PubMed

The PPAR-gamma agonist rosiglitazone facilitates Akt rephosphorylation and inhibits apoptosis in cardiomyocytes during hypoxia/reoxygenation.

Kilter H, Werner M, Roggia C, Reil JC, Schäfers HJ, Kintscher U, Böhm M.

Diabetes Obes Metab. 2009 Nov;11(11):1060-7. Epub 2009 Sep 3.PMID: 19732122 [PubMed - in process]Related articles

Chronic treatment with losartan results in sufficient serum levels of the metabolite EXP3179 for PPARgamma activation.

Kappert K, Tsuprykov O, Kaufmann J, Fritzsche J, Ott I, Goebel M, Bähr IN, Hässle PL, Gust R, Fleck E, Unger T, Stawowy P, Kintscher U.

Hypertension. 2009 Oct;54(4):738-43. Epub 2009 Aug 17.PMID: 19687349 [PubMed - indexed for MEDLINE]Related articles

ONTARGET, TRANSCEND, and PRoFESS: new-onset diabetes, atrial fibrillation, and left ventricular hypertrophy.

Kintscher U.

J Hypertens. 2009 Jun;27 Suppl 2:S36-9.PMID: 19491622 [PubMed - indexed for MEDLINE]Related articles

Characterization of new PPARgamma agonists: benzimidazole derivatives - the importance of position 2.

Goebel M, Staels B, Unger T, Kintscher U, Gust R.

ChemMedChem. 2009 Jul;4(7):1136-42.PMID: 19504532 [PubMed - indexed for MEDLINE]Related articles

Free fatty acids link metabolism and regulation of the insulin-sensitizing fibroblast growth factor-21.

Mai K, Andres J, Biedasek K, Weicht J, Bobbert T, Sabath M, Meinus S, Reinecke F, Möhlig M, Weickert MO, Clemenz M, Pfeiffer AF, Kintscher U, Spuler S, Spranger J.

Diabetes. 2009 Jul;58(7):1532-8. Epub 2009 Apr 28.PMID: 19401423 [PubMed - indexed for MEDLINE]Related articlesFree article

Estrogen receptor alpha supports cardiomyocytes indirectly through post-infarct cardiac c-kit+ cells.

Brinckmann M, Kaschina E, Altarche-Xifró W, Curato C, Timm M, Grzesiak A, Dong J, Kappert K, Kintscher U, Unger T, Li J.

J Mol Cell Cardiol. 2009 Jul;47(1):66-75. Epub 2009 Mar 31.PMID: 19341743 [PubMed - in process]Related articles

INT-131, a PPARgamma agonist for the treatment of type 2 diabetes.

Kintscher U, Goebel M.

Curr Opin Investig Drugs. 2009 Apr;10(4):381-7. Review.PMID: 19337960 [PubMed - indexed for MEDLINE]Related articles

Characterization of new PPARgamma agonists: analysis of telmisartan's structural components.

Goebel M, Clemenz M, Staels B, Unger T, Kintscher U, Gust R.

ChemMedChem. 2009 Mar;4(3):445-56.PMID: 19197922 [PubMed - indexed for MEDLINE]Related articles

Angiotensin II type 2 receptor stimulation: a novel option of therapeutic interference with the renin-angiotensin system in myocardial infarction?

Kaschina E, Grzesiak A, Li J, Foryst-Ludwig A, Timm M, Rompe F, Sommerfeld M, Kemnitz UR, Curato C, Namsolleck P, Tschöpe C, Hallberg A, Alterman M, Hucko T, Paetsch I, Dietrich T, Schnackenburg B, Graf K, Dahlöf B, Kintscher U, Unger T, Steckelings UM.

Circulation. 2008 Dec 9;118(24):2523-32. Epub 2008 Nov 24.PMID: 19029468 [PubMed - indexed for MEDLINE]Related articles

Inhibiting angiotensin type 1 receptors as a target for diabetes.

Kintscher U, Foryst-Ludwig A, Unger T.

Expert Opin Ther Targets. 2008 Oct;12(10):1257-63. Review.PMID: 18781824 [PubMed - indexed for MEDLINE]Related articles

Pharmacological differences of glitazones: does peroxisome proliferator-activated receptor-alpha activation make the difference?

Kintscher U.

J Am Coll Cardiol. 2008 Sep 2;52(10):882-4. Epub 2008 Jul 9. No abstract available. PMID: 18755354 [PubMed - indexed for MEDLINE]Related articles

Prorenin engages the (pro)renin receptor like renin and both ligand activities are unopposed by aliskiren.

Schefe JH, Neumann C, Goebel M, Danser J, Kirsch S, Gust R, Kintscher U, Unger T, Funke-Kaiser H.

J Hypertens. 2008 Sep;26(9):1787-94.PMID: 18698213 [PubMed - indexed for MEDLINE]Related articles

Metabolic actions of estrogen receptor beta (ERbeta) are mediated by a negative cross-talk with PPARgamma.

Foryst-Ludwig A, Clemenz M, Hohmann S, Hartge M, Sprang C, Frost N, Krikov M, Bhanot S, Barros R, Morani A, Gustafsson JA, Unger T, Kintscher U.

PLoS Genet. 2008 Jun 27;4(6):e1000108.PMID: 18584035 [PubMed - indexed for MEDLINE]Related articlesFree article

The cardiometabolic drug rimonabant: after 2 years of RIO-Europe and STRADIVARIUS.

Kintscher U.

Eur Heart J. 2008 Jul;29(14):1709-10. Epub 2008 Jun 13. No abstract available. PMID: 18556715 [PubMed - indexed for MEDLINE]Related articlesFree article

[Aliskiren hemifumarate]

Kappert K, Unger T, Kintscher U.

Dtsch Med Wochenschr. 2008 Jun;133(24):1308-12. Epub 2008 May 9. Review. German. PMID: 18465684 [PubMed - indexed for MEDLINE]Related articles

T-lymphocyte infiltration in visceral adipose tissue: a primary event in adipose tissue inflammation and the development of obesity-mediated insulin resistance.

Kintscher U, Hartge M, Hess K, Foryst-Ludwig A, Clemenz M, Wabitsch M, Fischer-Posovszky P, Barth TF, Dragun D, Skurk T, Hauner H, Blüher M, Unger T, Wolf AM, Knippschild U, Hombach V, Marx N.

Arterioscler Thromb Vasc Biol. 2008 Jul;28(7):1304-10. Epub 2008 Apr 17.PMID: 18420999 [PubMed - indexed for MEDLINE]Related articlesFree article

Comparison between single and combined treatment with candesartan and pioglitazone following transient focal ischemia in rat brain.

Schmerbach K, Schefe JH, Krikov M, Müller S, Villringer A, Kintscher U, Unger T, Thoene-Reineke C.

Brain Res. 2008 May 7;1208:225-33. Epub 2008 Mar 4.PMID: 18378216 [PubMed - indexed for MEDLINE]Related articles

Deoxycorticosterone acetate-salt mice exhibit blood pressure-independent sexual dimorphism.

Karatas A, Hegner B, de Windt LJ, Luft FC, Schubert C, Gross V, Akashi YJ, Gürgen D, Kintscher U, da Costa Goncalves AC, Regitz-Zagrosek V, Dragun D.

Hypertension. 2008 Apr;51(4):1177-83. Epub 2008 Feb 7.PMID: 18259006 [PubMed - indexed for MEDLINE]Related articlesFree article

Liver-specific peroxisome proliferator-activated receptor alpha target gene regulation by the angiotensin type 1 receptor blocker telmisartan.

Clemenz M, Frost N, Schupp M, Caron S, Foryst-Ludwig A, Böhm C, Hartge M, Gust R, Staels B, Unger T, Kintscher U.

Diabetes. 2008 May;57(5):1405-13. Epub 2008 Jan 9.PMID: 18184928 [PubMed - indexed for MEDLINE]Related articlesFree article

Telmisartan inhibits CD4-positive lymphocyte migration independent of the angiotensin type 1 receptor via peroxisome proliferator-activated receptor-gamma.

Walcher D, Hess K, Heinz P, Petscher K, Vasic D, Kintscher U, Clemenz M, Hartge M, Raps K, Hombach V, Marx N.

Hypertension. 2008 Feb;51(2):259-66. Epub 2007 Dec 24.PMID: 18158351 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin facilitates monocyte migration: a possible link to tissue inflammation in insulin-resistance.

Kappert K, Meyborg H, Clemenz M, Graf K, Fleck E, Kintscher U, Stawowy P.

Biochem Biophys Res Commun. 2008 Jan 18;365(3):503-8. Epub 2007 Nov 20.PMID: 17999918 [PubMed - indexed for MEDLINE]Related articles

The endothelium and vascular inflammation in diabetes.

Hartge MM, Unger T, Kintscher U.

Diab Vasc Dis Res. 2007 Jun;4(2):84-8. Review.PMID: 17654441 [PubMed - indexed for MEDLINE]Related articles

Does adiponectin resistance exist in chronic heart failure?

Kintscher U.

Eur Heart J. 2007 Jul;28(14):1676-7. Epub 2007 Jun 25. No abstract available. PMID: 17591684 [PubMed - indexed for MEDLINE]Related articlesFree article

Irbesartan for the treatment of hypertension in patients with the metabolic syndrome: a sub analysis of the Treat to Target post authorization survey. Prospective observational, two armed study in 14,200 patients.

Kintscher U, Bramlage P, Paar WD, Thoenes M, Unger T.

Cardiovasc Diabetol. 2007 Apr 3;6:12.PMID: 17407587 [PubMed - indexed for MEDLINE]Related articlesFree article

Optimal treatment of obesity-related hypertension: the Hypertension-Obesity-Sibutramine (HOS) study.

Scholze J, Grimm E, Herrmann D, Unger T, Kintscher U.

Circulation. 2007 Apr 17;115(15):1991-8. Epub 2007 Apr 2.PMID: 17404163 [PubMed - indexed for MEDLINE]Related articlesFree article

Endothelial dysfunction and its role in diabetic vascular disease.

Hartge MM, Kintscher U, Unger T.

Endocrinol Metab Clin North Am. 2006 Sep;35(3):551-60, viii-ix. Review.PMID: 16959585 [PubMed - indexed for MEDLINE]Related articles

The metabolic syndrome: cluster with a self-fulfilling loop?

Clemenz M, Kintscher U, Unger T.

J Hypertens. 2006 Feb;24(2):257-8. No abstract available. PMID: 16508565 [PubMed - indexed for MEDLINE]Related articles

Regulation of peroxisome proliferator-activated receptor gamma activity by losartan metabolites.

Schupp M, Lee LD, Frost N, Umbreen S, Schmidt B, Unger T, Kintscher U.

Hypertension. 2006 Mar;47(3):586-9. Epub 2005 Dec 19.PMID: 16365190 [PubMed - indexed for MEDLINE]Related articlesFree article

Cardiac PPARalpha expression in patients with dilated cardiomyopathy.

Schupp M, Kintscher U, Fielitz J, Thomas J, Pregla R, Hetzer R, Unger T, Regitz-Zagrosek V.

Eur J Heart Fail. 2006 May;8(3):290-4. Epub 2005 Nov 22.PMID: 16307905 [PubMed - indexed for MEDLINE]Related articles

Molecular characterization of new selective peroxisome proliferator-activated receptor gamma modulators with angiotensin receptor blocking activity.

Schupp M, Clemenz M, Gineste R, Witt H, Janke J, Helleboid S, Hennuyer N, Ruiz P, Unger T, Staels B, Kintscher U.

Diabetes. 2005 Dec;54(12):3442-52.PMID: 16306360 [PubMed - indexed for MEDLINE]Related articlesFree article

[Olmesartan after experimental myocardial infarct compared with ramipril: organ protective effect]

Kintscher U.

Krankenpfl J. 2005;43(4-6):112. German. No abstract available. PMID: 16171058 [PubMed - indexed for MEDLINE]Related articles

Does the AT2-receptor mediate anti-atherosclerotic actions?

Kintscher U, Unger T.

J Hypertens. 2005 Aug;23(8):1469-70. No abstract available. PMID: 16003170 [PubMed - indexed for MEDLINE]Related articles

Angiotensin II induces peroxisome proliferator-activated receptor gamma in PC12W cells via angiotensin type 2 receptor activation.

Zhao Y, Foryst-Ludwig A, Bruemmer D, Culman J, Bader M, Unger T, Kintscher U.

J Neurochem. 2005 Sep;94(5):1395-401. Epub 2005 Jun 30.PMID: 15992368 [PubMed - indexed for MEDLINE]Related articles

PPARgamma-activating angiotensin type-1 receptor blockers induce adiponectin.

Clasen R, Schupp M, Foryst-Ludwig A, Sprang C, Clemenz M, Krikov M, Thöne-Reineke C, Unger T, Kintscher U.

Hypertension. 2005 Jul;46(1):137-43. Epub 2005 Jun 6.PMID: 15939809 [PubMed - indexed for MEDLINE]Related articlesFree article

Vascular protection in diabetes: a pharmacological view of angiotensin II type 1 receptor blockers.

Kintscher U, Unger T.

Acta Diabetol. 2005 Apr;42 Suppl 1:S26-32. Review.PMID: 15868116 [PubMed - indexed for MEDLINE]Related articles

Angiotensin II type 1-receptor activating antibodies in renal-allograft rejection.

Dragun D, Müller DN, Bräsen JH, Fritsche L, Nieminen-Kelhä M, Dechend R, Kintscher U, Rudolph B, Hoebeke J, Eckert D, Mazak I, Plehm R, Schönemann C, Unger T, Budde K, Neumayer HH, Luft FC, Wallukat G.

N Engl J Med. 2005 Feb 10;352(6):558-69.PMID: 15703421 [PubMed - indexed for MEDLINE]Related articlesFree article

PPARgamma-mediated insulin sensitization: the importance of fat versus muscle.

Kintscher U, Law RE.

Am J Physiol Endocrinol Metab. 2005 Feb;288(2):E287-91. Review.PMID: 15637349 [PubMed - indexed for MEDLINE]Related articlesFree article

Angiotensin type 1 receptor blockers induce peroxisome proliferator-activated receptor-gamma activity.

Schupp M, Janke J, Clasen R, Unger T, Kintscher U.

Circulation. 2004 May 4;109(17):2054-7. Epub 2004 Apr 26.PMID: 15117841 [PubMed - indexed for MEDLINE]Related articlesFree article

Angiotensin II, PPAR-gamma and atherosclerosis.

Kintscher U, Lyon CJ, Law RE.

Front Biosci. 2004 Jan 1;9:359-69. Review.PMID: 14766373 [PubMed - indexed for MEDLINE]Related articles

Angiotensin II-accelerated atherosclerosis and aneurysm formation is attenuated in osteopontin-deficient mice.

Bruemmer D, Collins AR, Noh G, Wang W, Territo M, Arias-Magallona S, Fishbein MC, Blaschke F, Kintscher U, Graf K, Law RE, Hsueh WA.

J Clin Invest. 2003 Nov;112(9):1318-31.PMID: 14597759 [PubMed - indexed for MEDLINE]Related articlesFree article

Angiotensin II receptor expression: from maturation to pathogenesis.

Kintscher U, Unger T.

Am J Physiol Regul Integr Comp Physiol. 2003 Jul;285(1):R26-7. Review. No abstract available. PMID: 12793989 [PubMed - indexed for MEDLINE]Related articles

p38 MAP kinase negatively regulates angiotensin II-mediated effects on cell cycle molecules in human coronary smooth muscle cells.

Kintscher U, Bruemmer D, Blaschke F, Unger T, Law RE.

Biochem Biophys Res Commun. 2003 Jun 6;305(3):552-6.PMID: 12763029 [PubMed - indexed for MEDLINE]Related articles

A non-thiazolidinedione partial peroxisome proliferator-activated receptor gamma ligand inhibits vascular smooth muscle cell growth.

Bruemmer D, Berger JP, Liu J, Kintscher U, Wakino S, Fleck E, Moller DE, Law RE.

Eur J Pharmacol. 2003 Apr 18;466(3):225-34.PMID: 12694805 [PubMed - indexed for MEDLINE]Related articles

Statins regulate alpha2beta1-integrin expression and collagen I-dependent functions in human vascular smooth muscle cells.

Graf K, Kappert K, Stawowy P, Bokemeyer J, Blaschke F, Schmidt G, Kintscher U, Goetze S, Fleck E.

J Cardiovasc Pharmacol. 2003 Jan;41(1):89-96.PMID: 12500026 [PubMed - indexed for MEDLINE]Related articles

PPARalpha inhibits TGF-beta-induced beta5 integrin transcription in vascular smooth muscle cells by interacting with Smad4.

Kintscher U, Lyon C, Wakino S, Bruemmer D, Feng X, Goetze S, Graf K, Moustakas A, Staels B, Fleck E, Hsueh WA, Law RE.

Circ Res. 2002 Nov 29;91(11):e35-44.PMID: 12456495 [PubMed - indexed for MEDLINE]Related articlesFree article

Leptin induces endothelial cell migration through Akt, which is inhibited by PPARgamma-ligands.

Goetze S, Bungenstock A, Czupalla C, Eilers F, Stawowy P, Kintscher U, Spencer-Hänsch C, Graf K, Nürnberg B, Law RE, Fleck E, Gräfe M.

Hypertension. 2002 Nov;40(5):748-54.PMID: 12411472 [PubMed - indexed for MEDLINE]Related articlesFree article

TGF-beta(1) induces peroxisome proliferator-activated receptor gamma1 and gamma2 expression in human THP-1 monocytes.

Kintscher U, Wakino S, Bruemmer D, Goetze S, Graf K, Hsueh WA, Law RE.

Biochem Biophys Res Commun. 2002 Oct 4;297(4):794-9.PMID: 12359222 [PubMed - indexed for MEDLINE]Related articles

Hypoxia activates beta(1)-integrin via ERK 1/2 and p38 MAP kinase in human vascular smooth muscle cells.

Blaschke F, Stawowy P, Goetze S, Hintz O, Gräfe M, Kintscher U, Fleck E, Graf K.

Biochem Biophys Res Commun. 2002 Aug 30;296(4):890-6.PMID: 12200131 [PubMed - indexed for MEDLINE]Related articles

Angiotensin II-augmented migration of VSMCs towards PDGF-BB involves Pyk2 and ERK 1/2 activation.

Blaschke F, Stawowy P, Kappert K, Goetze S, Kintscher U, Wollert-Wulf B, Fleck E, Graf K.

Basic Res Cardiol. 2002 Jul;97(4):334-42.PMID: 12111044 [PubMed - indexed for MEDLINE]Related articles

PPAR activators inhibit endothelial cell migration by targeting Akt.

Goetze S, Eilers F, Bungenstock A, Kintscher U, Stawowy P, Blaschke F, Graf K, Law RE, Fleck E, Gräfe M.

Biochem Biophys Res Commun. 2002 May 24;293(5):1431-7.PMID: 12054675 [PubMed - indexed for MEDLINE]Related articles