PubMed

Activation of PKC-delta and SHP-1 by hyperglycemia causes vascular cell apoptosis and diabetic retinopathy.

Geraldes P, Hiraoka-Yamamoto J, Matsumoto M, Clermont A, Leitges M, Marette A, Aiello LP, Kern TS, King GL.

Nat Med. 2009 Nov;15(11):1298-306. Epub 2009 Nov 1.PMID: 19881493 [PubMed - in process]Related articles

Phosphoinositide 3-kinase Akt signaling pathway interacts with protein kinase Cbeta2 in the regulation of physiologic developmental hypertrophy and heart function.

Rigor DL, Bodyak N, Bae S, Choi JH, Zhang L, Ter-Ovanesyan D, He Z, McMullen JR, Shioi T, Izumo S, King GL, Kang PM.

Am J Physiol Heart Circ Physiol. 2009 Mar;296(3):H566-72. Epub 2009 Jan 2.PMID: 19122165 [PubMed - indexed for MEDLINE]Related articles

Insulin regulates SOCS2 expression and the mitogenic effect of IGF-1 in mesangial cells.

Isshiki K, He Z, Maeno Y, Ma RC, Yasuda Y, Kuroki T, White GS, Patti ME, Weir GC, King GL.

Kidney Int. 2008 Dec;74(11):1434-43. Epub 2008 Aug 13.PMID: 19008912 [PubMed - indexed for MEDLINE]Related articlesFree article

Selective regulation of heme oxygenase-1 expression and function by insulin through IRS1/phosphoinositide 3-kinase/Akt-2 pathway.

Geraldes P, Yagi K, Ohshiro Y, He Z, Maeno Y, Yamamoto-Hiraoka J, Rask-Madsen C, Chung SW, Perrella MA, King GL.

J Biol Chem. 2008 Dec 5;283(49):34327-36. Epub 2008 Oct 14.PMID: 18854316 [PubMed - indexed for MEDLINE]Related articles

The role of inflammatory cytokines in diabetes and its complications.

King GL.

J Periodontol. 2008 Aug;79(8 Suppl):1527-34. Review.PMID: 18673007 [PubMed - indexed for MEDLINE]Related articles

Promoter polymorphism of the erythropoietin gene in severe diabetic eye and kidney complications.

Tong Z, Yang Z, Patel S, Chen H, Gibbs D, Yang X, Hau VS, Kaminoh Y, Harmon J, Pearson E, Buehler J, Chen Y, Yu B, Tinkham NH, Zabriskie NA, Zeng J, Luo L, Sun JK, Prakash M, Hamam RN, Tonna S, Constantine R, Ronquillo CC, Sadda S, Avery RL, Brand JM, London N, Anduze AL, King GL, Bernstein PS, Watkins S; Genetics of Diabetes and Diabetic Complication Study Group, Jorde LB, Li DY, Aiello LP, Pollak MR, Zhang K.

Proc Natl Acad Sci U S A. 2008 May 13;105(19):6998-7003. Epub 2008 May 5.PMID: 18458324 [PubMed - indexed for MEDLINE]Related articlesFree article

More sugar, less blood vessels: another piece in the puzzle of increased cardiovascular risk in diabetes.

Rask-Madsen C, King GL.

Arterioscler Thromb Vasc Biol. 2008 Apr;28(4):608-10. No abstract available. PMID: 18354093 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential regulation of VEGF signaling by PKC-alpha and PKC-epsilon in endothelial cells.

Rask-Madsen C, King GL.

Arterioscler Thromb Vasc Biol. 2008 May;28(5):919-24. Epub 2008 Mar 6.PMID: 18323518 [PubMed - indexed for MEDLINE]Related articlesFree article

Hepatic insulin resistance is sufficient to produce dyslipidemia and susceptibility to atherosclerosis.

Biddinger SB, Hernandez-Ono A, Rask-Madsen C, Haas JT, Alemán JO, Suzuki R, Scapa EF, Agarwal C, Carey MC, Stephanopoulos G, Cohen DE, King GL, Ginsberg HN, Kahn CR.

Cell Metab. 2008 Feb;7(2):125-34.PMID: 18249172 [PubMed - indexed for MEDLINE]Related articles

Glypican 4, a membrane binding protein for bactericidal/permeability-increasing protein signaling pathways in retinal pigment epithelial cells.

Geraldes P, Yamagata M, Rook SL, Sassa Y, Ma RC, Clermont A, Gao B, Aiello LP, Feener EP, King GL.

Invest Ophthalmol Vis Sci. 2007 Dec;48(12):5750-5.PMID: 18055828 [PubMed - indexed for MEDLINE]Related articlesFree article

The role of protein kinase C activation in diabetic nephropathy.

Noh H, King GL.

Kidney Int Suppl. 2007 Aug;(106):S49-53. Review.PMID: 17653211 [PubMed - indexed for MEDLINE]Related articles

The role of protein kinase C activation and the vascular complications of diabetes.

Das Evcimen N, King GL.

Pharmacol Res. 2007 Jun;55(6):498-510. Epub 2007 May 5. Review.PMID: 17574431 [PubMed - indexed for MEDLINE]Related articles

Clinical factors associated with resistance to microvascular complications in diabetic patients of extreme disease duration: the 50-year medalist study.

Keenan HA, Costacou T, Sun JK, Doria A, Cavellerano J, Coney J, Orchard TJ, Aiello LP, King GL.

Diabetes Care. 2007 Aug;30(8):1995-7. Epub 2007 May 16. No abstract available. PMID: 17507696 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of insulin replacements, inhibitors of angiotensin, and PKCbeta's actions to normalize cardiac gene expression and fuel metabolism in diabetic rats.

Arikawa E, Ma RC, Isshiki K, Luptak I, He Z, Yasuda Y, Maeno Y, Patti ME, Weir GC, Harris RA, Zammit VA, Tian R, King GL.

Diabetes. 2007 May;56(5):1410-20. Epub 2007 Mar 15.PMID: 17363743 [PubMed - indexed for MEDLINE]Related articlesFree article

Downregulation of GLP-1 and GIP receptor expression by hyperglycemia: possible contribution to impaired incretin effects in diabetes.

Xu G, Kaneto H, Laybutt DR, Duvivier-Kali VF, Trivedi N, Suzuma K, King GL, Weir GC, Bonner-Weir S.

Diabetes. 2007 Jun;56(6):1551-8. Epub 2007 Mar 14.PMID: 17360984 [PubMed - indexed for MEDLINE]Related articlesFree article

Summary statement IV: Obesity and diabetes: opportunities for translation of basic research.

Engelgau MM, Vinicor F, Simionescu M, King GL, Meininger C, Mensah GA.

Vascul Pharmacol. 2007 May;46(5):324-6. Epub 2006 Nov 24.PMID: 17275418 [PubMed - indexed for MEDLINE]Related articles

Mechanisms of Disease: endothelial dysfunction in insulin resistance and diabetes.

Rask-Madsen C, King GL.

Nat Clin Pract Endocrinol Metab. 2007 Jan;3(1):46-56. Review.PMID: 17179929 [PubMed - indexed for MEDLINE]Related articles

Reduction of diabetes-induced oxidative stress, fibrotic cytokine expression, and renal dysfunction in protein kinase Cbeta-null mice.

Ohshiro Y, Ma RC, Yasuda Y, Hiraoka-Yamamoto J, Clermont AC, Isshiki K, Yagi K, Arikawa E, Kern TS, King GL.

Diabetes. 2006 Nov;55(11):3112-20.PMID: 17065350 [PubMed - indexed for MEDLINE]Related articlesFree article

Clinical safety of the selective PKC-beta inhibitor, ruboxistaurin.

McGill JB, King GL, Berg PH, Price KL, Kles KA, Bastyr EJ, Hyslop DL.

Expert Opin Drug Saf. 2006 Nov;5(6):835-45. Review.PMID: 17044810 [PubMed - indexed for MEDLINE]Related articles

Bactericidal/permeability-increasing protein's signaling pathways and its retinal trophic and anti-angiogenic effects.

Yamagata M, Rook SL, Sassa Y, Ma RC, Geraldes P, Goddard L, Clermont A, Gao B, Salti H, Gundel R, White M, Feener EP, Aiello LP, King GL.

FASEB J. 2006 Oct;20(12):2058-67.PMID: 17012258 [PubMed - indexed for MEDLINE]Related articlesFree article

Adipose-specific effect of rosiglitazone on vascular permeability and protein kinase C activation: novel mechanism for PPARgamma agonist's effects on edema and weight gain.

Sotiropoulos KB, Clermont A, Yasuda Y, Rask-Madsen C, Mastumoto M, Takahashi J, Della Vecchia K, Kondo T, Aiello LP, King GL.

FASEB J. 2006 Jun;20(8):1203-5. Epub 2006 May 3.PMID: 16672634 [PubMed - indexed for MEDLINE]Related articlesFree article

Activation of vascular protein kinase C-beta inhibits Akt-dependent endothelial nitric oxide synthase function in obesity-associated insulin resistance.

Naruse K, Rask-Madsen C, Takahara N, Ha SW, Suzuma K, Way KJ, Jacobs JR, Clermont AC, Ueki K, Ohshiro Y, Zhang J, Goldfine AB, King GL.

Diabetes. 2006 Mar;55(3):691-8.PMID: 16505232 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of vascular endothelial growth factor expression and vascularization in the myocardium by insulin receptor and PI3K/Akt pathways in insulin resistance and ischemia.

He Z, Opland DM, Way KJ, Ueki K, Bodyak N, Kang PM, Izumo S, Kulkarni RN, Wang B, Liao R, Kahn CR, King GL.

Arterioscler Thromb Vasc Biol. 2006 Apr;26(4):787-93. Epub 2006 Feb 9.PMID: 16469952 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of linguistic barriers to diabetes knowledge and glycemic control in Chinese Americans with diabetes.

Hsu WC, Cheung S, Ong E, Wong K, Lin S, Leon K, Weinger K, King GL.

Diabetes Care. 2006 Feb;29(2):415-6. No abstract available. PMID: 16443897 [PubMed - indexed for MEDLINE]Related articlesFree article

Can protein kinase C beta-selective inhibitor, ruboxistaurin, stop vascular complications in diabetic patients?

He Z, King GL.

Diabetes Care. 2005 Nov;28(11):2803-5. No abstract available. PMID: 16249561 [PubMed - indexed for MEDLINE]Related articlesFree article

Molecular targets of diabetic cardiovascular complications.

Ahmad FK, He Z, King GL.

Curr Drug Targets. 2005 Jun;6(4):487-94. Review.PMID: 16026267 [PubMed - indexed for MEDLINE]Related articles

Role of p90 ribosomal S6 kinase (p90RSK) in reactive oxygen species and protein kinase C beta (PKC-beta)-mediated cardiac troponin I phosphorylation.

Itoh S, Ding B, Bains CP, Wang N, Takeishi Y, Jalili T, King GL, Walsh RA, Yan C, Abe J.

J Biol Chem. 2005 Jun 24;280(25):24135-42. Epub 2005 Apr 19.PMID: 15840586 [PubMed - indexed for MEDLINE]Related articlesFree article

Introduction of hyperglycemia and dyslipidemia in the pathogenesis of diabetic vascular complications.

Xu Y, He Z, King GL.

Curr Diab Rep. 2005 Apr;5(2):91-7. Review.PMID: 15794910 [PubMed - indexed for MEDLINE]Related articles

Oxidative stress and antioxidant treatment in diabetes.

Scott JA, King GL.

Ann N Y Acad Sci. 2004 Dec;1031:204-13. Review.PMID: 15753146 [PubMed - indexed for MEDLINE]Related articles

Differential regulation of angiotensin II-induced expression of connective tissue growth factor by protein kinase C isoforms in the myocardium.

He Z, Way KJ, Arikawa E, Chou E, Opland DM, Clermont A, Isshiki K, Ma RC, Scott JA, Schoen FJ, Feener EP, King GL.

J Biol Chem. 2005 Apr 22;280(16):15719-26. Epub 2005 Feb 7.PMID: 15699040 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin receptor substrate 2 is essential for maturation and survival of photoreceptor cells.

Yi X, Schubert M, Peachey NS, Suzuma K, Burks DJ, Kushner JA, Suzuma I, Cahill C, Flint CL, Dow MA, Leshan RL, King GL, White MF.

J Neurosci. 2005 Feb 2;25(5):1240-8.PMID: 15689562 [PubMed - indexed for MEDLINE]Related articlesFree article

Double calcaneal osteotomy: realignment considerations in eight patients.

Catanzariti AR, Mendicino RW, King GL, Neerings B.

J Am Podiatr Med Assoc. 2005 Jan-Feb;95(1):53-9.PMID: 15659414 [PubMed - indexed for MEDLINE]Related articles

A systematic approach to evaluation of the rearfoot, ankle, and leg in reconstructive surgery.

Mendicino RW, Catanzariti AR, Reeves CL, King GL.

J Am Podiatr Med Assoc. 2005 Jan-Feb;95(1):2-12.PMID: 15659408 [PubMed - indexed for MEDLINE]Related articles

Proatherosclerotic mechanisms involving protein kinase C in diabetes and insulin resistance.

Rask-Madsen C, King GL.

Arterioscler Thromb Vasc Biol. 2005 Mar;25(3):487-96. Epub 2005 Jan 6. Review.PMID: 15637306 [PubMed - indexed for MEDLINE]Related articlesFree article

The effect of vitamin E on endothelial function of micro- and macrocirculation and left ventricular function in type 1 and type 2 diabetic patients.

Economides PA, Khaodhiar L, Caselli A, Caballero AE, Keenan H, Bursell SE, King GL, Johnstone MT, Horton ES, Veves A.

Diabetes. 2005 Jan;54(1):204-11.PMID: 15616030 [PubMed - indexed for MEDLINE]Related articlesFree article

Elevated C-reactive protein levels do not correspond to autoimmunity in type 1 diabetes.

Treszl A, Szereday L, Doria A, King GL, Orban T.

Diabetes Care. 2004 Nov;27(11):2769-70. No abstract available. PMID: 15505025 [PubMed - indexed for MEDLINE]Related articlesFree article

Hyperglycemia-induced oxidative stress in diabetic complications.

King GL, Loeken MR.

Histochem Cell Biol. 2004 Oct;122(4):333-8. Epub 2004 Jul 15. Review.PMID: 15257460 [PubMed - indexed for MEDLINE]Related articles

Protein kinase Cbeta isoform inhibitors: a new treatment for diabetic cardiovascular diseases.

He Z, King GL.

Circulation. 2004 Jul 6;110(1):7-9. No abstract available. PMID: 15238466 [PubMed - indexed for MEDLINE]Related articlesFree article

Hyperglycemia promotes oxidative stress through inhibition of thioredoxin function by thioredoxin-interacting protein.

Schulze PC, Yoshioka J, Takahashi T, He Z, King GL, Lee RT.

J Biol Chem. 2004 Jul 16;279(29):30369-74. Epub 2004 May 5.PMID: 15128745 [PubMed - indexed for MEDLINE]Related articlesFree article

Microvascular complications of diabetes.

He Z, King GL.

Endocrinol Metab Clin North Am. 2004 Mar;33(1):215-38, xi-xii. Review. No abstract available. PMID: 15053904 [PubMed - indexed for MEDLINE]Related articles

Retinopathy in diabetes.

Fong DS, Aiello L, Gardner TW, King GL, Blankenship G, Cavallerano JD, Ferris FL 3rd, Klein R; American Diabetes Association.

Diabetes Care. 2004 Jan;27 Suppl 1:S84-7. No abstract available. PMID: 14693935 [PubMed - indexed for MEDLINE]Related articlesFree article

Oxidative stress: the lead or supporting actor in the pathogenesis of diabetic complications.

Kuroki T, Isshiki K, King GL.

J Am Soc Nephrol. 2003 Aug;14(8 Suppl 3):S216-20. Review. No abstract available. PMID: 12874434 [PubMed - indexed for MEDLINE]Related articlesFree article

Applications of inhibitors for protein kinase C and their isoforms.

Shen GX, Way KJ, Jacobs JR, King GL.

Methods Mol Biol. 2003;233:397-422. No abstract available. PMID: 12840525 [PubMed - indexed for MEDLINE]Related articles

Knockout of insulin and IGF-1 receptors on vascular endothelial cells protects against retinal neovascularization.

Kondo T, Vicent D, Suzuma K, Yanagisawa M, King GL, Holzenberger M, Kahn CR.

J Clin Invest. 2003 Jun;111(12):1835-42.PMID: 12813019 [PubMed - indexed for MEDLINE]Related articlesFree article

Characterization of multiple signaling pathways of insulin in the regulation of vascular endothelial growth factor expression in vascular cells and angiogenesis.

Jiang ZY, He Z, King BL, Kuroki T, Opland DM, Suzuma K, Suzuma I, Ueki K, Kulkarni RN, Kahn CR, King GL.

J Biol Chem. 2003 Aug 22;278(34):31964-71. Epub 2003 May 29.PMID: 12775712 [PubMed - indexed for MEDLINE]Related articlesFree article

The role of endothelial insulin signaling in the regulation of vascular tone and insulin resistance.

Vicent D, Ilany J, Kondo T, Naruse K, Fisher SJ, Kisanuki YY, Bursell S, Yanagisawa M, King GL, Kahn CR.

J Clin Invest. 2003 May;111(9):1373-80.PMID: 12727929 [PubMed - indexed for MEDLINE]Related articlesFree article

Endothelial dysfunction in diabetes mellitus: role in cardiovascular disease.

Feener EP, King GL.

Heart Fail Monit. 2001;1(3):74-82. Review.PMID: 12634871 [PubMed - indexed for MEDLINE]Related articles

Role of protein kinase C on the expression of platelet-derived growth factor and endothelin-1 in the retina of diabetic rats and cultured retinal capillary pericytes.

Yokota T, Ma RC, Park JY, Isshiki K, Sotiropoulos KB, Rauniyar RK, Bornfeldt KE, King GL.

Diabetes. 2003 Mar;52(3):838-45.PMID: 12606528 [PubMed - indexed for MEDLINE]Related articlesFree article

Characterization of retinal leukostasis and hemodynamics in insulin resistance and diabetes: role of oxidants and protein kinase-C activation.

Abiko T, Abiko A, Clermont AC, Shoelson B, Horio N, Takahashi J, Adamis AP, King GL, Bursell SE.

Diabetes. 2003 Mar;52(3):829-37.PMID: 12606527 [PubMed - indexed for MEDLINE]Related articlesFree article

Diabetic retinopathy.

Fong DS, Aiello L, Gardner TW, King GL, Blankenship G, Cavallerano JD, Ferris FL 3rd, Klein R; American Diabetes Association.

Diabetes Care. 2003 Jan;26(1):226-9. Review. No abstract available. PMID: 12502685 [PubMed - indexed for MEDLINE]Related articlesFree article