PubMed

New role for plasmin in sodium homeostasis.

Passero CJ, Hughey RP, Kleyman TR.

Curr Opin Nephrol Hypertens. 2009 Oct 27. [Epub ahead of print]PMID: 19864949 [PubMed - as supplied by publisher]Related articles

Re: research in areas of transport physiology.

Kleyman TR, Gamba G.

Am J Physiol Renal Physiol. 2009 Oct;297(4):F837. Epub 2009 Aug 19. No abstract available. PMID: 19692482 [PubMed - indexed for MEDLINE]Related articles

Mechanoregulation of BK channel activity in the mammalian cortical collecting duct: role of protein kinases A and C.

Liu W, Wei Y, Sun P, Wang WH, Kleyman TR, Satlin LM.

Am J Physiol Renal Physiol. 2009 Oct;297(4):F904-15. Epub 2009 Aug 5.PMID: 19656909 [PubMed - indexed for MEDLINE]Related articles

ENaC at the cutting edge: regulation of epithelial sodium channels by proteases.

Kleyman TR, Carattino MD, Hughey RP.

J Biol Chem. 2009 Jul 31;284(31):20447-51. Epub 2009 Apr 28. Review.PMID: 19401469 [PubMed - indexed for MEDLINE]Related articles

Plasmin and sodium retention in nephrotic syndrome.

Kleyman TR, Hughey RP.

J Am Soc Nephrol. 2009 Feb;20(2):233-4. Epub 2009 Jan 28. No abstract available. PMID: 19176698 [PubMed - indexed for MEDLINE]Related articles

Novel determinants of epithelial sodium channel gating within extracellular thumb domains.

Maarouf AB, Sheng N, Chen J, Winarski KL, Okumura S, Carattino MD, Boyd CR, Kleyman TR, Sheng S.

J Biol Chem. 2009 Mar 20;284(12):7756-65. Epub 2009 Jan 21.PMID: 19158091 [PubMed - indexed for MEDLINE]Related articles

Plasmin activates epithelial Na+ channels by cleaving the gamma subunit.

Passero CJ, Mueller GM, Rondon-Berrios H, Tofovic SP, Hughey RP, Kleyman TR.

J Biol Chem. 2008 Dec 26;283(52):36586-91. Epub 2008 Nov 3.PMID: 18981180 [PubMed - indexed for MEDLINE]Related articles

Proteolytic processing of the epithelial sodium channel gamma subunit has a dominant role in channel activation.

Carattino MD, Hughey RP, Kleyman TR.

J Biol Chem. 2008 Sep 12;283(37):25290-5. Epub 2008 Jul 23.PMID: 18650438 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of aldosterone on BK channel expression in mammalian cortical collecting duct.

Estilo G, Liu W, Pastor-Soler N, Mitchell P, Carattino MD, Kleyman TR, Satlin LM.

Am J Physiol Renal Physiol. 2008 Sep;295(3):F780-8. Epub 2008 Jun 25.PMID: 18579708 [PubMed - indexed for MEDLINE]Related articlesFree article

Prostasin expression is regulated by airway surface liquid volume and is increased in cystic fibrosis.

Myerburg MM, McKenna EE, Luke CJ, Frizzell RA, Kleyman TR, Pilewski JM.

Am J Physiol Lung Cell Mol Physiol. 2008 May;294(5):L932-41. Epub 2008 Feb 29.PMID: 18310226 [PubMed - indexed for MEDLINE]Related articlesFree article

Defining an inhibitory domain in the alpha-subunit of the epithelial sodium channel.

Carattino MD, Passero CJ, Steren CA, Maarouf AB, Pilewski JM, Myerburg MM, Hughey RP, Kleyman TR.

Am J Physiol Renal Physiol. 2008 Jan;294(1):F47-52. Epub 2007 Nov 21.PMID: 18032549 [PubMed - indexed for MEDLINE]Related articlesFree article

Phosphatidylinositol 4-phosphate 5-kinase reduces cell surface expression of the epithelial sodium channel (ENaC) in cultured collecting duct cells.

Weixel KM, Edinger RS, Kester L, Guerriero CJ, Wang H, Fang L, Kleyman TR, Welling PA, Weisz OA, Johnson JP.

J Biol Chem. 2007 Dec 14;282(50):36534-42. Epub 2007 Oct 16.PMID: 17940289 [PubMed - indexed for MEDLINE]Related articlesFree article

Functional cross talk between ENaC and pendrin.

Hughey RP, Kleyman TR.

Am J Physiol Renal Physiol. 2007 Nov;293(5):F1439-40. Epub 2007 Sep 12. Review. No abstract available. PMID: 17855481 [PubMed - indexed for MEDLINE]Related articlesFree article

Epithelial sodium channel exit from the endoplasmic reticulum is regulated by a signal within the carboxyl cytoplasmic domain of the alpha subunit.

Mueller GM, Kashlan OB, Bruns JB, Maarouf AB, Aridor M, Kleyman TR, Hughey RP.

J Biol Chem. 2007 Nov 16;282(46):33475-83. Epub 2007 Sep 12.PMID: 17855354 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of proteolysis in the activation of epithelial sodium channels.

Hughey RP, Carattino MD, Kleyman TR.

Curr Opin Nephrol Hypertens. 2007 Sep;16(5):444-50. Review.PMID: 17693760 [PubMed - indexed for MEDLINE]Related articles

Small heat shock protein alphaA-crystallin regulates epithelial sodium channel expression.

Kashlan OB, Mueller GM, Qamar MZ, Poland PA, Ahner A, Rubenstein RC, Hughey RP, Brodsky JL, Kleyman TR.

J Biol Chem. 2007 Sep 21;282(38):28149-56. Epub 2007 Jul 30.PMID: 17664274 [PubMed - indexed for MEDLINE]Related articlesFree article

Intracellular trafficking of a polymorphism in the COOH terminus of the alpha-subunit of the human epithelial sodium channel is modulated by casein kinase 1.

Yan W, Spruce L, Rosenblatt MM, Kleyman TR, Rubenstein RC.

Am J Physiol Renal Physiol. 2007 Sep;293(3):F868-76. Epub 2007 Jun 27.PMID: 17596527 [PubMed - indexed for MEDLINE]Related articlesFree article

Functional role of extracellular loop cysteine residues of the epithelial Na+ channel in Na+ self-inhibition.

Sheng S, Maarouf AB, Bruns JB, Hughey RP, Kleyman TR.

J Biol Chem. 2007 Jul 13;282(28):20180-90. Epub 2007 May 23.PMID: 17522058 [PubMed - indexed for MEDLINE]Related articlesFree article

Renal physiology: an evolving field.

Kleyman TR.

Am J Physiol Renal Physiol. 2007 Jul;293(1):F1. Epub 2007 Apr 25. No abstract available. PMID: 17459955 [PubMed - indexed for MEDLINE]Related articlesFree article

Lack of a role of membrane-protein interactions in flow-dependent activation of ENaC.

Carattino MD, Liu W, Hill WG, Satlin LM, Kleyman TR.

Am J Physiol Renal Physiol. 2007 Jul;293(1):F316-24. Epub 2007 Apr 25.PMID: 17459954 [PubMed - indexed for MEDLINE]Related articlesFree article

Ca2+ dependence of flow-stimulated K secretion in the mammalian cortical collecting duct.

Liu W, Morimoto T, Woda C, Kleyman TR, Satlin LM.

Am J Physiol Renal Physiol. 2007 Jul;293(1):F227-35. Epub 2007 Mar 27.PMID: 17389680 [PubMed - indexed for MEDLINE]Related articlesFree article

Salt, sodium channels, and SGK1.

Pearce D, Kleyman TR.

J Clin Invest. 2007 Mar;117(3):592-5.PMID: 17332888 [PubMed - indexed for MEDLINE]Related articlesFree article

Epithelial Na+ channels are fully activated by furin- and prostasin-dependent release of an inhibitory peptide from the gamma-subunit.

Bruns JB, Carattino MD, Sheng S, Maarouf AB, Weisz OA, Pilewski JM, Hughey RP, Kleyman TR.

J Biol Chem. 2007 Mar 2;282(9):6153-60. Epub 2007 Jan 1.PMID: 17199078 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulatory interactions of N1303K-CFTR and ENaC in Xenopus oocytes: evidence that chloride transport is not necessary for inhibition of ENaC.

Suaud L, Yan W, Carattino MD, Robay A, Kleyman TR, Rubenstein RC.

Am J Physiol Cell Physiol. 2007 Apr;292(4):C1553-61. Epub 2006 Dec 20.PMID: 17182731 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of ENaCs by proteases: An increasingly complex story.

Kleyman TR, Myerburg MM, Hughey RP.

Kidney Int. 2006 Oct;70(8):1391-2.PMID: 17024162 [PubMed - indexed for MEDLINE]Related articles

Biophysical approach to determine the subunit stoichiometry of the epithelial sodium channel using the Xenopus laevis oocyte expression system.

Kosari F, Sheng S, Kleyman TR.

Methods Mol Biol. 2006;337:53-63.PMID: 16929938 [PubMed - indexed for MEDLINE]Related articles

Distinct structural elements in the first membrane-spanning segment of the epithelial sodium channel.

Kashlan OB, Maarouf AB, Kussius C, Denshaw RM, Blumenthal KM, Kleyman TR.

J Biol Chem. 2006 Oct 13;281(41):30455-62. Epub 2006 Aug 14.PMID: 16912051 [PubMed - indexed for MEDLINE]Related articlesFree article

Airway surface liquid volume regulates ENaC by altering the serine protease-protease inhibitor balance: a mechanism for sodium hyperabsorption in cystic fibrosis.

Myerburg MM, Butterworth MB, McKenna EE, Peters KW, Frizzell RA, Kleyman TR, Pilewski JM.

J Biol Chem. 2006 Sep 22;281(38):27942-9. Epub 2006 Jul 26.PMID: 16873367 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of cation transport in the distal nephron by mechanical forces.

Satlin LM, Carattino MD, Liu W, Kleyman TR.

Am J Physiol Renal Physiol. 2006 Nov;291(5):F923-31. Epub 2006 Jul 18. Review.PMID: 16849691 [PubMed - indexed for MEDLINE]Related articlesFree article

The epithelial Na+ channel is inhibited by a peptide derived from proteolytic processing of its alpha subunit.

Carattino MD, Sheng S, Bruns JB, Pilewski JM, Hughey RP, Kleyman TR.

J Biol Chem. 2006 Jul 7;281(27):18901-7. Epub 2006 May 11.PMID: 16690613 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanism underlying flow stimulation of sodium absorption in the mammalian collecting duct.

Morimoto T, Liu W, Woda C, Carattino MD, Wei Y, Hughey RP, Apodaca G, Satlin LM, Kleyman TR.

Am J Physiol Renal Physiol. 2006 Sep;291(3):F663-9. Epub 2006 Apr 25.PMID: 16638910 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential effects of Hsc70 and Hsp70 on the intracellular trafficking and functional expression of epithelial sodium channels.

Goldfarb SB, Kashlan OB, Watkins JN, Suaud L, Yan W, Kleyman TR, Rubenstein RC.

Proc Natl Acad Sci U S A. 2006 Apr 11;103(15):5817-22. Epub 2006 Apr 3.PMID: 16585520 [PubMed - indexed for MEDLINE]Related articlesFree article

Clathrin-mediated endocytosis of the epithelial sodium channel. Role of epsin.

Wang H, Traub LM, Weixel KM, Hawryluk MJ, Shah N, Edinger RS, Perry CJ, Kester L, Butterworth MB, Peters KW, Kleyman TR, Frizzell RA, Johnson JP.

J Biol Chem. 2006 May 19;281(20):14129-35. Epub 2006 Mar 30.PMID: 16574660 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of epithelial Na+ channels (ENaC) by methylation: a novel methyltransferase stimulates ENaC activity.

Edinger RS, Yospin J, Perry C, Kleyman TR, Johnson JP.

J Biol Chem. 2006 Apr 7;281(14):9110-7. Epub 2006 Feb 8.PMID: 16469734 [PubMed - indexed for MEDLINE]Related articlesFree article

Furin cleavage activates the epithelial Na+ channel by relieving Na+ self-inhibition.

Sheng S, Carattino MD, Bruns JB, Hughey RP, Kleyman TR.

Am J Physiol Renal Physiol. 2006 Jun;290(6):F1488-96. Epub 2006 Jan 31.PMID: 16449353 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential modulation of a polymorphism in the COOH terminus of the alpha-subunit of the human epithelial sodium channel by protein kinase Cdelta.

Yan W, Suaud L, Kleyman TR, Rubenstein RC.

Am J Physiol Renal Physiol. 2006 Feb;290(2):F279-88. Epub 2005 Sep 20.PMID: 16174865 [PubMed - indexed for MEDLINE]Related articlesFree article

Dietary K+ regulates apical membrane expression of maxi-K channels in rabbit cortical collecting duct.

Najjar F, Zhou H, Morimoto T, Bruns JB, Li HS, Liu W, Kleyman TR, Satlin LM.

Am J Physiol Renal Physiol. 2005 Oct;289(4):F922-32. Epub 2005 May 24.PMID: 15914780 [PubMed - indexed for MEDLINE]Related articlesFree article

On the interaction between amiloride and its putative alpha-subunit epithelial Na+ channel binding site.

Kashlan OB, Sheng S, Kleyman TR.

J Biol Chem. 2005 Jul 15;280(28):26206-15. Epub 2005 May 20.PMID: 15908426 [PubMed - indexed for MEDLINE]Related articlesFree article

Epithelial sodium channel inhibition by AMP-activated protein kinase in oocytes and polarized renal epithelial cells.

Carattino MD, Edinger RS, Grieser HJ, Wise R, Neumann D, Schlattner U, Johnson JP, Kleyman TR, Hallows KR.

J Biol Chem. 2005 May 6;280(18):17608-16. Epub 2005 Mar 7.PMID: 15753079 [PubMed - indexed for MEDLINE]Related articlesFree article

Side chain orientation of residues lining the selectivity filter of epithelial Na+ channels.

Sheng S, Perry CJ, Kashlan OB, Kleyman TR.

J Biol Chem. 2005 Mar 4;280(9):8513-22. Epub 2004 Dec 20.PMID: 15611061 [PubMed - indexed for MEDLINE]Related articlesFree article

Mutations in the pore region modify epithelial sodium channel gating by shear stress.

Carattino MD, Sheng S, Kleyman TR.

J Biol Chem. 2005 Feb 11;280(6):4393-401. Epub 2004 Nov 29.PMID: 15569663 [PubMed - indexed for MEDLINE]Related articlesFree article

Distinct pools of epithelial sodium channels are expressed at the plasma membrane.

Hughey RP, Bruns JB, Kinlough CL, Kleyman TR.

J Biol Chem. 2004 Nov 19;279(47):48491-4. Epub 2004 Oct 4.PMID: 15466477 [PubMed - indexed for MEDLINE]Related articlesFree article

Ikappab kinase-beta (ikkbeta) modulation of epithelial sodium channel activity.

Lebowitz J, Edinger RS, An B, Perry CJ, Onate S, Kleyman TR, Johnson JP.

J Biol Chem. 2004 Oct 1;279(40):41985-90. Epub 2004 Jul 28.PMID: 15292220 [PubMed - indexed for MEDLINE]Related articlesFree article

Mild nephrogenic diabetes insipidus caused by Foxa1 deficiency.

Behr R, Brestelli J, Fulmer JT, Miyawaki N, Kleyman TR, Kaestner KH.

J Biol Chem. 2004 Oct 1;279(40):41936-41. Epub 2004 Jul 13.PMID: 15252040 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential current decay profiles of epithelial sodium channel subunit combinations in polarized renal epithelial cells.

Mohan S, Bruns JR, Weixel KM, Edinger RS, Bruns JB, Kleyman TR, Johnson JP, Weisz OA.

J Biol Chem. 2004 Jul 30;279(31):32071-8. Epub 2004 May 27.PMID: 15166222 [PubMed - indexed for MEDLINE]Related articlesFree article

Extracellular Zn2+ activates epithelial Na+ channels by eliminating Na+ self-inhibition.

Sheng S, Perry CJ, Kleyman TR.

J Biol Chem. 2004 Jul 23;279(30):31687-96. Epub 2004 May 15.PMID: 15145943 [PubMed - indexed for MEDLINE]Related articlesFree article

Functional polymorphism in the carboxyl terminus of the alpha-subunit of the human epithelial sodium channel.

Samaha FF, Rubenstein RC, Yan W, Ramkumar M, Levy DI, Ahn YJ, Sheng S, Kleyman TR.

J Biol Chem. 2004 Jun 4;279(23):23900-7. Epub 2004 Apr 6.PMID: 15069064 [PubMed - indexed for MEDLINE]Related articlesFree article

Cystic fibrosis transmembrane conductance regulator differentially regulates human and mouse epithelial sodium channels in Xenopus oocytes.

Yan W, Samaha FF, Ramkumar M, Kleyman TR, Rubenstein RC.

J Biol Chem. 2004 May 28;279(22):23183-92. Epub 2004 Mar 26.PMID: 15047694 [PubMed - indexed for MEDLINE]Related articlesFree article

Epithelial sodium channels are activated by furin-dependent proteolysis.

Hughey RP, Bruns JB, Kinlough CL, Harkleroad KL, Tong Q, Carattino MD, Johnson JP, Stockand JD, Kleyman TR.

J Biol Chem. 2004 Apr 30;279(18):18111-4. Epub 2004 Mar 7.PMID: 15007080 [PubMed - indexed for MEDLINE]Related articlesFree article

Mutations in the extracellular loop of alpha-rENaC alter sensitivity to amiloride and reactive species.

Chen L, Fuller CM, Kleyman TR, Matalon S.

Am J Physiol Renal Physiol. 2004 Jun;286(6):F1202-8. Epub 2004 Feb 17.PMID: 14969999 [PubMed - indexed for MEDLINE]Related articlesFree article