PubMed

Exploring functional beta-cell heterogeneity in vivo using PSA-NCAM as a specific marker.

Karaca M, Castel J, Tourrel-Cuzin C, Brun M, Géant A, Dubois M, Catesson S, Rodriguez M, Luquet S, Cattan P, Lockhart B, Lang J, Ktorza A, Magnan C, Kargar C.

PLoS One. 2009;4(5):e5555. Epub 2009 May 18.PMID: 19440374 [PubMed - indexed for MEDLINE]Related articlesFree article

4,4-Dimethyl-1,2,3,4-tetrahydroquinoline-based PPARalpha/gamma agonists. Part. II: Synthesis and pharmacological evaluation of oxime and acidic head group structural variations.

Parmenon C, Guillard J, Caignard DH, Hennuyer N, Staels B, Audinot-Bouchez V, Boutin JA, Dacquet C, Ktorza A, Viaud-Massuard MC.

Bioorg Med Chem Lett. 2009 May 15;19(10):2683-7. Epub 2009 Apr 1.PMID: 19376700 [PubMed - indexed for MEDLINE]Related articles

S26948, a new specific peroxisome proliferator activated receptor gamma modulator improved in vivo hepatic insulin sensitivity in 48 h lipid infused rats.

Sohn KA, Cruciani-Guglielmacci C, Kassis N, Clément L, Ouali F, Caüzac M, Lebègue N, Berthelot P, Caignard DH, Pégorier JP, Renard P, Dacquet C, Ktorza A, Magnan C; Consortium of the French Ministry of Research and Technology.

Eur J Pharmacol. 2009 Apr 17;608(1-3):104-11. Epub 2009 Feb 26.PMID: 19250932 [PubMed - indexed for MEDLINE]Related articles

Coadministration of coenzyme Q prevents rosiglitazone-induced adipogenesis in ob/ob mice.

Carmona MC, Lefebvre P, Lefebvre B, Galinier A, Benani A, Jeanson Y, Louche K, Flajollet S, Ktorza A, Dacquet C, Pénicaud L, Casteilla L; Consortium of the French Ministry of Research and Technology: 'Molecules and New Therapeutic Targets'.

Int J Obes (Lond). 2009 Feb;33(2):204-11. Epub 2009 Jan 6.PMID: 19125161 [PubMed - indexed for MEDLINE]Related articles

Mitochondrial reactive oxygen species are obligatory signals for glucose-induced insulin secretion.

Leloup C, Tourrel-Cuzin C, Magnan C, Karaca M, Castel J, Carneiro L, Colombani AL, Ktorza A, Casteilla L, Pénicaud L.

Diabetes. 2009 Mar;58(3):673-81. Epub 2008 Dec 10.PMID: 19073765 [PubMed - indexed for MEDLINE]Related articlesFree article

Anatomical versus functional beta-cell mass in experimental diabetes.

Kargar C, Ktorza A.

Diabetes Obes Metab. 2008 Nov;10 Suppl 4:43-53.PMID: 18834432 [PubMed - indexed for MEDLINE]Related articles

Pathophysiological, genetic and gene expression features of a novel rodent model of the cardio-metabolic syndrome.

Wallis RH, Collins SC, Kaisaki PJ, Argoud K, Wilder SP, Wallace KJ, Ria M, Ktorza A, Rorsman P, Bihoreau MT, Gauguier D.

PLoS One. 2008 Aug 13;3(8):e2962.PMID: 18698428 [PubMed - indexed for MEDLINE]Related articlesFree article

4,4-Dimethyl-1,2,3,4-tetrahydroquinoline-based PPARalpha/gamma agonists. Part I: synthesis and pharmacological evaluation.

Parmenon C, Guillard J, Caignard DH, Hennuyer N, Staels B, Audinot-Bouchez V, Boutin JA, Dacquet C, Ktorza A, Viaud-Massuard MC.

Bioorg Med Chem Lett. 2008 Mar 1;18(5):1617-22. Epub 2008 Jan 19.PMID: 18255290 [PubMed - indexed for MEDLINE]Related articles

[Anatomical and functional plasticity of pancreatic beta-cells and type 2 diabetes]

Cerasi E, Ktorza A.

Med Sci (Paris). 2007 Oct;23(10):885-94. Review. French. PMID: 17937902 [PubMed - indexed for MEDLINE]Related articles

Transgenic expression of human INS gene in Ins1/Ins2 double knockout mice leads to insulin underproduction and diabetes in some male mice.

Karaca M, Durel B, Languille L, Lamotte L, Tourrel-Cuzin C, Leroux L, Abou Sleymane G, Saint-Just S, Bucchini D, Ktorza A, Joshi RL.

Front Biosci. 2007 Jan 1;12:1586-93.PMID: 17127405 [PubMed - indexed for MEDLINE]Related articles

Genetic control of plasma lipid levels in a cross derived from normoglycaemic Brown Norway and spontaneously diabetic Goto-Kakizaki rats.

Argoud K, Wilder SP, McAteer MA, Bihoreau MT, Ouali F, Woon PY, Wallis RH, Ktorza A, Gauguier D.

Diabetologia. 2006 Nov;49(11):2679-88. Epub 2006 Sep 16.PMID: 16983556 [PubMed - indexed for MEDLINE]Related articles

Design and synthesis of novel imidazoline derivatives with potent antihyperglycemic activity in a rat model of type 2 diabetes.

Crane L, Anastassiadou M, El Hage S, Stigliani JL, Baziard-Mouysset G, Payard M, Leger JM, Bizot-Espiard JG, Ktorza A, Caignard DH, Renard P.

Bioorg Med Chem. 2006 Nov 15;14(22):7419-33. Epub 2006 Aug 2.PMID: 16889967 [PubMed - indexed for MEDLINE]Related articles

Mitochondrial reactive oxygen species are required for hypothalamic glucose sensing.

Leloup C, Magnan C, Benani A, Bonnet E, Alquier T, Offer G, Carriere A, Périquet A, Fernandez Y, Ktorza A, Casteilla L, Pénicaud L.

Diabetes. 2006 Jul;55(7):2084-90.PMID: 16804079 [PubMed - indexed for MEDLINE]Related articlesFree article

Psammomys obesus, a model for environment-gene interactions in type 2 diabetes.

Kaiser N, Nesher R, Donath MY, Fraenkel M, Behar V, Magnan C, Ktorza A, Cerasi E, Leibowitz G.

Diabetes. 2005 Dec;54 Suppl 2:S137-44. Review.PMID: 16306331 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of glucose in IRS signaling in rat pancreatic islets: specific effects and interplay with insulin.

Paris M, Bernard-Kargar C, Vilar J, Kassis N, Ktorza A.

Exp Diabesity Res. 2004 Oct-Dec;5(4):257-63.PMID: 15763940 [PubMed - indexed for MEDLINE]Related articlesFree article

Improvement of metabolic state in an animal model of nutrition-dependent type 2 diabetes following treatment with S 23521, a new glucagon-like peptide 1 (GLP-1) analogue.

Uçkaya G, Delagrange P, Chavanieu A, Grassy G, Berthault MF, Ktorza A, Cerasi E, Leibowitz G, Kaiser N.

J Endocrinol. 2005 Mar;184(3):505-13.PMID: 15749809 [PubMed - indexed for MEDLINE]Related articlesFree article

Dynamic changes in {beta}-cell mass and pancreatic insulin during the evolution of nutrition-dependent diabetes in psammomys obesus: impact of glycemic control.

Kaiser N, Yuli M, Uçkaya G, Oprescu AI, Berthault MF, Kargar C, Donath MY, Cerasi E, Ktorza A.

Diabetes. 2005 Jan;54(1):138-45.PMID: 15616021 [PubMed - indexed for MEDLINE]Related articlesFree article

Beta oxidation in the brain is required for the effects of non-esterified fatty acids on glucose-induced insulin secretion in rats.

Cruciani-Guglielmacci C, Hervalet A, Douared L, Sanders NM, Levin BE, Ktorza A, Magnan C.

Diabetologia. 2004 Nov;47(11):2032-8. Epub 2004 Nov 30.PMID: 15599702 [PubMed - indexed for MEDLINE]Related articles

Early changes in insulin secretion and action induced by high-fat diet are related to a decreased sympathetic tone.

Cruciani-Guglielmacci C, Vincent-Lamon M, Rouch C, Orosco M, Ktorza A, Magnan C.

Am J Physiol Endocrinol Metab. 2005 Jan;288(1):E148-54. Epub 2004 Sep 7.PMID: 15353406 [PubMed - indexed for MEDLINE]Related articlesFree article

Quantitative trait locus dissection in congenic strains of the Goto-Kakizaki rat identifies a region conserved with diabetes loci in human chromosome 1q.

Wallace KJ, Wallis RH, Collins SC, Argoud K, Kaisaki PJ, Ktorza A, Woon PY, Bihoreau MT, Gauguier D.

Physiol Genomics. 2004 Sep 16;19(1):1-10. Epub 2004 Jul 20.PMID: 15266047 [PubMed - indexed for MEDLINE]Related articlesFree article

Review: pancreatic beta-cell neogenesis revisited.

Paris M, Tourrel-Cuzin C, Plachot C, Ktorza A.

Exp Diabesity Res. 2004 Apr-Jun;5(2):111-21. Review.PMID: 15203882 [PubMed - indexed for MEDLINE]Related articlesFree article

Structural requirements of the N-terminal region of GLP-1-[7-37]-NH2 for receptor interaction and cAMP production.

Sarrauste de Menthière C, Chavanieu A, Grassy G, Dalle S, Salazar G, Kervran A, Pfeiffer B, Renard P, Delagrange P, Manechez D, Bakes D, Ktorza A, Calas B.

Eur J Med Chem. 2004 Jun;39(6):473-80.PMID: 15183905 [PubMed - indexed for MEDLINE]Related articles

Intrauterine hyperglycemia increases insulin binding sites but not glucose transporter expression in discrete brain areas in term rat fetuses.

Leloup C, Magnan C, Alquier T, Mistry S, Offer G, Arnaud E, Kassis N, Ktorza A, Pénicaud L.

Pediatr Res. 2004 Aug;56(2):263-7. Epub 2004 Jun 4.PMID: 15181191 [PubMed - indexed for MEDLINE]Related articles

Insulinotropic agent ID-1101 (4-hydroxyisoleucine) activates insulin signaling in rat.

Broca C, Breil V, Cruciani-Guglielmacci C, Manteghetti M, Rouault C, Derouet M, Rizkalla S, Pau B, Petit P, Ribes G, Ktorza A, Gross R, Reach G, Taouis M.

Am J Physiol Endocrinol Metab. 2004 Sep;287(3):E463-71. Epub 2004 Apr 13.PMID: 15082420 [PubMed - indexed for MEDLINE]Related articlesFree article

Specific and combined effects of insulin and glucose on functional pancreatic beta-cell mass in vivo in adult rats.

Paris M, Bernard-Kargar C, Berthault MF, Bouwens L, Ktorza A.

Endocrinology. 2003 Jun;144(6):2717-27.PMID: 12746336 [PubMed - indexed for MEDLINE]Related articlesFree article

Intracerebroventricular infusion of a triglyceride emulsion leads to both altered insulin secretion and hepatic glucose production in rats.

Clément L, Cruciani-Guglielmacci C, Magnan C, Vincent M, Douared L, Orosco M, Assimacopoulos-Jeannet F, Pénicaud L, Ktorza A.

Pflugers Arch. 2002 Dec;445(3):375-80. Epub 2002 Nov 1.PMID: 12466940 [PubMed - indexed for MEDLINE]Related articles

Pancreatic beta-cell alpha2A adrenoceptor and phospholipid changes in hyperlipidemic rats.

Clément L, Kim-Sohn KA, Magnan C, Kassis N, Adnot P, Kergoat M, Assimacopoulos-Jeannet F, Pénicaud L, Hsu F, Turk J, Ktorza A.

Lipids. 2002 May;37(5):501-6.PMID: 12056593 [PubMed - indexed for MEDLINE]Related articles

Glucose-induced insulin hypersecretion in lipid-infused healthy subjects is associated with a decrease in plasma norepinephrine concentration and urinary excretion.

Magnan C, Cruciani C, Clément L, Adnot P, Vincent M, Kergoat M, Girard A, Elghozi JL, Velho G, Beressi N, Bresson JL, Ktorza A.

J Clin Endocrinol Metab. 2001 Oct;86(10):4901-7.PMID: 11600560 [PubMed - indexed for MEDLINE]Related articlesFree article

Correlation between pancreatic islet uncoupling protein-2 (UCP2) mRNA concentration and insulin status in rats.

Kassis N, Bernard C, Pusterla A, Casteilla L, Pénicaud L, Richard D, Ricquier D, Ktorza A.

Int J Exp Diabetes Res. 2000;1(3):185-93.PMID: 11467409 [PubMed - indexed for MEDLINE]Related articlesFree article

Endocrine pancreas plasticity under physiological and pathological conditions.

Bernard-Kargar C, Ktorza A.

Diabetes. 2001 Feb;50 Suppl 1:S30-5. Review.PMID: 11272194 [PubMed - indexed for MEDLINE]Related articles

Sialylated form of the neural cell adhesion molecule (NCAM): a new tool for the identification and sorting of beta-cell subpopulations with different functional activity.

Bernard-Kargar C, Kassis N, Berthault MF, Pralong W, Ktorza A.

Diabetes. 2001 Feb;50 Suppl 1:S125-30.PMID: 11272170 [PubMed - indexed for MEDLINE]Related articles

Glucose regulates proinsulin and prosomatostatin but not proglucagon messenger ribonucleic acid levels in rat pancreatic islets.

Dumonteil E, Magnan C, Ritz-Laser B, Ktorza A, Meda P, Philippe J.

Endocrinology. 2000 Jan;141(1):174-80.PMID: 10614637 [PubMed - indexed for MEDLINE]Related articlesFree article

Chronic exposure to high glucose concentrations increases proglucagon messenger ribonucleic acid levels and glucagon release from InR1G9 cells.

Dumonteil E, Ritz-Laser B, Magnan C, Grigorescu I, Ktorza A, Philippe J.

Endocrinology. 1999 Oct;140(10):4644-50.PMID: 10499521 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose-induced preproinsulin gene expression is inhibited by the free fatty acid palmitate.

Ritz-Laser B, Meda P, Constant I, Klages N, Charollais A, Morales A, Magnan C, Ktorza A, Philippe J.

Endocrinology. 1999 Sep;140(9):4005-14.PMID: 10465270 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of the new imidazoline derivative S-22068 (PMS 847) on insulin secretion in vitro and glucose turnover in vivo in rats.

Pelé-Tounian A, Chan SL, Rondu F, Le Bihan G, Giroix MH, Lamouri A, Touboul E, Pfeiffer B, Manechez D, Renard P, Guardiola-Lemaître B, Godfroid JJ, Pénicaud L, Morgan NG, Ktorza A.

Eur J Pharmacol. 1999 Jul 14;377(1):81-7.PMID: 10448930 [PubMed - indexed for MEDLINE]Related articles

Neogenesis vs. apoptosis As main components of pancreatic beta cell ass changes in glucose-infused normal and mildly diabetic adult rats.

Bernard C, Berthault MF, Saulnier C, Ktorza A.

FASEB J. 1999 Jul;13(10):1195-205.PMID: 10385610 [PubMed - indexed for MEDLINE]Related articlesFree article

Design and synthesis of imidazoline derivatives active on glucose homeostasis in a rat model of type II diabetes. 2. Syntheses and biological activities of 1,4-dialkyl-, 1,4-dibenzyl, and 1-benzyl-4-alkyl-2-(4',5'-dihydro-1'H-imidazol-2'-yl)piperazines and isosteric analogues of imidazoline.

Le Bihan G, Rondu F, Pelé-Tounian A, Wang X, Lidy S, Touboul E, Lamouri A, Dive G, Huet J, Pfeiffer B, Renard P, Guardiola-Lemaître B, Manéchez D, Pénicaud L, Ktorza A, Godfroid JJ.

J Med Chem. 1999 May 6;42(9):1587-603.PMID: 10229628 [PubMed - indexed for MEDLINE]Related articles

Lack of melatonin effects on insulin action in normal rats.

Bizot-Espiard JG, Doublé A, Cousin B, Lesieur D, Guardiola-Lemaître B, Delagrange P, Ktorza A, Pénicaud L.

Horm Metab Res. 1998 Dec;30(12):711-6.PMID: 9930627 [PubMed - indexed for MEDLINE]Related articles

Lipid infusion lowers sympathetic nervous activity and leads to increased beta-cell responsiveness to glucose.

Magnan C, Collins S, Berthault MF, Kassis N, Vincent M, Gilbert M, Pénicaud L, Ktorza A, Assimacopoulos-Jeannet F.

J Clin Invest. 1999 Feb;103(3):413-9.PMID: 9927503 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin, but not glucose lowering corrects the hyperglucagonemia and increased proglucagon messenger ribonucleic acid levels observed in insulinopenic diabetes.

Dumonteil E, Magnan C, Ritz-Laser B, Meda P, Dussoix P, Gilbert M, Ktorza A, Philippe J.

Endocrinology. 1998 Nov;139(11):4540-6.PMID: 9794463 [PubMed - indexed for MEDLINE]Related articlesFree article

Potent antihyperglycaemic property of a new imidazoline derivative S-22068 (PMS 847) in a rat model of NIDDM.

Pelé-Tounian A, Wang X, Rondu F, Lamouri A, Touboul E, Marc S, Dokhan R, Pfeiffer B, Manechez D, Renard P, Guardiola-Lemaître B, Godfroid JJ, Pénicaud L, Ktorza A.

Br J Pharmacol. 1998 Aug;124(8):1591-6.PMID: 9756373 [PubMed - indexed for MEDLINE]Related articlesFree article

Rilmenidine normalizes fructose-induced insulin resistance and hypertension in rats.

Pénicaud L, Berthault MF, Morin J, Dubar M, Ktorza A, Ferre P.

J Hypertens Suppl. 1998 Aug;16(3):S45-9.PMID: 9747910 [PubMed - indexed for MEDLINE]Related articles

Diurnal rhythms in plasma glucose, insulin, growth hormone and melatonin levels in fasted and hyperglycaemic rats.

Bizot-Espiard JG, Doublé A, Guardiola-Lemaitre B, Delagrange P, Ktorza A, Pénicaud L.

Diabetes Metab. 1998 Jun;24(3):235-40.PMID: 9690056 [PubMed - indexed for MEDLINE]Related articlesFree article

Pancreatic beta-cell regeneration after 48-h glucose infusion in mildly diabetic rats is not correlated with functional improvement.

Bernard C, Thibault C, Berthault MF, Magnan C, Saulnier C, Portha B, Pralong WF, Pénicaud L, Ktorza A.

Diabetes. 1998 Jul;47(7):1058-65.PMID: 9648829 [PubMed - indexed for MEDLINE]Related articlesFree article

Hormonal counterregulation failure in rats is related to previous hyperglycaemia-hyperinsulinaemia.

Magnan C, Laury MC, Adnot P, Doaré L, Boucontet L, Kergoat M, Pénicaud L, Ktorza A, Gilbert M.

Diabetes Metab. 1998 Feb;24(1):46-54.PMID: 9534009 [PubMed - indexed for MEDLINE]Related articlesFree article

Design and synthesis of imidazoline derivatives active on glucose homeostasis in a rat model of type II diabetes. 1. Synthesis and biological activities of N-benzyl-N'-(arylalkyl)-2-(4',5'-dihydro-1'H-imidazol-2'-yl)piperazines .

Rondu F, Le Bihan G, Wang X, Lamouri A, Touboul E, Dive G, Bellahsene T, Pfeiffer B, Renard P, Guardiola-Lemaitre B, Manechez D, Penicaud L, Ktorza A, Godfroid JJ.

J Med Chem. 1997 Nov 7;40(23):3793-803.PMID: 9371245 [PubMed - indexed for MEDLINE]Related articles

Increased pancreatic islet blood flow in 48-hour glucose-infused rats: involvement of central and autonomic nervous systems.

Atef N, Laury MC, N'Guyen JM, Mokhtar N, Ktorza A, Penicaud L.

Endocrinology. 1997 May;138(5):1836-40.PMID: 9112376 [PubMed - indexed for MEDLINE]Related articlesFree article

Are animal models of diabetes relevant to the study of the genetics of non-insulin-dependent diabetes in humans?

Ktorza A, Bernard C, Parent V, Penicaud L, Froguel P, Lathrop M, Gauguier D.

Diabetes Metab. 1997 Mar;23 Suppl 2:38-46. Review.PMID: 9105782 [PubMed - indexed for MEDLINE]Related articles

[Possible contribution of hyperglycemia in utero to glucose homeostasis disorders in the adult]

Ktorza A, Gauguier D, Bihoreau MT, Berthault MF, Marfaing P, Penicaud L.

Journ Annu Diabetol Hotel Dieu. 1997:55-68. Review. French. No abstract available. PMID: 9296992 [PubMed - indexed for MEDLINE]Related articles

[Effects of rilmenidine on rats made insulin resistant and hypertensive by a high fructose diet]

Berthault MF, Morin J, Dubar M, Ktorza A, Ferré P, Pénicaud L.

Arch Mal Coeur Vaiss. 1996 Aug;89(8):1103-6. French. PMID: 8949387 [PubMed - indexed for MEDLINE]Related articles