PubMed

Direct and macrophage-mediated actions of fatty acids causing insulin resistance in muscle cells.

Bilan PJ, Samokhvalov V, Koshkina A, Schertzer JD, Samaan MC, Klip A.

Arch Physiol Biochem. 2009 Oct;115(4):176-90.PMID: 19671019 [PubMed - in process]Related articles

The F-BAR protein CIP4 promotes GLUT4 endocytosis through bidirectional interactions with N-WASp and Dynamin-2.

Hartig SM, Ishikura S, Hicklen RS, Feng Y, Blanchard EG, Voelker KA, Pichot CS, Grange RW, Raphael RM, Klip A, Corey SJ.

J Cell Sci. 2009 Jul 1;122(Pt 13):2283-91. Epub 2009 Jun 9.PMID: 19509061 [PubMed - indexed for MEDLINE]Related articles

Health care crisis in Gaza.

Schimmer AD, Malkin D, Zackenhaus E, Kagal A, Klip A, Rotin D, Minden MD, Teitel J.

CMAJ. 2009 Jun 9;180(12):1230. No abstract available. PMID: 19506287 [PubMed - indexed for MEDLINE]Related articlesFree article

The many ways to regulate glucose transporter 4.

Klip A.

Appl Physiol Nutr Metab. 2009 Jun;34(3):481-7. Review.PMID: 19448718 [PubMed - indexed for MEDLINE]Related articles

Regulation of glucose transporter 4 traffic by energy deprivation from mitochondrial compromise.

Klip A, Schertzer JD, Bilan PJ, Thong F, Antonescu C.

Acta Physiol (Oxf). 2009 May;196(1):27-35. Epub 2009 Feb 19.PMID: 19245652 [PubMed - in process]Related articles

Ready, set, internalize: mechanisms and regulation of GLUT4 endocytosis.

Antonescu CN, Foti M, Sauvonnet N, Klip A.

Biosci Rep. 2009 Feb;29(1):1-11. Review.PMID: 19143591 [PubMed - indexed for MEDLINE]Related articles

GAPDH binds GLUT4 reciprocally to hexokinase-II and regulates glucose transport activity.

Zaid H, Talior-Volodarsky I, Antonescu C, Liu Z, Klip A.

Biochem J. 2009 Apr 15;419(2):475-84.PMID: 19140804 [PubMed - indexed for MEDLINE]Related articles

A transgenic mouse model to study glucose transporter 4myc regulation in skeletal muscle.

Schertzer JD, Antonescu CN, Bilan PJ, Jain S, Huang X, Liu Z, Bonen A, Klip A.

Endocrinology. 2009 Apr;150(4):1935-40. Epub 2008 Dec 12.PMID: 19074577 [PubMed - indexed for MEDLINE]Related articles

Dissecting GLUT4 traffic components in L6 myocytes by fluorescence-based, single-cell assays.

Antonescu CN, Randhawa VK, Klip A.

Methods Mol Biol. 2008;457:367-78.PMID: 19066041 [PubMed - indexed for MEDLINE]Related articles

A novel inhibitor of glucose uptake sensitizes cells to FAS-induced cell death.

Wood TE, Dalili S, Simpson CD, Hurren R, Mao X, Saiz FS, Gronda M, Eberhard Y, Minden MD, Bilan PJ, Klip A, Batey RA, Schimmer AD.

Mol Cancer Ther. 2008 Nov;7(11):3546-55.PMID: 19001437 [PubMed - indexed for MEDLINE]Related articlesFree article

Palmitate- and lipopolysaccharide-activated macrophages evoke contrasting insulin responses in muscle cells.

Samokhvalov V, Bilan PJ, Schertzer JD, Antonescu CN, Klip A.

Am J Physiol Endocrinol Metab. 2009 Jan;296(1):E37-46. Epub 2008 Oct 7.PMID: 18840759 [PubMed - indexed for MEDLINE]Related articles

Muscle cells engage Rab8A and myosin Vb in insulin-dependent GLUT4 translocation.

Ishikura S, Klip A.

Am J Physiol Cell Physiol. 2008 Oct;295(4):C1016-25. Epub 2008 Aug 13.PMID: 18701652 [PubMed - indexed for MEDLINE]Related articlesFree article

GLUT4 vesicle recruitment and fusion are differentially regulated by Rac, AS160, and Rab8A in muscle cells.

Randhawa VK, Ishikura S, Talior-Volodarsky I, Cheng AW, Patel N, Hartwig JH, Klip A.

J Biol Chem. 2008 Oct 3;283(40):27208-19. Epub 2008 Jul 23.PMID: 18650435 [PubMed - indexed for MEDLINE]Related articlesFree article

Alpha-actinin-4 is selectively required for insulin-induced GLUT4 translocation.

Talior-Volodarsky I, Randhawa VK, Zaid H, Klip A.

J Biol Chem. 2008 Sep 12;283(37):25115-23. Epub 2008 Jul 10.PMID: 18617516 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin action on glucose transporters through molecular switches, tracks and tethers.

Zaid H, Antonescu CN, Randhawa VK, Klip A.

Biochem J. 2008 Jul 15;413(2):201-15. Review.PMID: 18570632 [PubMed - indexed for MEDLINE]Related articles

Clathrin-dependent and independent endocytosis of glucose transporter 4 (GLUT4) in myoblasts: regulation by mitochondrial uncoupling.

Antonescu CN, Díaz M, Femia G, Planas JV, Klip A.

Traffic. 2008 Jul;9(7):1173-90. Epub 2008 Apr 24.PMID: 18435821 [PubMed - indexed for MEDLINE]Related articles

Selective regulation of the perinuclear distribution of glucose transporter 4 (GLUT4) by insulin signals in muscle cells.

Dugani CB, Randhawa VK, Cheng AW, Patel N, Klip A.

Eur J Cell Biol. 2008 Jun;87(6):337-51. Epub 2008 Apr 15.PMID: 18417252 [PubMed - indexed for MEDLINE]Related articles

Small G proteins in insulin action: Rab and Rho families at the crossroads of signal transduction and GLUT4 vesicle traffic.

Ishikura S, Koshkina A, Klip A.

Acta Physiol (Oxf). 2008 Jan;192(1):61-74. Review.PMID: 18171430 [PubMed - indexed for MEDLINE]Related articles

The proinflammatory cytokine tumor necrosis factor-alpha increases the amount of glucose transporter-4 at the surface of muscle cells independently of changes in interleukin-6.

Roher N, Samokhvalov V, Díaz M, MacKenzie S, Klip A, Planas JV.

Endocrinology. 2008 Apr;149(4):1880-9. Epub 2007 Dec 27.PMID: 18162526 [PubMed - indexed for MEDLINE]Related articlesFree article

Kei on GSK: a contribution by the 2007 recipient of the Young Scientist Award.

Klip A.

Am J Physiol Endocrinol Metab. 2008 Jan;294(1):E27. Epub 2007 Nov 27. No abstract available. PMID: 18042667 [PubMed - indexed for MEDLINE]Related articlesFree article

Fish glucose transporter (GLUT)-4 differs from rat GLUT4 in its traffic characteristics but can translocate to the cell surface in response to insulin in skeletal muscle cells.

Díaz M, Antonescu CN, Capilla E, Klip A, Planas JV.

Endocrinology. 2007 Nov;148(11):5248-57. Epub 2007 Aug 16.PMID: 17702851 [PubMed - indexed for MEDLINE]Related articlesFree article

The Rab GTPase-activating protein AS160 integrates Akt, protein kinase C, and AMP-activated protein kinase signals regulating GLUT4 traffic.

Thong FS, Bilan PJ, Klip A.

Diabetes. 2007 Feb;56(2):414-23.PMID: 17259386 [PubMed - indexed for MEDLINE]Related articlesFree article

Ceramide- and oxidant-induced insulin resistance involve loss of insulin-dependent Rac-activation and actin remodeling in muscle cells.

JeBailey L, Wanono O, Niu W, Roessler J, Rudich A, Klip A.

Diabetes. 2007 Feb;56(2):394-403.PMID: 17259384 [PubMed - indexed for MEDLINE]Related articlesFree article

Rabs 8A and 14 are targets of the insulin-regulated Rab-GAP AS160 regulating GLUT4 traffic in muscle cells.

Ishikura S, Bilan PJ, Klip A.

Biochem Biophys Res Commun. 2007 Feb 23;353(4):1074-9. Epub 2006 Dec 27.PMID: 17208202 [PubMed - indexed for MEDLINE]Related articles

Muscle, liver, and pancreas: Three Musketeers fighting to control glycemia.

Klip A, Vranic M.

Am J Physiol Endocrinol Metab. 2006 Dec;291(6):E1141-3. No abstract available. PMID: 17082345 [PubMed - indexed for MEDLINE]Related articlesFree article

Opposite effect of JAK2 on insulin-dependent activation of mitogen-activated protein kinases and Akt in muscle cells: possible target to ameliorate insulin resistance.

Thirone AC, JeBailey L, Bilan PJ, Klip A.

Diabetes. 2006 Apr;55(4):942-51.PMID: 16567515 [PubMed - indexed for MEDLINE]Related articlesFree article

Tissue-specific roles of IRS proteins in insulin signaling and glucose transport.

Thirone AC, Huang C, Klip A.

Trends Endocrinol Metab. 2006 Mar;17(2):72-8. Epub 2006 Feb 3. Review.PMID: 16458527 [PubMed - indexed for MEDLINE]Related articles

Muscle cell depolarization induces a gain in surface GLUT4 via reduced endocytosis independently of AMPK.

Wijesekara N, Tung A, Thong F, Klip A.

Am J Physiol Endocrinol Metab. 2006 Jun;290(6):E1276-86. Epub 2006 Jan 17.PMID: 16418206 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin-dependent interactions of proteins with GLUT4 revealed through stable isotope labeling by amino acids in cell culture (SILAC).

Foster LJ, Rudich A, Talior I, Patel N, Huang X, Furtado LM, Bilan PJ, Mann M, Klip A.

J Proteome Res. 2006 Jan;5(1):64-75.PMID: 16396496 [PubMed - indexed for MEDLINE]Related articles

Desperately seeking sugar: glial cells as hypoglycemia sensors.

Klip A, Hawkins M.

J Clin Invest. 2005 Dec;115(12):3403-5.PMID: 16322788 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose transporter 4: cycling, compartments and controversies.

Dugani CB, Klip A.

EMBO Rep. 2005 Dec;6(12):1137-42. Review.PMID: 16319959 [PubMed - indexed for MEDLINE]Related articlesFree article

Cellular location of insulin-triggered signals and implications for glucose uptake.

Patel N, Huang C, Klip A.

Pflugers Arch. 2006 Jan;451(4):499-510. Epub 2005 Nov 12. Review.PMID: 16284741 [PubMed - indexed for MEDLINE]Related articles

Minireview: recent developments in the regulation of glucose transporter-4 traffic: new signals, locations, and partners.

Ishiki M, Klip A.

Endocrinology. 2005 Dec;146(12):5071-8. Epub 2005 Sep 8. Review.PMID: 16150904 [PubMed - indexed for MEDLINE]Related articlesFree article

Intracellular traffic and activation of the muscle glucose transporter.

Klip A.

J Muscle Res Cell Motil. 2004;25(8):595-6. No abstract available. PMID: 16118849 [PubMed - indexed for MEDLINE]Related articles

Turning signals on and off: GLUT4 traffic in the insulin-signaling highway.

Thong FS, Dugani CB, Klip A.

Physiology (Bethesda). 2005 Aug;20:271-84. Review. Erratum in: Physiology (Bethesda). 2005 Oct;20:table of contents. PMID: 16024515 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin regulates the membrane arrival, fusion, and C-terminal unmasking of glucose transporter-4 via distinct phosphoinositides.

Ishiki M, Randhawa VK, Poon V, Jebailey L, Klip A.

J Biol Chem. 2005 Aug 5;280(31):28792-802. Epub 2005 Jun 13.PMID: 15955810 [PubMed - indexed for MEDLINE]Related articlesFree article

Reduction of insulin-stimulated glucose uptake in L6 myotubes by the protein kinase inhibitor SB203580 is independent of p38MAPK activity.

Antonescu CN, Huang C, Niu W, Liu Z, Eyers PA, Heidenreich KA, Bilan PJ, Klip A.

Endocrinology. 2005 Sep;146(9):3773-81. Epub 2005 Jun 9.PMID: 15947002 [PubMed - indexed for MEDLINE]Related articlesFree article

Troglitazone causes acute mitochondrial membrane depolarisation and an AMPK-mediated increase in glucose phosphorylation in muscle cells.

Konrad D, Rudich A, Bilan PJ, Patel N, Richardson C, Witters LA, Klip A.

Diabetologia. 2005 May;48(5):954-66. Epub 2005 Apr 15.PMID: 15834551 [PubMed - indexed for MEDLINE]Related articles

Differential contribution of insulin receptor substrates 1 versus 2 to insulin signaling and glucose uptake in l6 myotubes.

Huang C, Thirone AC, Huang X, Klip A.

J Biol Chem. 2005 May 13;280(19):19426-35. Epub 2005 Mar 11.PMID: 15764603 [PubMed - indexed for MEDLINE]Related articlesFree article

Muscle-specific Pten deletion protects against insulin resistance and diabetes.

Wijesekara N, Konrad D, Eweida M, Jefferies C, Liadis N, Giacca A, Crackower M, Suzuki A, Mak TW, Kahn CR, Klip A, Woo M.

Mol Cell Biol. 2005 Feb;25(3):1135-45.PMID: 15657439 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin and hypertonicity recruit GLUT4 to the plasma membrane of muscle cells by using N-ethylmaleimide-sensitive factor-dependent SNARE mechanisms but different v-SNAREs: role of TI-VAMP.

Randhawa VK, Thong FS, Lim DY, Li D, Garg RR, Rudge R, Galli T, Rudich A, Klip A.

Mol Biol Cell. 2004 Dec;15(12):5565-73. Epub 2004 Oct 6.PMID: 15469990 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin but not PDGF relies on actin remodeling and on VAMP2 for GLUT4 translocation in myoblasts.

Török D, Patel N, Jebailey L, Thong FS, Randhawa VK, Klip A, Rudich A.

J Cell Sci. 2004 Oct 15;117(Pt 22):5447-55. Epub 2004 Oct 5.PMID: 15466888 [PubMed - indexed for MEDLINE]Related articlesFree article

Intracellular delivery of phosphatidylinositol (3,4,5)-trisphosphate causes incorporation of glucose transporter 4 into the plasma membrane of muscle and fat cells without increasing glucose uptake.

Sweeney G, Garg RR, Ceddia RB, Li D, Ishiki M, Somwar R, Foster LJ, Neilsen PO, Prestwich GD, Rudich A, Klip A.

J Biol Chem. 2004 Jul 30;279(31):32233-42. Epub 2004 May 27.PMID: 15166230 [PubMed - indexed for MEDLINE]Related articlesFree article

Skeletal muscle cells and adipocytes differ in their reliance on TC10 and Rac for insulin-induced actin remodeling.

JeBailey L, Rudich A, Huang X, Di Ciano-Oliveira C, Kapus A, Klip A.

Mol Endocrinol. 2004 Feb;18(2):359-72. Epub 2003 Nov 13.PMID: 14615606 [PubMed - indexed for MEDLINE]Related articlesFree article

The AMP-activated protein kinase activator AICAR does not induce GLUT4 translocation to transverse tubules but stimulates glucose uptake and p38 mitogen-activated protein kinases alpha and beta in skeletal muscle.

Lemieux K, Konrad D, Klip A, Marette A.

FASEB J. 2003 Sep;17(12):1658-65.PMID: 12958172 [PubMed - indexed for MEDLINE]Related articlesFree article

Push/pull mechanisms of GLUT4 traffic in muscle cells.

Rudich A, Klip A.

Acta Physiol Scand. 2003 Aug;178(4):297-308. Review.PMID: 12864734 [PubMed - indexed for MEDLINE]Related articles

GLUT4 activation: thoughts on possible mechanisms.

Michelle Furtado L, Poon V, Klip A.

Acta Physiol Scand. 2003 Aug;178(4):287-96. Review.PMID: 12864733 [PubMed - indexed for MEDLINE]Related articles

Intracellular segregation of phosphatidylinositol-3,4,5-trisphosphate by insulin-dependent actin remodeling in L6 skeletal muscle cells.

Patel N, Rudich A, Khayat ZA, Garg R, Klip A.

Mol Cell Biol. 2003 Jul;23(13):4611-26.PMID: 12808101 [PubMed - indexed for MEDLINE]Related articlesFree article

Indinavir uncovers different contributions of GLUT4 and GLUT1 towards glucose uptake in muscle and fat cells and tissues.

Rudich A, Konrad D, Török D, Ben-Romano R, Huang C, Niu W, Garg RR, Wijesekara N, Germinario RJ, Bilan PJ, Klip A.

Diabetologia. 2003 May;46(5):649-58. Epub 2003 Apr 24.PMID: 12712244 [PubMed - indexed for MEDLINE]Related articles

Maturation of the regulation of GLUT4 activity by p38 MAPK during L6 cell myogenesis.

Niu W, Huang C, Nawaz Z, Levy M, Somwar R, Li D, Bilan PJ, Klip A.

J Biol Chem. 2003 May 16;278(20):17953-62. Epub 2003 Mar 11.PMID: 12637564 [PubMed - indexed for MEDLINE]Related articlesFree article