PubMed

Crystal structure of glucagon-like peptide-1 in complex with the extracellular domain of the glucagon-like peptide-1 receptor.

Underwood CR, Garibay P, Knudsen LB, Hastrup S, Peters GH, Rudolph R, Reedtz-Runge S.

J Biol Chem. 2009 Oct 27. [Epub ahead of print]PMID: 19861722 [PubMed - as supplied by publisher]Related articlesFree article

Liraglutide, a long-acting human glucagon-like peptide 1 analogue, improves human islet survival in culture.

Toso C, McCall M, Emamaullee J, Merani S, Davis J, Edgar R, Pawlick R, Kin T, Knudsen LB, Shapiro AM.

Transpl Int. 2009 Oct 12. [Epub ahead of print]PMID: 19821955 [PubMed - as supplied by publisher]Related articles

Synergistic effect of the human GLP-1 analogue liraglutide and a dual PPARalpha/gamma agonist on glycaemic control in Zucker diabetic fatty rats.

Brand CL, Galsgaard ED, Tornehave D, Rømer J, Gotfredsen CF, Wassermann K, Knudsen LB, Vølund A, Sturis J.

Diabetes Obes Metab. 2009 Aug;11(8):795-803. Epub 2009 Jun 10.PMID: 19519868 [PubMed - in process]Related articles

Human glucagon receptor antagonists with thiazole cores. A novel series with superior pharmacokinetic properties.

Madsen P, Kodra JT, Behrens C, Nishimura E, Jeppesen CB, Pridal L, Andersen B, Knudsen LB, Valcarce-Aspegren C, Guldbrandt M, Christensen IT, Jørgensen AS, Ynddal L, Brand CL, Bagger MA, Lau J.

J Med Chem. 2009 May 14;52(9):2989-3000.PMID: 19385613 [PubMed - indexed for MEDLINE]Related articles

A long-acting glucagon-like peptide-1 analogue attenuates induction of plasminogen activator inhibitor type-1 and vascular adhesion molecules.

Liu H, Dear AE, Knudsen LB, Simpson RW.

J Endocrinol. 2009 Apr;201(1):59-66. Epub 2009 Jan 9.PMID: 19136619 [PubMed - indexed for MEDLINE]Related articles

Porcine marginal mass islet autografts resist metabolic failure over time and are enhanced by early treatment with liraglutide.

Emamaullee JA, Merani S, Toso C, Kin T, Al-Saif F, Truong W, Pawlick R, Davis J, Edgar R, Lock J, Bonner-Weir S, Knudsen LB, Shapiro AM.

Endocrinology. 2009 May;150(5):2145-52. Epub 2009 Jan 8.PMID: 19131571 [PubMed - indexed for MEDLINE]Related articles

Novel glucagon receptor antagonists with improved selectivity over the glucose-dependent insulinotropic polypeptide receptor.

Kodra JT, Jørgensen AS, Andersen B, Behrens C, Brand CL, Christensen IT, Guldbrandt M, Jeppesen CB, Knudsen LB, Madsen P, Nishimura E, Sams C, Sidelmann UG, Pedersen RA, Lynn FC, Lau J.

J Med Chem. 2008 Sep 11;51(17):5387-96. Epub 2008 Aug 16.PMID: 18707090 [PubMed - indexed for MEDLINE]Related articles

The once-daily human GLP-1 analog, liraglutide, reduces olanzapine-induced weight gain and glucose intolerance.

Lykkegaard K, Larsen PJ, Vrang N, Bock C, Bock T, Knudsen LB.

Schizophr Res. 2008 Aug;103(1-3):94-103. Epub 2008 Jun 25.PMID: 18579346 [PubMed - indexed for MEDLINE]Related articles

Expression of the GLP-1 receptor in mouse, rat, and human pancreas.

Tornehave D, Kristensen P, Rømer J, Knudsen LB, Heller RS.

J Histochem Cytochem. 2008 Sep;56(9):841-51. Epub 2008 Jun 9.PMID: 18541709 [PubMed - indexed for MEDLINE]Related articlesFree article

Liraglutide, a long-acting human glucagon-like peptide 1 analog, improves glucose homeostasis in marginal mass islet transplantation in mice.

Merani S, Truong W, Emamaullee JA, Toso C, Knudsen LB, Shapiro AM.

Endocrinology. 2008 Sep;149(9):4322-8. Epub 2008 May 29.PMID: 18511515 [PubMed - indexed for MEDLINE]Related articlesFree article

Combination of the insulin sensitizer, pioglitazone, and the long-acting GLP-1 human analog, liraglutide, exerts potent synergistic glucose-lowering efficacy in severely diabetic ZDF rats.

Larsen PJ, Wulff EM, Gotfredsen CF, Brand CL, Sturis J, Vrang N, Knudsen LB, Lykkegaard K.

Diabetes Obes Metab. 2008 Apr;10(4):301-11.PMID: 18333889 [PubMed - indexed for MEDLINE]Related articles

Induced abortion in Denmark: effect of socio-economic situation and country of birth.

Rasch V, Gammeltoft T, Knudsen LB, Tobiassen C, Ginzel A, Kempf L.

Eur J Public Health. 2008 Apr;18(2):144-9. Epub 2007 Dec 7.PMID: 18065434 [PubMed - indexed for MEDLINE]Related articlesFree article

Structure-activity and protraction relationship of long-acting glucagon-like peptide-1 derivatives: importance of fatty acid length, polarity, and bulkiness.

Madsen K, Knudsen LB, Agersoe H, Nielsen PF, Thøgersen H, Wilken M, Johansen NL.

J Med Chem. 2007 Nov 29;50(24):6126-32. Epub 2007 Nov 2.PMID: 17975905 [PubMed - indexed for MEDLINE]Related articles

Small molecule ago-allosteric modulators of the human glucagon-like peptide-1 (hGLP-1) receptor.

Teng M, Johnson MD, Thomas C, Kiel D, Lakis JN, Kercher T, Aytes S, Kostrowicki J, Bhumralkar D, Truesdale L, May J, Sidelman U, Kodra JT, Jørgensen AS, Olesen PH, de Jong JC, Madsen P, Behrens C, Pettersson I, Knudsen LB, Holst JJ, Lau J.

Bioorg Med Chem Lett. 2007 Oct 1;17(19):5472-8. Epub 2007 Jul 4.PMID: 17827014 [PubMed - indexed for MEDLINE]Related articles

Liraglutide, a once-daily human glucagon-like peptide-1 analog, minimizes food intake in severely obese minipigs.

Raun K, von Voss P, Knudsen LB.

Obesity (Silver Spring). 2007 Jul;15(7):1710-6.PMID: 17636089 [PubMed - indexed for MEDLINE]Related articles

Contraceptive attitudes and contraceptive failure among women requesting induced abortion in Denmark.

Rasch V, Knudsen LB, Gammeltoft T, Christensen JT, Erenbjerg M, Christensen JJ, Sorensen JB.

Hum Reprod. 2007 May;22(5):1320-6. Epub 2007 Feb 12.PMID: 17296620 [PubMed - indexed for MEDLINE]Related articlesFree article

Small-molecule agonists for the glucagon-like peptide 1 receptor.

Knudsen LB, Kiel D, Teng M, Behrens C, Bhumralkar D, Kodra JT, Holst JJ, Jeppesen CB, Johnson MD, de Jong JC, Jorgensen AS, Kercher T, Kostrowicki J, Madsen P, Olesen PH, Petersen JS, Poulsen F, Sidelmann UG, Sturis J, Truesdale L, May J, Lau J.

Proc Natl Acad Sci U S A. 2007 Jan 16;104(3):937-42. Epub 2007 Jan 9.PMID: 17213325 [PubMed - indexed for MEDLINE]Related articlesFree article

New beta-alanine derivatives are orally available glucagon receptor antagonists.

Lau J, Behrens C, Sidelmann UG, Knudsen LB, Lundt B, Sams C, Ynddal L, Brand CL, Pridal L, Ling A, Kiel D, Plewe M, Shi S, Madsen P.

J Med Chem. 2007 Jan 11;50(1):113-28.PMID: 17201415 [PubMed - indexed for MEDLINE]Related articles

Liraglutide, a long-acting glucagon-like peptide-1 analog, reduces body weight and food intake in obese candy-fed rats, whereas a dipeptidyl peptidase-IV inhibitor, vildagliptin, does not.

Raun K, von Voss P, Gotfredsen CF, Golozoubova V, Rolin B, Knudsen LB.

Diabetes. 2007 Jan;56(1):8-15.PMID: 17192459 [PubMed - indexed for MEDLINE]Related articlesFree article

Low birthweight and mortality: the tendency to repeat low birthweight and its association with early neonatal and infant morbidity and mortality.

Bakketeig LS, Jacobsen G, Skjaerven R, Carneiro IG, Knudsen LB.

Paediatr Perinat Epidemiol. 2006 Nov;20(6):507-11.PMID: 17052288 [PubMed - indexed for MEDLINE]Related articles

Halogenated organic contaminants and mercury in northern fulmars (Fulmarus glacialis): levels, relationships to dietary descriptors and blood to liver comparison.

Knudsen LB, Borgå K, Jørgensen EH, van Bavel B, Schlabach M, Verreault J, Gabrielsen GW.

Environ Pollut. 2007 Mar;146(1):25-33. Epub 2006 Sep 25.PMID: 17000037 [PubMed - indexed for MEDLINE]Related articles

Changing lifestyles and oral clefts occurrence in Denmark.

Bille C, Knudsen LB, Christensen K.

Cleft Palate Craniofac J. 2005 May;42(3):255-9.PMID: 15865458 [PubMed - indexed for MEDLINE]Related articles

Parent's age and the risk of oral clefts.

Bille C, Skytthe A, Vach W, Knudsen LB, Andersen AM, Murray JC, Christensen K.

Epidemiology. 2005 May;16(3):311-6.PMID: 15824545 [PubMed - indexed for MEDLINE]Related articles

The long-acting glucagon-like peptide-1 analogue, liraglutide, inhibits beta-cell apoptosis in vitro.

Bregenholt S, Møldrup A, Blume N, Karlsen AE, Nissen Friedrichsen B, Tornhave D, Knudsen LB, Petersen JS.

Biochem Biophys Res Commun. 2005 May 6;330(2):577-84.PMID: 15796922 [PubMed - indexed for MEDLINE]Related articles

Glucagon-like peptide-1: the basis of a new class of treatment for type 2 diabetes.

Knudsen LB.

J Med Chem. 2004 Aug 12;47(17):4128-34. Review. No abstract available. PMID: 15293981 [PubMed - indexed for MEDLINE]Related articles

GLP-1 derivative liraglutide in rats with beta-cell deficiencies: influence of metabolic state on beta-cell mass dynamics.

Sturis J, Gotfredsen CF, Rømer J, Rolin B, Ribel U, Brand CL, Wilken M, Wassermann K, Deacon CF, Carr RD, Knudsen LB.

Br J Pharmacol. 2003 Sep;140(1):123-32. Epub 2003 Jul 29.PMID: 12967942 [PubMed - indexed for MEDLINE]Related articlesFree article

Three distinct epitopes on the extracellular face of the glucagon receptor determine specificity for the glucagon amino terminus.

Runge S, Gram C, Brauner-Osborne H, Madsen K, Knudsen LB, Wulff BS.

J Biol Chem. 2003 Jul 25;278(30):28005-10. Epub 2003 Apr 29.PMID: 12724331 [PubMed - indexed for MEDLINE]Related articlesFree article

Induced abortion in the Nordic countries: special emphasis on young women.

Knudsen LB, Gissler M, Bender SS, Hedberg C, Ollendorff U, Sundström K, Totlandsdal K, Vilhjalmsdottir S.

Acta Obstet Gynecol Scand. 2003 Mar;82(3):257-68.PMID: 12694123 [PubMed - indexed for MEDLINE]Related articles

Living conditions, contraceptive use and the choice of induced abortion among pregnant women in Denmark.

Rasch V, Wielandt H, Knudsen LB.

Scand J Public Health. 2002;30(4):293-9.PMID: 12680506 [PubMed - indexed for MEDLINE]Related articles

Different domains of the glucagon and glucagon-like peptide-1 receptors provide the critical determinants of ligand selectivity.

Runge S, Wulff BS, Madsen K, Bräuner-Osborne H, Knudsen LB.

Br J Pharmacol. 2003 Mar;138(5):787-94.PMID: 12642379 [PubMed - indexed for MEDLINE]Related articlesFree article

The intergenerational transmission of fertility in contemporary Denmark: the effects of number of siblings (full and half), birth order, and whether male or female.

Murphy M, Knudsen LB.

Popul Stud (Camb). 2002 Nov;56(3):235-48.PMID: 12553320 [PubMed - indexed for MEDLINE]Related articles

Optimization of alkylidene hydrazide based human glucagon receptor antagonists. Discovery of the highly potent and orally available 3-cyano-4-hydroxybenzoic acid [1-(2,3,5,6-tetramethylbenzyl)-1H-indol-4-ylmethylene]hydrazide.

Madsen P, Ling A, Plewe M, Sams CK, Knudsen LB, Sidelmann UG, Ynddal L, Brand CL, Andersen B, Murphy D, Teng M, Truesdale L, Kiel D, May J, Kuki A, Shi S, Johnson MD, Teston KA, Feng J, Lakis J, Anderes K, Gregor V, Lau J.

J Med Chem. 2002 Dec 19;45(26):5755-75.PMID: 12477359 [PubMed - indexed for MEDLINE]Related articles

Women in Denmark--why do they die so young? Risk factors for premature death.

Helweg-larsen K, Knudsen LB, Petersson B.

Scand J Soc Welf. 1998 Oct;7(4):266-76.PMID: 12294849 [PubMed - indexed for MEDLINE]Related articles

NN2211: a long-acting glucagon-like peptide-1 derivative with anti-diabetic effects in glucose-intolerant pigs.

Ribel U, Larsen MO, Rolin B, Carr RD, Wilken M, Sturis J, Westergaard L, Deacon CF, Knudsen LB.

Eur J Pharmacol. 2002 Sep 13;451(2):217-25.PMID: 12231394 [PubMed - indexed for MEDLINE]Related articles

The long-acting GLP-1 derivative NN2211 ameliorates glycemia and increases beta-cell mass in diabetic mice.

Rolin B, Larsen MO, Gotfredsen CF, Deacon CF, Carr RD, Wilken M, Knudsen LB.

Am J Physiol Endocrinol Metab. 2002 Oct;283(4):E745-52.PMID: 12217892 [PubMed - indexed for MEDLINE]Related articlesFree article

Poor semen quality may contribute to recent decline in fertility rates.

Jensen TK, Carlsen E, Jørgensen N, Berthelsen JG, Keiding N, Christensen K, Petersen JH, Knudsen LB, Skakkebaek NE.

Hum Reprod. 2002 Jun;17(6):1437-40.PMID: 12042257 [PubMed - indexed for MEDLINE]Related articlesFree article

Human glucagon receptor antagonists based on alkylidene hydrazides.

Ling A, Plewe M, Gonzalez J, Madsen P, Sams CK, Lau J, Gregor V, Murphy D, Teston K, Kuki A, Shi S, Truesdale L, Kiel D, May J, Lakis J, Anderes K, Iatsimirskaia E, Sidelmann UG, Knudsen LB, Brand CL, Polinsky A.

Bioorg Med Chem Lett. 2002 Feb 25;12(4):663-6.PMID: 11844695 [PubMed - indexed for MEDLINE]Related articles

[Contraception and abortions]

Rasch V, Knudsen LB.

Ugeskr Laeger. 2001 Nov 12;163(46):6451-3. Danish. No abstract available. PMID: 11816930 [PubMed - indexed for MEDLINE]Related articles

The prevalent use of contraception among teenagers in Denmark and the corresponding low pregnancy rate.

Wielandt H, Boldsen J, Knudsen LB.

J Biosoc Sci. 2002 Jan;34(1):1-11.PMID: 11814208 [PubMed - indexed for MEDLINE]Related articles

The truncated metabolite GLP-2 (3-33) interacts with the GLP-2 receptor as a partial agonist.

Thulesen J, Knudsen LB, Hartmann B, Hastrup S, Kissow H, Jeppesen PB, Ørskov C, Holst JJ, Poulsen SS.

Regul Pept. 2002 Jan 15;103(1):9-15.PMID: 11738243 [PubMed - indexed for MEDLINE]Related articles

Pregnancy planning and acceptance among Danish pregnant women.

Rasch V, Knudsen LB, Wielandt H.

Acta Obstet Gynecol Scand. 2001 Nov;80(11):1030-5.PMID: 11703201 [PubMed - indexed for MEDLINE]Related articles

Systemic administration of the long-acting GLP-1 derivative NN2211 induces lasting and reversible weight loss in both normal and obese rats.

Larsen PJ, Fledelius C, Knudsen LB, Tang-Christensen M.

Diabetes. 2001 Nov;50(11):2530-9.PMID: 11679431 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of alkylidene hydrazides as glucagon receptor antagonists.

Ling A, Hong Y, Gonzalez J, Gregor V, Polinsky A, Kuki A, Shi S, Teston K, Murphy D, Porter J, Kiel D, Lakis J, Anderes K, May J, Knudsen LB, Lau J.

J Med Chem. 2001 Sep 13;44(19):3141-9.PMID: 11543683 [PubMed - indexed for MEDLINE]Related articles

[Differences when it comes to induced abortion in different Danish counties]

Knudsen LB.

Ugeskr Laeger. 2000 Apr 3;162(14):2041-5. Danish. PMID: 10815520 [PubMed - indexed for MEDLINE]Related articles

Potent derivatives of glucagon-like peptide-1 with pharmacokinetic properties suitable for once daily administration.

Knudsen LB, Nielsen PF, Huusfeldt PO, Johansen NL, Madsen K, Pedersen FZ, Thøgersen H, Wilken M, Agersø H.

J Med Chem. 2000 May 4;43(9):1664-9.PMID: 10794683 [PubMed - indexed for MEDLINE]Related articles

[25 years of free abortion. Jubilee of abortion law in Denmark]

Knudsen LB, Petersson B, Helweg-Larsen K.

Nord Med. 1998 Dec;113(10):350. Danish. No abstract available. PMID: 9894413 [PubMed - indexed for MEDLINE]Related articles

Discovery and structure-activity relationship of the first non-peptide competitive human glucagon receptor antagonists.

Madsen P, Knudsen LB, Wiberg FC, Carr RD.

J Med Chem. 1998 Dec 17;41(26):5150-7.PMID: 9857085 [PubMed - indexed for MEDLINE]Related articles

The Danish Medical Birth Registry.

Knudsen LB, Olsen J.

Dan Med Bull. 1998 Jun;45(3):320-3.PMID: 9675544 [PubMed - indexed for MEDLINE]Related articles

The Danish Fertility Database.

Knudsen LB.

Dan Med Bull. 1998 Apr;45(2):221-5.PMID: 9587707 [PubMed - indexed for MEDLINE]Related articles

Glucagon-like peptide-1 receptor expression in Xenopus oocytes stimulates inositol trisphosphate-dependent intracellular Ca2+ mobilization.

Gromada J, Anker C, Bokvist K, Knudsen LB, Wahl P.

FEBS Lett. 1998 Mar 27;425(2):277-80.PMID: 9559665 [PubMed - indexed for MEDLINE]Related articles