PubMed

A rare variant of the TYK2 gene is confirmed to be associated with multiple sclerosis.

Mero IL, Lorentzen AR, Ban M, Smestad C, Celius EG, Aarseth JH, Myhr KM, Link J, Hillert J, Olsson T, Kockum I, Masterman T, Oturai AB, Søndergaard HB, Sellebjerg F, Saarela J, Kemppinen A, Elovaara I, Spurkland A, Dudbridge F, Lie BA, Harbo HF.

Eur J Hum Genet. 2009 Nov 4. [Epub ahead of print]PMID: 19888296 [PubMed - as supplied by publisher]Related articles

Genetic variants of CC chemokine genes in experimental autoimmune encephalomyelitis, multiple sclerosis and rheumatoid arthritis.

Ockinger J, Stridh P, Beyeen AD, Lundmark F, Seddighzadeh M, Oturai A, Sørensen PS, Lorentzen AR, Celius EG, Leppä V, Koivisto K, Tienari PJ, Alfredsson L, Padyukov L, Hillert J, Kockum I, Jagodic M, Olsson T.

Genes Immun. 2009 Oct 29. [Epub ahead of print]PMID: 19865101 [PubMed - as supplied by publisher]Related articles

Lack of association between neuropeptide S receptor 1 gene (NPSR1) and eczema in five European populations.

Ekelund E, Bradley M, Weidinger S, Jovanovic DL, Johansson C, Lindgren CM, Todorova A, Jakob T, Illig T, von Mutius E, Braun-Fahrländer C, Doekes G, Riedler J, Scheynius A, Pershagen G, Kockum I, Kere J.

Acta Derm Venereol. 2009;89(2):115-21.PMID: 19325992 [PubMed - indexed for MEDLINE]Related articles

Reproducible association with type 1 diabetes in the extended class I region of the major histocompatibility complex.

Viken MK, Blomhoff A, Olsson M, Akselsen HE, Pociot F, Nerup J, Kockum I, Cambon-Thomsen A, Thorsby E, Undlien DE, Lie BA.

Genes Immun. 2009 Jun;10(4):323-33. Epub 2009 Mar 19.PMID: 19295542 [PubMed - indexed for MEDLINE]Related articles

Cornulin, a marker of late epidermal differentiation, is down-regulated in eczema.

Liedén A, Ekelund E, Kuo IC, Kockum I, Huang CH, Mallbris L, Lee SP, Seng LK, Chin GY, Wahlgren CF, Palmer CN, Björkstén B, Ståhle M, Nordenskjöld M, Bradley M, Chua KY, D'Amato M.

Allergy. 2009 Feb;64(2):304-11. Epub 2008 Dec 24. Erratum in: Allergy. 2009 Apr;64(4):667.. Nordenskold, M [corrected to Nordenskjöld, M]. PMID: 19133922 [PubMed - indexed for MEDLINE]Related articles

Risk conferred by HLA-DR and DQ for type 1 diabetes in 0-35-year age group in Sweden.

Sanjeevi CB, Sedimbi SK, Landin-Olsson M, Kockum I, Lernmark A; Swedish Childhood Diabetes and the Diabetes Incidence in Sweden Study Groups.

Ann N Y Acad Sci. 2008 Dec;1150:106-11.PMID: 19120278 [PubMed - indexed for MEDLINE]Related articles

The non-inherited maternal HLA haplotype affects the risk for type 1 diabetes.

Akesson K, Carlsson A, Ivarsson SA, Johansson C, Weidby BM, Ludvigsson J, Gustavsson B, Lernmark A, Kockum I.

Int J Immunogenet. 2009 Feb;36(1):1-8. Epub 2008 Nov 25.PMID: 19055605 [PubMed - indexed for MEDLINE]Related articles

A new susceptibility locus for hypospadias on chromosome 7q32.2-q36.1.

Thai HT, Söderhäll C, Lagerstedt K, Omrani MD, Frisén L, Lundin J, Kockum I, Nordenskjöld A.

Hum Genet. 2008 Sep;124(2):155-60. Epub 2008 Jul 27.PMID: 18661284 [PubMed - indexed for MEDLINE]Related articles

Activating transcription factor 3: a hormone responsive gene in the etiology of hypospadias.

Beleza-Meireles A, Töhönen V, Söderhäll C, Schwentner C, Radmayr C, Kockum I, Nordenskjöld A.

Eur J Endocrinol. 2008 May;158(5):729-39.PMID: 18426833 [PubMed - indexed for MEDLINE]Related articlesFree article

The effect of polymorphisms in the renin-angiotensin-aldosterone system on diabetic nephropathy risk.

Möllsten A, Kockum I, Svensson M, Rudberg S, Ugarph-Morawski A, Brismar K, Eriksson JW, Dahlquist G.

J Diabetes Complications. 2008 Nov-Dec;22(6):377-83. Epub 2008 Apr 16.PMID: 18413189 [PubMed - indexed for MEDLINE]Related articles

The lack of anti-idiotypic antibodies, not the presence of the corresponding autoantibodies to glutamate decarboxylase, defines type 1 diabetes.

Oak S, Gilliam LK, Landin-Olsson M, Törn C, Kockum I, Pennington CR, Rowley MJ, Christie MR, Banga JP, Hampe CS.

Proc Natl Acad Sci U S A. 2008 Apr 8;105(14):5471-6. Epub 2008 Mar 26.PMID: 18367670 [PubMed - indexed for MEDLINE]Related articlesFree article

Complex aetiology of an apparently Mendelian form of mental retardation.

Beleza-Meireles A, Kockum I, Yuan QP, Picelli S, Wetterberg L, Gustavson KH, Schalling M.

BMC Med Genet. 2008 Feb 6;9:6.PMID: 18254962 [PubMed - indexed for MEDLINE]Related articlesFree article

Loss-of-function variants of the filaggrin gene are associated with atopic eczema and associated phenotypes in Swedish families.

Ekelund E, Liedén A, Link J, Lee SP, D'Amato M, Palmer CN, Kockum I, Bradley M.

Acta Derm Venereol. 2008;88(1):15-9.PMID: 18176743 [PubMed - indexed for MEDLINE]Related articles

The interleukin 23 receptor gene in multiple sclerosis: a case-control study.

Roos IM, Kockum I, Hillert J.

J Neuroimmunol. 2008 Feb;194(1-2):173-80.PMID: 18164077 [PubMed - indexed for MEDLINE]Related articles

No evidence of association of the PDCD1 gene with Type 1 diabetes.

Asad S, Nikamo P, Törn C, Landin-Olsson M, Lernmark A, Alarcón-Riquelme M, Kockum I; Diabetes Incidence in Sweden Study Group.

Diabet Med. 2007 Dec;24(12):1473-7. Erratum in: Diabet Med. 2008 Feb;25(2):243. Fawwaz, S [corrected to Asad, S]. PMID: 18042085 [PubMed - indexed for MEDLINE]Related articles

Islet cell autoantibody levels after the diagnosis of young adult diabetic patients.

Jensen R, Gilliam L, Torn C, Landin-Olsson M, Palmer J, Akesson K, Kockum I, Lernmark B, Karlsson AF, Lynch KF, Breslow N, Lernmark A, Sundkvist G; Diabetes Incidence Study in Sweden group.

Diabet Med. 2007 Nov;24(11):1221-8. Epub 2007 Aug 24.PMID: 17725633 [PubMed - indexed for MEDLINE]Related articles

Variation in interleukin 7 receptor alpha chain (IL7R) influences risk of multiple sclerosis.

Lundmark F, Duvefelt K, Iacobaeus E, Kockum I, Wallström E, Khademi M, Oturai A, Ryder LP, Saarela J, Harbo HF, Celius EG, Salter H, Olsson T, Hillert J.

Nat Genet. 2007 Sep;39(9):1108-13. Epub 2007 Jul 29.PMID: 17660816 [PubMed - indexed for MEDLINE]Related articles

IA-2 autoantibodies in incident type I diabetes patients are associated with a polyadenylation signal polymorphism in GIMAP5.

Shin JH, Janer M, McNeney B, Blay S, Deutsch K, Sanjeevi CB, Kockum I, Lernmark A, Graham J; Swedish Childhood Diabetes Study Group; Diabetes Incidence in Sweden Study Group, Arnqvist H, Björck E, Eriksson J, Nyström L, Ohlson LO, Scherstén B, Ostman J, Aili M, Bååth LE, Carlsson E, Edenwall H, Forsander G, Granström BW, Gustavsson I, Hanås R, Hellenberg L, Hellgren H, Holmberg E, Hörnell H, Ivarsson SA, Johansson C, Jonsell G, Kockum K, Lindblad B, Lindh A, Ludvigsson J, Myrdal U, Neiderud J, Segnestam K, Sjöblad S, Skogsberg L, Strömberg L, Ståhle U, Thalme B, Tullus K, Tuvemo T, Wallensteen M, Westphal O, Aman J.

Genes Immun. 2007 Sep;8(6):503-12. Epub 2007 Jul 19.PMID: 17641683 [PubMed - indexed for MEDLINE]Related articles

Multiple factors affect the loss of measurable C-peptide over 6 years in newly diagnosed 15- to 35-year-old diabetic subjects.

Jensen RA, Gilliam LK, Törn C, Landin-Olsson M, Karlsson FA, Palmer JP, Kockum I, Akesson K, Lernmark B, Lynch K, Breslow N, Lernmark A; Diabetes Incidence Study in Sweden (DISS) group.

J Diabetes Complications. 2007 Jul-Aug;21(4):205-13.PMID: 17616349 [PubMed - indexed for MEDLINE]Related articles

Relative predispositional effects of HLA class II DRB1-DQB1 haplotypes and genotypes on type 1 diabetes: a meta-analysis.

Thomson G, Valdes AM, Noble JA, Kockum I, Grote MN, Najman J, Erlich HA, Cucca F, Pugliese A, Steenkiste A, Dorman JS, Caillat-Zucman S, Hermann R, Ilonen J, Lambert AP, Bingley PJ, Gillespie KM, Lernmark A, Sanjeevi CB, Rønningen KS, Undlien DE, Thorsby E, Petrone A, Buzzetti R, Koeleman BP, Roep BO, Saruhan-Direskeneli G, Uyar FA, Günoz H, Gorodezky C, Alaez C, Boehm BO, Mlynarski W, Ikegami H, Berrino M, Fasano ME, Dametto E, Israel S, Brautbar C, Santiago-Cortes A, Frazer de Llado T, She JX, Bugawan TL, Rotter JI, Raffel L, Zeidler A, Leyva-Cobian F, Hawkins BR, Chan SH, Castano L, Pociot F, Nerup J.

Tissue Antigens. 2007 Aug;70(2):110-27.PMID: 17610416 [PubMed - indexed for MEDLINE]Related articles

Association analysis in type 1 diabetes of the PRSS16 gene encoding a thymus-specific serine protease.

Lie BA, Viken MK, Akselsen HE, Flåm ST, Pociot F, Nerup J, Kockum I, Cambon-Thomsen A, Thorsby E, Undlien DE.

Hum Immunol. 2007 Jul;68(7):592-8. Epub 2007 Apr 13.PMID: 17584581 [PubMed - indexed for MEDLINE]Related articles

Risk factors for hypospadias in the estrogen receptor 2 gene.

Beleza-Meireles A, Kockum I, Lundberg F, Söderhäll C, Nordenskjöld A.

J Clin Endocrinol Metab. 2007 Sep;92(9):3712-8. Epub 2007 Jun 19.PMID: 17579196 [PubMed - indexed for MEDLINE]Related articlesFree article

Elevated expression and genetic association links the SOCS3 gene to atopic dermatitis.

Ekelund E, Saaf A, Tengvall-Linder M, Melen E, Link J, Barker J, Reynolds NJ, Meggitt SJ, Kere J, Wahlgren CF, Pershagen G, Wickman M, Nordenskjold M, Kockum I, Bradley M.

Am J Hum Genet. 2006 Jun;78(6):1060-5. Epub 2006 Apr 14.PMID: 16685656 [PubMed - indexed for MEDLINE]Related articlesFree article

Susceptibility loci for atopic dermatitis on chromosome 21 in a Swedish population.

Bu LM, Bradley M, Söderhäll C, Wahlgren CF, Kockum I, Nordenskjold M.

Allergy. 2006 May;61(5):617-21.PMID: 16629793 [PubMed - indexed for MEDLINE]Related articles

Immune-mediated beta-cell destruction in vitro and in vivo-A pivotal role for galectin-3.

Karlsen AE, Størling ZM, Sparre T, Larsen MR, Mahmood A, Størling J, Roepstorff P, Wrzesinski K, Larsen PM, Fey S, Nielsen K, Heding P, Ricordi C, Johannesen J, Kristiansen OP, Christensen UB, Kockum I, Luthman H, Nerup J, Pociot F.

Biochem Biophys Res Commun. 2006 May 26;344(1):406-15. Epub 2006 Mar 29.PMID: 16600178 [PubMed - indexed for MEDLINE]Related articles

Polymorphisms of estrogen receptor beta gene are associated with hypospadias.

Beleza-Meireles A, Omrani D, Kockum I, Frisén L, Lagerstedt K, Nordenskjöld A.

J Endocrinol Invest. 2006 Jan;29(1):5-10.PMID: 16553027 [PubMed - indexed for MEDLINE]Related articles

Genome-wide linkage analysis of allergic rhinoconjunctivitis in a Swedish population.

Bu LM, Bradley M, Söderhäll C, Wahlgren CF, Kockum I, Nordenskjöld M.

Clin Exp Allergy. 2006 Feb;36(2):204-10.PMID: 16433858 [PubMed - indexed for MEDLINE]Related articles

Linkage disequilibrium and haplotype blocks in the MHC vary in an HLA haplotype specific manner assessed mainly by DRB1*03 and DRB1*04 haplotypes.

Blomhoff A, Olsson M, Johansson S, Akselsen HE, Pociot F, Nerup J, Kockum I, Cambon-Thomsen A, Thorsby E, Undlien DE, Lie BA.

Genes Immun. 2006 Mar;7(2):130-40.PMID: 16395395 [PubMed - indexed for MEDLINE]Related articles

D6S265*15 marks a DRB1*15, DQB1*0602 haplotype associated with attenuated protection from type 1 diabetes mellitus.

Valdes AM, Thomson G, Graham J, Zarghami M, McNeney B, Kockum I, Smith A, Lathrop M, Steenkiste AR, Dorman JS, Noble JA, Hansen JA, Pugliese A, Lernmark A; Swedish Childhood Study Group; Diabetes Incidence in Sweden Study Group; Type 1 Diabetes Component of the 13th International Histocompatibility Working Group.

Diabetologia. 2005 Dec;48(12):2540-3. Epub 2005 Nov 18.PMID: 16320082 [PubMed - indexed for MEDLINE]Related articles

Increased risk of diabetes among relatives of female insulin-treated patients diagnosed at 15-34 years of age.

Akesson K, Nyström L, Färnkvist L, Ostman J, Lernmark A, Kockum I.

Diabet Med. 2005 Nov;22(11):1551-7.PMID: 16241921 [PubMed - indexed for MEDLINE]Related articles

Crohn's disease associated CARD15 (NOD2) variants are not involved in the susceptibility to type 1 diabetes.

Ghandil P, Chelala C, Dubois-Laforgue D, Senée V, Caillat-Zucman S, Kockum I, Luthman H, Nerup J, Pociot F, Timsit J, Julier C.

Mol Genet Metab. 2005 Nov;86(3):379-83. Epub 2005 Sep 28.PMID: 16198136 [PubMed - indexed for MEDLINE]Related articles

The valine allele of the V89L polymorphism in the 5-alpha-reductase gene confers a reduced risk for hypospadias.

Thai HT, Kalbasi M, Lagerstedt K, Frisén L, Kockum I, Nordenskjöld A.

J Clin Endocrinol Metab. 2005 Dec;90(12):6695-8. Epub 2005 Sep 20.PMID: 16174723 [PubMed - indexed for MEDLINE]Related articlesFree article

Retrovirus-like long-terminal repeat DQ-LTR13 and genetic susceptibility to type 1 diabetes and autoimmune Addison's disease.

Gambelunghe G, Kockum I, Bini V, De Giorgi G, Celi F, Betterle C, Giordano R, Libè R, Falorni A; Umbria Type 1 Diabetes Registry; Italian Addison Network.

Diabetes. 2005 Mar;54(3):900-5.PMID: 15734871 [PubMed - indexed for MEDLINE]Related articlesFree article

Multiplicity of the antibody response to GAD65 in Type I diabetes.

Gilliam LK, Binder KA, Banga JP, Madec AM, Ortqvist E, Kockum I, Luo D, Hampe CS.

Clin Exp Immunol. 2004 Nov;138(2):337-41.PMID: 15498046 [PubMed - indexed for MEDLINE]Related articlesFree article

Genome-wide linkage analysis for hypospadias susceptibility genes.

Frisén L, Söderhäll C, Tapper-Persson M, Luthman H, Kockum I, Nordenskjöld A.

J Urol. 2004 Oct;172(4 Pt 1):1460-3.PMID: 15371870 [PubMed - indexed for MEDLINE]Related articles

Conformation-dependent GAD65 autoantibodies in diabetes.

Luo D, Gilliam LK, Greenbaum C, Bekris L, Hampe CS, Daniels T, Richter W, Marcovina SM, Rolandsson O, Landin-Olsson M, Kockum I, Lernmark A.

Diabetologia. 2004 Sep;47(9):1581-91. Epub 2004 Sep 8.PMID: 15365614 [PubMed - indexed for MEDLINE]Related articles

Interaction and association analysis of a type 1 diabetes susceptibility locus on chromosome 5q11-q13 and the 7q32 chromosomal region in Scandinavian families.

Holm P, Rydlander B, Luthman H, Kockum I; European Consortium for IDDM Genome Studies.

Diabetes. 2004 Jun;53(6):1584-91.PMID: 15161765 [PubMed - indexed for MEDLINE]Related articlesFree article

Normal weight promotes remission and low number of islet antibodies prolong the duration of remission in Type 1 diabetes.

Schölin A, Törn C, Nyström L, Berne C, Arnqvist H, Blohmé G, Bolinder J, Eriksson JW, Kockum I, Landin-Olsson M, Ostman J, Karlsson FA, Sundkvist G, Björk E.

Diabet Med. 2004 May;21(5):447-55.PMID: 15089789 [PubMed - indexed for MEDLINE]Related articles

Genetic and functional evaluation of an interleukin-12 polymorphism (IDDM18) in families with type 1 diabetes.

Bergholdt R, Ghandil P, Johannesen J, Kristiansen OP, Kockum I, Luthman H, Rønningen KS, Nerup J, Julier C, Pociot F.

J Med Genet. 2004 Apr;41(4):e39. No abstract available. PMID: 15060115 [PubMed - indexed for MEDLINE]Related articlesFree article

No evidence for linkage in Swedish multiplex T1DM families to IL12B on chromosome 5q33-34.

Holm P, Luthman H, Kockum I.

Ann N Y Acad Sci. 2003 Nov;1005:352-5.PMID: 14679090 [PubMed - indexed for MEDLINE]Related articles

Recombinant Fabs of human monoclonal antibodies specific to the middle epitope of GAD65 inhibit type 1 diabetes-specific GAD65Abs.

Padoa CJ, Banga JP, Madec AM, Ziegler M, Schlosser M, Ortqvist E, Kockum I, Palmer J, Rolandsson O, Binder KA, Foote J, Luo D, Hampe CS.

Diabetes. 2003 Nov;52(11):2689-95.PMID: 14578287 [PubMed - indexed for MEDLINE]Related articlesFree article

No evidence of type 1 diabetes susceptibility genes in the region centromeric of the HLA complex.

Johansson S, Lie BA, Cambon-Thomsen A, Pociot F, Nerup J, Kockum I, Thorsby E, Undlien DE.

Hum Immunol. 2003 Oct;64(10):951-9.PMID: 14522092 [PubMed - indexed for MEDLINE]Related articles

Coxsackie virus B antibodies are increased in HLA DR3-MICA5.1 positive type 1 diabetes patients in the Linköping region of Sweden.

Gupta M, Nikitina-Zake L, Landin-Olsson M, Kockum I, Sanjeevi CB.

Hum Immunol. 2003 Sep;64(9):874-9.PMID: 12941542 [PubMed - indexed for MEDLINE]Related articles

HLA associations in type 1 diabetes: DPB1 alleles may act as markers of other HLA-complex susceptibility genes.

Johansson S, Lie BA, Pociot F, Nerup J, Cambon-Thomsen A, Kockum I, Thorsby E, Undlien DE.

Tissue Antigens. 2003 May;61(5):344-51.PMID: 12753653 [PubMed - indexed for MEDLINE]Related articles

Association between the transmembrane region polymorphism of MHC class I chain related gene-A and type 1 diabetes mellitus in Sweden.

Gupta M, Nikitina-Zake L, Zarghami M, Landin-Olsson M, Kockum I, Lernmark A, Sanjeevi CB.

Hum Immunol. 2003 May;64(5):553-61.PMID: 12691706 [PubMed - indexed for MEDLINE]Related articles

A novel duplication in the HOXA13 gene in a family with atypical hand-foot-genital syndrome.

Frisén L, Lagerstedt K, Tapper-Persson M, Kockum I, Nordenskjöld A.

J Med Genet. 2003 Apr;40(4):e49. No abstract available. PMID: 12676922 [PubMed - indexed for MEDLINE]Related articlesFree article

Evidence of at least two type 1 diabetes susceptibility genes in the HLA complex distinct from HLA-DQB1, -DQA1 and -DRB1.

Johansson S, Lie BA, Todd JA, Pociot F, Nerup J, Cambon-Thomsen A, Kockum I, Akselsen HE, Thorsby E, Undlien DE.

Genes Immun. 2003 Jan;4(1):46-53.PMID: 12595901 [PubMed - indexed for MEDLINE]Related articles

Analysis of association and linkage for the interleukin-4 and interleukin-4 receptor b;alpha; regions in Swedish atopic dermatitis families.

Söderhäll C, Bradley M, Kockum I, Luthman H, Wahlgren CF, Nordenskjöld M.

Clin Exp Allergy. 2002 Aug;32(8):1199-202.PMID: 12190659 [PubMed - indexed for MEDLINE]Related articles

GAD65 antibody epitope patterns of type 1.5 diabetic patients are consistent with slow-onset autoimmune diabetes.

Hampe CS, Kockum I, Landin-Olsson M, Törn C, Ortqvist E, Persson B, Rolandsson O, Palmer J, Lernmark A.

Diabetes Care. 2002 Aug;25(8):1481-2. No abstract available. PMID: 12145258 [PubMed - indexed for MEDLINE]Related articlesFree article

Susceptibility loci for atopic dermatitis on chromosomes 3, 13, 15, 17 and 18 in a Swedish population.

Bradley M, Söderhäll C, Luthman H, Wahlgren CF, Kockum I, Nordenskjöld M.

Hum Mol Genet. 2002 Jun 15;11(13):1539-48.PMID: 12045207 [PubMed - indexed for MEDLINE]Related articlesFree article