson JT.

Chem Res Toxicol. 2003 Apr;16(4):536-40.PMID: 12703971 [PubMed - indexed for MEDLINE]Related articles

Differential expression of Candida albicans phospholipase B (PLB1) under various environmental and physiological conditions.

Mukherjee PK, Chandra J, Kuhn DM, Ghannoum MA.

Microbiology. 2003 Jan;149(Pt 1):261-7.PMID: 12576599 [PubMed - indexed for MEDLINE]Related articlesFree article

Indoor mold, toxigenic fungi, and Stachybotrys chartarum: infectious disease perspective.

Kuhn DM, Ghannoum MA.

Clin Microbiol Rev. 2003 Jan;16(1):144-72. Review.PMID: 12525430 [PubMed - indexed for MEDLINE]Related articlesFree article

Uses and limitations of the XTT assay in studies of Candida growth and metabolism.

Kuhn DM, Balkis M, Chandra J, Mukherjee PK, Ghannoum MA.

J Clin Microbiol. 2003 Jan;41(1):506-8.PMID: 12517908 [PubMed - indexed for MEDLINE]Related articlesFree article

Dopamine biosynthesis is regulated by S-glutathionylation. Potential mechanism of tyrosine hydroxylast inhibition during oxidative stress.

Borges CR, Geddes T, Watson JT, Kuhn DM.

J Biol Chem. 2002 Dec 13;277(50):48295-302. Epub 2002 Oct 9. Erratum in: J Biol Chem. 2003 Jan 31;278(5):3407. PMID: 12376535 [PubMed - indexed for MEDLINE]Related articlesFree article

Voriconazole -- better chances for patients with invasive mycoses.

Ghannoum MA, Kuhn DM.

Eur J Med Res. 2002 May 31;7(5):242-56. Review.PMID: 12069915 [PubMed - indexed for MEDLINE]Related articles

Peroxynitrite inactivates the human dopamine transporter by modification of cysteine 342: potential mechanism of neurotoxicity in dopamine neurons.

Park SU, Ferrer JV, Javitch JA, Kuhn DM.

J Neurosci. 2002 Jun 1;22(11):4399-405.PMID: 12040046 [PubMed - indexed for MEDLINE]Related articlesFree article

Antifungal susceptibility of Candida biofilms: unique efficacy of amphotericin B lipid formulations and echinocandins.

Kuhn DM, George T, Chandra J, Mukherjee PK, Ghannoum MA.

Antimicrob Agents Chemother. 2002 Jun;46(6):1773-80.PMID: 12019089 [PubMed - indexed for MEDLINE]Related articlesFree article

Reduced nicotinamide nucleotides prevent nitration of tyrosine hydroxylase by peroxynitrite.

Kuhn DM, Geddes TJ.

Brain Res. 2002 Apr 12;933(1):85-9.PMID: 11929639 [PubMed - indexed for MEDLINE]Related articles

Peroxynitrite-induced nitration of tyrosine hydroxylase: identification of tyrosines 423, 428, and 432 as sites of modification by matrix-assisted laser desorption ionization time-of-flight mass spectrometry and tyrosine-scanning mutagenesis.

Kuhn DM, Sadidi M, Liu X, Kreipke C, Geddes T, Borges C, Watson JT.

J Biol Chem. 2002 Apr 19;277(16):14336-42. Epub 2002 Feb 7.PMID: 11834745 [PubMed - indexed for MEDLINE]Related articlesFree article

Comparison of biofilms formed by Candida albicans and Candida parapsilosis on bioprosthetic surfaces.

Kuhn DM, Chandra J, Mukherjee PK, Ghannoum MA.

Infect Immun. 2002 Feb;70(2):878-88.PMID: 11796623 [PubMed - indexed for MEDLINE]Related articlesFree article

Biofilm formation by the fungal pathogen Candida albicans: development, architecture, and drug resistance.

Chandra J, Kuhn DM, Mukherjee PK, Hoyer LL, McCormick T, Ghannoum MA.

J Bacteriol. 2001 Sep;183(18):5385-94.PMID: 11514524 [PubMed - indexed for MEDLINE]Related articlesFree article

Tetrahydrobiopterin enhances apoptotic PC12 cell death following withdrawal of trophic support.

Anastasiadis PZ, Jiang H, Bezin L, Kuhn DM, Levine RA.

J Biol Chem. 2001 Mar 23;276(12):9050-8. Epub 2000 Dec 21.PMID: 11124941 [PubMed - indexed for MEDLINE]Related articles

Molecular footprints of neurotoxic amphetamine action.

Kuhn DM, Geddes TJ.

Ann N Y Acad Sci. 2000 Sep;914:92-103.PMID: 11085312 [PubMed - indexed for MEDLINE]Related articles

Tryptophan hydroxylase regulation. Drug-induced modifications that alter serotonin neuronal function.

Kuhn DM.

Adv Exp Med Biol. 1999;467:19-27. Review.PMID: 10721034 [PubMed - indexed for MEDLINE]Related articles

L-DOPA-quinone inactivates tryptophan hydroxylase and converts the enzyme to a redox-cycling quinoprotein.

Kuhn DM, Arthur RE Jr.

Brain Res Mol Brain Res. 1999 Nov 10;73(1-2):78-84.PMID: 10581400 [PubMed - indexed for MEDLINE]Related articles

Peroxynitrite inactivation of tyrosine hydroxylase: mediation by sulfhydryl oxidation, not tyrosine nitration.

Kuhn DM, Aretha CW, Geddes TJ.

J Neurosci. 1999 Dec 1;19(23):10289-94.PMID: 10575026 [PubMed - indexed for MEDLINE]Related articlesFree article

Peroxynitrite inactivates tryptophan hydroxylase via sulfhydryl oxidation. Coincident nitration of enzyme tyrosyl residues has minimal impact on catalytic activity.

Kuhn DM, Geddes TJ.

J Biol Chem. 1999 Oct 15;274(42):29726-32.PMID: 10514446 [PubMed - indexed for MEDLINE]Related articlesFree article

Tyrosine hydroxylase is inactivated by catechol-quinones and converted to a redox-cycling quinoprotein: possible relevance to Parkinson's disease.

Kuhn DM, Arthur RE Jr, Thomas DM, Elferink LA.

J Neurochem. 1999 Sep;73(3):1309-17.PMID: 10461926 [PubMed - indexed for MEDLINE]Related articles

Case 27-1998: eosinophilic cystitis.

Kuhn DM.

N Engl J Med. 1999 Apr 1;340(13):1049. No abstract available. PMID: 10189294 [PubMed - indexed for MEDLINE]Related articles

Dopamine inactivates tryptophan hydroxylase and forms a redox-cycling quinoprotein: possible endogenous toxin to serotonin neurons.

Kuhn DM, Arthur R Jr.

J Neurosci. 1998 Sep 15;18(18):7111-7.PMID: 9736634 [PubMed - indexed for MEDLINE]Related articlesFree article

Vasoactive intestinal peptide induces both tyrosine hydroxylase activity and tetrahydrobiopterin biosynthesis in PC12 cells.

Anastasiadis PZ, Bezin L, Gordon LJ, Imerman B, Blitz J, Kuhn DM, Levine RA.

Neuroscience. 1998 Sep;86(1):179-89. Erratum in: Neuroscience 1999 Jan;88(2):665. PMID: 9692753 [PubMed - indexed for MEDLINE]Related articles