PubMed

Neuronal Insulin Receptor Substrate (IRS)-2 Expression is Regulated by ZBP89 and SP1 Binding to the IRS-2 Promoter.

Udelhoven M, Pasieka M, Leeser U, Krone W, Schubert M.

J Endocrinol. 2009 Oct 29. [Epub ahead of print]PMID: 19875459 [PubMed - as supplied by publisher]Related articles

Identification of a region in the human IRS-2 promoter essential for stress induced transcription depending on SP1, NF1 binding and ERK activation in HepG2 cells.

Udelhoven M, Leeser U, Freude S, Hettich M, Laudes M, Schnitker J, Krone W, Schubert M.

J Mol Endocrinol. 2009 Sep 16. [Epub ahead of print]PMID: 19755487 [PubMed - as supplied by publisher]Related articles

Vitamin D and cardiovascular disease.

Gouni-Berthold I, Krone W, Berthold HK.

Curr Vasc Pharmacol. 2009 Jul;7(3):414-22. Review.PMID: 19601865 [PubMed - indexed for MEDLINE]Related articles

Neuronal IGF-1 resistance reduces Abeta accumulation and protects against premature death in a model of Alzheimer's disease.

Freude S, Hettich MM, Schumann C, Stöhr O, Koch L, Köhler C, Udelhoven M, Leeser U, Müller M, Kubota N, Kadowaki T, Krone W, Schröder H, Brüning JC, Schubert M.

FASEB J. 2009 Oct;23(10):3315-24. Epub 2009 Jun 1.PMID: 19487308 [PubMed - indexed for MEDLINE]Related articles

Patterns and predictors of statin prescription in patients with type 2 diabetes.

Berthold HK, Gouni-Berthold I, Böhm M, Krone W, Bestehorn KP.

Cardiovasc Diabetol. 2009 May 13;8:25.PMID: 19439071 [PubMed - indexed for MEDLINE]Related articlesFree article

Comparison of phenotypes in male and female individuals of a new family with Dunnigan type of familial partial lipodystrophy due to a lamin A/C R482W mutation.

Laudes M, Oberhauser F, Walgenbach K, Schubert M, Schulte DM, Faust M, Krone W.

Horm Metab Res. 2009 May;41(5):414-7. Epub 2009 Feb 9. No abstract available. PMID: 19204888 [PubMed - indexed for MEDLINE]Related articles

Human fetal adiponectin and retinol-binding protein (RBP)-4 levels in relation to birth weight and maternal obesity.

Laudes M, Oberhauser F, Bilkovski R, Schubert M, Udelhoven M, Wassmer G, Roth B, Krone W.

Exp Clin Endocrinol Diabetes. 2009 Mar;117(3):146-9. Epub 2008 Dec 3.PMID: 19053019 [PubMed - indexed for MEDLINE]Related articles

Comparison of a new long-acting testosterone undecanoate formulation vs testosterone enanthate for intramuscular androgen therapy in male hypogonadism.

Minnemann T, Schubert M, Freude S, Hübler D, Gouni-Berthold I, Schumann C, Christoph A, Oettel M, Ernst M, Mellinger U, Krone W, Jockenhövel F.

J Endocrinol Invest. 2008 Aug;31(8):718-23.PMID: 18852533 [PubMed - indexed for MEDLINE]Related articles

The Leu72Met polymorphism of the ghrelin gene is associated with a decreased risk for type 2 diabetes.

Berthold HK, Giannakidou E, Krone W, Mantzoros CS, Gouni-Berthold I.

Clin Chim Acta. 2009 Jan;399(1-2):112-6. Epub 2008 Sep 25.PMID: 18848536 [PubMed - indexed for MEDLINE]Related articles

IRS-2 branch of IGF-1 receptor signaling is essential for appropriate timing of myelination.

Freude S, Leeser U, Müller M, Hettich MM, Udelhoven M, Schilbach K, Tobe K, Kadowaki T, Köhler C, Schröder H, Krone W, Brüning JC, Schubert M.

J Neurochem. 2008 Nov;107(4):907-17. Epub 2008 Sep 18.PMID: 18717815 [PubMed - indexed for MEDLINE]Related articles

Autocrine IGF-1 action in adipocytes controls systemic IGF-1 concentrations and growth.

Klöting N, Koch L, Wunderlich T, Kern M, Ruschke K, Krone W, Brüning JC, Blüher M.

Diabetes. 2008 Aug;57(8):2074-82. Epub 2008 Apr 28.PMID: 18443199 [PubMed - indexed for MEDLINE]Related articlesFree article

Physician gender is associated with the quality of type 2 diabetes care.

Berthold HK, Gouni-Berthold I, Bestehorn KP, Böhm M, Krone W.

J Intern Med. 2008 Oct;264(4):340-50. Epub 2008 Apr 4.PMID: 18397244 [PubMed - indexed for MEDLINE]Related articles

Sex disparities in the treatment and control of cardiovascular risk factors in type 2 diabetes.

Gouni-Berthold I, Berthold HK, Mantzoros CS, Böhm M, Krone W.

Diabetes Care. 2008 Jul;31(7):1389-91. Epub 2008 Mar 28.PMID: 18375411 [PubMed - indexed for MEDLINE]Related articlesFree article

Transcription factor FBI-1 acts as a dual regulator in adipogenesis by coordinated regulation of cyclin-A and E2F-4.

Laudes M, Bilkovski R, Oberhauser F, Droste A, Gomolka M, Leeser U, Udelhoven M, Krone W.

J Mol Med. 2008 May;86(5):597-608. Epub 2008 Mar 27.PMID: 18368381 [PubMed - indexed for MEDLINE]Related articles

SREBP-1c gene polymorphism is associated with increased inhibition of cholesterol-absorption in response to ezetimibe treatment.

Berthold HK, Laaksonen R, Lehtimäki T, Gylling H, Krone W, Gouni-Berthold I.

Exp Clin Endocrinol Diabetes. 2008 May;116(5):262-7. Epub 2007 Dec 10.PMID: 18072016 [PubMed - indexed for MEDLINE]Related articles

Enhanced leptin-stimulated Pi3k activation in the CNS promotes white adipose tissue transdifferentiation.

Plum L, Rother E, Münzberg H, Wunderlich FT, Morgan DA, Hampel B, Shanabrough M, Janoschek R, Könner AC, Alber J, Suzuki A, Krone W, Horvath TL, Rahmouni K, Brüning JC.

Cell Metab. 2007 Dec;6(6):431-45.PMID: 18054313 [PubMed - indexed for MEDLINE]Related articles

Effects of ezetimibe and/or simvastatin on LDL receptor protein expression and on LDL receptor and HMG-CoA reductase gene expression: a randomized trial in healthy men.

Gouni-Berthold I, Berthold HK, Gylling H, Hallikainen M, Giannakidou E, Stier S, Ko Y, Patel D, Soutar AK, Seedorf U, Mantzoros CS, Plat J, Krone W.

Atherosclerosis. 2008 May;198(1):198-207. Epub 2007 Nov 5.PMID: 17980884 [PubMed - indexed for MEDLINE]Related articles

Short-term treatment with ezetimibe, simvastatin or their combination does not alter circulating adiponectin, resistin or leptin levels in healthy men.

Gouni-Berthold I, Berthold HK, Chamberland JP, Krone W, Mantzoros CS.

Clin Endocrinol (Oxf). 2008 Apr;68(4):536-41. Epub 2007 Oct 31.PMID: 17973945 [PubMed - indexed for MEDLINE]Related articles

[Type 1 diabetes: what are the alternatives for lowering cholesterol levels with statins?]

Krone W, Berthold J.

Dtsch Med Wochenschr. 2007 Nov;132(44):2344. German. No abstract available. PMID: 17957603 [PubMed - indexed for MEDLINE]Related articles

A four-year efficacy and safety study of the long-acting parenteral testosterone undecanoate.

Minnemann T, Schubert M, Hübler D, Gouni-Berthold I, Freude S, Schumann C, Oettel M, Ernst M, Mellinger U, Sommer F, Krone W, Jockenhövel F.

Aging Male. 2007 Sep;10(3):155-8.PMID: 17701659 [PubMed - indexed for MEDLINE]Related articles

[Favorable effects of decreasing lipids in patients with diabetes mellitus]

Gouni-Berthold I, Krone W.

Dtsch Med Wochenschr. 2006 Dec;131 Suppl 8:S252-4. Review. German. PMID: 17139581 [PubMed - indexed for MEDLINE]Related articles

The K121Q polymorphism of the plasma cell glycoprotein-1 gene is not associated with diabetes mellitus type 2 in German Caucasians.

Gouni-Berthold I, Giannakidou E, Faust M, Berthold HK, Krone W.

Horm Metab Res. 2006 Aug;38(8):524-9.PMID: 16941279 [PubMed - indexed for MEDLINE]Related articles

Linear accelerator radiosurgery for pituitary macroadenomas: a 7-year follow-up study.

Voges J, Kocher M, Runge M, Poggenborg J, Lehrke R, Lenartz D, Maarouf M, Gouni-Berthold I, Krone W, Muller RP, Sturm V.

Cancer. 2006 Sep 15;107(6):1355-64.PMID: 16894526 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of ezetimibe and/or simvastatin on coenzyme Q10 levels in plasma: a randomised trial.

Berthold HK, Naini A, Di Mauro S, Hallikainen M, Gylling H, Krone W, Gouni-Berthold I.

Drug Saf. 2006;29(8):703-12.PMID: 16872244 [PubMed - indexed for MEDLINE]Related articles

[LDL target values in diabetic patients]

Krone W.

Dtsch Med Wochenschr. 2006 Jun 2;131(22):1288. German. No abstract available. PMID: 16817249 [PubMed - indexed for MEDLINE]Related articles

Diabetic ketoacidosis and hyperosmolar hyperglycemic state.

Gouni-Berthold I, Krone W.

Med Klin (Munich). 2006 Mar 22;101 Suppl 1:100-5.PMID: 16802531 [PubMed - indexed for MEDLINE]Related articles

Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity.

Plum L, Ma X, Hampel B, Balthasar N, Coppari R, Münzberg H, Shanabrough M, Burdakov D, Rother E, Janoschek R, Alber J, Belgardt BF, Koch L, Seibler J, Schwenk F, Fekete C, Suzuki A, Mak TW, Krone W, Horvath TL, Ashcroft FM, Brüning JC.

J Clin Invest. 2006 Jul;116(7):1886-901. Epub 2006 Jun 22.PMID: 16794735 [PubMed - indexed for MEDLINE]Related articlesFree article

[The significance of the 1 hour value of the oral glucose tolerance test]

Krone W.

Dtsch Med Wochenschr. 2006 Jun 2;131(22):1288. German. No abstract available. PMID: 16755427 [PubMed - indexed for MEDLINE]Related articles

Association of the promoter polymorphism -232C/G of the phosphoenolpyruvate carboxykinase gene (PCK1) with Type 2 diabetes mellitus.

Gouni-Berthold I, Giannakidou E, Faust M, Berthold HK, Krone W.

Diabet Med. 2006 Apr;23(4):419-25.PMID: 16620271 [PubMed - indexed for MEDLINE]Related articles

Myeloid lineage cell-restricted insulin resistance protects apolipoproteinE-deficient mice against atherosclerosis.

Baumgartl J, Baudler S, Scherner M, Babaev V, Makowski L, Suttles J, McDuffie M, Tobe K, Kadowaki T, Fazio S, Kahn CR, Hotamisligil GS, Krone W, Linton M, Brüning JC.

Cell Metab. 2006 Apr;3(4):247-56. Erratum in: Cell Metab. 2006 Jun;3(6):469. Tobe, Kazuyuki [added]; Kadowaki, Takashi [added]. PMID: 16581002 [PubMed - indexed for MEDLINE]Related articles

Peroxisome proliferator-activated receptor alpha (PPARalpha) and athero-sclerosis.

Gouni-Berthold I, Krone W.

Curr Drug Targets Cardiovasc Haematol Disord. 2005 Dec;5(6):513-23. Review.PMID: 16503871 [PubMed - indexed for MEDLINE]Related articles

Resistin gene 3'-untranslated region +62G-->A polymorphism is associated with hypertension but not diabetes mellitus type 2 in a German population.

Gouni-Berthold I, Giannakidou E, Faust M, Kratzsch J, Berthold HK, Krone W.

J Intern Med. 2005 Dec;258(6):518-26.PMID: 16313475 [PubMed - indexed for MEDLINE]Related articles

Peripheral hyperinsulinemia promotes tau phosphorylation in vivo.

Freude S, Plum L, Schnitker J, Leeser U, Udelhoven M, Krone W, Bruning JC, Schubert M.

Diabetes. 2005 Dec;54(12):3343-8.PMID: 16306348 [PubMed - indexed for MEDLINE]Related articlesFree article

The peroxisome proliferator-activated receptor delta +294T/C polymorphism in relation to lipoprotein metabolism in patients with diabetes mellitus type 2 and in non-diabetic controls.

Gouni-Berthold I, Giannakidou E, Faust M, Berthold HK, Krone W.

Atherosclerosis. 2005 Dec;183(2):336-41. Epub 2005 Apr 19.PMID: 16285997 [PubMed - indexed for MEDLINE]Related articles

Hypertriglyceridemia-why, when and how should it be treated?

Gouni-Berthold I, Krone W.

Z Kardiol. 2005 Nov;94(11):731-9. Review.PMID: 16258774 [PubMed - indexed for MEDLINE]Related articles

Autoimmune polyglandular syndrome associated with idiopathic giant cell myocarditis.

Schumann C, Faust M, Gerharz M, Ortmann M, Schubert M, Krone W.

Exp Clin Endocrinol Diabetes. 2005 May;113(5):302-7.PMID: 15926118 [PubMed - indexed for MEDLINE]Related articles

Transgenic and knockout mice in diabetes research: novel insights into pathophysiology, limitations, and perspectives.

Plum L, Wunderlich FT, Baudler S, Krone W, Brüning JC.

Physiology (Bethesda). 2005 Jun;20:152-61. Review.PMID: 15888572 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin-like growth factor-1 controls type 2 T cell-independent B cell response.

Baudler S, Baumgartl J, Hampel B, Buch T, Waisman A, Snapper CM, Krone W, Brüning JC.

J Immunol. 2005 May 1;174(9):5516-25.PMID: 15843550 [PubMed - indexed for MEDLINE]Related articlesFree article

The Pro387Leu variant of protein tyrosine phosphatase-1B is not associated with diabetes mellitus type 2 in a German population.

Gouni-Berthold I, Giannakidou E, Müller-Wieland D, Faust M, Kotzka J, Berthold HK, Krone W.

J Intern Med. 2005 Mar;257(3):272-80.PMID: 15715684 [PubMed - indexed for MEDLINE]Related articles

Peroxisome proliferator-activated receptor-gamma2 Pro12Ala and endothelial nitric oxide synthase-4a/b gene polymorphisms are not associated with hypertension in diabetes mellitus type 2.

Gouni-Berthold I, Giannakidou E, Müller-Wieland D, Faust M, Kotzka J, Berthold HK, Krone W.

J Hypertens. 2005 Feb;23(2):301-8.PMID: 15662218 [PubMed - indexed for MEDLINE]Related articles

Intramuscular testosterone undecanoate: pharmacokinetic aspects of a novel testosterone formulation during long-term treatment of men with hypogonadism.

Schubert M, Minnemann T, Hübler D, Rouskova D, Christoph A, Oettel M, Ernst M, Mellinger U, Krone W, Jockenhövel F.

J Clin Endocrinol Metab. 2004 Nov;89(11):5429-34.PMID: 15531493 [PubMed - indexed for MEDLINE]Related articlesFree article

[Diabetes mellitus needs unrestricted evaluation of patient data to yield treatment progress. The DUTY Register]

Krone W, Böhm M.

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2004 Jun;47(6):540-6. German. PMID: 15221103 [PubMed - indexed for MEDLINE]Related articles

Age-dependent effects of atorvastatin on biochemical bone turnover markers: a randomized controlled trial in postmenopausal women.

Berthold HK, Unverdorben S, Zittermann A, Degenhardt R, Baumeister B, Unverdorben M, Krone W, Vetter H, Gouni-Berthold I.

Osteoporos Int. 2004 Jun;15(6):459-67. Epub 2004 Feb 14.PMID: 15205717 [PubMed - indexed for MEDLINE]Related articles

Association between the PPARalpha L162V polymorphism, plasma lipoprotein levels, and atherosclerotic disease in patients with diabetes mellitus type 2 and in nondiabetic controls.

Gouni-Berthold I, Giannakidou E, Müller-Wieland D, Faust M, Kotzka J, Berthold HK, Krone W.

Am Heart J. 2004 Jun;147(6):1117-24.PMID: 15199365 [PubMed - indexed for MEDLINE]Related articles

Role for neuronal insulin resistance in neurodegenerative diseases.

Schubert M, Gautam D, Surjo D, Ueki K, Baudler S, Schubert D, Kondo T, Alber J, Galldiks N, Küstermann E, Arndt S, Jacobs AH, Krone W, Kahn CR, Brüning JC.

Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):3100-5. Epub 2004 Feb 23.PMID: 14981233 [PubMed - indexed for MEDLINE]Related articlesFree article

Conditional disruption of IkappaB kinase 2 fails to prevent obesity-induced insulin resistance.

Röhl M, Pasparakis M, Baudler S, Baumgartl J, Gautam D, Huth M, De Lorenzi R, Krone W, Rajewsky K, Brüning JC.

J Clin Invest. 2004 Feb;113(3):474-81.PMID: 14755344 [PubMed - indexed for MEDLINE]Related articlesFree article

[Hyperlipidemia: therapeutic principles in clinical practice]

Müller-Wieland D, Krone W.

Med Klin (Munich). 2003 Dec 15;98(12):739-43. Review. German. PMID: 14685674 [PubMed - indexed for MEDLINE]Related articles

Somatic NF1 mutation spectra in a family with neurofibromatosis type 1: toward a theory of genetic modifiers.

Wiest V, Eisenbarth I, Schmegner C, Krone W, Assum G.

Hum Mutat. 2003 Dec;22(6):423-7.PMID: 14635100 [PubMed - indexed for MEDLINE]Related articles

[End-organ damage in hyperlipidemias]

Faust M, Krone W.

Internist (Berl). 2003 Jul;44(7):831-2, 835-9. Review. German. PMID: 14631579 [PubMed - indexed for MEDLINE]Related articles

Estrogen receptor-alpha and Sp1 interact in the induction of the low density lipoprotein-receptor.

Brüning JC, Lingohr P, Gillette J, Hanstein B, Avci H, Krone W, Müller-Wieland D, Kotzka J.

J Steroid Biochem Mol Biol. 2003 Aug;86(2):113-21.PMID: 14568562 [PubMed - indexed for MEDLINE]Related articles