PubMed

Insulin resistance is a cellular antioxidant defense mechanism.

Hoehn KL, Salmon AB, Hohnen-Behrens C, Turner N, Hoy AJ, Maghzal GJ, Stocker R, Van Remmen H, Kraegen EW, Cooney GJ, Richardson AR, James DE.

Proc Natl Acad Sci U S A. 2009 Oct 20;106(42):17787-92. Epub 2009 Sep 30.PMID: 19805130 [PubMed - in process]Related articles

Enhancement of muscle mitochondrial oxidative capacity and alterations in insulin action are lipid species dependent: potent tissue-specific effects of medium-chain fatty acids.

Turner N, Hariharan K, TidAng J, Frangioudakis G, Beale SM, Wright LE, Zeng XY, Leslie SJ, Li JY, Kraegen EW, Cooney GJ, Ye JM.

Diabetes. 2009 Nov;58(11):2547-54. Epub 2009 Aug 31.PMID: 19720794 [PubMed - in process]Related articles

APPL1 potentiates insulin-mediated inhibition of hepatic glucose production and alleviates diabetes via Akt activation in mice.

Cheng KK, Iglesias MA, Lam KS, Wang Y, Sweeney G, Zhu W, Vanhoutte PM, Kraegen EW, Xu A.

Cell Metab. 2009 May;9(5):417-27.PMID: 19416712 [PubMed - indexed for MEDLINE]Related articles

Lipid and insulin infusion-induced skeletal muscle insulin resistance is likely due to metabolic feedback and not changes in IRS-1, Akt, or AS160 phosphorylation.

Hoy AJ, Brandon AE, Turner N, Watt MJ, Bruce CR, Cooney GJ, Kraegen EW.

Am J Physiol Endocrinol Metab. 2009 Jul;297(1):E67-75. Epub 2009 Apr 14.PMID: 19366875 [PubMed - indexed for MEDLINE]Related articles

Major urinary protein-1 increases energy expenditure and improves glucose intolerance through enhancing mitochondrial function in skeletal muscle of diabetic mice.

Hui X, Zhu W, Wang Y, Lam KS, Zhang J, Wu D, Kraegen EW, Li Y, Xu A.

J Biol Chem. 2009 May 22;284(21):14050-7. Epub 2009 Mar 31.PMID: 19336396 [PubMed - indexed for MEDLINE]Related articles

AMP-activated protein kinase and muscle insulin resistance.

Kraegen EW, Bruce C, Hegarty BD, Ye JM, Turner N, Cooney G.

Front Biosci. 2009 Jan 1;14:4658-72. Review.PMID: 19273380 [PubMed - indexed for MEDLINE]Related articles

Insulin resistance and fuel homeostasis: the role of AMP-activated protein kinase.

Hegarty BD, Turner N, Cooney GJ, Kraegen EW.

Acta Physiol (Oxf). 2009 May;196(1):129-45. Epub 2009 Feb 19.PMID: 19245658 [PubMed - in process]Related articles

Fat partitioning and insulin sensitivity: robbing Peter to pay Paul?

Watt MJ, Kraegen EW.

Diabetes. 2009 Jan;58(1):16-7. No abstract available. PMID: 19114724 [PubMed - indexed for MEDLINE]Related articlesFree article

Overexpression of carnitine palmitoyltransferase-1 in skeletal muscle is sufficient to enhance fatty acid oxidation and improve high-fat diet-induced insulin resistance.

Bruce CR, Hoy AJ, Turner N, Watt MJ, Allen TL, Carpenter K, Cooney GJ, Febbraio MA, Kraegen EW.

Diabetes. 2009 Mar;58(3):550-8. Epub 2008 Dec 10.PMID: 19073774 [PubMed - indexed for MEDLINE]Related articlesFree article

Muscle insulin resistance: a case of fat overconsumption, not mitochondrial dysfunction.

Kraegen EW, Cooney GJ, Turner N.

Proc Natl Acad Sci U S A. 2008 Jun 3;105(22):7627-8. Epub 2008 May 28. No abstract available. PMID: 18509057 [PubMed - indexed for MEDLINE]Related articlesFree article

Free fatty acids and skeletal muscle insulin resistance.

Kraegen EW, Cooney GJ.

Curr Opin Lipidol. 2008 Jun;19(3):235-41. Review.PMID: 18460913 [PubMed - indexed for MEDLINE]Related articles

Berberine and its more biologically available derivative, dihydroberberine, inhibit mitochondrial respiratory complex I: a mechanism for the action of berberine to activate AMP-activated protein kinase and improve insulin action.

Turner N, Li JY, Gosby A, To SW, Cheng Z, Miyoshi H, Taketo MM, Cooney GJ, Kraegen EW, James DE, Hu LH, Li J, Ye JM.

Diabetes. 2008 May;57(5):1414-8. Epub 2008 Feb 19.PMID: 18285556 [PubMed - indexed for MEDLINE]Related articlesFree article

Adipose triglyceride lipase regulation of skeletal muscle lipid metabolism and insulin responsiveness.

Watt MJ, van Denderen BJ, Castelli LA, Bruce CR, Hoy AJ, Kraegen EW, Macaulay L, Kemp BE.

Mol Endocrinol. 2008 May;22(5):1200-12. Epub 2008 Jan 17.PMID: 18202145 [PubMed - indexed for MEDLINE]Related articlesFree article

Local activation of the IkappaK-NF-kappaB pathway in muscle does not cause insulin resistance.

Polkinghorne E, Lau Q, Cooney GJ, Kraegen EW, Cleasby ME.

Am J Physiol Endocrinol Metab. 2008 Feb;294(2):E316-25. Epub 2007 Nov 20.PMID: 18029440 [PubMed - indexed for MEDLINE]Related articlesFree article

Evidence that alpha-calcitonin gene-related peptide is a neurohormone that controls systemic lipid availability and utilization.

Danaher RN, Loomes KM, Leonard BL, Whiting L, Hay DL, Xu LY, Kraegen EW, Phillips AR, Cooper GJ.

Endocrinology. 2008 Jan;149(1):154-60. Epub 2007 Oct 11.PMID: 17932220 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose infusion causes insulin resistance in skeletal muscle of rats without changes in Akt and AS160 phosphorylation.

Hoy AJ, Bruce CR, Cederberg A, Turner N, James DE, Cooney GJ, Kraegen EW.

Am J Physiol Endocrinol Metab. 2007 Nov;293(5):E1358-64. Epub 2007 Sep 4.PMID: 17785505 [PubMed - indexed for MEDLINE]Related articlesFree article

Overexpression of carnitine palmitoyltransferase I in skeletal muscle in vivo increases fatty acid oxidation and reduces triacylglycerol esterification.

Bruce CR, Brolin C, Turner N, Cleasby ME, van der Leij FR, Cooney GJ, Kraegen EW.

Am J Physiol Endocrinol Metab. 2007 Apr;292(4):E1231-7. Epub 2006 Dec 19.PMID: 17179390 [PubMed - indexed for MEDLINE]Related articlesFree article

Lipocalin-2 is an inflammatory marker closely associated with obesity, insulin resistance, and hyperglycemia in humans.

Wang Y, Lam KS, Kraegen EW, Sweeney G, Zhang J, Tso AW, Chow WS, Wat NM, Xu JY, Hoo RL, Xu A.

Clin Chem. 2007 Jan;53(1):34-41. Epub 2006 Oct 13.PMID: 17040956 [PubMed - indexed for MEDLINE]Related articlesFree article

Functional studies of Akt isoform specificity in skeletal muscle in vivo; maintained insulin sensitivity despite reduced insulin receptor substrate-1 expression.

Cleasby ME, Reinten TA, Cooney GJ, James DE, Kraegen EW.

Mol Endocrinol. 2007 Jan;21(1):215-28. Epub 2006 Oct 4.PMID: 17021050 [PubMed - indexed for MEDLINE]Related articlesFree article

Oral administration of glucose promotes intracellular partitioning of fatty acid toward storage in white but not in red muscle.

Fosgerau K, Fledelius C, Pedersen KE, Kristensen JB, Daugaard JR, Iglesias MA, Kraegen EW, Furler SM.

J Endocrinol. 2006 Sep;190(3):651-8.PMID: 17003266 [PubMed - indexed for MEDLINE]Related articlesFree article

Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant states.

Lee YS, Kim WS, Kim KH, Yoon MJ, Cho HJ, Shen Y, Ye JM, Lee CH, Oh WK, Kim CT, Hohnen-Behrens C, Gosby A, Kraegen EW, James DE, Kim JB.

Diabetes. 2006 Aug;55(8):2256-64.PMID: 16873688 [PubMed - indexed for MEDLINE]Related articlesFree article

Overexpression of acyl-CoA synthetase-1 increases lipid deposition in hepatic (HepG2) cells and rodent liver in vivo.

Parkes HA, Preston E, Wilks D, Ballesteros M, Carpenter L, Wood L, Kraegen EW, Furler SM, Cooney GJ.

Am J Physiol Endocrinol Metab. 2006 Oct;291(4):E737-44. Epub 2006 May 16.PMID: 16705061 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased malonyl-CoA and diacylglycerol content and reduced AMPK activity accompany insulin resistance induced by glucose infusion in muscle and liver of rats.

Kraegen EW, Saha AK, Preston E, Wilks D, Hoy AJ, Cooney GJ, Ruderman NB.

Am J Physiol Endocrinol Metab. 2006 Mar;290(3):E471-9. Epub 2005 Oct 18.PMID: 16234268 [PubMed - indexed for MEDLINE]Related articlesFree article

Acute bidirectional manipulation of muscle glucose uptake by in vivo electrotransfer of constructs targeting glucose transporter genes.

Cleasby ME, Davey JR, Reinten TA, Graham MW, James DE, Kraegen EW, Cooney GJ.

Diabetes. 2005 Sep;54(9):2702-11.PMID: 16123360 [PubMed - indexed for MEDLINE]Related articlesFree article

Metformin prevents the development of acute lipid-induced insulin resistance in the rat through altered hepatic signaling mechanisms.

Cleasby ME, Dzamko N, Hegarty BD, Cooney GJ, Kraegen EW, Ye JM.

Diabetes. 2004 Dec;53(12):3258-66.PMID: 15561958 [PubMed - indexed for MEDLINE]Related articlesFree article

Direct demonstration of lipid sequestration as a mechanism by which rosiglitazone prevents fatty-acid-induced insulin resistance in the rat: comparison with metformin.

Ye JM, Dzamko N, Cleasby ME, Hegarty BD, Furler SM, Cooney GJ, Kraegen EW.

Diabetologia. 2004 Jul;47(7):1306-13. Epub 2004 Jul 1.PMID: 15232684 [PubMed - indexed for MEDLINE]Related articles

AMP-activated protein kinase activation by AICAR increases both muscle fatty acid and glucose uptake in white muscle of insulin-resistant rats in vivo.

Iglesias MA, Furler SM, Cooney GJ, Kraegen EW, Ye JM.

Diabetes. 2004 Jul;53(7):1649-54.PMID: 15220186 [PubMed - indexed for MEDLINE]Related articlesFree article

Peroxisome proliferator-activated receptor (PPAR) activation induces tissue-specific effects on fatty acid uptake and metabolism in vivo--a study using the novel PPARalpha/gamma agonist tesaglitazar.

Hegarty BD, Furler SM, Oakes ND, Kraegen EW, Cooney GJ.

Endocrinology. 2004 Jul;145(7):3158-64. Epub 2004 Apr 1.PMID: 15059948 [PubMed - indexed for MEDLINE]Related articlesFree article

Pioglitazone treatment activates AMP-activated protein kinase in rat liver and adipose tissue in vivo.

Saha AK, Avilucea PR, Ye JM, Assifi MM, Kraegen EW, Ruderman NB.

Biochem Biophys Res Commun. 2004 Feb 6;314(2):580-5.PMID: 14733947 [PubMed - indexed for MEDLINE]Related articles

Insulin action, regional fat, and myocyte lipid: altered relationships with increased adiposity.

Gan SK, Kriketos AD, Poynten AM, Furler SM, Thompson CH, Kraegen EW, Campbell LV, Chisholm DJ.

Obes Res. 2003 Nov;11(11):1295-305.PMID: 14627749 [PubMed - indexed for MEDLINE]Related articles

Minireview: malonyl CoA, AMP-activated protein kinase, and adiposity.

Ruderman NB, Saha AK, Kraegen EW.

Endocrinology. 2003 Dec;144(12):5166-71. Epub 2003 Sep 18. Review.PMID: 14500570 [PubMed - indexed for MEDLINE]Related articlesFree article

Peripheral insulin resistance develops in transgenic rats overexpressing phosphoenolpyruvate carboxykinase in the kidney.

Lamont BJ, Andrikopoulos S, Funkat A, Favaloro J, Ye JM, Kraegen EW, Howlett KF, Zajac JD, Proietto J.

Diabetologia. 2003 Oct;46(10):1338-47. Epub 2003 Jul 29.PMID: 12898008 [PubMed - indexed for MEDLINE]Related articles

The role of intramuscular lipid in insulin resistance.

Hegarty BD, Furler SM, Ye J, Cooney GJ, Kraegen EW.

Acta Physiol Scand. 2003 Aug;178(4):373-83. Review.PMID: 12864742 [PubMed - indexed for MEDLINE]Related articles

Changes in aerobic capacity and visceral fat but not myocyte lipid levels predict increased insulin action after exercise in overweight and obese men.

Gan SK, Kriketos AD, Ellis BA, Thompson CH, Kraegen EW, Chisholm DJ.

Diabetes Care. 2003 Jun;26(6):1706-13.PMID: 12766098 [PubMed - indexed for MEDLINE]Related articlesFree article

PPARalpha /gamma ragaglitazar eliminates fatty liver and enhances insulin action in fat-fed rats in the absence of hepatomegaly.

Ye JM, Iglesias MA, Watson DG, Ellis B, Wood L, Jensen PB, Sørensen RV, Larsen PJ, Cooney GJ, Wassermann K, Kraegen EW.

Am J Physiol Endocrinol Metab. 2003 Mar;284(3):E531-40.PMID: 12556350 [PubMed - indexed for MEDLINE]Related articlesFree article

Malonyl-CoA and AMP-activated protein kinase (AMPK): possible links between insulin resistance in muscle and early endothelial cell damage in diabetes.

Ruderman NB, Cacicedo JM, Itani S, Yagihashi N, Saha AK, Ye JM, Chen K, Zou M, Carling D, Boden G, Cohen RA, Keaney J, Kraegen EW, Ido Y.

Biochem Soc Trans. 2003 Feb;31(Pt 1):202-6. Review.PMID: 12546685 [PubMed - indexed for MEDLINE]Related articles

Prior thiazolidinedione treatment preserves insulin sensitivity in normal rats during acute fatty acid elevation: role of the liver.

Ye JM, Frangioudakis G, Iglesias MA, Furler SM, Ellis B, Dzamko N, Cooney GJ, Kraegen EW.

Endocrinology. 2002 Dec;143(12):4527-35.PMID: 12446579 [PubMed - indexed for MEDLINE]Related articlesFree article

Altered myocellular and abdominal fat partitioning predict disturbance in insulin action in HIV protease inhibitor-related lipodystrophy.

Gan SK, Samaras K, Thompson CH, Kraegen EW, Carr A, Cooper DA, Chisholm DJ.

Diabetes. 2002 Nov;51(11):3163-9.PMID: 12401706 [PubMed - indexed for MEDLINE]Related articlesFree article

AICAR administration causes an apparent enhancement of muscle and liver insulin action in insulin-resistant high-fat-fed rats.

Iglesias MA, Ye JM, Frangioudakis G, Saha AK, Tomas E, Ruderman NB, Cooney GJ, Kraegen EW.

Diabetes. 2002 Oct;51(10):2886-94. Erratum in: Diabetes 2003 Jan;52(1):223-4. PMID: 12351423 [PubMed - indexed for MEDLINE]Related articlesFree article

Muscle long-chain acyl CoA esters and insulin resistance.

Cooney GJ, Thompson AL, Furler SM, Ye J, Kraegen EW.

Ann N Y Acad Sci. 2002 Jun;967:196-207. Review.PMID: 12079848 [PubMed - indexed for MEDLINE]Related articles

Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle.

Yu C, Chen Y, Cline GW, Zhang D, Zong H, Wang Y, Bergeron R, Kim JK, Cushman SW, Cooney GJ, Atcheson B, White MF, Kraegen EW, Shulman GI.

J Biol Chem. 2002 Dec 27;277(52):50230-6. Epub 2002 Nov 14.PMID: 12006582 [PubMed - indexed for MEDLINE]Related articlesFree article

Long-term high-fat feeding leads to severe insulin resistance but not diabetes in Wistar rats.

Chalkley SM, Hettiarachchi M, Chisholm DJ, Kraegen EW.

Am J Physiol Endocrinol Metab. 2002 Jun;282(6):E1231-8.PMID: 12006352 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased efficiency of fatty acid uptake contributes to lipid accumulation in skeletal muscle of high fat-fed insulin-resistant rats.

Hegarty BD, Cooney GJ, Kraegen EW, Furler SM.

Diabetes. 2002 May;51(5):1477-84.PMID: 11978645 [PubMed - indexed for MEDLINE]Related articlesFree article

Chronic central melanocortin-4 receptor antagonism and central neuropeptide-Y infusion in rats produce increased adiposity by divergent pathways.

Baran K, Preston E, Wilks D, Cooney GJ, Kraegen EW, Sainsbury A.

Diabetes. 2002 Jan;51(1):152-8.PMID: 11756335 [PubMed - indexed for MEDLINE]Related articlesFree article

Independent influences of central fat and skeletal muscle lipids on insulin sensitivity.

Furler SM, Poynten AM, Kriketos AD, Lowy AJ, Ellis BA, Maclean EL, Courtenay BG, Kraegen EW, Campbell LV, Chisholm DJ.

Obes Res. 2001 Sep;9(9):535-43.PMID: 11557834 [PubMed - indexed for MEDLINE]Related articles

Alteration in phosphorylation of P20 is associated with insulin resistance.

Wang Y, Xu A, Ye J, Kraegen EW, Tse CA, Cooper GJ.

Diabetes. 2001 Aug;50(8):1821-7.PMID: 11473044 [PubMed - indexed for MEDLINE]Related articlesFree article

The role of lipids in the pathogenesis of muscle insulin resistance and beta cell failure in type II diabetes and obesity.

Kraegen EW, Cooney GJ, Ye JM, Thompson AL, Furler SM.

Exp Clin Endocrinol Diabetes. 2001;109 Suppl 2:S189-201. Review.PMID: 11460570 [PubMed - indexed for MEDLINE]Related articles

Triglycerides, fatty acids and insulin resistance--hyperinsulinemia.

Kraegen EW, Cooney GJ, Ye J, Thompson AL.

Exp Clin Endocrinol Diabetes. 2001;109(4):S516-26. Review.PMID: 11453039 [PubMed - indexed for MEDLINE]Related articles

Peroxisome proliferator-activated receptor (PPAR)-alpha activation lowers muscle lipids and improves insulin sensitivity in high fat-fed rats: comparison with PPAR-gamma activation.

Ye JM, Doyle PJ, Iglesias MA, Watson DG, Cooney GJ, Kraegen EW.

Diabetes. 2001 Feb;50(2):411-7.PMID: 11272155 [PubMed - indexed for MEDLINE]Related articlesFree article

Evidence that amylin stimulates lipolysis in vivo: a possible mediator of induced insulin resistance.

Ye JM, Lim-Fraser M, Cooney GJ, Cooper GJ, Iglesias MA, Watson DG, Choong B, Kraegen EW.

Am J Physiol Endocrinol Metab. 2001 Apr;280(4):E562-9.PMID: 11254462 [PubMed - indexed for MEDLINE]Related articlesFree article