PubMed

Substance P promotes expansion of human mesenteric preadipocytes through proliferative and antiapoptotic pathways.

Gross K, Karagiannides I, Thomou T, Koon HW, Bowe C, Kim H, Giorgadze N, Tchkonia T, Pirtskhalava T, Kirkland JL, Pothoulakis C.

Am J Physiol Gastrointest Liver Physiol. 2009 May;296(5):G1012-9. Epub 2009 Mar 12.PMID: 19282377 [PubMed - indexed for MEDLINE]Related articles

Healthspan, translation, and new outcomes for animal studies of aging.

Kirkland JL, Peterson C.

J Gerontol A Biol Sci Med Sci. 2009 Feb;64(2):209-12. Epub 2009 Feb 5. Review.PMID: 19196900 [PubMed - indexed for MEDLINE]Related articles

Effects of dihydrotestosterone on differentiation and proliferation of human mesenchymal stem cells and preadipocytes.

Gupta V, Bhasin S, Guo W, Singh R, Miki R, Chauhan P, Choong K, Tchkonia T, Lebrasseur NK, Flanagan JN, Hamilton JA, Viereck JC, Narula NS, Kirkland JL, Jasuja R.

Mol Cell Endocrinol. 2008 Dec 16;296(1-2):32-40. Epub 2008 Aug 28.PMID: 18801408 [PubMed - indexed for MEDLINE]Related articles

Inducible Toll-like receptor and NF-kappaB regulatory pathway expression in human adipose tissue.

Vitseva OI, Tanriverdi K, Tchkonia TT, Kirkland JL, McDonnell ME, Apovian CM, Freedman J, Gokce N.

Obesity (Silver Spring). 2008 May;16(5):932-7. Epub 2008 Feb 21.PMID: 18292749 [PubMed - indexed for MEDLINE]Related articles

Increased TNFalpha and CCAAT/enhancer-binding protein homologous protein with aging predispose preadipocytes to resist adipogenesis.

Tchkonia T, Pirtskhalava T, Thomou T, Cartwright MJ, Wise B, Karagiannides I, Shpilman A, Lash TL, Becherer JD, Kirkland JL.

Am J Physiol Endocrinol Metab. 2007 Dec;293(6):E1810-9. Epub 2007 Oct 2.PMID: 17911345 [PubMed - indexed for MEDLINE]Related articlesFree article

New scanning electron microscopic method for determination of adipocyte size in humans and mice.

Guo W, Bigornia S, Leizerman I, Xie W, McDonnell M, Clemente K, Pirtskhalava T, Kirkland JL, Gokce N, Corkey BE, Sullivan LM, Apovian CM.

Obesity (Silver Spring). 2007 Jul;15(7):1657-65.PMID: 17636083 [PubMed - indexed for MEDLINE]Related articles

Effects of dietary medium-chain triglyceride on weight loss and insulin sensitivity in a group of moderately overweight free-living type 2 diabetic Chinese subjects.

Han JR, Deng B, Sun J, Chen CG, Corkey BE, Kirkland JL, Ma J, Guo W.

Metabolism. 2007 Jul;56(7):985-91.PMID: 17570262 [PubMed - indexed for MEDLINE]Related articles

Aging in adipocytes: potential impact of inherent, depot-specific mechanisms.

Cartwright MJ, Tchkonia T, Kirkland JL.

Exp Gerontol. 2007 Jun;42(6):463-71. Epub 2007 Mar 25. Review.PMID: 17507194 [PubMed - indexed for MEDLINE]Related articlesFree article

Aging results in paradoxical susceptibility of fat cell progenitors to lipotoxicity.

Guo W, Pirtskhalava T, Tchkonia T, Xie W, Thomou T, Han J, Wang T, Wong S, Cartwright A, Hegardt FG, Corkey BE, Kirkland JL.

Am J Physiol Endocrinol Metab. 2007 Apr;292(4):E1041-51. Epub 2006 Dec 5.PMID: 17148751 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of depot-specific human fat cell progenitors through distinct expression profiles and developmental gene patterns.

Tchkonia T, Lenburg M, Thomou T, Giorgadze N, Frampton G, Pirtskhalava T, Cartwright A, Cartwright M, Flanagan J, Karagiannides I, Gerry N, Forse RA, Tchoukalova Y, Jensen MD, Pothoulakis C, Kirkland JL.

Am J Physiol Endocrinol Metab. 2007 Jan;292(1):E298-307. Epub 2006 Sep 19.PMID: 16985259 [PubMed - indexed for MEDLINE]Related articlesFree article

Fat depot-specific characteristics are retained in strains derived from single human preadipocytes.

Tchkonia T, Giorgadze N, Pirtskhalava T, Thomou T, DePonte M, Koo A, Forse RA, Chinnappan D, Martin-Ruiz C, von Zglinicki T, Kirkland JL.

Diabetes. 2006 Sep;55(9):2571-8.PMID: 16936206 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased CUG triplet repeat-binding protein-1 predisposes to impaired adipogenesis with aging.

Karagiannides I, Thomou T, Tchkonia T, Pirtskhalava T, Kypreos KE, Cartwright A, Dalagiorgou G, Lash TL, Farmer SR, Timchenko NA, Kirkland JL.

J Biol Chem. 2006 Aug 11;281(32):23025-33. Epub 2006 Jun 5.PMID: 16754681 [PubMed - indexed for MEDLINE]Related articlesFree article

Oleate-induced formation of fat cells with impaired insulin sensitivity.

Xie W, Hamilton JA, Kirkland JL, Corkey BE, Guo W.

Lipids. 2006 Mar;41(3):267-71.PMID: 16711601 [PubMed - indexed for MEDLINE]Related articles

Induction of colitis causes inflammatory responses in fat depots: evidence for substance P pathways in human mesenteric preadipocytes.

Karagiannides I, Kokkotou E, Tansky M, Tchkonia T, Giorgadze N, O'Brien M, Leeman SE, Kirkland JL, Pothoulakis C.

Proc Natl Acad Sci U S A. 2006 Mar 28;103(13):5207-12. Epub 2006 Mar 20.PMID: 16549770 [PubMed - indexed for MEDLINE]Related articlesFree article

Abundance of two human preadipocyte subtypes with distinct capacities for replication, adipogenesis, and apoptosis varies among fat depots.

Tchkonia T, Tchoukalova YD, Giorgadze N, Pirtskhalava T, Karagiannides I, Forse RA, Koo A, Stevenson M, Chinnappan D, Cartwright A, Jensen MD, Kirkland JL.

Am J Physiol Endocrinol Metab. 2005 Jan;288(1):E267-77. Epub 2004 Sep 21.PMID: 15383371 [PubMed - indexed for MEDLINE]Related articlesFree article

Medium-chain oil reduces fat mass and down-regulates expression of adipogenic genes in rats.

Han J, Hamilton JA, Kirkland JL, Corkey BE, Guo W.

Obes Res. 2003 Jun;11(6):734-44.PMID: 12805394 [PubMed - indexed for MEDLINE]Related articles

The biology of senescence: potential for prevention of disease.

Kirkland JL.

Clin Geriatr Med. 2002 Aug;18(3):383-405. Review.PMID: 12424865 [PubMed - indexed for MEDLINE]Related articles

Adipogenesis and aging: does aging make fat go MAD?

Kirkland JL, Tchkonia T, Pirtskhalava T, Han J, Karagiannides I.

Exp Gerontol. 2002 Jun;37(6):757-67. Review.PMID: 12175476 [PubMed - indexed for MEDLINE]Related articles

Interdisciplinary inpatient care for elderly people with hip fracture: a randomized controlled trial.

Naglie G, Tansey C, Kirkland JL, Ogilvie-Harris DJ, Detsky AS, Etchells E, Tomlinson G, O'Rourke K, Goldlist B.

CMAJ. 2002 Jul 9;167(1):25-32.PMID: 12137074 [PubMed - indexed for MEDLINE]Related articlesFree article

Octanoate attenuates adipogenesis in 3T3-L1 preadipocytes.

Han J, Farmer SR, Kirkland JL, Corkey BE, Yoon R, Pirtskhalava T, Ido Y, Guo W.

J Nutr. 2002 May;132(5):904-10.PMID: 11983812 [PubMed - indexed for MEDLINE]Related articlesFree article

Fat depot origin affects adipogenesis in primary cultured and cloned human preadipocytes.

Tchkonia T, Giorgadze N, Pirtskhalava T, Tchoukalova Y, Karagiannides I, Forse RA, DePonte M, Stevenson M, Guo W, Han J, Waloga G, Lash TL, Jensen MD, Kirkland JL.

Am J Physiol Regul Integr Comp Physiol. 2002 May;282(5):R1286-96.PMID: 11959668 [PubMed - indexed for MEDLINE]Related articles

Nutritional risk in an urban homebound older population. The nutrition and healthy aging project.

Millen BE, Silliman RA, Cantey-Kiser J, Copenhafer DL, Ewart CV, Ritchie CS, Quatromoni PA, Kirkland JL, Chipkin SR, Fearon NA, Lund ME, Garcia PI, Barry PP.

J Nutr Health Aging. 2001;5(4):269-77.PMID: 11753494 [PubMed - indexed for MEDLINE]Related articles

Controlling health care expenditures.

Kirkland JL.

N Engl J Med. 2001 Sep 6;345(10):771; author reply 771-2. No abstract available. PMID: 11547759 [PubMed - indexed for MEDLINE]Related articles

Altered expression of C/EBP family members results in decreased adipogenesis with aging.

Karagiannides I, Tchkonia T, Dobson DE, Steppan CM, Cummins P, Chan G, Salvatori K, Hadzopoulou-Cladaras M, Kirkland JL.

Am J Physiol Regul Integr Comp Physiol. 2001 Jun;280(6):R1772-80.PMID: 11353682 [PubMed - indexed for MEDLINE]Related articles

Fat depot origin affects fatty acid handling in cultured rat and human preadipocytes.

Caserta F, Tchkonia T, Civelek VN, Prentki M, Brown NF, McGarry JD, Forse RA, Corkey BE, Hamilton JA, Kirkland JL.

Am J Physiol Endocrinol Metab. 2001 Feb;280(2):E238-47.PMID: 11158926 [PubMed - indexed for MEDLINE]Related articlesFree article

Esterification of free fatty acids in adipocytes: a comparison between octanoate and oleate.

Guo W, Choi JK, Kirkland JL, Corkey BE, Hamilton JA.

Biochem J. 2000 Jul 15;349(Pt 2):463-71.PMID: 10880345 [PubMed - indexed for MEDLINE]Related articlesFree article

Improved inpatient billing metrics by physician-directed billing software.

Beckett PR, Spare WL, Kirkland JL.

J Health Care Finance. 2000 Summer;26(4):70-7.PMID: 10845388 [PubMed - indexed for MEDLINE]Related articles

Incorporation of [1-13C]oleate into cellular triglycerides in differentiating 3T3L1 cells.

Guo W, Choi JK, Kirkland JL, Corkey BE, Hamilton JA.

Lipids. 1999 Aug;34(8):825-31.PMID: 10529093 [PubMed - indexed for MEDLINE]Related articles

Read this--it's important.

Beckett PR, Kirkland JL.

Pediatrics. 1999 Sep;104(3 Pt 1):577. No abstract available. PMID: 10515768 [PubMed - indexed for MEDLINE]Related articles

Commentary: aging, differentiation-dependent gene expression, and fat cell function.

Kirkland JL.

J Gerontol A Biol Sci Med Sci. 1999 May;54(5):B189-90; discussion B191. No abstract available. PMID: 10361997 [PubMed - indexed for MEDLINE]Related articles

Inhibitors of preadipocyte replication: opportunities for the treatment of obesity.

Kirkland JL, Hollenberg CH.

Prog Mol Subcell Biol. 1998;20:177-95. Review. No abstract available. PMID: 9928531 [PubMed - indexed for MEDLINE]Related articles

A case of a laboratory animal feed with high estrogenic activity and its impact on in vivo responses to exogenously administered estrogens.

Boettger-Tong H, Murthy L, Chiappetta C, Kirkland JL, Goodwin B, Adlercreutz H, Stancel GM, Mäkelä S.

Environ Health Perspect. 1998 Jul;106(7):369-73. Review.PMID: 9637793 [PubMed - indexed for MEDLINE]Related articlesFree article

A 13C nuclear magnetic resonance study of free fatty acid incorporation in acylated lipids in differentiating preadipocytes.

Guo W, Kirkland JL, Corkey B, Hamilton JA.

Lipids. 1998 May;33(5):449-54.PMID: 9625591 [PubMed - indexed for MEDLINE]Related articles

Telephone charges and payments in a diabetes clinic.

Kirkland JL, Copeland KC.

Pediatrics. 1998 Apr;101(4):E2.PMID: 9521969 [PubMed - indexed for MEDLINE]Related articles

Frequency and necessity of thyroid function tests in neonates and infants with congenital hypothyroidism.

Vogiatzi MG, Kirkland JL.

Pediatrics. 1997 Sep;100(3):E6.PMID: 9271621 [PubMed - indexed for MEDLINE]Related articles

Phorbol ester inhibition of estrogen-induced uterine deoxyribonucleic acid synthesis.

Kirkland JL, Murthy L, Thomazy V, Hyder SM, Stancel GM.

Biol Reprod. 1998 Mar;58(3):778-85.PMID: 9510966 [PubMed - indexed for MEDLINE]Related articlesFree article

Mouse white adipocytes and 3T3-L1 cells display an anomalous pattern of carnitine palmitoyltransferase (CPT) I isoform expression during differentiation. Inter-tissue and inter-species expression of CPT I and CPT II enzymes.

Brown NF, Hill JK, Esser V, Kirkland JL, Corkey BE, Foster DW, McGarry JD.

Biochem J. 1997 Oct 1;327 ( Pt 1):225-31.PMID: 9355756 [PubMed - indexed for MEDLINE]Related articlesFree article

Preadipocyte function and aging: links between age-related changes in cell dynamics and altered fat tissue function.

Kirkland JL, Dobson DE.

J Am Geriatr Soc. 1997 Aug;45(8):959-67. Review.PMID: 9256849 [PubMed - indexed for MEDLINE]Related articles

Papillary thyroid cancer: a pediatric perspective.

Flannery TK, Kirkland JL, Copeland KC, Bertuch AA, Karaviti LP, Brandt ML.

Pediatrics. 1996 Sep;98(3 Pt 1):464-6. Review. No abstract available. PMID: 8784379 [PubMed - indexed for MEDLINE]Related articles

Increasing vimentin expression associated with differentiation of human and rat preadipocytes.

Teichert-Kuliszewska K, Hamilton BS, Roncari DA, Kirkland JL, Gillon WS, Deitel M, Hollenberg CH.

Int J Obes Relat Metab Disord. 1996 Mar;20 Suppl 3:S108-13.PMID: 8680470 [PubMed - indexed for MEDLINE]Related articles

Effects of fat depot site on differentiation-dependent gene expression in rat preadipocytes.

Kirkland JL, Hollenberg CH, Gillon WS.

Int J Obes Relat Metab Disord. 1996 Mar;20 Suppl 3:S102-7.PMID: 8680469 [PubMed - indexed for MEDLINE]Related articles

Glomerular dysfunction in the aging Fischer 344 rat is associated with excessive growth and normal mesangial cell function.

McDermott GF, Ingram A, Scholey J, Kirkland JL, Whiteside CI.

J Gerontol A Biol Sci Med Sci. 1996 Mar;51(2):M80-5.PMID: 8612108 [PubMed - indexed for MEDLINE]Related articles

Toxicity of endogenous and environmental estrogens: what is the role of elemental interactions?

Stancel GM, Boettger-Tong HL, Chiappetta C, Hyder SM, Kirkland JL, Murthy L, Loose-Mitchell DS.

Environ Health Perspect. 1995 Oct;103 Suppl 7:29-33. Review.PMID: 8593870 [PubMed - indexed for MEDLINE]Related articlesFree article

Do geriatric programs decrease long-term use of acute care beds?

Brymer CD, Kohm CA, Naglie G, Shekter-Wolfson L, Zorzitto ML, O'Rourke K, Kirkland JL.

J Am Geriatr Soc. 1995 Aug;43(8):885-9.PMID: 7636096 [PubMed - indexed for MEDLINE]Related articles

Adult height in girls with Turner syndrome treated with low-dose estrogens and androgens.

Lin TH, Kirkland RT, Kirkland JL.

Ann Pharmacother. 1994 May;28(5):570-1.PMID: 8068990 [PubMed - indexed for MEDLINE]Related articles

Long-chain fatty acids decrease lipoprotein lipase activity of cultured rat adipocyte precursors.

Kirkland JL, Hollenberg CH, Kindler S, Roncari DA.

Metabolism. 1994 Feb;43(2):144-51.PMID: 8121293 [PubMed - indexed for MEDLINE]Related articles

Effects of age and anatomic site on preadipocyte number in rat fat depots.

Kirkland JL, Hollenberg CH, Kindler S, Gillon WS.

J Gerontol. 1994 Jan;49(1):B31-5.PMID: 8282974 [PubMed - indexed for MEDLINE]Related articles

Ageing, differentiation, and gene expression in rat epididymal preadipocytes.

Kirkland JL, Hollenberg CH, Gillon WS.

Biochem Cell Biol. 1993 Nov-Dec;71(11-12):556-61.PMID: 8192892 [PubMed - indexed for MEDLINE]Related articles

Effects of aging on ribosomal protein L7 messenger RNA levels in cultured rat preadipocytes.

Kirkland JL, Hollenberg CH, Gillon WS.

Exp Gerontol. 1993 Nov-Dec;28(6):557-63.PMID: 8137892 [PubMed - indexed for MEDLINE]Related articles

Tamoxifen stimulates expression of the c-fos proto-oncogene in rodent uterus.

Kirkland JL, Murthy L, Stancel GM.

Mol Pharmacol. 1993 May;43(5):709-14.PMID: 8502228 [PubMed - indexed for MEDLINE]Related articles