PubMed

AIMing 2 detect foreign DNA.

Krieg AM.

Sci Signal. 2009 Jun 30;2(77):pe39.PMID: 19567913 [PubMed - indexed for MEDLINE]Related articles

CpG oligodeoxynucleotides augment the murine immune response to the Yersinia pestis F1-V vaccine in bubonic and pneumonic models of plague.

Amemiya K, Meyers JL, Rogers TE, Fast RL, Bassett AD, Worsham PL, Powell BS, Norris SL, Krieg AM, Adamovicz JJ.

Vaccine. 2009 Apr 6;27(16):2220-9. Epub 2009 Feb 13.PMID: 19428836 [PubMed - indexed for MEDLINE]Related articles

Sequences derived from self-RNA containing certain natural modifications act as suppressors of RNA-mediated inflammatory immune responses.

Tluk S, Jurk M, Forsbach A, Weeratna R, Samulowitz U, Krieg AM, Bauer S, Vollmer J.

Int Immunol. 2009 May;21(5):607-19. Epub 2009 Mar 30.PMID: 19332442 [PubMed - indexed for MEDLINE]Related articles

Immunotherapeutic applications of CpG oligodeoxynucleotide TLR9 agonists.

Vollmer J, Krieg AM.

Adv Drug Deliv Rev. 2009 Mar 28;61(3):195-204. Epub 2009 Jan 13. Review.PMID: 19211030 [PubMed - indexed for MEDLINE]Related articles

Toll-like receptor 9 activation with CpG oligodeoxynucleotides for asthma therapy.

Kline JN, Krieg AM.

Drug News Perspect. 2008 Oct;21(8):434-9. Review.PMID: 19034349 [PubMed - indexed for MEDLINE]Related articles

NK cells activated in vivo by bacterial DNA control the intracellular growth of Francisella tularensis LVS.

Elkins KL, Colombini SM, Krieg AM, De Pascalis R.

Microbes Infect. 2009 Jan;11(1):49-56. Epub 2008 Oct 22.PMID: 18992838 [PubMed - indexed for MEDLINE]Related articles

Paclitaxel reduces regulatory T cell numbers and inhibitory function and enhances the anti-tumor effects of the TLR9 agonist PF-3512676 in the mouse.

Vicari AP, Luu R, Zhang N, Patel S, Makinen SR, Hanson DC, Weeratna RD, Krieg AM.

Cancer Immunol Immunother. 2009 Apr;58(4):615-28. Epub 2008 Sep 19.PMID: 18802696 [PubMed - indexed for MEDLINE]Related articles

CD14+ cells are required for IL-12 response in bovine blood mononuclear cells activated with Toll-like receptor (TLR) 7 and TLR8 ligands.

Buza J, Benjamin P, Zhu J, Wilson HL, Lipford G, Krieg AM, Babiuk LA, Mutwiri GK.

Vet Immunol Immunopathol. 2008 Dec 15;126(3-4):273-82. Epub 2008 Aug 20.PMID: 18789542 [PubMed - indexed for MEDLINE]Related articles

Randomized phase II trial of a toll-like receptor 9 agonist oligodeoxynucleotide, PF-3512676, in combination with first-line taxane plus platinum chemotherapy for advanced-stage non-small-cell lung cancer.

Manegold C, Gravenor D, Woytowitz D, Mezger J, Hirsh V, Albert G, Al-Adhami M, Readett D, Krieg AM, Leichman CG.

J Clin Oncol. 2008 Aug 20;26(24):3979-86.PMID: 18711188 [PubMed - indexed for MEDLINE]Related articles

A combination of Flt3 ligand cDNA and CpG ODN as nasal adjuvant elicits NALT dendritic cells for prolonged mucosal immunity.

Fukuiwa T, Sekine S, Kobayashi R, Suzuki H, Kataoka K, Gilbert RS, Kurono Y, Boyaka PN, Krieg AM, McGhee JR, Fujihashi K.

Vaccine. 2008 Sep 2;26(37):4849-59. Epub 2008 Jul 14.PMID: 18625280 [PubMed - indexed for MEDLINE]Related articlesFree article

TLR agonists regulate alloresponses and uncover a critical role for donor APCs in allogeneic bone marrow rejection.

Taylor PA, Ehrhardt MJ, Lees CJ, Panoskaltsis-Mortari A, Krieg AM, Sharpe AH, Murphy WJ, Serody JS, Hemmi H, Akira S, Levy RB, Blazar BR.

Blood. 2008 Oct 15;112(8):3508-16. Epub 2008 Jul 9.PMID: 18614760 [PubMed - indexed for MEDLINE]Related articlesFree article

Immunostimulatory effects of three classes of CpG oligodeoxynucleotides on PBMC from HCV chronic carriers.

Cooper CL, Ahluwalia NK, Efler SM, Vollmer J, Krieg AM, Davis HL.

J Immune Based Ther Vaccines. 2008 Jun 9;6:3.PMID: 18541039 [PubMed - in process]Related articlesFree article

Toll-like receptor 9 regulates the lung macrophage phenotype and host immunity in murine pneumonia caused by Legionella pneumophila.

Bhan U, Trujillo G, Lyn-Kew K, Newstead MW, Zeng X, Hogaboam CM, Krieg AM, Standiford TJ.

Infect Immun. 2008 Jul;76(7):2895-904. Epub 2008 Apr 21.PMID: 18426877 [PubMed - indexed for MEDLINE]Related articlesFree article

Attenuated cytokine responses in porcine lymph node cells stimulated with CpG DNA are associated with low frequency of IFNalpha-producing cells and TLR9 mRNA expression.

Dar A, Nichani AK, Benjamin P, Lai K, Soita H, Krieg AM, Potter A, Babiuk LA, Mutwiri GK.

Vet Immunol Immunopathol. 2008 Jun 15;123(3-4):324-36. Epub 2008 Feb 17.PMID: 18367252 [PubMed - indexed for MEDLINE]Related articles

Dendritic cells from HIV-1 infected individuals are less responsive to toll-like receptor (TLR) ligands.

Martinson JA, Roman-Gonzalez A, Tenorio AR, Montoya CJ, Gichinga CN, Rugeles MT, Tomai M, Krieg AM, Ghanekar S, Baum LL, Landay AL.

Cell Immunol. 2007 Nov-Dec;250(1-2):75-84. Epub 2008 Mar 10.PMID: 18334250 [PubMed - indexed for MEDLINE]Related articles

Identification of RNA sequence motifs stimulating sequence-specific TLR8-dependent immune responses.

Forsbach A, Nemorin JG, Montino C, Müller C, Samulowitz U, Vicari AP, Jurk M, Mutwiri GK, Krieg AM, Lipford GB, Vollmer J.

J Immunol. 2008 Mar 15;180(6):3729-38.PMID: 18322178 [PubMed - indexed for MEDLINE]Related articlesFree article

Immunology. The toll of cathepsin K deficiency.

Krieg AM, Lipford GB.

Science. 2008 Feb 1;319(5863):576-7. No abstract available. PMID: 18239112 [PubMed - indexed for MEDLINE]Related articles

Toll-like receptor 9 (TLR9) agonists in the treatment of cancer.

Krieg AM.

Oncogene. 2008 Jan 7;27(2):161-7. Review.PMID: 18176597 [PubMed - indexed for MEDLINE]Related articles

Activation of innate immunity in healthy Macaca mulatta macaques by a single subcutaneous dose of GMP CpG 7909: safety data and interferon-inducible protein-10 kinetics for humans and macaques.

Stewart VA, McGrath S, Krieg AM, Larson NS, Angov E, Smith CL, Brewer TG, Heppner DG Jr.

Clin Vaccine Immunol. 2008 Feb;15(2):221-6. Epub 2007 Dec 12.PMID: 18077623 [PubMed - indexed for MEDLINE]Related articlesFree article

The toll of too much TLR7.

Krieg AM.

Immunity. 2007 Nov;27(5):695-7. Review.PMID: 18031693 [PubMed - indexed for MEDLINE]Related articles

The CpG motif: implications for clinical immunology.

Krieg AM.

BioDrugs. 1998 Nov;10(5):341-6.PMID: 18020606 [PubMed - in process]Related articles

Toll-like receptors 7, 8, and 9: linking innate immunity to autoimmunity.

Krieg AM, Vollmer J.

Immunol Rev. 2007 Dec;220:251-69. Review.PMID: 17979852 [PubMed - indexed for MEDLINE]Related articles

Phase I trial of toll-like receptor 9 agonist PF-3512676 with and following rituximab in patients with recurrent indolent and aggressive non Hodgkin's lymphoma.

Leonard JP, Link BK, Emmanouilides C, Gregory SA, Weisdorf D, Andrey J, Hainsworth J, Sparano JA, Tsai DE, Horning S, Krieg AM, Weiner GJ.

Clin Cancer Res. 2007 Oct 15;13(20):6168-74.PMID: 17947483 [PubMed - indexed for MEDLINE]Related articlesFree article

TLR9 is required for protective innate immunity in Gram-negative bacterial pneumonia: role of dendritic cells.

Bhan U, Lukacs NW, Osterholzer JJ, Newstead MW, Zeng X, Moore TA, McMillan TR, Krieg AM, Akira S, Standiford TJ.

J Immunol. 2007 Sep 15;179(6):3937-46.PMID: 17785831 [PubMed - indexed for MEDLINE]Related articlesFree article

Safety, pharmacokinetics and immune effects in normal volunteers of CPG 10101 (ACTILON), an investigational synthetic toll-like receptor 9 agonist.

Vicari AP, Schmalbach T, Lekstrom-Himes J, Morris ML, Al-Adhami MJ, Laframboise C, Leese P, Krieg AM, Efler SM, Davis HL.

Antivir Ther. 2007;12(5):741-51.PMID: 17713157 [PubMed - indexed for MEDLINE]Related articles

Lymphoma immunotherapy with CpG oligodeoxynucleotides requires TLR9 either in the host or in the tumor itself.

Li J, Song W, Czerwinski DK, Varghese B, Uematsu S, Akira S, Krieg AM, Levy R.

J Immunol. 2007 Aug 15;179(4):2493-500.PMID: 17675511 [PubMed - indexed for MEDLINE]Related articlesFree article

Antiinfective applications of toll-like receptor 9 agonists.

Krieg AM.

Proc Am Thorac Soc. 2007 Jul;4(3):289-94. Review.PMID: 17607015 [PubMed - indexed for MEDLINE]Related articlesFree article

Paradoxical enhancement of CD8 T cell-dependent anti-tumor protection despite reduced CD8 T cell responses with addition of a TLR9 agonist to a tumor vaccine.

Karan D, Krieg AM, Lubaroff DM.

Int J Cancer. 2007 Oct 1;121(7):1520-8.PMID: 17565748 [PubMed - indexed for MEDLINE]Related articles

Development of TLR9 agonists for cancer therapy.

Krieg AM.

J Clin Invest. 2007 May;117(5):1184-94. Review.PMID: 17476348 [PubMed - indexed for MEDLINE]Related articlesFree article

TLR9 and DNA 'feel' RAGE.

Krieg AM.

Nat Immunol. 2007 May;8(5):475-7. No abstract available. PMID: 17440455 [PubMed - indexed for MEDLINE]Related articles

Toll-free vaccines?

Krieg AM.

Nat Biotechnol. 2007 Mar;25(3):303-5. No abstract available. Erratum in: Nat Biotechnol. 2007 Jun;25(6):687. PMID: 17344883 [PubMed - indexed for MEDLINE]Related articles

Impact of class A, B and C CpG-oligodeoxynucleotides on in vitro activation of innate immune cells in human immunodeficiency virus-1 infected individuals.

Martinson JA, Tenorio AR, Montoya CJ, Al-Harthi L, Gichinga CN, Krieg AM, Baum LL, Landay AL.

Immunology. 2007 Apr;120(4):526-35.PMID: 17343615 [PubMed - indexed for MEDLINE]Related articlesFree article

Systemic innate immune responses following intrapulmonary delivery of CpG oligodeoxynucleotides in sheep.

Nichani AK, Dar MA, Krieg AM, Mirakhur KK, Kaushik RS, Griebel PJ, Manuja A, Townsend HG, Babiuk LA, Mutwiri GK.

Vet Immunol Immunopathol. 2007 Feb 15;115(3-4):357-68. Epub 2006 Dec 1.PMID: 17194483 [PubMed - indexed for MEDLINE]Related articles

Phase II trial of a toll-like receptor 9-activating oligonucleotide in patients with metastatic melanoma.

Pashenkov M, Goëss G, Wagner C, Hörmann M, Jandl T, Moser A, Britten CM, Smolle J, Koller S, Mauch C, Tantcheva-Poor I, Grabbe S, Loquai C, Esser S, Franckson T, Schneeberger A, Haarmann C, Krieg AM, Stingl G, Wagner SN.

J Clin Oncol. 2006 Dec 20;24(36):5716-24.PMID: 17179105 [PubMed - indexed for MEDLINE]Related articles

High mobility group B1 protein suppresses the human plasmacytoid dendritic cell response to TLR9 agonists.

Popovic PJ, DeMarco R, Lotze MT, Winikoff SE, Bartlett DL, Krieg AM, Guo ZS, Brown CK, Tracey KJ, Zeh HJ 3rd.

J Immunol. 2006 Dec 15;177(12):8701-7.PMID: 17142771 [PubMed - indexed for MEDLINE]Related articlesFree article

Innate immune responses induced by classes of CpG oligodeoxynucleotides in ovine lymph node and blood mononuclear cells.

Booth JS, Nichani AK, Benjamin P, Dar A, Krieg AM, Babiuk LA, Mutwiri GK.

Vet Immunol Immunopathol. 2007 Jan 15;115(1-2):24-34. Epub 2006 Sep 26.PMID: 17067685 [PubMed - indexed for MEDLINE]Related articles

Enhancement of infectious disease vaccines through TLR9-dependent recognition of CpG DNA.

McCluskie MJ, Krieg AM.

Curr Top Microbiol Immunol. 2006;311:155-78. Review.PMID: 17048708 [PubMed - indexed for MEDLINE]Related articles

Dendritic cells pulsed or fused with AML cellular antigen provide comparable in vivo antitumor protective responses.

Weigel BJ, Panoskaltsis-Mortari A, Diers M, Garcia M, Lees C, Krieg AM, Chen W, Blazar BR.

Exp Hematol. 2006 Oct;34(10):1403-12.PMID: 16982333 [PubMed - indexed for MEDLINE]Related articles

Oligodeoxynucleotide CpG 7909 delivered as intravenous infusion demonstrates immunologic modulation in patients with previously treated non-Hodgkin lymphoma.

Link BK, Ballas ZK, Weisdorf D, Wooldridge JE, Bossler AD, Shannon M, Rasmussen WL, Krieg AM, Weiner GJ.

J Immunother. 2006 Sep-Oct;29(5):558-68.PMID: 16971811 [PubMed - indexed for MEDLINE]Related articles

Structure-activity relationship studies on the immune stimulatory effects of base-modified CpG toll-like receptor 9 agonists.

Jurk M, Kritzler A, Debelak H, Vollmer J, Krieg AM, Uhlmann E.

ChemMedChem. 2006 Sep;1(9):1007-14.PMID: 16952134 [PubMed - indexed for MEDLINE]Related articles

Decreased cytotoxic T cell activity generated by co-administration of PSA vaccine and CpG ODN is associated with increased tumor protection in a mouse model of prostate cancer.

Lubaroff DM, Karan D, Andrews MP, Acosta A, Abouassaly C, Sharma M, Krieg AM.

Vaccine. 2006 Aug 28;24(35-36):6155-62. Epub 2006 May 3.PMID: 16876291 [PubMed - indexed for MEDLINE]Related articles

Surgical excision combined with autologous whole tumor cell vaccination is an effective therapy for murine neuroblastoma.

Ohashi K, Kobayashi G, Fang S, Zhu X, Antonia SJ, Krieg AM, Sandler AD.

J Pediatr Surg. 2006 Aug;41(8):1361-8.PMID: 16863838 [PubMed - indexed for MEDLINE]Related articles

New generation vaccine induces effective melanoma-specific CD8+ T cells in the circulation but not in the tumor site.

Appay V, Jandus C, Voelter V, Reynard S, Coupland SE, Rimoldi D, Lienard D, Guillaume P, Krieg AM, Cerottini JC, Romero P, Leyvraz S, Rufer N, Speiser DE.

J Immunol. 2006 Aug 1;177(3):1670-8.PMID: 16849476 [PubMed - indexed for MEDLINE]Related articlesFree article

Activation of plasmacytoid dendritic cells with TLR9 agonists initiates invariant NKT cell-mediated cross-talk with myeloid dendritic cells.

Montoya CJ, Jie HB, Al-Harthi L, Mulder C, Patiño PJ, Rugeles MT, Krieg AM, Landay AL, Wilson SB.

J Immunol. 2006 Jul 15;177(2):1028-39.PMID: 16818759 [PubMed - indexed for MEDLINE]Related articlesFree article

Modulating responsiveness of human TLR7 and 8 to small molecule ligands with T-rich phosphorothiate oligodeoxynucleotides.

Jurk M, Kritzler A, Schulte B, Tluk S, Schetter C, Krieg AM, Vollmer J.

Eur J Immunol. 2006 Jul;36(7):1815-26.PMID: 16783850 [PubMed - indexed for MEDLINE]Related articles

Therapeutic potential of Toll-like receptor 9 activation.

Krieg AM.

Nat Rev Drug Discov. 2006 Jun;5(6):471-84. Review.PMID: 16763660 [PubMed - indexed for MEDLINE]Related articles

Stimulation of innate immune responses by CpG oligodeoxynucleotide in newborn lambs can reduce bovine herpesvirus-1 shedding.

Nichani AK, Mena A, Kaushik RS, Mutwiri GK, Townsend HG, Hecker R, Krieg AM, Babiuk LA, Griebel PJ.

Oligonucleotides. 2006 Spring;16(1):58-67.PMID: 16584295 [PubMed - indexed for MEDLINE]Related articles

A CpG oligonucleotide can protect mice from a low aerosol challenge dose of Burkholderia mallei.

Waag DM, McCluskie MJ, Zhang N, Krieg AM.

Infect Immun. 2006 Mar;74(3):1944-8.PMID: 16495571 [PubMed - indexed for MEDLINE]Related articlesFree article

Immune stimulation mediated by autoantigen binding sites within small nuclear RNAs involves Toll-like receptors 7 and 8.

Vollmer J, Tluk S, Schmitz C, Hamm S, Jurk M, Forsbach A, Akira S, Kelly KM, Reeves WH, Bauer S, Krieg AM.

J Exp Med. 2005 Dec 5;202(11):1575-85.PMID: 16330816 [PubMed - indexed for MEDLINE]Related articlesFree article

Antibody repertoire development in fetal and neonatal piglets. IX. Three pathogen-associated molecular patterns act synergistically to allow germfree piglets to respond to type 2 thymus-independent and thymus-dependent antigens.

Butler JE, Francis DH, Freeling J, Weber P, Krieg AM.

J Immunol. 2005 Nov 15;175(10):6772-85.PMID: 16272334 [PubMed - indexed for MEDLINE]Related articlesFree article