PubMed

The International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes--chapter 3: Pig islet product manufacturing and release testing.

Korbutt GS.

Xenotransplantation. 2009 Jul;16(4):223-8.PMID: 19799762 [PubMed - in process]Related articles

The International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes-- executive summary.

Hering BJ, Cooper DK, Cozzi E, Schuurman HJ, Korbutt GS, Denner J, O'Connell PJ, Vanderpool HY, Pierson RN 3rd.

Xenotransplantation. 2009 Jul;16(4):196-202.PMID: 19799759 [PubMed - in process]Related articles

Prolonged survival of microencapsulated neonatal porcine islet xenografts in immune-competent mice without antirejection therapy.

Kobayashi T, Arefanian H, Harb G, Tredget EB, Rajotte RV, Korbutt GS, Rayat GR.

Cell Transplant. 2008;17(10-11):1243-56.PMID: 19181218 [PubMed - indexed for MEDLINE]Related articles

The use of an approved biodegradable polymer scaffold as a solid support system for improvement of islet engraftment.

Kin T, O'Neil JJ, Pawlick R, Korbutt GS, Shapiro AM, Lakey JR.

Artif Organs. 2008 Dec;32(12):990-3.PMID: 19133030 [PubMed - indexed for MEDLINE]Related articles

Epithelial cells within the human pancreas do not coexpress mesenchymal antigens: epithelial-mesenchymal transition is an artifact of cell culture.

Seeberger KL, Eshpeter A, Rajotte RV, Korbutt GS.

Lab Invest. 2009 Feb;89(2):110-21. Epub 2008 Dec 15.PMID: 19079324 [PubMed - indexed for MEDLINE]Related articles

In vivo characterization of transplanted human embryonic stem cell-derived pancreatic endocrine islet cells.

Eshpeter A, Jiang J, Au M, Rajotte RV, Lu K, Lebkowski JS, Majumdar AS, Korbutt GS.

Cell Prolif. 2008 Dec;41(6):843-58.PMID: 19040565 [PubMed - indexed for MEDLINE]Related articles

Alginate modification improves long-term survival and function of transplanted encapsulated islets.

Mallett AG, Korbutt GS.

Tissue Eng Part A. 2009 Jun;15(6):1301-9.PMID: 18950258 [PubMed - indexed for MEDLINE]Related articles

Sertoli cell line lacks the immunoprotective properties associated with primary Sertoli cells.

Dufour JM, Dass B, Halley KR, Korbutt GS, Dixon DE, Rajotte RV.

Cell Transplant. 2008;17(5):525-34.PMID: 18714671 [PubMed - indexed for MEDLINE]Related articles

What type of islets should be used?

Korbutt GS.

Xenotransplantation. 2008 Mar;15(2):81-2. No abstract available. PMID: 18447872 [PubMed - indexed for MEDLINE]Related articles

Treatment of obesity and diabetes in mice by transplant of gut cells engineered to produce leptin.

Oosman SN, Lam AW, Harb G, Unniappan S, Lam NT, Webber T, Bruch D, Zhang QX, Korbutt GS, Kieffer TJ.

Mol Ther. 2008 Jun;16(6):1138-45. Epub 2008 Apr 15.PMID: 18414479 [PubMed - indexed for MEDLINE]Related articles

Comparison of successful and unsuccessful islet/Sertoli cell cotransplant grafts in streptozotocin-induced diabetic mice.

Dufour JM, Lord SJ, Kin T, Rayat GR, Dixon DE, Bleackley RC, Korbutt GS, Rajotte RV.

Cell Transplant. 2008;16(10):1029-38.PMID: 18351019 [PubMed - indexed for MEDLINE]Related articles

Combination of anti-CD4 with anti-LFA-1 and anti-CD154 monoclonal antibodies promotes long-term survival and function of neonatal porcine islet xenografts in spontaneously diabetic NOD mice.

Arefanian H, Tredget EB, Rajotte RV, Korbutt GS, Gill RG, Rayat GR.

Cell Transplant. 2007;16(8):787-98.PMID: 18087999 [PubMed - indexed for MEDLINE]Related articles

Delayed functional maturation of neonatal porcine islets in recipients under strict glycemic control.

Kin T, Korbutt GS.

Xenotransplantation. 2007 Jul;14(4):333-8.PMID: 17669175 [PubMed - indexed for MEDLINE]Related articles

Long-term graft function after allogeneic islet transplantation.

Lakey JR, Kin T, Warnock GL, Shapiro AM, Tsapogas P, Imes S, Korbutt GS, Kneteman NM, Rajotte RV, Ryan EA.

Cell Transplant. 2007;16(4):441-6.PMID: 17658134 [PubMed - indexed for MEDLINE]Related articles

NMR assessment of Me(2)SO in decellularized cryopreserved aortic valve conduits.

Lehr EJ, Hermary S, McKay RT, Webb DN, Abazari A, McGann LE, Coe JY, Korbutt GS, Ross DB.

J Surg Res. 2007 Jul;141(1):60-7. Epub 2007 May 18.PMID: 17512545 [PubMed - indexed for MEDLINE]Related articles

Enriched human pancreatic ductal cultures obtained from selective death of acinar cells express pancreatic and duodenal homeobox gene-1 age-dependently.

Street CN, Lakey JR, Rajotte RV, Shapiro AM, Kieffer TJ, Lyon JG, Kin T, Korbutt GS.

Rev Diabet Stud. 2004 Summer;1(2):66-79. Epub 2004 Aug 10.PMID: 17491668 [PubMed]Related articlesFree article

Effect of prolonged in vitro exposure to high glucose on neonatal porcine pancreatic islets.

Harb G, Korbutt GS.

J Endocrinol. 2006 Oct;191(1):37-44.PMID: 17065387 [PubMed - indexed for MEDLINE]Related articlesFree article

Inbred or outbred? An evaluation of the functional allogenicity of farm sheep used in cardiac valve studies.

Lehr EJ, Rayat GR, Desai LS, Coe JY, Korbutt GS, Ross DB.

J Thorac Cardiovasc Surg. 2006 Nov;132(5):1156-61.PMID: 17059938 [PubMed - indexed for MEDLINE]Related articles

Immune mechanisms associated with the rejection of encapsulated neonatal porcine islet xenografts.

Kobayashi T, Harb G, Rajotte RV, Korbutt GS, Mallett AG, Arefanian H, Mok D, Rayat GR.

Xenotransplantation. 2006 Nov;13(6):547-59.PMID: 17059582 [PubMed - indexed for MEDLINE]Related articles

Identification of a novel human granzyme B inhibitor secreted by cultured sertoli cells.

Sipione S, Simmen KC, Lord SJ, Motyka B, Ewen C, Shostak I, Rayat GR, Dufour JM, Korbutt GS, Rajotte RV, Bleackley RC.

J Immunol. 2006 Oct 15;177(8):5051-8.PMID: 17015688 [PubMed - indexed for MEDLINE]Related articlesFree article

International trial of the Edmonton protocol for islet transplantation.

Shapiro AM, Ricordi C, Hering BJ, Auchincloss H, Lindblad R, Robertson RP, Secchi A, Brendel MD, Berney T, Brennan DC, Cagliero E, Alejandro R, Ryan EA, DiMercurio B, Morel P, Polonsky KS, Reems JA, Bretzel RG, Bertuzzi F, Froud T, Kandaswamy R, Sutherland DE, Eisenbarth G, Segal M, Preiksaitis J, Korbutt GS, Barton FB, Viviano L, Seyfert-Margolis V, Bluestone J, Lakey JR.

N Engl J Med. 2006 Sep 28;355(13):1318-30.PMID: 17005949 [PubMed - indexed for MEDLINE]Related articlesFree article

The impact of the mTOR inhibitor sirolimus on the proliferation and function of pancreatic islets and ductal cells.

Bussiere CT, Lakey JR, Shapiro AM, Korbutt GS.

Diabetologia. 2006 Oct;49(10):2341-9. Epub 2006 Aug 9.PMID: 16896936 [PubMed - indexed for MEDLINE]Related articles

Glutaraldehyde-fixed bioprosthetic heart valve conduits calcify and fail from xenograft rejection.

Manji RA, Zhu LF, Nijjar NK, Rayner DC, Korbutt GS, Churchill TA, Rajotte RV, Koshal A, Ross DB.

Circulation. 2006 Jul 25;114(4):318-27. Epub 2006 Jul 10.PMID: 16831988 [PubMed - indexed for MEDLINE]Related articlesFree article

Ectopic expression of neurogenin 3 in neonatal pig pancreatic precursor cells induces (trans)differentiation to functional alpha cells.

Harb G, Heremans Y, Heimberg H, Korbutt GS.

Diabetologia. 2006 Aug;49(8):1855-63. Epub 2006 May 31.PMID: 16736130 [PubMed - indexed for MEDLINE]Related articles

Long-term survival of neonatal porcine islets in nonhuman primates by targeting costimulation pathways.

Cardona K, Korbutt GS, Milas Z, Lyon J, Cano J, Jiang W, Bello-Laborn H, Hacquoil B, Strobert E, Gangappa S, Weber CJ, Pearson TC, Rajotte RV, Larsen CP.

Nat Med. 2006 Mar;12(3):304-6. Epub 2006 Feb 26.PMID: 16501570 [PubMed - indexed for MEDLINE]Related articles

Expansion of mesenchymal stem cells from human pancreatic ductal epithelium.

Seeberger KL, Dufour JM, Shapiro AM, Lakey JR, Rajotte RV, Korbutt GS.

Lab Invest. 2006 Feb;86(2):141-53.PMID: 16402034 [PubMed - indexed for MEDLINE]Related articlesFree article

Development of an ectopic site for islet transplantation, using biodegradable scaffolds.

Dufour JM, Rajotte RV, Zimmerman M, Rezania A, Kin T, Dixon DE, Korbutt GS.

Tissue Eng. 2005 Sep-Oct;11(9-10):1323-31.PMID: 16259588 [PubMed - indexed for MEDLINE]Related articles

Reversal of diabetes in pancreatectomized pigs after transplantation of neonatal porcine islets.

Kin T, Korbutt GS, Kobayashi T, Dufour JM, Rajotte RV.

Diabetes. 2005 Apr;54(4):1032-9.PMID: 15793241 [PubMed - indexed for MEDLINE]Related articlesFree article

Neonatal porcine Sertoli cells inhibit human natural antibody-mediated lysis.

Dufour JM, Hamilton M, Rajotte RV, Korbutt GS.

Biol Reprod. 2005 May;72(5):1224-31. Epub 2005 Jan 19.PMID: 15659703 [PubMed - indexed for MEDLINE]Related articlesFree article

Islet graft assessment in the Edmonton Protocol: implications for predicting long-term clinical outcome.

Street CN, Lakey JR, Shapiro AM, Imes S, Rajotte RV, Ryan EA, Lyon JG, Kin T, Avila J, Tsujimura T, Korbutt GS.

Diabetes. 2004 Dec;53(12):3107-14.PMID: 15561940 [PubMed - indexed for MEDLINE]Related articlesFree article

Improved survival of microencapsulated islets during in vitro culture and enhanced metabolic function following transplantation.

Korbutt GS, Mallett AG, Ao Z, Flashner M, Rajotte RV.

Diabetologia. 2004 Oct;47(10):1810-8. Epub 2004 Oct 23.PMID: 15517151 [PubMed - indexed for MEDLINE]Related articles

Reassessment of the vascularization of renal subcapsular islet grafts.

Kin T, Rajotte RV, Korbutt GS.

Pancreas. 2004 Oct;29(3):e59-63.PMID: 15367895 [PubMed - indexed for MEDLINE]Related articles

Porcine endogenous retroviral nucleic acid in peripheral tissues is associated with migration of porcine cells post islet transplant.

Binette TM, Seeberger KL, Lyon JG, Rajotte RV, Korbutt GS.

Am J Transplant. 2004 Jul;4(7):1051-60.PMID: 15196061 [PubMed - indexed for MEDLINE]Related articles

Stem cell-based approaches to solving the problem of tissue supply for islet transplantation in type 1 diabetes.

Street CN, Sipione S, Helms L, Binette T, Rajotte RV, Bleackley RC, Korbutt GS.

Int J Biochem Cell Biol. 2004 Apr;36(4):667-83. Review.PMID: 15010331 [PubMed - indexed for MEDLINE]Related articles

Insulin expressing cells from differentiated embryonic stem cells are not beta cells.

Sipione S, Eshpeter A, Lyon JG, Korbutt GS, Bleackley RC.

Diabetologia. 2004 Mar;47(3):499-508. Epub 2004 Feb 14.PMID: 14968299 [PubMed - indexed for MEDLINE]Related articles

Metformin, but not leptin, regulates AMP-activated protein kinase in pancreatic islets: impact on glucose-stimulated insulin secretion.

Leclerc I, Woltersdorf WW, da Silva Xavier G, Rowe RL, Cross SE, Korbutt GS, Rajotte RV, Smith R, Rutter GA.

Am J Physiol Endocrinol Metab. 2004 Jun;286(6):E1023-31. Epub 2004 Feb 10.PMID: 14871885 [PubMed - indexed for MEDLINE]Related articlesFree article

Heterogenous expression of nestin in human pancreatic tissue precludes its use as an islet precursor marker.

Street CN, Lakey JR, Seeberger K, Helms L, Rajotte RV, Shapiro AM, Korbutt GS.

J Endocrinol. 2004 Feb;180(2):213-25.PMID: 14765974 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetically engineered Sertoli cells are able to survive allogeneic transplantation.

Dufour JM, Hemendinger R, Halberstadt CR, Gores P, Emerich DF, Korbutt GS, Rajotte RV.

Gene Ther. 2004 Apr;11(8):694-700.PMID: 14724669 [PubMed - indexed for MEDLINE]Related articles

Stem cells: a promising source of pancreatic islets for transplantation in type 1 diabetes.

Street CN, Rajotte RV, Korbutt GS.

Curr Top Dev Biol. 2003;58:111-36. Review.PMID: 14711014 [PubMed - indexed for MEDLINE]Related articles

Long-term survival of neonatal porcine Sertoli cells in non-immunosuppressed rats.

Dufour JM, Rajotte RV, Seeberger K, Kin T, Korbutt GS.

Xenotransplantation. 2003 Nov;10(6):577-86.PMID: 14708526 [PubMed - indexed for MEDLINE]Related articles

Harnessing the immunomodulatory properties of Sertoli cells to enable xenotransplantation in type I diabetes.

Dufour JM, Rajotte RV, Korbutt GS, Emerich DF.

Immunol Invest. 2003 Nov;32(4):275-97. Review.PMID: 14603995 [PubMed - indexed for MEDLINE]Related articles

Current status of islet cell transplantation.

Oberholzer J, Shapiro AM, Lakey JR, Ryan EA, Rajotte RV, Korbutt GS, Morel P, Kneteman NM.

Adv Surg. 2003;37:253-82. Review. No abstract available. PMID: 12953637 [PubMed - indexed for MEDLINE]Related articles

Percutaneous transhepatic pancreatic islet cell transplantation in type 1 diabetes mellitus: radiologic aspects.

Owen RJ, Ryan EA, O'Kelly K, Lakey JR, McCarthy MC, Paty BW, Bigam DL, Kneteman NM, Korbutt GS, Rajotte RV, Shapiro AM.

Radiology. 2003 Oct;229(1):165-70. Epub 2003 Aug 27.PMID: 12944593 [PubMed - indexed for MEDLINE]Related articlesFree article

Immunization with streptozotocin-treated NOD mouse islets inhibits the onset of autoimmune diabetes in NOD mice.

Rayat GR, Rajotte RV, Lyon JG, Dufour JM, Hacquoil BV, Korbutt GS.

J Autoimmun. 2003 Aug;21(1):11-5.PMID: 12892731 [PubMed - indexed for MEDLINE]Related articles

Immunoprotection of rat islet xenografts by cotransplantation with sertoli cells and a single injection of antilymphocyte serum.

Dufour JM, Rajotte RV, Kin T, Korbutt GS.

Transplantation. 2003 May 15;75(9):1594-6.PMID: 12792521 [PubMed - indexed for MEDLINE]Related articles

The degree of phylogenetic disparity of islet grafts dictates the reliance on indirect CD4 T-cell antigen recognition for rejection.

Rayat GR, Johnson ZA, Beilke JN, Korbutt GS, Rajotte RV, Gill RG.

Diabetes. 2003 Jun;52(6):1433-40.PMID: 12765954 [PubMed - indexed for MEDLINE]Related articlesFree article

Granzyme B: a natural born killer.

Lord SJ, Rajotte RV, Korbutt GS, Bleackley RC.

Immunol Rev. 2003 Jun;193:31-8. Review.PMID: 12752668 [PubMed - indexed for MEDLINE]Related articles

In vitro and in vivo expression of Galalpha-(1,3)Gal on porcine islet cells is age dependent.

Rayat GR, Rajotte RV, Hering BJ, Binette TM, Korbutt GS.

J Endocrinol. 2003 Apr;177(1):127-35.PMID: 12697044 [PubMed - indexed for MEDLINE]Related articlesFree article

Long-term survival of intratesticular porcine islets in nonimmunosuppressed beagles.

Gores PF, Hayes DH, Copeland MJ, Korbutt GS, Halberstadt C, Kirkpatrick SA, Rajotte RV.

Transplantation. 2003 Mar 15;75(5):613-8.PMID: 12640298 [PubMed - indexed for MEDLINE]Related articles

Human ABO blood group is important in survival and function of porcine working hearts.

Manji RA, Manji JS, Koshal A, Korbutt GS, Rajotte RV.

Am J Transplant. 2003 Mar;3(3):286-93.PMID: 12614283 [PubMed - indexed for MEDLINE]Related articles