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Small G Proteins in Islet {beta}-Cell Function.

Kowluru A.

Endocr Rev. 2009 Nov 4. [Epub ahead of print]PMID: 19890090 [PubMed - as supplied by publisher]Related articles

Down-regulation of expression and function of nucleoside diphosphate kinase in insulin-secreting beta-cells under in vitro conditions of glucolipotoxicity.

Veluthakal R, Suresh MV, Kowluru A.

Mol Cell Biochem. 2009 Sep;329(1-2):121-9. Epub 2009 Apr 15.PMID: 19367376 [PubMed - indexed for MEDLINE]Related articles

A novel histone deacetylase inhibitor prevents IL-1beta-induced metabolic dysfunction in pancreatic beta-cells.

Susick L, Senanayake T, Veluthakal R, Woster PM, Kowluru A.

J Cell Mol Med. 2009 Jan 28. [Epub ahead of print]PMID: 19187126 [PubMed - as supplied by publisher]Related articles

Regulatory roles for Tiam1, a guanine nucleotide exchange factor for Rac1, in glucose-stimulated insulin secretion in pancreatic beta-cells.

Veluthakal R, Madathilparambil SV, McDonald P, Olson LK, Kowluru A.

Biochem Pharmacol. 2009 Jan 1;77(1):101-13. Epub 2008 Sep 27.PMID: 18930714 [PubMed - indexed for MEDLINE]Related articles

Emerging roles for protein histidine phosphorylation in cellular signal transduction: lessons from the islet beta-cell.

Kowluru A.

J Cell Mol Med. 2008 Oct;12(5B):1885-908. Epub 2008 Apr 8. Review.PMID: 18400053 [PubMed - indexed for MEDLINE]Related articles

Protein prenylation in glucose-induced insulin secretion from the pancreatic islet beta cell: a perspective.

Kowluru A.

J Cell Mol Med. 2008 Jan-Feb;12(1):164-73. Epub 2007 Dec 5. Review.PMID: 18053094 [PubMed - indexed for MEDLINE]Related articles

Regulatory roles for histone deacetylation in IL-1beta-induced nitric oxide release in pancreatic beta-cells.

Susick L, Veluthakal R, Suresh MV, Hadden T, Kowluru A.

J Cell Mol Med. 2008 Sep-Oct;12(5A):1571-83. Epub 2007 Dec 5.PMID: 18053091 [PubMed - indexed for MEDLINE]Related articles

Depletion of the catalytic subunit of protein phosphatase-2A (PP2Ac) markedly attenuates glucose-stimulated insulin secretion in pancreatic beta-cells.

Jangati GR, Veluthakal R, Susick L, Gruber SA, Kowluru A.

Endocrine. 2007 Jun;31(3):248-53.PMID: 17906371 [PubMed - indexed for MEDLINE]Related articles

Bridging the gap between protein carboxyl methylation and phospholipid methylation to understand glucose-stimulated insulin secretion from the pancreatic beta cell.

Kowluru A.

Biochem Pharmacol. 2008 Jan 15;75(2):335-45. Epub 2007 Jun 28. Review.PMID: 17662254 [PubMed - indexed for MEDLINE]Related articlesFree article

Dominant-negative alpha-subunit of farnesyl- and geranyltransferase inhibits glucose-stimulated, but not KCl-stimulated, insulin secretion in INS 832/13 cells.

Veluthakal R, Kaur H, Goalstone M, Kowluru A.

Diabetes. 2007 Jan;56(1):204-10.PMID: 17192483 [PubMed - indexed for MEDLINE]Related articlesFree article

IL-1beta-induced iNOS expression, NO release and loss in metabolic cell viability are resistant to inhibitors of ceramide synthase and sphingomyelinase in INS 832/13 cells.

Veluthakal R, Jangati GR, Kowluru A.

JOP. 2006 Nov 10;7(6):593-601.PMID: 17095838 [PubMed - indexed for MEDLINE]Related articlesFree article

Biologically active lipids promote trafficking and membrane association of Rac1 in insulin-secreting INS 832/13 cells.

McDonald P, Veluthakal R, Kaur H, Kowluru A.

Am J Physiol Cell Physiol. 2007 Mar;292(3):C1216-20. Epub 2006 Oct 11.PMID: 17035298 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulatory roles for nm23/nucleoside diphosphate kinase-like enzymes in insulin secretion from the pancreatic islet beta cell.

Kowluru A, Veluthakal R, Kaetzel DM.

J Bioenerg Biomembr. 2006 Aug;38(3-4):227-32.PMID: 16957985 [PubMed - indexed for MEDLINE]Related articles

Small molecular weight G-protein, H-Ras, and retinal endothelial cell apoptosis in diabetes.

Kowluru RA, Kowluru A, Kanwar M.

Mol Cell Biochem. 2007 Feb;296(1-2):69-76. Epub 2006 Aug 19.PMID: 16924412 [PubMed - indexed for MEDLINE]Related articles

siRNA-mediated depletion of endogenous protein phosphatase 2Acalpha markedly attenuates ceramide-activated protein phosphatase activity in insulin-secreting INS-832/13 cells.

Jangati GR, Veluthakal R, Kowluru A.

Biochem Biophys Res Commun. 2006 Sep 22;348(2):649-52. Epub 2006 Jul 28.PMID: 16884689 [PubMed - indexed for MEDLINE]Related articles

Localization of a nuclear serine/threonine protein phosphatase in insulin-secreting INS-1 cells: potential regulation by IL-1beta.

Veluthakal R, Wadzinski BE, Kowluru A.

Apoptosis. 2006 Aug;11(8):1401-11.PMID: 16830232 [PubMed - indexed for MEDLINE]Related articles

Rho guanosine diphosphate-dissociation inhibitor plays a negative modulatory role in glucose-stimulated insulin secretion.

Kowluru A, Veluthakal R.

Diabetes. 2005 Dec;54(12):3523-9.PMID: 16306371 [PubMed - indexed for MEDLINE]Related articlesFree article

Ceramide induces mitochondrial abnormalities in insulin-secreting INS-1 cells: potential mechanisms underlying ceramide-mediated metabolic dysfunction of the beta cell.

Veluthakal R, Palanivel R, Zhao Y, McDonald P, Gruber S, Kowluru A.

Apoptosis. 2005 Aug;10(4):841-50.PMID: 16133874 [PubMed - indexed for MEDLINE]Related articles

Essential role for membrane lipid rafts in interleukin-1beta-induced nitric oxide release from insulin-secreting cells: potential regulation by caveolin-1+.

Veluthakal R, Chvyrkova I, Tannous M, McDonald P, Amin R, Hadden T, Thurmond DC, Quon MJ, Kowluru A.

Diabetes. 2005 Sep;54(9):2576-85.PMID: 16123345 [PubMed - indexed for MEDLINE]Related articlesFree article

Novel regulatory roles for protein phosphatase-2A in the islet beta cell.

Kowluru A.

Biochem Pharmacol. 2005 Jun 15;69(12):1681-91. Epub 2005 Apr 26. Review.PMID: 15935144 [PubMed - indexed for MEDLINE]Related articles

Further evidence for the regulation of acetyl-CoA carboxylase activity by a glutamate- and magnesium-activated protein phosphatase in the pancreatic beta cell: defective regulation in the diabetic GK rat islet.

Palanivel R, Veluthakal R, McDonald P, Kowluru A.

Endocrine. 2005 Feb;26(1):71-7.PMID: 15805588 [PubMed - indexed for MEDLINE]Related articles

Differential regulation by fatty acids of protein histidine phosphorylation in rat pancreatic islets.

Kowluru A.

Mol Cell Biochem. 2004 Nov;266(1-2):175-82.PMID: 15646040 [PubMed - indexed for MEDLINE]Related articles

Interleukin-1 beta induces posttranslational carboxymethylation and alterations in subnuclear distribution of lamin B in insulin-secreting RINm5F cells.

Veluthakal R, Amin R, Kowluru A.

Am J Physiol Cell Physiol. 2004 Oct;287(4):C1152-62. Epub 2004 Jun 16.PMID: 15201138 [PubMed - indexed for MEDLINE]Related articlesFree article

GTP-binding protein-independent potentiation by mastoparan of IL-1beta-induced nitric oxide release from insulin-secreting HIT-T15 cells.

Chen HQ, Veluthakal R, Palanivel R, Kowluru A.

Apoptosis. 2004 Mar;9(2):145-8.PMID: 15004511 [PubMed - indexed for MEDLINE]Related articles

Potential contributory role of H-Ras, a small G-protein, in the development of retinopathy in diabetic rats.

Kowluru RA, Kowluru A, Chakrabarti S, Khan Z.

Diabetes. 2004 Mar;53(3):775-83.PMID: 14988264 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation by glucose and calcium of the carboxylmethylation of the catalytic subunit of protein phosphatase 2A in insulin-secreting INS-1 cells.

Palanivel R, Veluthakal R, Kowluru A.

Am J Physiol Endocrinol Metab. 2004 Jun;286(6):E1032-41. Epub 2004 Feb 17.PMID: 14970009 [PubMed - indexed for MEDLINE]Related articlesFree article

Novel regulation by Rac1 of glucose- and forskolin-induced insulin secretion in INS-1 beta-cells.

Li J, Luo R, Kowluru A, Li G.

Am J Physiol Endocrinol Metab. 2004 May;286(5):E818-27. Epub 2004 Jan 21.PMID: 14736704 [PubMed - indexed for MEDLINE]Related articlesFree article

Novel roles for palmitoylation of Ras in IL-1 beta-induced nitric oxide release and caspase 3 activation in insulin-secreting beta cells.

Chen HQ, Tannous M, Veluthakal R, Amin R, Kowluru A.

Biochem Pharmacol. 2003 Nov 1;66(9):1681-94.PMID: 14563479 [PubMed - indexed for MEDLINE]Related articles

Novel roles for the rho subfamily of GTP-binding proteins in succinate-induced insulin secretion from betaTC3 cells: further evidence in support of the succinate mechanism of insulin release.

Kowluru A, Chen HQ, Tannous M.

Endocr Res. 2003 Aug;29(3):363-76.PMID: 14535637 [PubMed - indexed for MEDLINE]Related articles

Mastoparan-induced insulin secretion from insulin-secreting betaTC3 and INS-1 cells: evidence for its regulation by Rho subfamily of G proteins.

Amin RH, Chen HQ, Veluthakal R, Silver RB, Li J, Li G, Kowluru A.

Endocrinology. 2003 Oct;144(10):4508-18. Epub 2003 Jun 19.PMID: 12960065 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulatory roles for small G proteins in the pancreatic beta-cell: lessons from models of impaired insulin secretion.

Kowluru A.

Am J Physiol Endocrinol Metab. 2003 Oct;285(4):E669-84. Review.PMID: 12959934 [PubMed - indexed for MEDLINE]Related articlesFree article

Defective protein histidine phosphorylation in islets from the Goto-Kakizaki diabetic rat.

Kowluru A.

Am J Physiol Endocrinol Metab. 2003 Sep;285(3):E498-503. Epub 2003 Jun 10.PMID: 12799314 [PubMed - indexed for MEDLINE]Related articlesFree article

IL-1beta-induced nitric oxide release from insulin-secreting beta-cells: further evidence for the involvement of GTP-binding proteins.

Tannous M, Veluthakal R, Amin R, Kowluru A.

Diabetes Metab. 2002 Dec;28(6 Pt 2):3S78-84; discussion 3S108-12.PMID: 12688637 [PubMed - indexed for MEDLINE]Related articles

Inhibitors of post-translational modifications of G-proteins as probes to study the pancreatic beta cell function: potential therapeutic implications.

Kowluru A, Amin R.

Curr Drug Targets Immune Endocr Metabol Disord. 2002 Jul;2(2):129-39. Review.PMID: 12476787 [PubMed - indexed for MEDLINE]Related articles

Inhibition of glucose- and calcium-induced insulin secretion from betaTC3 cells by novel inhibitors of protein isoprenylation.

Amin R, Chen HQ, Tannous M, Gibbs R, Kowluru A.

J Pharmacol Exp Ther. 2002 Oct;303(1):82-8.PMID: 12235236 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification and characterization of a novel protein histidine kinase in the islet beta cell: evidence for its regulation by mastoparan, an activator of G-proteins and insulin secretion.

Kowluru A.

Biochem Pharmacol. 2002 Jun 15;63(12):2091-100.PMID: 12110368 [PubMed - indexed for MEDLINE]Related articles

Functional inactivation by interleukin-1beta of glyceraldehyde-3-phosphate dehydrogenase in insulin-secreting cells.

Veluthakal R, Khan I, Tannous M, Kowluru A.

Apoptosis. 2002 Jun;7(3):241-6.PMID: 11997668 [PubMed - indexed for MEDLINE]Related articles

GTP-binding proteins in cell survival and demise: the emerging picture in the pancreatic beta-cell.

Kowluru A, Morgan NG.

Biochem Pharmacol. 2002 Mar 15;63(6):1027-35. Review.PMID: 11931834 [PubMed - indexed for MEDLINE]Related articles

Localization and characterization of the mitochondrial isoform of the nucleoside diphosphate kinase in the pancreatic beta cell: evidence for its complexation with mitochondrial succinyl-CoA synthetase.

Kowluru A, Tannous M, Chen HQ.

Arch Biochem Biophys. 2002 Feb 15;398(2):160-9.PMID: 11831846 [PubMed - indexed for MEDLINE]Related articles

Positive modulation by Ras of interleukin-1beta-mediated nitric oxide generation in insulin-secreting clonal beta (HIT-T15) cells.

Tannous M, Amin R, Popoff MR, Fiorentini C, Kowluru A.

Biochem Pharmacol. 2001 Dec 1;62(11):1459-68.PMID: 11728382 [PubMed - indexed for MEDLINE]Related articles

Activation of acetyl-CoA carboxylase by a glutamate- and magnesium-sensitive protein phosphatase in the islet beta-cell.

Kowluru A, Chen HQ, Modrick LM, Stefanelli C.

Diabetes. 2001 Jul;50(7):1580-7.PMID: 11423479 [PubMed - indexed for MEDLINE]Related articlesFree article

Adenine and guanine nucleotide-specific succinyl-CoA synthetases in the clonal beta-cell mitochondria: implications in the beta-cell high-energy phosphate metabolism in relation to physiological insulin secretion.

Kowluru A.

Diabetologia. 2001 Jan;44(1):89-94.PMID: 11206416 [PubMed - indexed for MEDLINE]Related articles

Evidence for the carboxyl methylation of nuclear lamin-B in the pancreatic beta cell.

Kowluru A.

Biochem Biophys Res Commun. 2000 Feb 16;268(2):249-54.PMID: 10679189 [PubMed - indexed for MEDLINE]Related articles

A defect late in stimulus-secretion coupling impairs insulin secretion in Goto-Kakizaki diabetic rats.

Metz SA, Meredith M, Vadakekalam J, Rabaglia ME, Kowluru A.

Diabetes. 1999 Sep;48(9):1754-62.PMID: 10480605 [PubMed - indexed for MEDLINE]Related articlesFree article

Inosine monophosphate dehydrogenase: A molecular switch integrating pleiotropic GTP-dependent beta-cell functions.

Metz SA, Kowluru A.

Proc Assoc Am Physicians. 1999 Jul-Aug;111(4):335-46. Review.PMID: 10417742 [PubMed - indexed for MEDLINE]Related articles

Subcellular localization and characterization of nucleoside diphosphate kinase in rat retina: effect of diabetes.

Kowluru A, Kowluru RA.

Biosci Rep. 1998 Aug;18(4):187-98.PMID: 9877232 [PubMed - indexed for MEDLINE]Related articles

Purine nucleotide- and sugar phosphate-induced inhibition of the carboxyl methylation and catalysis of protein phosphatase-2A in insulin-secreting cells: protection by divalent cations.

Kowluru A, Metz SA.

Biosci Rep. 1998 Aug;18(4):171-86.PMID: 9877231 [PubMed - indexed for MEDLINE]Related articles

Prolonged depletion of guanosine triphosphate induces death of insulin-secreting cells by apoptosis.

Li G, Segu VB, Rabaglia ME, Luo RH, Kowluru A, Metz SA.

Endocrinology. 1998 Sep;139(9):3752-62.PMID: 9724027 [PubMed - indexed for MEDLINE]Related articlesFree article

Evidence for differential roles of the Rho subfamily of GTP-binding proteins in glucose- and calcium-induced insulin secretion from pancreatic beta cells.

Kowluru A, Li G, Rabaglia ME, Segu VB, Hofmann F, Aktories K, Metz SA.

Biochem Pharmacol. 1997 Nov 15;54(10):1097-108.PMID: 9464452 [PubMed - indexed for MEDLINE]Related articles

Ceramide-activated protein phosphatase-2A activity in insulin-secreting cells.

Kowluru A, Metz SA.

FEBS Lett. 1997 Nov 24;418(1-2):179-82.PMID: 9414122 [PubMed - indexed for MEDLINE]Related articles