PubMed

11beta-hydroxysteroid dehydrogenase type 1 inhibitors: a review of recent patents.

Boyle CD, Kowalski TJ.

Expert Opin Ther Pat. 2009 Jun;19(6):801-25. Review.PMID: 19456274 [PubMed - indexed for MEDLINE]Related articles

GPR119 is required for physiological regulation of glucagon-like peptide-1 secretion but not for metabolic homeostasis.

Lan H, Vassileva G, Corona A, Liu L, Baker H, Golovko A, Abbondanzo SJ, Hu W, Yang S, Ning Y, Del Vecchio RA, Poulet F, Laverty M, Gustafson EL, Hedrick JA, Kowalski TJ.

J Endocrinol. 2009 May;201(2):219-30. Epub 2009 Mar 12.PMID: 19282326 [PubMed - indexed for MEDLINE]Related articles

Art supports new plague science.

Kowalski TJ, Agger WA.

Clin Infect Dis. 2009 Jan 1;48(1):137-8. No abstract available. PMID: 19067623 [PubMed - indexed for MEDLINE]Related articles

Truffle's revenge: a pig-eating fungus.

Greer EL, Kowalski TJ, Cole ML, Miller DV, Baddour LM.

Cardiovasc Pathol. 2008 Sep-Oct;17(5):342-3. Epub 2007 Jun 20.PMID: 18402787 [PubMed - indexed for MEDLINE]Related articles

Single nucleotide polymorphisms in the cadherin 23 (CDH23) gene in Polish workers exposed to industrial noise.

Sliwinska-Kowalska M, Noben-Trauth K, Pawelczyk M, Kowalski TJ.

Am J Hum Biol. 2008 Jul-Aug;20(4):481-3.PMID: 18348277 [PubMed - indexed for MEDLINE]Related articles

Patentability issues surrounding antivirals.

Lu DL, Collison AM, Kowalski TJ.

Nat Biotechnol. 2007 Dec;25(12):1403-4. Review. No abstract available. PMID: 18066035 [PubMed - indexed for MEDLINE]Related articles

Melanin-concentrating hormone receptor-1 antagonists as antiobesity therapeutics: current status.

Kowalski TJ, Sasikumar T.

BioDrugs. 2007;21(5):311-21. Review.PMID: 17896837 [PubMed - indexed for MEDLINE]Related articles

Propionibacterium acnes vertebral osteomyelitis: seek and ye shall find?

Kowalski TJ, Berbari EF, Huddleston PM, Steckelberg JM, Osmon DR.

Clin Orthop Relat Res. 2007 Aug;461:25-30.PMID: 17483730 [PubMed - indexed for MEDLINE]Related articles

Follow-up MR imaging in patients with pyogenic spine infections: lack of correlation with clinical features.

Kowalski TJ, Layton KF, Berbari EF, Steckelberg JM, Huddleston PM, Wald JT, Osmon DR.

AJNR Am J Neuroradiol. 2007 Apr;28(4):693-9.PMID: 17416823 [PubMed - indexed for MEDLINE]Related articlesFree article

The management and outcome of spinal implant infections: contemporary retrospective cohort study.

Kowalski TJ, Berbari EF, Huddleston PM, Steckelberg JM, Mandrekar JN, Osmon DR.

Clin Infect Dis. 2007 Apr 1;44(7):913-20. Epub 2007 Feb 14.PMID: 17342641 [PubMed - indexed for MEDLINE]Related articles

[Genetic factors in susceptibility to age- and noise-related hearing loss]

Sliwińiska-Kowalska M, Pawelczyk M, Kowalski TJ.

Pol Merkur Lekarski. 2006 Oct;21(124):384-8. Review. Polish. PMID: 17205784 [PubMed - indexed for MEDLINE]Related articles

Skin and soft tissue infections due to rapidly growing mycobacteria: comparison of clinical features, treatment, and susceptibility.

Uslan DZ, Kowalski TJ, Wengenack NL, Virk A, Wilson JW.

Arch Dermatol. 2006 Oct;142(10):1287-92.PMID: 17043183 [PubMed - indexed for MEDLINE]Related articlesFree article

Novel aminobenzimidazoles as selective MCH-R1 antagonists for the treatment of metabolic diseases.

Sasikumar TK, Qiang L, Burnett DA, Greenlee WJ, Hawes BE, Kowalski TJ, O'Neill K, Spar BD, Weig B.

Bioorg Med Chem Lett. 2006 Oct 15;16(20):5427-31. Epub 2006 Aug 2.PMID: 16889961 [PubMed - indexed for MEDLINE]Related articles

Do follow-up imaging examinations provide useful prognostic information in patients with spine infection?

Kowalski TJ, Berbari EF, Huddleston PM, Steckelberg JM, Osmon DR.

Clin Infect Dis. 2006 Jul 15;43(2):172-9. Epub 2006 Jun 5.PMID: 16779743 [PubMed - indexed for MEDLINE]Related articles

Discovery of orally efficacious melanin-concentrating hormone receptor-1 antagonists as antiobesity agents. Synthesis, SAR, and biological evaluation of bicyclo[3.1.0]hexyl ureas.

McBriar MD, Guzik H, Shapiro S, Paruchova J, Xu R, Palani A, Clader JW, Cox K, Greenlee WJ, Hawes BE, Kowalski TJ, O'neill K, Spar BD, Weig B, Weston DJ, Farley C, Cook J.

J Med Chem. 2006 Apr 6;49(7):2294-310.PMID: 16570926 [PubMed - indexed for MEDLINE]Related articles

Effects of a selective melanin-concentrating hormone 1 receptor antagonist on food intake and energy homeostasis in diet-induced obese mice.

Kowalski TJ, Spar BD, Weig B, Farley C, Cook J, Ghibaudi L, Fried S, O'Neill K, Del Vecchio RA, McBriar M, Guzik H, Clader J, Hawes BE, Hwa J.

Eur J Pharmacol. 2006 Mar 27;535(1-3):182-91. Epub 2006 Mar 13.PMID: 16540104 [PubMed - indexed for MEDLINE]Related articles

Bicyclic[4.1.0]heptanes as phenyl replacements for melanin concentrating hormone receptor antagonists.

Xu R, Li S, Paruchova J, McBriar MD, Guzik H, Palani A, Clader JW, Cox K, Greenlee WJ, Hawes BE, Kowalski TJ, O'Neill K, Spar BD, Weig B, Weston DJ.

Bioorg Med Chem. 2006 May 15;14(10):3285-99. Epub 2006 Jan 26.PMID: 16442800 [PubMed - indexed for MEDLINE]Related articles

Complete rescue of obesity, diabetes, and infertility in db/db mice by neuron-specific LEPR-B transgenes.

de Luca C, Kowalski TJ, Zhang Y, Elmquist JK, Lee C, Kilimann MW, Ludwig T, Liu SM, Chua SC Jr.

J Clin Invest. 2005 Dec;115(12):3484-93. Epub 2005 Nov 10.PMID: 16284652 [PubMed - indexed for MEDLINE]Related articlesFree article

Epidemiology, treatment, and prevention of community-acquired methicillin-resistant Staphylococcus aureus infections.

Kowalski TJ, Berbari EF, Osmon DR.

Mayo Clin Proc. 2005 Sep;80(9):1201-7; quiz 1208. Review.PMID: 16178500 [PubMed - indexed for MEDLINE]Related articlesFree article

The patentability of antibodies in the United States.

Lu DL, Collison AM, Kowalski TJ.

Nat Biotechnol. 2005 Sep;23(9):1079-80.PMID: 16151395 [PubMed - indexed for MEDLINE]Related articles

Biaryl ureas as potent and orally efficacious melanin concentrating hormone receptor 1 antagonists for the treatment of obesity.

Palani A, Shapiro S, McBriar MD, Clader JW, Greenlee WJ, Spar B, Kowalski TJ, Farley C, Cook J, van Heek M, Weig B, O'neill K, Graziano M, Hawes B.

J Med Chem. 2005 Jul 28;48(15):4746-9.PMID: 16033253 [PubMed - indexed for MEDLINE]Related articles

Transgenic overexpression of neuromedin U promotes leanness and hypophagia in mice.

Kowalski TJ, Spar BD, Markowitz L, Maguire M, Golovko A, Yang S, Farley C, Cook JA, Tetzloff G, Hoos L, Del Vecchio RA, Kazdoba TM, McCool MF, Hwa JJ, Hyde LA, Davis H, Vassileva G, Hedrick JA, Gustafson EL.

J Endocrinol. 2005 Apr;185(1):151-64.PMID: 15817836 [PubMed - indexed for MEDLINE]Related articlesFree article

Discovery of bicycloalkyl urea melanin concentrating hormone receptor antagonists: orally efficacious antiobesity therapeutics.

McBriar MD, Guzik H, Xu R, Paruchova J, Li S, Palani A, Clader JW, Greenlee WJ, Hawes BE, Kowalski TJ, O'Neill K, Spar B, Weig B.

J Med Chem. 2005 Apr 7;48(7):2274-7.PMID: 15801820 [PubMed - indexed for MEDLINE]Related articles

Furazolidone-induced pulmonary hypersensitivity.

Kowalski TJ, Henry MJ, Zlabek JA.

Ann Pharmacother. 2005 Feb;39(2):377-9. Epub 2005 Jan 11.PMID: 15644484 [PubMed - indexed for MEDLINE]Related articles

Intellectual property law in Israel, and US and European objections: Market exclusivity vs. data exclusivity.

Morag-Sela T, Cohn I, Kowalski TJ, Jarecki-Black J, Clyde-Watson Z.

Nat Biotechnol. 2004 Dec;22(12):1591-2. No abstract available. PMID: 15583670 [PubMed - indexed for MEDLINE]Related articles

Inventive step and genomics.

Soames CJ, Kowalski TJ.

Nat Rev Drug Discov. 2004 Sep;3(9):729. No abstract available. PMID: 15368655 [PubMed - indexed for MEDLINE]Related articles

Therapeutic potential of melanin-concentrating hormone-1 receptor antagonists for the treatment of obesity.

Kowalski TJ, McBriar MD.

Expert Opin Investig Drugs. 2004 Sep;13(9):1113-22. Review.PMID: 15330743 [PubMed - indexed for MEDLINE]Related articles

Melanin-concentrating hormone-1 receptor antagonism decreases feeding by reducing meal size.

Kowalski TJ, Farley C, Cohen-Williams ME, Varty G, Spar BD.

Eur J Pharmacol. 2004 Aug 16;497(1):41-7.PMID: 15321733 [PubMed - indexed for MEDLINE]Related articles

The future of genetic research on appetitive behavior.

Kowalski TJ.

Appetite. 2004 Feb;42(1):11-4. Review.PMID: 15036778 [PubMed - indexed for MEDLINE]Related articles

Integra v. Merck: a mixed bag for research tool patents.

Raubicheck C, White BS, Kowalski TJ, Brown DG, Leahy A, Fekete P.

Nat Biotechnol. 2003 Sep;21(9):1099-101. No abstract available. PMID: 12949571 [PubMed - indexed for MEDLINE]Related articles

Meal pattern analysis of diet-induced obesity in susceptible and resistant rats.

Farley C, Cook JA, Spar BD, Austin TM, Kowalski TJ.

Obes Res. 2003 Jul;11(7):845-51.PMID: 12855753 [PubMed - indexed for MEDLINE]Related articles

Decreased hypothalamic concentration of neuropeptide Y correlates with onset of hyperphagia in fa/fa rats on postnatal day 12.

Ster AM, Kowalski TJ, Dube MG, Kalra SP, Smith GP.

Physiol Behav. 2003 Apr;78(4-5):517-20.PMID: 12782203 [PubMed - indexed for MEDLINE]Related articles

Ability of the borreliacidal antibody test to confirm lyme disease in clinical practice.

Callister SM, Jobe DA, Agger WA, Schell RF, Kowalski TJ, Lovrich SD, Marks JA.

Clin Diagn Lab Immunol. 2002 Jul;9(4):908-12.PMID: 12093694 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased hypothalamic neuropeptide Y expression in deprived preweanling rats is reversed by intragastric infusion of milk.

Kowalski TJ, Ster AM, Smith GP.

Physiol Behav. 2002 Mar;75(3):425-32.PMID: 11897270 [PubMed - indexed for MEDLINE]Related articles

Transgenic complementation of leptin-receptor deficiency. I. Rescue of the obesity/diabetes phenotype of LEPR-null mice expressing a LEPR-B transgene.

Kowalski TJ, Liu SM, Leibel RL, Chua SC Jr.

Diabetes. 2001 Feb;50(2):425-35.PMID: 11272157 [PubMed - indexed for MEDLINE]Related articlesFree article

Analyzing the new written description guidelines. With the USPTO's revised guidelines, the patent landscape has changed yet again.

Kowalski TJ.

Nat Biotechnol. 2000 Apr;18(4):461-2. No abstract available. PMID: 10748533 [PubMed - indexed for MEDLINE]Related articles

Analyzing the USPTO's revised utility guidelines. United States Patent and Trademark Office.

Kowalski TJ.

Nat Biotechnol. 2000 Mar;18(3):349-50. No abstract available. PMID: 10700156 [PubMed - indexed for MEDLINE]Related articles

Neuropeptide Y overexpression in the preweanling Zucker (fa/fa) rat.

Kowalski TJ, Houpt TA, Jahng J, Okada N, Liu SM, Chua SC Jr, Smith GP.

Physiol Behav. 1999 Oct;67(4):521-5.PMID: 10549888 [PubMed - indexed for MEDLINE]Related articles

Ontogeny of hyperphagia in the Zucker (fa/fa) rat: role of neuropeptide Y.

Kowalski TJ.

Appetite. 1999 Apr;32(2):275. No abstract available. PMID: 10097033 [PubMed - indexed for MEDLINE]Related articles

Distribution of phosphate-activated glutaminase isozymes in the chicken: absence from liver but presence of high activity in pectoralis muscle.

Wu G, Chung-Bok MI, Vincent N, Kowalski TJ, Choi YH, Watford M.

Comp Biochem Physiol B Biochem Mol Biol. 1998 Jun;120(2):285-90.PMID: 9787797 [PubMed - indexed for MEDLINE]Related articles

Ontogeny of hyperphagia in the Zucker (fa/fa) rat.

Kowalski TJ, Ster AM, Smith GP.

Am J Physiol. 1998 Oct;275(4 Pt 2):R1106-9.PMID: 9756540 [PubMed - indexed for MEDLINE]Related articlesFree article

Ontogeny of neuropeptide Y expression in response to deprivation in lean Zucker rat pups.

Kowalski TJ, Houpt TA, Jahng J, Okada N, Chua SC Jr, Smith GP.

Am J Physiol. 1998 Aug;275(2 Pt 2):R466-70.PMID: 9688681 [PubMed - indexed for MEDLINE]Related articlesFree article

The leptin receptor mediates apparent autocrine regulation of leptin gene expression.

Zhang Y, Olbort M, Schwarzer K, Nuesslein-Hildesheim B, Nicolson M, Murphy E, Kowalski TJ, Schmidt I, Leibel RL.

Biochem Biophys Res Commun. 1997 Nov 17;240(2):492-5.PMID: 9388507 [PubMed - indexed for MEDLINE]Related articles

Rat adipose tissue amino acid metabolism in vivo as assessed by microdialysis and arteriovenous techniques.

Kowalski TJ, Wu G, Watford M.

Am J Physiol. 1997 Sep;273(3 Pt 1):E613-22.PMID: 9316453 [PubMed - indexed for MEDLINE]Related articles

Inhibition of LTB4 biosynthesis in situ by CGS 23885, a potent 5-lipoxygenase inhibitor, correlates with its pleural fluid concentrations in an experimentally induced rat pleurisy model.

Raychaudhuri A, Chertock H, Chovan J, Jones LS, Kimble EF, Kowalski TJ, Peppard J, White DH, Satoh Y, Roland D.

Naunyn Schmiedebergs Arch Pharmacol. 1997 Apr;355(4):470-4.PMID: 9109363 [PubMed - indexed for MEDLINE]Related articles

Suicide prevention in an army infantry division: a multi-disciplinary program.

James LC, Kowalski TJ.

Mil Med. 1996 Feb;161(2):97-101.PMID: 8857222 [PubMed - indexed for MEDLINE]Related articles

Derivatives of 2-[[N-(Aminocarbonyl)-N-hydroxyamino]methyl]-1,4- benzodioxan as orally active 5-lipoxygenase inhibitors.

Satoh Y, Powers C, Toledo LM, Kowalski TJ, Peters PA, Kimble EF.

J Med Chem. 1995 Jan 6;38(1):68-75.PMID: 7837242 [PubMed - indexed for MEDLINE]Related articles

Production of glutamine and utilization of glutamate by rat subcutaneous adipose tissue in vivo.

Kowalski TJ, Watford M.

Am J Physiol. 1994 Jan;266(1 Pt 1):E151-4.PMID: 7905708 [PubMed - indexed for MEDLINE]Related articles

Substituted chromenes as potent, orally active 5-lipoxygenase inhibitors.

Satoh Y, Stanton JL, Hutchison AJ, Libby AH, Kowalski TJ, Lee WH, White DH, Kimble EF.

J Med Chem. 1993 Nov 12;36(23):3580-94.PMID: 8246226 [PubMed - indexed for MEDLINE]Related articles

Leukotriene biosynthesis inhibition by aryl and aroyl substituted naphthoquinones.

Roland DM, Macchia WM, Grim KS, Kimble EF, White DH, Kowalski TJ.

Agents Actions. 1991 Sep;34(1-2):145-7.PMID: 1665288 [PubMed - indexed for MEDLINE]Related articles