PubMed

AAV9-mediated erythropoietin gene delivery into the brain protects nigral dopaminergic neurons in a rat model of Parkinson's disease.

Xue YQ, Ma BF, Zhao LR, Tatom JB, Li B, Jiang LX, Klein RL, Duan WM.

Gene Ther. 2009 Sep 3. [Epub ahead of print]PMID: 19727138 [PubMed - as supplied by publisher]Related articles

Association of Midgestational Paraoxonase 1 Activity with Pregnancies Complicated by Preeclampsia.

Baker AM, Klein RL, Haeri S, Moss KL, Boggess KA.

Am J Perinatol. 2009 Aug 14. [Epub ahead of print]PMID: 19685420 [PubMed - as supplied by publisher]Related articles

Versatile somatic gene transfer for modeling neurodegenerative diseases.

Klein RL, Wang DB, King MA.

Neurotox Res. 2009 Oct;16(3):329-42. Epub 2009 Aug 11.PMID: 19669852 [PubMed - in process]Related articles

Maternal serum dyslipidemia occurs early in pregnancy in women with mild but not severe preeclampsia.

Baker AM, Klein RL, Moss KL, Haeri S, Boggess K.

Am J Obstet Gynecol. 2009 Sep;201(3):293.e1-4. Epub 2009 Jul 24.PMID: 19631926 [PubMed - indexed for MEDLINE]Related articles

Bilateral effects of unilateral GDNF administration on dopamine- and GABA-regulating proteins in the rat nigrostriatal system.

Salvatore MF, Gerhardt GA, Dayton RD, Klein RL, Stanford JA.

Exp Neurol. 2009 Sep;219(1):197-207. Epub 2009 May 19.PMID: 19460370 [PubMed - indexed for MEDLINE]Related articles

PET imaging in rats to discern temporal onset differences between 6-hydroxydopamine and tau gene vector neurodegeneration models.

Klein RL, Dayton RD, Terry TL, Vascoe C, Sunderland JJ, Tainter KH.

Brain Res. 2009 Mar 9;1259:113-22. Epub 2009 Feb 10.PMID: 19368808 [PubMed - indexed for MEDLINE]Related articles

Evaluation of genome-wide association study results through development of ontology fingerprints.

Tsoi LC, Boehnke M, Klein RL, Zheng WJ.

Bioinformatics. 2009 May 15;25(10):1314-20. Epub 2009 Apr 5.PMID: 19349285 [PubMed - indexed for MEDLINE]Related articles

Mimicking aspects of frontotemporal lobar degeneration and Lou Gehrig's disease in rats via TDP-43 overexpression.

Tatom JB, Wang DB, Dayton RD, Skalli O, Hutton ML, Dickson DW, Klein RL.

Mol Ther. 2009 Apr;17(4):607-13. Epub 2009 Feb 17.PMID: 19223871 [PubMed - indexed for MEDLINE]Related articles

Pronounced microgliosis and neurodegeneration in aged rats after tau gene transfer.

Klein RL, Dayton RD, Diaczynsky CG, Wang DB.

Neurobiol Aging. 2009 Jan 18. [Epub ahead of print]PMID: 19155101 [PubMed - as supplied by publisher]Related articles

Effect of CNTF on retinal ganglion cell survival in experimental glaucoma.

Pease ME, Zack DJ, Berlinicke C, Bloom K, Cone F, Wang Y, Klein RL, Hauswirth WW, Quigley HA.

Invest Ophthalmol Vis Sci. 2009 May;50(5):2194-200. Epub 2008 Dec 5.PMID: 19060281 [PubMed - indexed for MEDLINE]Related articles

The adiponectin receptors AdipoR1 and AdipoR2 activate ERK1/2 through a Src/Ras-dependent pathway and stimulate cell growth.

Lee MH, Klein RL, El-Shewy HM, Luttrell DK, Luttrell LM.

Biochemistry. 2008 Nov 4;47(44):11682-92. Epub 2008 Oct 9.PMID: 18842004 [PubMed - indexed for MEDLINE]Related articlesFree article

Risk factors related to inflammation and endothelial dysfunction in the DCCT/EDIC cohort and their relationship with nephropathy and macrovascular complications.

Lopes-Virella MF, Carter RE, Gilbert GE, Klein RL, Jaffa M, Jenkins AJ, Lyons TJ, Garvey WT, Virella G; Diabetes Control and Complications Trial/Epidemiology of Diabetes Intervention and Complications Cohort Study Group.

Diabetes Care. 2008 Oct;31(10):2006-12. Epub 2008 Jul 15.PMID: 18628568 [PubMed - indexed for MEDLINE]Related articlesFree article

Adiponectin reduces lipid accumulation in macrophage foam cells.

Tian L, Luo N, Klein RL, Chung BH, Garvey WT, Fu Y.

Atherosclerosis. 2009 Jan;202(1):152-61. Epub 2008 Apr 20.PMID: 18511057 [PubMed - indexed for MEDLINE]Related articles

Cross-sectional associations of C-reactive protein with vascular risk factors and vascular complications in the DCCT/EDIC cohort.

Jenkins AJ, Rothen M, Klein RL, Moller K, Eldridge L, Zheng D, Durazo-Arvizu R, McGee D, Lackland D, Thorpe SR, Garvey WT, Lyons TJ; DCCT/EDIC Research Group.

J Diabetes Complications. 2008 May-Jun;22(3):153-63. Epub 2008 Apr 16.PMID: 18413218 [PubMed - indexed for MEDLINE]Related articles

Tau expression levels from various adeno-associated virus vector serotypes produce graded neurodegenerative disease states.

Klein RL, Dayton RD, Tatom JB, Diaczynsky CG, Salvatore MF.

Eur J Neurosci. 2008 Apr;27(7):1615-25.PMID: 18380664 [PubMed - indexed for MEDLINE]Related articles

Increased methionine sulfoxide content of apoA-I in type 1 diabetes.

Brock JW, Jenkins AJ, Lyons TJ, Klein RL, Yim E, Lopes-Virella M, Carter RE; (DCCT/EDIC) Research Group, Thorpe SR, Baynes JW.

J Lipid Res. 2008 Apr;49(4):847-55. Epub 2008 Jan 17.PMID: 18202432 [PubMed - indexed for MEDLINE]Related articlesFree article

AAV8, 9, Rh10, Rh43 vector gene transfer in the rat brain: effects of serotype, promoter and purification method.

Klein RL, Dayton RD, Tatom JB, Henderson KM, Henning PP.

Mol Ther. 2008 Jan;16(1):89-96. Epub 2007 Oct 23.PMID: 17955025 [PubMed - indexed for MEDLINE]Related articles

Case report of symptomatic cholelithiasis after ventricular cholecystic shunt.

Surfield GA, Klein RL.

J Pediatr Surg. 2006 Nov;41(11):1933-4.PMID: 17101375 [PubMed - indexed for MEDLINE]Related articles

Nuclear magnetic resonance-determined lipoprotein subclass profile in the DCCT/EDIC cohort: associations with carotid intima-media thickness.

Lyons TJ, Jenkins AJ, Zheng D, Klein RL, Otvos JD, Yu Y, Lackland DT, McGee D, McHenry MB, Lopes-Virella M, Garvey WT; DCCT/EDIC Research Group.

Diabet Med. 2006 Sep;23(9):955-66.PMID: 16922701 [PubMed - indexed for MEDLINE]Related articles

Memory-related deficits following selective hippocampal expression of Swedish mutation amyloid precursor protein in the rat.

Gong Y, Meyer EM, Meyers CA, Klein RL, King MA, Hughes JA.

Exp Neurol. 2006 Aug;200(2):371-7. Epub 2006 Jun 15.PMID: 16780838 [PubMed - indexed for MEDLINE]Related articles

Effect of blood transfusion on outcome after major burn injury: a multicenter study.

Palmieri TL, Caruso DM, Foster KN, Cairns BA, Peck MD, Gamelli RL, Mozingo DW, Kagan RJ, Wahl W, Kemalyan NA, Fish JS, Gomez M, Sheridan RL, Faucher LD, Latenser BA, Gibran NS, Klein RL, Solem LD, Saffle JR, Morris SE, Jeng JC, Voigt D, Howard PA, Molitor F, Greenhalgh DG; American Burn Association Burn Multicenter Trials Group.

Crit Care Med. 2006 Jun;34(6):1602-7.PMID: 16607231 [PubMed - indexed for MEDLINE]Related articles

Effects of oxandrolone on outcome measures in the severely burned: a multicenter prospective randomized double-blind trial.

Wolf SE, Edelman LS, Kemalyan N, Donison L, Cross J, Underwood M, Spence RJ, Noppenberger D, Palmieri TL, Greenhalgh DG, Lawless M, Voigt D, Edwards P, Warner P, Kagan R, Hatfield S, Jeng J, Crean D, Hunt J, Purdue G, Burris A, Cairns B, Kessler M, Klein RL, Baker R, Yowler C, Tutulo W, Foster K, Caruso D, Hildebrand B, Benjamin W, Villarreal C, Sanford AP, Saffle J.

J Burn Care Res. 2006 Mar-Apr;27(2):131-9; discussion 140-1.PMID: 16566555 [PubMed - indexed for MEDLINE]Related articles

Parkin is protective for substantia nigra dopamine neurons in a tau gene transfer neurodegeneration model.

Klein RL, Dayton RD, Henderson KM, Petrucelli L.

Neurosci Lett. 2006 Jun 19;401(1-2):130-5. Epub 2006 Mar 22.PMID: 16554120 [PubMed - indexed for MEDLINE]Related articles

Adiponectin multimeric complexes and the metabolic syndrome trait cluster.

Lara-Castro C, Luo N, Wallace P, Klein RL, Garvey WT.

Diabetes. 2006 Jan;55(1):249-59.PMID: 16380500 [PubMed - indexed for MEDLINE]Related articlesFree article

Efficient neuronal gene transfer with AAV8 leads to neurotoxic levels of tau or green fluorescent proteins.

Klein RL, Dayton RD, Leidenheimer NJ, Jansen K, Golde TE, Zweig RM.

Mol Ther. 2006 Mar;13(3):517-27. Epub 2005 Dec 1.PMID: 16325474 [PubMed - indexed for MEDLINE]Related articles

Mechanisms of low-density lipoprotein-induced expression of connective tissue growth factor in human aortic endothelial cells.

Sohn M, Tan Y, Wang B, Klein RL, Trojanowska M, Jaffa AA.

Am J Physiol Heart Circ Physiol. 2006 Apr;290(4):H1624-34. Epub 2005 Nov 4.PMID: 16272194 [PubMed - indexed for MEDLINE]Related articlesFree article

Tau gene transfer, but not alpha-synuclein, induces both progressive dopamine neuron degeneration and rotational behavior in the rat.

Klein RL, Dayton RD, Lin WL, Dickson DW.

Neurobiol Dis. 2005 Oct;20(1):64-73.PMID: 16137567 [PubMed - indexed for MEDLINE]Related articles

Glycation does not alter LDL-induced secretion of tissue plasminogen activator and plasminogen activator inhibitor-1 from human aortic endothelial cells.

Klein RL, Semler AJ, Baynes JW, Thorpe SR, Lyons TJ, Jenkins AJ.

Ann N Y Acad Sci. 2005 Jun;1043:379-89.PMID: 16037259 [PubMed - indexed for MEDLINE]Related articles

Adiponectin promotes adipocyte differentiation, insulin sensitivity, and lipid accumulation.

Fu Y, Luo N, Klein RL, Garvey WT.

J Lipid Res. 2005 Jul;46(7):1369-79. Epub 2005 Apr 16.PMID: 15834118 [PubMed - indexed for MEDLINE]Related articlesFree article

Iron loading increases cholesterol accumulation and macrophage scavenger receptor I expression in THP-1 mononuclear phagocytes.

Kraml PJ, Klein RL, Huang Y, Nareika A, Lopes-Virella MF.

Metabolism. 2005 Apr;54(4):453-9. Erratum in: Metabolism. 2005 Jul;54(7):982. PMID: 15798950 [PubMed - indexed for MEDLINE]Related articles

Evidence for low-density lipoprotein-induced expression of connective tissue growth factor in mesangial cells.

Sohn M, Tan Y, Klein RL, Jaffa AA.

Kidney Int. 2005 Apr;67(4):1286-96.PMID: 15780081 [PubMed - indexed for MEDLINE]Related articles

Adeno-associated viruses containing bFGF or BDNF are neuroprotective against excitotoxicity.

Schuettauf F, Vorwerk C, Naskar R, Orlin A, Quinto K, Zurakowski D, Dejneka NS, Klein RL, Meyer EM, Bennett J.

Curr Eye Res. 2004 Dec;29(6):379-86.PMID: 15764082 [PubMed - indexed for MEDLINE]Related articles

Apolipoprotein C-III protein concentrations and gene polymorphisms in Type 1 diabetes: associations with microvascular disease complications in the DCCT/EDIC cohort.

Klein RL, McHenry MB, Lok KH, Hunter SJ, Le NA, Jenkins AJ, Zheng D, Semler A, Page G, Brown WV, Lyons TJ, Garvey WT; DCCT/EDIC Research Group.

J Diabetes Complications. 2005 Jan-Feb;19(1):18-25.PMID: 15642486 [PubMed - indexed for MEDLINE]Related articles

Lipoproteins and diabetic microvascular complications.

Jenkins AJ, Rowley KG, Lyons TJ, Best JD, Hill MA, Klein RL.

Curr Pharm Des. 2004;10(27):3395-418. Review.PMID: 15544524 [PubMed - indexed for MEDLINE]Related articles

Recombinant adeno-associated virus serotype 2 effectively transduces primary rat brain astrocytes and microglia.

Gong Y, Chen S, Sonntag CF, Sumners C, Klein RL, King MA, Hughes JA, Meyer EM.

Brain Res Brain Res Protoc. 2004 Nov;14(1):18-24.PMID: 15519948 [PubMed - indexed for MEDLINE]Related articles

Apolipoprotein C-III protein concentrations and gene polymorphisms in type 1 diabetes: associations with lipoprotein subclasses.

Klein RL, McHenry MB, Lok KH, Hunter SJ, Le NA, Jenkins AJ, Zheng D, Semler AJ, Brown WV, Lyons TJ, Garvey WT; DCCT/EDIC Research Group.

Metabolism. 2004 Oct;53(10):1296-304.PMID: 15375785 [PubMed - indexed for MEDLINE]Related articles

Diagnosing suspected acute nonclassic appendicitis with sulesomab, a radiolabeled antigranulocyte antibody imaging agent.

Passalaqua AM, Klein RL, Wegener WA, Crawford JA, Crow JP, Andrews DA, Goldenberg DM.

J Pediatr Surg. 2004 Sep;39(9):1338-44.PMID: 15359387 [PubMed - indexed for MEDLINE]Related articles

'Lipoproteins, glycoxidation and diabetic angiopathy'.

Jenkins AJ, Best JD, Klein RL, Lyons TJ.

Diabetes Metab Res Rev. 2004 Sep-Oct;20(5):349-68. Review.PMID: 15343582 [PubMed - indexed for MEDLINE]Related articles

In vivo glycated low-density lipoprotein is not more susceptible to oxidation than nonglycated low-density lipoprotein in type 1 diabetes.

Jenkins AJ, Thorpe SR, Alderson NL, Hermayer KL, Lyons TJ, King LP, Chassereau CN, Klein RL.

Metabolism. 2004 Aug;53(8):969-76.PMID: 15281003 [PubMed - indexed for MEDLINE]Related articles

Critical evaluation of adult treatment panel III criteria in identifying insulin resistance with dyslipidemia.

Liao Y, Kwon S, Shaughnessy S, Wallace P, Hutto A, Jenkins AJ, Klein RL, Garvey WT.

Diabetes Care. 2004 Apr;27(4):978-83.PMID: 15047659 [PubMed - indexed for MEDLINE]Related articlesFree article

Diabetic retinopathy and serum lipoprotein subclasses in the DCCT/EDIC cohort.

Lyons TJ, Jenkins AJ, Zheng D, Lackland DT, McGee D, Garvey WT, Klein RL.

Invest Ophthalmol Vis Sci. 2004 Mar;45(3):910-8.PMID: 14985310 [PubMed - indexed for MEDLINE]Related articlesFree article

Rapid neurofibrillary tangle formation after localized gene transfer of mutated tau.

Klein RL, Lin WL, Dickson DW, Lewis J, Hutton M, Duff K, Meyer EM, King MA.

Am J Pathol. 2004 Jan;164(1):347-53.PMID: 14695347 [PubMed - indexed for MEDLINE]Related articlesFree article

Long-term neuronal effects and disposition of ectopic preproNGF gene transfer into the rat septum.

Wu K, Klein RL, Meyers CA, King MA, Hughes JA, Millard WJ, Meyer EM.

Hum Gene Ther. 2003 Oct 10;14(15):1463-72.PMID: 14577926 [PubMed - indexed for MEDLINE]Related articles

Gene therapy with brain-derived neurotrophic factor as a protection: retinal ganglion cells in a rat glaucoma model.

Martin KR, Quigley HA, Zack DJ, Levkovitch-Verbin H, Kielczewski J, Valenta D, Baumrind L, Pease ME, Klein RL, Hauswirth WW.

Invest Ophthalmol Vis Sci. 2003 Oct;44(10):4357-65.PMID: 14507880 [PubMed - indexed for MEDLINE]Related articlesFree article

Lipoproteins in the DCCT/EDIC cohort: associations with diabetic nephropathy.

Jenkins AJ, Lyons TJ, Zheng D, Otvos JD, Lackland DT, McGee D, Garvey WT, Klein RL; DCCT/EDIC Research Group.

Kidney Int. 2003 Sep;64(3):817-28.PMID: 12911531 [PubMed - indexed for MEDLINE]Related articles

Fibrinogen is a marker for nephropathy and peripheral vascular disease in type 1 diabetes: studies of plasma fibrinogen and fibrinogen gene polymorphism in the DCCT/EDIC cohort.

Klein RL, Hunter SJ, Jenkins AJ, Zheng D, Semler AJ, Clore J, Garvey WT; DCCT/ECIC STUDY GROUP.

Diabetes Care. 2003 May;26(5):1439-48.PMID: 12716802 [PubMed - indexed for MEDLINE]Related articlesFree article

The patient who doesn't want care.

McKenna S, Quinn TE, Bissell P, Klein RL; 2001 Faculty Scholars of the Program in Palliative Care Education and Practice at Harvard Medical School.

J Palliat Med. 2002 Dec;5(6):921-4. No abstract available. PMID: 12685541 [PubMed - indexed for MEDLINE]Related articles

Adeno-associated virus vector expressing nerve growth factor enhances cholinergic axonal sprouting after cortical injury in rats.

Ramirez JJ, Caldwell JL, Majure M, Wessner DR, Klein RL, Meyer EM, King MA.

J Neurosci. 2003 Apr 1;23(7):2797-803.PMID: 12684466 [PubMed - indexed for MEDLINE]Related articlesFree article

Serum lipoproteins in the diabetes control and complications trial/epidemiology of diabetes intervention and complications cohort: associations with gender and glycemia.

Jenkins AJ, Lyons TJ, Zheng D, Otvos JD, Lackland DT, McGee D, Garvey WT, Klein RL; DCC/EDIC Research Group.

Diabetes Care. 2003 Mar;26(3):810-8.PMID: 12610042 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of insulin resistance and type 2 diabetes on lipoprotein subclass particle size and concentration determined by nuclear magnetic resonance.

Garvey WT, Kwon S, Zheng D, Shaughnessy S, Wallace P, Hutto A, Pugh K, Jenkins AJ, Klein RL, Liao Y.

Diabetes. 2003 Feb;52(2):453-62.PMID: 12540621 [PubMed - indexed for MEDLINE]Related articlesFree article