PubMed

Interpreting registry-derived drug studies: Does societal context matter?

Kremer JM, Greenberg J.

Arthritis Rheum. 2009 Nov;60(11):3155-7. No abstract available. PMID: 19877064 [PubMed - in process]Related articles

Gene-gene interactions in folate and adenosine biosynthesis pathways affect methotrexate efficacy and tolerability in rheumatoid arthritis.

Dervieux T, Wessels JA, van der Straaten T, Penrod N, Moore JH, Guchelaar HJ, Kremer JM.

Pharmacogenet Genomics. 2009 Oct 24. [Epub ahead of print]PMID: 19858780 [PubMed - as supplied by publisher]Related articles

Prevalence of low hemoglobin levels and associations with other disease parameters in rheumatoid arthritis patients: evidence from the CORRONA registry.

Furst DE, Chang H, Greenberg JD, Ranganath VK, Reed G, Ozturk ZE, Kremer JM.

Clin Exp Rheumatol. 2009 Jul-Aug;27(4):560-6.PMID: 19772785 [PubMed - indexed for MEDLINE]Related articles

Improved pain, physical functioning, and health status in rheumatoid arthritis patients treated with CP-690,550, an orally active Janus kinase (JAK)inhibitor: results from a randomized, double-blind, placebo-controlled trial.

Coombs JH, Bloom BJ, Breedveld FC, Fletcher MP, Gruben D, Kremer JM, Burgos-Vargas R, Wilkinson B, Zerbini CA, Zwillich SH.

Ann Rheum Dis. 2009 Jul 8. [Epub ahead of print]PMID: 19587388 [PubMed - as supplied by publisher]Related articles

The safety and efficacy of a JAK inhibitor in patients with active rheumatoid arthritis: Results of a double-blind, placebo-controlled phase IIa trial of three dosage levels of CP-690,550 versus placebo.

Kremer JM, Bloom BJ, Breedveld FC, Coombs JH, Fletcher MP, Gruben D, Krishnaswami S, Burgos-Vargas R, Wilkinson B, Zerbini CA, Zwillich SH.

Arthritis Rheum. 2009 Jul;60(7):1895-905.PMID: 19565475 [PubMed - indexed for MEDLINE]Related articles

Utilization trends of tumor necrosis factor inhibitors among patients with rheumatoid arthritis in a United States observational cohort study.

Lee SJ, Chang H, Yazici Y, Greenberg JD, Kremer JM, Kavanaugh A.

J Rheumatol. 2009 Aug;36(8):1611-7. Epub 2009 Apr 15.PMID: 19369454 [PubMed - indexed for MEDLINE]Related articles

Factors influencing fracture risk, T score, and management of osteoporosis in patients with rheumatoid arthritis in the Consortium of Rheumatology Researchers of North America (CORRONA) registry.

Coulson KA, Reed G, Gilliam BE, Kremer JM, Pepmueller PH.

J Clin Rheumatol. 2009 Jun;15(4):155-60.PMID: 19363452 [PubMed - indexed for MEDLINE]Related articles

Association of Methotrexate and TNF antagonists with risk of infection outcomes including opportunistic infections in the CORRONA registry.

Greenberg JD, Reed G, Kremer JM, Tindall E, Kavanaugh A, Zheng C, Bishai W, Hochberg M.

Ann Rheum Dis. 2009 Apr 8. [Epub ahead of print]PMID: 19359261 [PubMed - as supplied by publisher]Related articles

Therapy: methotrexate guidelines: compromise to reach consensus.

Kremer JM.

Nat Rev Rheumatol. 2009 Apr;5(4):186-7. No abstract available. PMID: 19337280 [PubMed - indexed for MEDLINE]Related articles

Safety and efficacy of the selective costimulation modulator abatacept in patients with rheumatoid arthritis receiving background methotrexate: a 5-year extended phase IIB study.

Westhovens R, Kremer JM, Moreland LW, Emery P, Russell AS, Li T, Aranda R, Becker JC, Qi K, Dougados M.

J Rheumatol. 2009 Apr;36(4):736-42. Epub 2009 Feb 27.PMID: 19273451 [PubMed - indexed for MEDLINE]Related articles

Elevated liver enzyme tests among rheumatoid arthritis and psoriatic arthritis patients treated with methotrexate and/or leflunomide.

Curtis JR, Beukelman T, Onofrei A, Cassell S, Greenberg J, Kavanaugh A, Reed G, Strand V, Kremer JM.

Ann Rheum Dis. 2009 Jan 15. [Epub ahead of print]PMID: 19147616 [PubMed - as supplied by publisher]Related articles

Methotrexate treatment of rheumatic diseases: can we do better?

Kremer JM.

Arthritis Rheum. 2008 Nov;58(11):3279-82. No abstract available. PMID: 18975304 [PubMed - indexed for MEDLINE]Related articlesFree article

Etanercept for patients with RA: more is not always better.

Kremer JM.

Nat Clin Pract Rheumatol. 2009 Jan;5(1):10-1. Epub 2008 Oct 28. No abstract available. PMID: 18957946 [PubMed]Related articles

Functional improvement after patients with rheumatoid arthritis start a new disease modifying antirheumatic drug (DMARD) associated with frequent changes in DMARD: the CORRONA database.

Ranganath VK, Paulus HE, Onofrei A, Khanna D, Reed G, Elashoff DA, Kremer JM, Furst DE.

J Rheumatol. 2008 Oct;35(10):1966-71. Epub 2008 Sep 1.PMID: 18785317 [PubMed - indexed for MEDLINE]Related articlesFree article

COMET's path, and the new biologicals in rheumatoid arthritis.

Kremer JM.

Lancet. 2008 Aug 2;372(9636):347-8. Epub 2008 Jul 16. No abstract available. PMID: 18635257 [PubMed - indexed for MEDLINE]Related articles

Tumor necrosis factor antagonist responsiveness in a United States rheumatoid arthritis cohort.

Greenberg JD, Kishimoto M, Strand V, Cohen SB, Olenginski TP, Harrington T, Kafka SP, Reed G, Kremer JM; Consortium of Rheumatology Researchers of North America Investigators.

Am J Med. 2008 Jun;121(6):532-8.PMID: 18501236 [PubMed - indexed for MEDLINE]Related articlesFree article

Results of a two-year followup study of patients with rheumatoid arthritis who received a combination of abatacept and methotrexate.

Kremer JM, Genant HK, Moreland LW, Russell AS, Emery P, Abud-Mendoza C, Szechiński J, Li T, Teng J, Becker JC, Westhovens R.

Arthritis Rheum. 2008 Apr;58(4):953-63.PMID: 18383390 [PubMed - indexed for MEDLINE]Related articlesFree article

The role of drug and disease registries in rheumatic disease epidemiology.

Kremer JM, Gibofsky A, Greenberg JD.

Curr Opin Rheumatol. 2008 Mar;20(2):123-30. Review.PMID: 18349740 [PubMed - indexed for MEDLINE]Related articles

Abatacept inhibits progression of structural damage in rheumatoid arthritis: results from the long-term extension of the AIM trial.

Genant HK, Peterfy CG, Westhovens R, Becker JC, Aranda R, Vratsanos G, Teng J, Kremer JM.

Ann Rheum Dis. 2008 Aug;67(8):1084-9. Epub 2007 Dec 17.PMID: 18086727 [PubMed - indexed for MEDLINE]Related articlesFree article

Does DMARD treatment slow or prevent development of RA in patients with UA?

Kremer JM.

Nat Clin Pract Rheumatol. 2007 Dec;3(12):690-1. Epub 2007 Oct 9. No abstract available. PMID: 17925807 [PubMed]Related articles

Rheumatoid arthritis: a rapidly evolving treatment paradigm.

Kremer JM.

Manag Care Interface. 2007 Jul;20(7):17, 24. No abstract available. PMID: 17849728 [PubMed - indexed for MEDLINE]Related articles

Rheumatoid arthritis-is methotrexate re-employment an effective treatment option?

Kremer JM.

Nat Clin Pract Rheumatol. 2006 May;2(5):246-7. No abstract available. PMID: 16932695 [PubMed]Related articles

Methotrexate pharmacogenomics.

Kremer JM.

Ann Rheum Dis. 2006 Sep;65(9):1121-3. Review. No abstract available. PMID: 16905578 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of abatacept in patients with methotrexate-resistant active rheumatoid arthritis: a randomized trial.

Kremer JM, Genant HK, Moreland LW, Russell AS, Emery P, Abud-Mendoza C, Szechinski J, Li T, Ge Z, Becker JC, Westhovens R.

Ann Intern Med. 2006 Jun 20;144(12):865-76.PMID: 16785475 [PubMed - indexed for MEDLINE]Related articlesFree article

Etanercept treatment in adults with established rheumatoid arthritis: 7 years of clinical experience.

Moreland LW, Weinblatt ME, Keystone EC, Kremer JM, Martin RW, Schiff MH, Whitmore JB, White BW.

J Rheumatol. 2006 May;33(5):854-61. Epub 2006 Mar 15.PMID: 16541481 [PubMed - indexed for MEDLINE]Related articles

Risk genotypes in folate-dependent enzymes and their association with methotrexate-related side effects in rheumatoid arthritis.

Weisman MH, Furst DE, Park GS, Kremer JM, Smith KM, Wallace DJ, Caldwell JR, Dervieux T.

Arthritis Rheum. 2006 Feb;54(2):607-12.PMID: 16447238 [PubMed - indexed for MEDLINE]Related articlesFree article

Selective costimulation modulators: a novel approach for the treatment of rheumatoid arthritis.

Kremer JM.

J Clin Rheumatol. 2005 Jun;11(3 Suppl):S55-62. Review.PMID: 16357751 [PubMed - indexed for MEDLINE]Related articles

[From gene to disease; a progressive cochlear-vestibular dysfunction with onset in middle-age (DFNA9)]

Cremers CW, Kemperman MH, Bom SJ, Huygen PL, Verhagen WI, Kremer JM.

Ned Tijdschr Geneeskd. 2005 Nov 19;149(47):2619-21. Review. Dutch. PMID: 16355574 [PubMed - indexed for MEDLINE]Related articles

The CORRONA database.

Kremer JM.

Autoimmun Rev. 2006 Jan;5(1):46-54. Epub 2005 Aug 30. Review.PMID: 16338211 [PubMed - indexed for MEDLINE]Related articles

Radiographic benefit without clinical improvement in infliximab-treated patients with rheumatoid arthritis: comment on the article by Smolen et al.

Pincus T, Yazici Y, Yazici H, Kavanaugh AF, Kremer JM, Wolfe F.

Arthritis Rheum. 2005 Dec;52(12):4044-5; author reply 4045-7. No abstract available. PMID: 16320353 [PubMed - indexed for MEDLINE]Related articlesFree article

The CORRONA database.

Kremer JM.

Clin Exp Rheumatol. 2005 Sep-Oct;23(5 Suppl 39):S172-7.PMID: 16273803 [PubMed - indexed for MEDLINE]Related articles

Methotrexate dosage reduction in patients with rheumatoid arthritis beginning therapy with infliximab: the Infliximab Rheumatoid Arthritis Methotrexate Tapering (iRAMT) trial.

Fleischmann RM, Cohen SB, Moreland LW, Schiff M, Mease PJ, Smith DB, Keenan G, Kremer JM; iRAMT Study Group.

Curr Med Res Opin. 2005 Aug;21(8):1181-90.PMID: 16083527 [PubMed - indexed for MEDLINE]Related articles

Use of combination of leflunomide with biological agents in treatment of rheumatoid arthritis.

Kalden JR, Antoni C, Alvaro-Gracia JM, Combe B, Emery P, Kremer JM, Strand CV, Van Riel P, Smolen JS.

J Rheumatol. 2005 Aug;32(8):1620-31. Review.PMID: 16078347 [PubMed - indexed for MEDLINE]Related articles

Treatment of rheumatoid arthritis with the selective costimulation modulator abatacept: twelve-month results of a phase iib, double-blind, randomized, placebo-controlled trial.

Kremer JM, Dougados M, Emery P, Durez P, Sibilia J, Shergy W, Steinfeld S, Tindall E, Becker JC, Li T, Nuamah IF, Aranda R, Moreland LW.

Arthritis Rheum. 2005 Aug;52(8):2263-71. Erratum in: Arthritis Rheum. 2005 Oct;52(10):3321. PMID: 16052582 [PubMed - indexed for MEDLINE]Related articlesFree article

Benefit/risk of leflunomide in rheumatoid arthritis.

Kremer JM, Cannon GW.

Clin Exp Rheumatol. 2004 Sep-Oct;22(5 Suppl 35):S95-100. Review.PMID: 15552521 [PubMed - indexed for MEDLINE]Related articles

New and emerging therapies for rheumatoid arthritis.

Kremer JM.

Rheum Dis Clin North Am. 2004 May;30(2):xi-xii. No abstract available. PMID: 15172051 [PubMed - indexed for MEDLINE]Related articles

Cytotoxic T-lymphocyte antigen 4-immunoglobulin in rheumatoid arthritis.

Kremer JM.

Rheum Dis Clin North Am. 2004 May;30(2):381-91, viii. Review.PMID: 15172047 [PubMed - indexed for MEDLINE]Related articles

Treatment of rheumatoid arthritis with etanercept.

Genovese MC, Kremer JM.

Rheum Dis Clin North Am. 2004 May;30(2):311-28, vi-vii. Review.PMID: 15172043 [PubMed - indexed for MEDLINE]Related articles

Leflunomide.

Cannon GW, Kremer JM.

Rheum Dis Clin North Am. 2004 May;30(2):295-309, vi. Review.PMID: 15172042 [PubMed - indexed for MEDLINE]Related articles

What I would like to know about leflunomide.

Kremer JM.

J Rheumatol. 2004 Jun;31(6):1029-31. Review. No abstract available. PMID: 15170910 [PubMed - indexed for MEDLINE]Related articlesFree article

Toward a better understanding of methotrexate.

Kremer JM.

Arthritis Rheum. 2004 May;50(5):1370-82. Review. No abstract available. PMID: 15146406 [PubMed - indexed for MEDLINE]Related articlesFree article

Once-weekly administration of 50 mg etanercept in patients with active rheumatoid arthritis: results of a multicenter, randomized, double-blind, placebo-controlled trial.

Keystone EC, Schiff MH, Kremer JM, Kafka S, Lovy M, DeVries T, Burge DJ.

Arthritis Rheum. 2004 Feb;50(2):353-63.PMID: 14872476 [PubMed - indexed for MEDLINE]Related articlesFree article

Rheumatological creativity and leflunomide.

Kremer JM.

J Rheumatol. 2004 Feb;31(2):203-4. Review. No abstract available. PMID: 14760784 [PubMed - indexed for MEDLINE]Related articlesFree article

CANDOO and CANOAR, CORRONA and more: advancing therapeutics through layered-in clinical data collection and feedback at the point of care.

Sebaldt RJ, Kremer JM.

J Rheumatol. 2003 Nov;30(11):2308-11. No abstract available. PMID: 14677168 [PubMed - indexed for MEDLINE]Related articles

Treatment of rheumatoid arthritis by selective inhibition of T-cell activation with fusion protein CTLA4Ig.

Kremer JM, Westhovens R, Leon M, Di Giorgio E, Alten R, Steinfeld S, Russell A, Dougados M, Emery P, Nuamah IF, Williams GR, Becker JC, Hagerty DT, Moreland LW.

N Engl J Med. 2003 Nov 13;349(20):1907-15.PMID: 14614165 [PubMed - indexed for MEDLINE]Related articlesFree article

Tacrolimus in rheumatoid arthritis patients receiving concomitant methotrexate: a six-month, open-label study.

Kremer JM, Habros JS, Kolba KS, Kaine JL, Borton MA, Mengle-Gaw LJ, Schwartz BD, Wisemandle W, Mekki QA; Tacrolimus-Methotrexate Rheumatoid Arthritis Study Group.

Arthritis Rheum. 2003 Oct;48(10):2763-8.PMID: 14558080 [PubMed - indexed for MEDLINE]Related articlesFree article

Potential of tumor necrosis factor neutralization strategies in rheumatologic disorders other than rheumatoid arthritis.

Stokes DG, Kremer JM.

Semin Arthritis Rheum. 2003 Aug;33(1):1-18. Review.PMID: 12920692 [PubMed - indexed for MEDLINE]Related articles

Etanercept added to background methotrexate therapy in patients with rheumatoid arthritis: continued observations.

Kremer JM, Weinblatt ME, Bankhurst AD, Bulpitt KJ, Fleischmann RM, Jackson CG, Atkins KM, Feng A, Burge DJ.

Arthritis Rheum. 2003 Jun;48(6):1493-9.PMID: 12794815 [PubMed - indexed for MEDLINE]Related articlesFree article

Concomitant leflunomide therapy in patients with active rheumatoid arthritis despite stable doses of methotrexate. A randomized, double-blind, placebo-controlled trial.

Kremer JM, Genovese MC, Cannon GW, Caldwell JR, Cush JJ, Furst DE, Luggen ME, Keystone E, Weisman MH, Bensen WM, Kaine JL, Ruderman EM, Coleman P, Curtis DL, Kopp EJ, Kantor SM, Waltuck J, Lindsley HB, Markenson JA, Strand V, Crawford B, Fernando I, Simpson K, Bathon JM.

Ann Intern Med. 2002 Nov 5;137(9):726-33.PMID: 12416946 [PubMed - indexed for MEDLINE]Related articlesFree article

Not yet time to change the guidelines for monitoring methotrexate liver toxicity: they have served us well.

Kremer JM.

J Rheumatol. 2002 Aug;29(8):1590-2. Review. No abstract available. PMID: 12180714 [PubMed - indexed for MEDLINE]Related articlesFree article