PubMed

Increased prevalence and coincidence of antinuclear and antithyroid antibodies in the population exposed to high levels of polychlorinated pollutants cocktail.

Cebecauer L, Radikova Z, Rovensky J, Koska, Imrich R, Ksinantova L, Susienkova K, Vigas M, Klimes I, Langer P.

Endocr Regul. 2009 Apr;43(2):75-81.PMID: 19856712 [PubMed - indexed for MEDLINE]Related articlesFree article

Severe insulin resistance and intrauterine growth deficiency associated with haploinsufficiency for INSR and CHN2: new insights into synergistic pathways involved in growth and metabolism.

Suliman SG, Stanik J, McCulloch LJ, Wilson N, Edghill EL, Misovicova N, Gasperikova D, Sandrikova V, Elliott KS, Barak L, Ellard S, Volpi EV, Klimes I, Gloyn AL.

Diabetes. 2009 Dec;58(12):2954-61. Epub 2009 Aug 31.PMID: 19720790 [PubMed - in process]Related articles

Identification of a novel beta-cell glucokinase (GCK) promoter mutation (-71G>C) that modulates GCK gene expression through loss of allele-specific Sp1 binding causing mild fasting hyperglycemia in humans.

Gasperíková D, Tribble ND, Staník J, Hucková M, Misovicová N, van de Bunt M, Valentínová L, Barrow BA, Barák L, Dobránsky R, Bereczková E, Michálek J, Wicks K, Colclough K, Knight JC, Ellard S, Klimes I, Gloyn AL.

Diabetes. 2009 Aug;58(8):1929-35. Epub 2009 May 1.PMID: 19411616 [PubMed - indexed for MEDLINE]Related articlesFree article

Multiple adverse thyroid and metabolic health signs in the population from the area heavily polluted by organochlorine cocktail (PCB, DDE, HCB, dioxin).

Langer P, Kocan A, Tajtáková M, Susienková K, Rádiková Z, Koska J, Ksinantová L, Imrich R, Hucková M, Drobná B, Gasperíková D, Trnovec T, Klimes I.

Thyroid Res. 2009 Mar 31;2(1):3.PMID: 19335881 [PubMed - in process]Related articlesFree article

Medium-chain fatty acids ameliorate insulin resistance caused by high-fat diets in rats.

Wein S, Wolffram S, Schrezenmeir J, Gasperiková D, Klimes I, Seböková E.

Diabetes Metab Res Rev. 2009 Feb;25(2):185-94.PMID: 19219861 [PubMed - indexed for MEDLINE]Related articles

Adipose tissue and skeletal muscle plasticity modulates metabolic health.

Ukropec J, Ukropcova B, Kurdiova T, Gasperikova D, Klimes I.

Arch Physiol Biochem. 2008 Dec;114(5):357-68. Review.PMID: 19016045 [PubMed - indexed for MEDLINE]Related articles

Increased thyroid volume, prevalence of thyroid antibodies and impaired fasting glucose in young adults from organochlorine cocktail polluted area: outcome of transgenerational transmission?

Langer P, Kocan A, Tajtáková M, Koska J, Rádiková Z, Ksinantová L, Imrich R, Hucková M, Drobná B, Gasperíková D, Seböková E, Klimes I.

Chemosphere. 2008 Oct;73(7):1145-50. Epub 2008 Sep 14.PMID: 18790515 [PubMed - indexed for MEDLINE]Related articles

Cardiovascular risk and insulin resistance in patients with obstructive sleep apnea.

Tkacova R, Dorkova Z, Molcanyiova A, Radikova Z, Klimes I, Tkac I.

Med Sci Monit. 2008 Sep;14(9):CR438-44.PMID: 18758413 [PubMed - indexed for MEDLINE]Related articlesFree article

Coincidence of a novel KCNJ11 missense variant R365H with a paternally inherited 6q24 duplication in a patient with transient neonatal diabetes.

Staník J, Lethby M, Flanagan SE, Gasperíková D, Milosovicová B, Lever M, Bullman H, Zubcevic L, Hattersley AT, Ellard S, Ashcroft FM, Klimes I.

Diabetes Care. 2008 Sep;31(9):1736-7. Epub 2008 Jun 12.PMID: 18556340 [PubMed - indexed for MEDLINE]Related articlesFree article

A Kir6.2 mutation causing severe functional effects in vitro produces neonatal diabetes without the expected neurological complications.

Tammaro P, Flanagan SE, Zadek B, Srinivasan S, Woodhead H, Hameed S, Klimes I, Hattersley AT, Ellard S, Ashcroft FM.

Diabetologia. 2008 May;51(5):802-10. Epub 2008 Mar 12.PMID: 18335204 [PubMed - indexed for MEDLINE]Related articlesFree article

Adipokine protein expression pattern in growth hormone deficiency predisposes to the increased fat cell size and the whole body metabolic derangements.

Ukropec J, Penesová A, Skopková M, Pura M, Vlcek M, Rádiková Z, Imrich R, Ukropcová B, Tajtáková M, Koska J, Zórad S, Belan V, Vanuga P, Payer J, Eckel J, Klimes I, Gasperíková D.

J Clin Endocrinol Metab. 2008 Jun;93(6):2255-62. Epub 2008 Mar 11.PMID: 18334583 [PubMed - indexed for MEDLINE]Related articlesFree article

Possible effects of environmental nitrates and toxic organochlorines on human thyroid in highly polluted areas in Slovakia.

Rádiková Z, Tajtáková M, Kocan A, Trnovec T, Seböková E, Klimes I, Langer P.

Thyroid. 2008 Mar;18(3):353-62.PMID: 18298316 [PubMed - indexed for MEDLINE]Related articles

Protein array reveals differentially expressed proteins in subcutaneous adipose tissue in obesity.

Skopková M, Penesová A, Sell H, Rádiková Z, Vlcek M, Imrich R, Koska J, Ukropec J, Eckel J, Klimes I, Gasperíková D.

Obesity (Silver Spring). 2007 Oct;15(10):2396-406.PMID: 17925465 [PubMed - indexed for MEDLINE]Related articles

Lipoprotein lipase HindIII polymorphism influences HDL-cholesterol levels in statin-treated patients with coronary artery disease.

Javorský M, Gasperíková D, Ukropec J, Sedláková B, Riecanský I, Krizanová O, Seböková E, Dobríková M, Klimes I, Tkác I.

Wien Klin Wochenschr. 2007;119(15-16):476-82.PMID: 17721767 [PubMed - indexed for MEDLINE]Related articles

Possible effects of persistent organochlorinated pollutants cocktail on thyroid hormone levels and pituitary-thyroid interrelations.

Langer P, Kocan A, Tajtáková M, Rádiková Z, Petrík J, Koska J, Ksinantová L, Imrich R, Hucková M, Chovancová J, Drobná B, Jursa S, Bergman A, Athanasiadou M, Hovander L, Gasperíková D, Trnovec T, Seböková E, Klimes I.

Chemosphere. 2007 Nov;70(1):110-8. Epub 2007 Aug 10.PMID: 17692893 [PubMed - indexed for MEDLINE]Related articles

Thyroid ultrasound volume, structure and function after long-term high exposure of large population to polychlorinated biphenyls, pesticides and dioxin.

Langer P, Tajtáková M, Kocan A, Petrík J, Koska J, Ksinantová L, Rádiková Z, Ukropec J, Imrich R, Hucková M, Chovancová J, Drobná B, Jursa S, Vlcek M, Bergman A, Athanasiadou M, Hovander L, Shishiba Y, Trnovec T, Seböková E, Klimes I.

Chemosphere. 2007 Aug;69(1):118-27. Epub 2007 May 29.PMID: 17537484 [PubMed - indexed for MEDLINE]Related articles

Concerted action of leptin in regulation of fatty acid oxidation in skeletal muscle and liver.

Wein S, Ukropec J, Gasperíková D, Klimes I, Seböková E.

Exp Clin Endocrinol Diabetes. 2007 Apr;115(4):244-51.PMID: 17479441 [PubMed - indexed for MEDLINE]Related articles

Fish from industrially polluted freshwater as the main source of organochlorinated pollutants and increased frequency of thyroid disorders and dysglycemia.

Langer P, Kocan A, Tajtaková M, Petrík J, Chovancová J, Drobná B, Jursa S, Rádiková Z, Koska J, Ksinantová L, Hucková M, Imrich R, Wimmerová S, Gasperíková D, Shishiba Y, Trnovec T, Seböková E, Klimes I.

Chemosphere. 2007 Apr;67(9):S379-85. Epub 2007 Jan 11.PMID: 17222442 [PubMed - indexed for MEDLINE]Related articles

Prevalence of permanent neonatal diabetes in Slovakia and successful replacement of insulin with sulfonylurea therapy in KCNJ11 and ABCC8 mutation carriers.

Stanik J, Gasperikova D, Paskova M, Barak L, Javorkova J, Jancova E, Ciljakova M, Hlava P, Michalek J, Flanagan SE, Pearson E, Hattersley AT, Ellard S, Klimes I.

J Clin Endocrinol Metab. 2007 Apr;92(4):1276-82. Epub 2007 Jan 9.PMID: 17213273 [PubMed - indexed for MEDLINE]Related articlesFree article

Multiple organochlorine pollution and the thyroid.

Langer P, Tajtaková M, Kocan A, Vlcek M, Petrik J, Chovancova J, Drobna B, Jursa S, Pavuk M, Trnovec T, Sebokova E, Klimes I.

Endocr Regul. 2006 Jun;40(2):46-52.PMID: 17100546 [PubMed - indexed for MEDLINE]Related articlesFree article

Randomised controlled trial of a parenting intervention in the voluntary sector for reducing child conduct problems: outcomes and mechanisms of change.

Gardner F, Burton J, Klimes I.

J Child Psychol Psychiatry. 2006 Nov;47(11):1123-32.PMID: 17076751 [PubMed - indexed for MEDLINE]Related articles

Switching from insulin to oral sulfonylureas in patients with diabetes due to Kir6.2 mutations.

Pearson ER, Flechtner I, Njølstad PR, Malecki MT, Flanagan SE, Larkin B, Ashcroft FM, Klimes I, Codner E, Iotova V, Slingerland AS, Shield J, Robert JJ, Holst JJ, Clark PM, Ellard S, Søvik O, Polak M, Hattersley AT; Neonatal Diabetes International Collaborative Group.

N Engl J Med. 2006 Aug 3;355(5):467-77.PMID: 16885550 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin sensitivity indices: a proposal of cut-off points for simple identification of insulin-resistant subjects.

Radikova Z, Koska J, Huckova M, Ksinantova L, Imrich R, Vigas M, Trnovec T, Langer P, Sebokova E, Klimes I.

Exp Clin Endocrinol Diabetes. 2006 May;114(5):249-56.PMID: 16804799 [PubMed - indexed for MEDLINE]Related articles

Human thyroid in the population exposed to high environmental pollution by organochlorinated pollutants for several decades.

Langer P, Kocan A, Tajtakova M, Petrik J, Chovancova J, Drobna B, Jursa S, Pavuk M, Trnovec T, Seböková E, Klimes I.

Endocr Regul. 2005 Jan;39(1):13-20.PMID: 16107134 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased thyroid volume and frequency of thyroid disorders signs in schoolchildren from nitrate polluted area.

Tajtáková M, Semanová Z, Tomková Z, Szökeová E, Majoros J, Rádiková Z, Seböková E, Klimes I, Langer P.

Chemosphere. 2006 Jan;62(4):559-64. Epub 2005 Aug 10.PMID: 16095667 [PubMed - indexed for MEDLINE]Related articles

[Epidemiological profile of thyroid volume and disorders in Slovakia]

Tajtáková M, Langer P, Fodor G, Hanzen E, Putz Z, Kost'álová L, Michálek J, Kreze A, Klimes I, Seböková E.

Vnitr Lek. 2000 Nov;46(11):756-63. Slovak. PMID: 15637890 [PubMed - indexed for MEDLINE]Related articles

Mapping of genetic determinants of the sympathoneural response to stress.

Klimes I, Weston K, Gasperíková D, Kovács P, Kvetnanský R, Jezová D, Dixon R, Thompson JR, Seböková E, Samani NJ.

Physiol Genomics. 2005 Jan 20;20(2):183-7. Epub 2004 Nov 16.PMID: 15547139 [PubMed - indexed for MEDLINE]Related articlesFree article

Impact of a general practice based group parenting programme: quantitative and qualitative results from a controlled trial at 12 months.

Stewart-Brown S, Patterson J, Mockford C, Barlow J, Klimes I, Pyper C.

Arch Dis Child. 2004 Jun;89(6):519-25.PMID: 15155394 [PubMed - indexed for MEDLINE]Related articlesFree article

Thyroid function and cholesterol level: paradoxical findings in large groups of population with high cholesterol food intake.

Langer P, Kocan A, Tajtakova M, Petrik J, Koska J, Hucková M, Hanzen E, Ksinantova L, Radikova Z, Imrich R, Trnovec T, Blazicek P, Sebokova E, Klimes I.

Endocr Regul. 2003 Sep;37(3):175-80.PMID: 14986723 [PubMed - indexed for MEDLINE]Related articlesFree article

The hypotriglyceridemic effect of dietary n-3 FA is associated with increased beta-oxidation and reduced leptin expression.

Ukropec J, Reseland JE, Gasperikova D, Demcakova E, Madsen L, Berge RK, Rustan AC, Klimes I, Drevon CA, Sebökova E.

Lipids. 2003 Oct;38(10):1023-9.PMID: 14669966 [PubMed - indexed for MEDLINE]Related articles

From naturally occurring goitrogens to the effects of anthropogenic endocrine disruptors on the thyroid in Slovakia.

Langer P, Tajtakova M, Kocan A, Trnovec T, Sebokova E, Klimes I.

Bratisl Lek Listy. 2003;104(3):101-7. Review.PMID: 12940694 [PubMed - indexed for MEDLINE]Related articles

Multimodal distribution versus logarithmic transformation of thyroid volumes in adolescents: detection of subgroup with subclinical thyroid disorders and its impact on the assessment of the upper limit of normal thyroid volumes.

Langer P, Tajtáková M, Koska J, Bohov P, Seböková E, Klimes I.

Endocr J. 2003 Apr;50(2):117-25.PMID: 12803231 [PubMed - indexed for MEDLINE]Related articlesFree article

Possible effects of polychlorinated biphenyls and organochlorinated pesticides on the thyroid after long-term exposure to heavy environmental pollution.

Langer P, Kocan A, Tajtáková M, Petrík J, Chovancová J, Drobná B, Jursa S, Pavúk M, Koska J, Trnovec T, Seböková E, Klimes I.

J Occup Environ Med. 2003 May;45(5):526-32.PMID: 12762077 [PubMed - indexed for MEDLINE]Related articles

Iodine deficiency in vegetarians and vegans.

Krajcovicová-Kudlácková M, Bucková K, Klimes I, Seboková E.

Ann Nutr Metab. 2003;47(5):183-5.PMID: 12748410 [PubMed - indexed for MEDLINE]Related articles

Effect of losartan on the Na+/Ca2+ exchanger in left ventricle of the insulin resistant and hypertensive hHTg rat.

Krizanova O, Sebokova E, Klimes I.

Gen Physiol Biophys. 2002 Dec;21(4):405-13.PMID: 12693712 [PubMed - indexed for MEDLINE]Related articlesFree article

Mapping of genetic loci predisposing to hypertriglyceridaemia in the hereditary hypertriglyceridaemic rat: analysis of genetic association with related traits of the insulin resistance syndrome.

Klimes I, Weston K, Kovacs P, Gasperikova D, Jezova D, Kvetnansky R, Thompson JR, Sebokova E, Samani NJ.

Diabetologia. 2003 Mar;46(3):352-8. Epub 2003 Mar 1.PMID: 12687333 [PubMed - indexed for MEDLINE]Related articles

High prevalence of anti-glutamic acid decarboxylase (anti-GAD) antibodies in employees at a polychlorinated biphenyl production factory.

Langer P, Tajtáková M, Guretzki HJ, Kocan A, Petrík J, Chovancová J, Drobná B, Jursa S, Pavúk M, Trnovec T, Seböková E, Klimes I.

Arch Environ Health. 2002 Sep-Oct;57(5):412-5.PMID: 12641181 [PubMed - indexed for MEDLINE]Related articles

Comparison of the extrapancreatic action of gamma-linolenic acid and n-3 PUFAs in the high fat diet-induced insulin resistance [corrected].

Simoncíkova P, Wein S, Gasperikova D, Ukropec J, Certik M, Klimes I, Sebokova E.

Endocr Regul. 2002 Nov;36(4):143-9. Erratum in: Endocr Regul. 2003 Mar;37(1):20. PMID: 12466014 [PubMed - indexed for MEDLINE]Related articlesFree article

Improving mental health through parenting programmes: block randomised controlled trial.

Patterson J, Barlow J, Mockford C, Klimes I, Pyper C, Stewart-Brown S.

Arch Dis Child. 2002 Dec;87(6):472-7.PMID: 12456542 [PubMed - indexed for MEDLINE]Related articlesFree article

Lipids and insulin resistance: what we've learned at the Fourth International Smolenice Symposium.

Ravussin E, Klimes I, Seböková E, Howard BV.

Ann N Y Acad Sci. 2002 Jun;967:576-80.PMID: 12079892 [PubMed - indexed for MEDLINE]Related articles

Endocrine regulation of subcutaneous fat metabolism during cold exposure in humans.

Koska J, Ksinantova L, Seböková E, Kvetnansky R, Klimes I, Chrousos G, Pacak K.

Ann N Y Acad Sci. 2002 Jun;967:500-5.PMID: 12079880 [PubMed - indexed for MEDLINE]Related articles

Impaired endothelial function of thoracic aorta in hereditary hypertriglyceridemic rats.

Török J, Babál P, Matusková J, Lupták I, Klimes I, Simko F.

Ann N Y Acad Sci. 2002 Jun;967:469-75.PMID: 12079876 [PubMed - indexed for MEDLINE]Related articles

Insulin resistance in the hereditary hypertriglyceridemic rat is associated with an impairment of delta-6 desaturase expression in liver.

Gasperíková D, Demcáková E, Ukropec J, Klimes I, Seböková E.

Ann N Y Acad Sci. 2002 Jun;967:446-53.PMID: 12079873 [PubMed - indexed for MEDLINE]Related articles

Comparison of the extrapancreatic action of BRX-220 and pioglitazone in the high-fat diet-induced insulin resistance.

Seböková E, Kürthy M, Mogyorosi T, Nagy K, Demcáková E, Ukropec J, Koranyi L, Klimes I.

Ann N Y Acad Sci. 2002 Jun;967:424-30.PMID: 12079870 [PubMed - indexed for MEDLINE]Related articles

An increase in peroxisomal fatty acid oxidation is not sufficient to prevent tissue lipid accumulation in hHTg rats.

Ukropec J, Klimes I, Gasperíková D, Demcáková E, Drevon CA, Reseland JE, Seböková E.

Ann N Y Acad Sci. 2002 Jun;967:71-9.PMID: 12079837 [PubMed - indexed for MEDLINE]Related articles

Tetradecylthioacetic acid prevents high fat diet induced adiposity and insulin resistance.

Madsen L, Guerre-Millo M, Flindt EN, Berge K, Tronstad KJ, Bergene E, Sebokova E, Rustan AC, Jensen J, Mandrup S, Kristiansen K, Klimes I, Staels B, Berge RK.

J Lipid Res. 2002 May;43(5):742-50.PMID: 11971945 [PubMed - indexed for MEDLINE]Related articlesFree article

Delta-6 desaturase activity and gene expression, tissue fatty acid profile and glucose turnover rate in hereditary hypertriglyceridemic rats.

Demcakova E, Sebokova, Ukropec J, Gasperikova D, Klimes I.

Endocr Regul. 2001 Dec;35(4):179-86.PMID: 11858764 [PubMed - indexed for MEDLINE]Related articlesFree article

Cognitive behavioral therapy for chronic fatigue syndrome in a general hospital--feasible and effective.

Akagi H, Klimes I, Bass C.

Gen Hosp Psychiatry. 2001 Sep-Oct;23(5):254-60.PMID: 11600166 [PubMed - indexed for MEDLINE]Related articles

Further studies of blood levels of some tumor markers in the area polluted by polychlorinated biphenyls and control population.

Langer P, Kausitz J, Tajtáková M, Kocan A, Bohov P, Hanzen E, Klimes I.

Neoplasma. 2001;48(2):139-43.PMID: 11478695 [PubMed - indexed for MEDLINE]Related articles

Nutrient sensing, leptin and insulin action.

Ukropec J, Seböková E, Klimes I.

Arch Physiol Biochem. 2001 Feb;109(1):38-51. Review.PMID: 11471070 [PubMed - indexed for MEDLINE]Related articles