PubMed

Glucocorticoid signaling in the cell.

Chrousos GP, Kino T.

Ann N Y Acad Sci. 2009 Oct;1179:153-66.PMID: 19906238 [PubMed - in process]Related articles

The human glucocorticoid receptor: Molecular basis of biologic function.

Nicolaides NC, Galata Z, Kino T, Chrousos GP, Charmandari E.

Steroids. 2009 Oct 7. [Epub ahead of print]PMID: 19818358 [PubMed - as supplied by publisher]Related articles

Identification of natural human glucocorticoid receptor (hGR) mutations or polymorphisms and their functional consequences at the hormone-receptor interaction level.

Charmandari E, Chrousos GP, Kino T.

Methods Mol Biol. 2009;590:33-60.PMID: 19763496 [PubMed - in process]Related articles

Human glucocorticoid receptor isoform beta: recent understanding of its potential implications in physiology and pathophysiology.

Kino T, Su YA, Chrousos GP.

Cell Mol Life Sci. 2009 Nov;66(21):3435-48. Epub 2009 Jul 26.PMID: 19633971 [PubMed - in process]Related articles

Evaluation of the hypothalamic-pituitary-adrenal axis function in childhood and adolescence.

Chrousos GP, Kino T, Charmandari E.

Neuroimmunomodulation. 2009;16(5):272-83. Epub 2009 Jun 29. Review.PMID: 19571588 [PubMed - indexed for MEDLINE]Related articles

Glucocorticoid receptor (GR) beta has intrinsic, GRalpha-independent transcriptional activity.

Kino T, Manoli I, Kelkar S, Wang Y, Su YA, Chrousos GP.

Biochem Biophys Res Commun. 2009 Apr 17;381(4):671-5. Epub 2009 Feb 25.PMID: 19248771 [PubMed - indexed for MEDLINE]Related articles

Brx mediates the response of lymphocytes to osmotic stress through the activation of NFAT5.

Kino T, Takatori H, Manoli I, Wang Y, Tiulpakov A, Blackman MR, Su YA, Chrousos GP, DeCherney AH, Segars JH.

Sci Signal. 2009 Feb 10;2(57):ra5.PMID: 19211510 [PubMed - indexed for MEDLINE]Related articles

Circadian rhythm transcription factor CLOCK regulates the transcriptional activity of the glucocorticoid receptor by acetylating its hinge region lysine cluster: potential physiological implications.

Nader N, Chrousos GP, Kino T.

FASEB J. 2009 May;23(5):1572-83. Epub 2009 Jan 13.PMID: 19141540 [PubMed - indexed for MEDLINE]Related articles

Enhanced adult neurogenesis and angiogenesis and altered affective behaviors in mice overexpressing vascular endothelial growth factor 120.

Udo H, Yoshida Y, Kino T, Ohnuki K, Mizunoya W, Mukuda T, Sugiyama H.

J Neurosci. 2008 Dec 31;28(53):14522-36.PMID: 19118187 [PubMed - indexed for MEDLINE]Related articlesFree article

A novel point mutation in the amino terminal domain of the human glucocorticoid receptor (hGR) gene enhancing hGR-mediated gene expression.

Charmandari E, Ichijo T, Jubiz W, Baid S, Zachman K, Chrousos GP, Kino T.

J Clin Endocrinol Metab. 2008 Dec;93(12):4963-8. Epub 2008 Sep 30.PMID: 18827003 [PubMed - indexed for MEDLINE]Related articles

Spinal dural arteriovenous fistula with hematomyelia caused by intraparenchymal varix of draining vein.

Minami M, Hanakita J, Takahashi T, Kitahama Y, Onoue S, Kino T, Ito K, Ezaki Y.

Spine J. 2009 Apr;9(4):e15-9. Epub 2008 Aug 30.PMID: 18757248 [PubMed - indexed for MEDLINE]Related articles

Generalized glucocorticoid resistance: clinical aspects, molecular mechanisms, and implications of a rare genetic disorder.

Charmandari E, Kino T, Ichijo T, Chrousos GP.

J Clin Endocrinol Metab. 2008 May;93(5):1563-72. Epub 2008 Mar 4. Review.PMID: 18319312 [PubMed - indexed for MEDLINE]Related articlesFree article

Activated glucocorticoid receptor interacts with the INHAT component Set/TAF-Ibeta and releases it from a glucocorticoid-responsive gene promoter, relieving repression: implications for the pathogenesis of glucocorticoid resistance in acute undifferentiated leukemia with Set-Can translocation.

Ichijo T, Chrousos GP, Kino T.

Mol Cell Endocrinol. 2008 Feb 13;283(1-2):19-31. Epub 2007 Nov 17.PMID: 18096310 [PubMed - indexed for MEDLINE]Related articlesFree article

Ascorbate analogs for use in medical imaging: synthesis and radical scavenging activity of 5-O-(4'-iodobenzyl)-L-ascorbic acid.

Kato H, Kino T, Yamamoto F, Kaneshiro T, Mukai T, Maeda M.

Chem Pharm Bull (Tokyo). 2007 Dec;55(12):1700-3.PMID: 18057742 [PubMed - indexed for MEDLINE]Related articlesFree article

Human immunodeficiency virus (HIV)-1 viral protein R suppresses transcriptional activity of peroxisome proliferator-activated receptor {gamma} and inhibits adipocyte differentiation: implications for HIV-associated lipodystrophy.

Shrivastav S, Kino T, Cunningham T, Ichijo T, Schubert U, Heinklein P, Chrousos GP, Kopp JB.

Mol Endocrinol. 2008 Feb;22(2):234-47. Epub 2007 Oct 11.PMID: 17932108 [PubMed - indexed for MEDLINE]Related articlesFree article

A novel point mutation in helix 11 of the ligand-binding domain of the human glucocorticoid receptor gene causing generalized glucocorticoid resistance.

Charmandari E, Kino T, Ichijo T, Jubiz W, Mejia L, Zachman K, Chrousos GP.

J Clin Endocrinol Metab. 2007 Oct;92(10):3986-90. Epub 2007 Jul 17.PMID: 17635946 [PubMed - indexed for MEDLINE]Related articlesFree article

Novel causes of generalized glucocorticoid resistance.

Charmandari E, Kino T.

Horm Metab Res. 2007 Jun;39(6):445-50. Review.PMID: 17578762 [PubMed - indexed for MEDLINE]Related articles

Tissue glucocorticoid sensitivity: beyond stochastic regulation on the diverse actions of glucocorticoids.

Kino T.

Horm Metab Res. 2007 Jun;39(6):420-4. Review.PMID: 17578758 [PubMed - indexed for MEDLINE]Related articles

Glucocorticoid action networks and complex psychiatric and/or somatic disorders.

Chrousos GP, Kino T.

Stress. 2007 Jun;10(2):213-9. Review.PMID: 17514590 [PubMed - indexed for MEDLINE]Related articles

The PPARdelta agonist GW501516 suppresses interleukin-6-mediated hepatocyte acute phase reaction via STAT3 inhibition.

Kino T, Rice KC, Chrousos GP.

Eur J Clin Invest. 2007 May;37(5):425-33.PMID: 17461989 [PubMed - indexed for MEDLINE]Related articles

3-O-Formyl-20R,21-epoxyresibufogenin suppresses IL-6-type cytokine actions by targeting the glycoprotein 130 subunit: potential clinical implications.

Kino T, Boos TL, Sulima A, Siegel EM, Gold PW, Rice KC, Chrousos GP.

J Allergy Clin Immunol. 2007 Aug;120(2):437-44. Epub 2007 Apr 23.PMID: 17451794 [PubMed - indexed for MEDLINE]Related articles

Cyclin-dependent kinase 5 differentially regulates the transcriptional activity of the glucocorticoid receptor through phosphorylation: clinical implications for the nervous system response to glucocorticoids and stress.

Kino T, Ichijo T, Amin ND, Kesavapany S, Wang Y, Kim N, Rao S, Player A, Zheng YL, Garabedian MJ, Kawasaki E, Pant HC, Chrousos GP.

Mol Endocrinol. 2007 Jul;21(7):1552-68. Epub 2007 Apr 17.PMID: 17440046 [PubMed - indexed for MEDLINE]Related articlesFree article

Virus-mediated modulation of the host endocrine signaling systems: clinical implications.

Kino T, Chrousos GP.

Trends Endocrinol Metab. 2007 May-Jun;18(4):159-66. Epub 2007 Apr 2. Review.PMID: 17400471 [PubMed - indexed for MEDLINE]Related articles

Rising incidence of primary central nervous system lymphoma in Kumamoto, Japan.

Makino K, Nakamura H, Kino T, Takeshima H, Kuratsu J.

Surg Neurol. 2006 Nov;66(5):503-6.PMID: 17084198 [PubMed - indexed for MEDLINE]Related articles

Effects of transgenic expression of HIV-1 Vpr on lipid and energy metabolism in mice.

Balasubramanyam A, Mersmann H, Jahoor F, Phillips TM, Sekhar RV, Schubert U, Brar B, Iyer D, Smith EO, Takahashi H, Lu H, Anderson P, Kino T, Henklein P, Kopp JB.

Am J Physiol Endocrinol Metab. 2007 Jan;292(1):E40-8. Epub 2006 Aug 1.PMID: 16882932 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibitory effects of pasuchaca (Geranium dielsiaum) extract on alpha-glucosidase in mouse.

Karato M, Yamaguchi K, Takei S, Kino T, Yazawa K.

Biosci Biotechnol Biochem. 2006 Jun;70(6):1482-4.PMID: 16794329 [PubMed - indexed for MEDLINE]Related articlesFree article

Rho family Guanine nucleotide exchange factor Brx couples extracellular signals to the glucocorticoid signaling system.

Kino T, Souvatzoglou E, Charmandari E, Ichijo T, Driggers P, Mayers C, Alatsatianos A, Manoli I, Westphal H, Chrousos GP, Segars JH.

J Biol Chem. 2006 Apr 7;281(14):9118-26. Epub 2006 Feb 8.PMID: 16469733 [PubMed - indexed for MEDLINE]Related articlesFree article

Functional characterization of the natural human glucocorticoid receptor (hGR) mutants hGRalphaR477H and hGRalphaG679S associated with generalized glucocorticoid resistance.

Charmandari E, Kino T, Ichijo T, Zachman K, Alatsatianos A, Chrousos GP.

J Clin Endocrinol Metab. 2006 Apr;91(4):1535-43. Epub 2006 Jan 31.PMID: 16449337 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucocorticoid receptor mutants demonstrate increased motility inside the nucleus of living cells: time of fluorescence recovery after photobleaching (FRAP) is an integrated measure of receptor function.

Kino T, Liou SH, Charmandari E, Chrousos GP.

Mol Med. 2004 Jul-Dec;10(7-12):80-8.PMID: 16307173 [PubMed - indexed for MEDLINE]Related articlesFree article

The Smad6-histone deacetylase 3 complex silences the transcriptional activity of the glucocorticoid receptor: potential clinical implications.

Ichijo T, Voutetakis A, Cotrim AP, Bhattachryya N, Fujii M, Chrousos GP, Kino T.

J Biol Chem. 2005 Dec 23;280(51):42067-77. Epub 2005 Oct 25.PMID: 16249187 [PubMed - indexed for MEDLINE]Related articlesFree article

Intracellular glucocorticoid signaling: a formerly simple system turns stochastic.

Chrousos GP, Kino T.

Sci STKE. 2005 Oct 4;2005(304):pe48. Review.PMID: 16204701 [PubMed - indexed for MEDLINE]Related articles

Statin-induced blockade of prenylation alters nucleocytoplasmic shuttling of GTP-binding proteins gamma2 and beta2 and enhances their suppressive effect on glucocorticoid receptor transcriptional activity.

Kino T, Kozasa T, Chrousos GP.

Eur J Clin Invest. 2005 Aug;35(8):508-13.PMID: 16101671 [PubMed - indexed for MEDLINE]Related articles

Interactive functional specificity of the stress and immune responses: the ying, the yang, and the defense against 2 major classes of bacteria.

Chrousos GP, Kino T.

J Infect Dis. 2005 Aug 15;192(4):551-5. Epub 2005 Jul 15. No abstract available. PMID: 16028122 [PubMed - indexed for MEDLINE]Related articles

Human renal mesangial cells produce aldosterone in response to low-density lipoprotein (LDL).

Nishikawa T, Suematsu S, Saito J, Soyama A, Ito H, Kino T, Chrousos G.

J Steroid Biochem Mol Biol. 2005 Aug;96(3-4):309-16.PMID: 15993578 [PubMed - indexed for MEDLINE]Related articles

G protein beta interacts with the glucocorticoid receptor and suppresses its transcriptional activity in the nucleus.

Kino T, Tiulpakov A, Ichijo T, Chheng L, Kozasa T, Chrousos GP.

J Cell Biol. 2005 Jun 20;169(6):885-96. Epub 2005 Jun 13.PMID: 15955845 [PubMed - indexed for MEDLINE]Related articlesFree article

Monoamine oxidase-A is a major target gene for glucocorticoids in human skeletal muscle cells.

Manoli I, Le H, Alesci S, McFann KK, Su YA, Kino T, Chrousos GP, Blackman MR.

FASEB J. 2005 Aug;19(10):1359-61. Epub 2005 Jun 9.PMID: 15946989 [PubMed - indexed for MEDLINE]Related articlesFree article

Ikaros transcription factors: flying between stress and inflammation.

Chrousos GP, Kino T.

J Clin Invest. 2005 Apr;115(4):844-8.PMID: 15841175 [PubMed - indexed for MEDLINE]Related articlesFree article

A novel point mutation in the ligand-binding domain (LBD) of the human glucocorticoid receptor (hGR) causing generalized glucocorticoid resistance: the importance of the C terminus of hGR LBD in conferring transactivational activity.

Charmandari E, Raji A, Kino T, Ichijo T, Tiulpakov A, Zachman K, Chrousos GP.

J Clin Endocrinol Metab. 2005 Jun;90(6):3696-705. Epub 2005 Mar 15.PMID: 15769988 [PubMed - indexed for MEDLINE]Related articlesFree article

The human glucocorticoid receptor (GR) isoform {beta} differentially suppresses GR{alpha}-induced transactivation stimulated by synthetic glucocorticoids.

Fruchter O, Kino T, Zoumakis E, Alesci S, De Martino M, Chrousos G, Hochberg Z.

J Clin Endocrinol Metab. 2005 Jun;90(6):3505-9. Epub 2005 Mar 8.PMID: 15755863 [PubMed - indexed for MEDLINE]Related articlesFree article

Vpr protein of human immunodeficiency virus type 1 binds to 14-3-3 proteins and facilitates complex formation with Cdc25C: implications for cell cycle arrest.

Kino T, Gragerov A, Valentin A, Tsopanomihalou M, Ilyina-Gragerova G, Erwin-Cohen R, Chrousos GP, Pavlakis GN.

J Virol. 2005 Mar;79(5):2780-7.PMID: 15708996 [PubMed - indexed for MEDLINE]Related articlesFree article

FLASH interacts with p160 coactivator subtypes and differentially suppresses transcriptional activity of steroid hormone receptors.

Kino T, Ichijo T, Chrousos GP.

J Steroid Biochem Mol Biol. 2004 Dec;92(5):357-63. Epub 2004 Dec 19.PMID: 15698540 [PubMed - indexed for MEDLINE]Related articles

HIV-1 accessory protein Vpr inhibits the effect of insulin on the Foxo subfamily of forkhead transcription factors by interfering with their binding to 14-3-3 proteins: potential clinical implications regarding the insulin resistance of HIV-1-infected patients.

Kino T, De Martino MU, Charmandari E, Ichijo T, Outas T, Chrousos GP.

Diabetes. 2005 Jan;54(1):23-31.PMID: 15616007 [PubMed - indexed for MEDLINE]Related articlesFree article

Modulatory effects of L-carnitine on glucocorticoid receptor activity.

Manoli I, De Martino MU, Kino T, Alesci S.

Ann N Y Acad Sci. 2004 Nov;1033:147-57. Review.PMID: 15591012 [PubMed - indexed for MEDLINE]Related articles

Combating atherosclerosis with LXR alpha and PPAR alpha agonists: is rational multitargeted polypharmacy the future of therapeutics in complex diseases?

Kino T, Chrousos GP.

Mol Interv. 2004 Oct;4(5):254-7. No abstract available. PMID: 15471908 [PubMed - indexed for MEDLINE]Related articlesFree article

The human glucocorticoid receptor (hGR) beta isoform suppresses the transcriptional activity of hGRalpha by interfering with formation of active coactivator complexes.

Charmandari E, Chrousos GP, Ichijo T, Bhattacharyya N, Vottero A, Souvatzoglou E, Kino T.

Mol Endocrinol. 2005 Jan;19(1):52-64. Epub 2004 Sep 30.PMID: 15459252 [PubMed - indexed for MEDLINE]Related articlesFree article

Familial/sporadic glucocorticoid resistance: clinical phenotype and molecular mechanisms.

Charmandari E, Kino T, Chrousos GP.

Ann N Y Acad Sci. 2004 Jun;1024:168-81. Review.PMID: 15265781 [PubMed - indexed for MEDLINE]Related articles

Human immunodeficiency virus type-1 accessory protein Vpr: a causative agent of the AIDS-related insulin resistance/lipodystrophy syndrome?

Kino T, Chrousos GP.

Ann N Y Acad Sci. 2004 Jun;1024:153-67. Review.PMID: 15265780 [PubMed - indexed for MEDLINE]Related articles

L-Carnitine is a modulator of the glucocorticoid receptor alpha.

Alesci S, De Martino MU, Kino T, Ilias I.

Ann N Y Acad Sci. 2004 Jun;1024:147-52. Review.PMID: 15265779 [PubMed - indexed for MEDLINE]Related articles

Interaction of the glucocorticoid receptor and the chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII): implications for the actions of glucocorticoids on glucose, lipoprotein, and xenobiotic metabolism.

De Martino MU, Alesci S, Chrousos GP, Kino T.

Ann N Y Acad Sci. 2004 Jun;1024:72-85. Review.PMID: 15265774 [PubMed - indexed for MEDLINE]Related articles

Glucocorticoids and their actions: an introduction.

Charmandari E, Kino T, Chrousos GP.

Ann N Y Acad Sci. 2004 Jun;1024:1-8. No abstract available. PMID: 15265770 [PubMed - indexed for MEDLINE]Related articles