PubMed

Cleavage of protein kinase D after acute hypoinsulinemia prevents excessive lipoprotein lipase-mediated cardiac triglyceride accumulation.

Kim MS, Wang F, Puthanveetil P, Kewalramani G, Innis S, Marzban L, Steinberg SF, Webber TD, Kieffer TJ, Abrahani A, Rodrigues B.

Diabetes. 2009 Nov;58(11):2464-75.PMID: 19875622 [PubMed - in process]Related articles

Alotaketals A and B, sesterterpenoids from the marine sponge Hamigera species that activate the cAMP cell signaling pathway.

Forestieri R, Merchant CE, de Voogd NJ, Matainaho T, Kieffer TJ, Andersen RJ.

Org Lett. 2009 Nov 19;11(22):5166-9.PMID: 19873990 [PubMed - in process]Related articles

DsAAV8-mediated expression of glucagon-like peptide-1 in pancreatic beta-cells ameliorates streptozotocin-induced diabetes.

Riedel MJ, Gaddy DF, Asadi A, Robbins PD, Kieffer TJ.

Gene Ther. 2009 Oct 29. [Epub ahead of print]PMID: 19865180 [PubMed - as supplied by publisher]Related articles

Mining incretin hormone pathways for novel therapies.

Wideman RD, Kieffer TJ.

Trends Endocrinol Metab. 2009 Aug;20(6):280-6. Review.PMID: 19595611 [PubMed - indexed for MEDLINE]Related articles

Treatment of diabetes by transplantation of drug-inducible insulin-producing gut cells.

Unniappan S, Wideman RD, Donald C, Gunn V, Wall JL, Zhang QX, Webber TD, Cheung AT, Kieffer TJ.

J Mol Med. 2009 Jul;87(7):703-12. Epub 2009 Apr 23.PMID: 19387601 [PubMed - indexed for MEDLINE]Related articles

Regulation of somatostatin release by adenosine in the mouse stomach.

Yang GK, Chen JF, Kieffer TJ, Kwok YN.

J Pharmacol Exp Ther. 2009 May;329(2):729-37. Epub 2009 Feb 10. Erratum in: J Pharmacol Exp Ther. 2009 Jun;329(3):1187. PMID: 19208896 [PubMed - indexed for MEDLINE]Related articles

Engineered glucagon-like peptide-1-producing hepatocytes lower plasma glucose levels in mice.

Riedel MJ, Lee CW, Kieffer TJ.

Am J Physiol Endocrinol Metab. 2009 Apr;296(4):E936-44. Epub 2009 Feb 3.PMID: 19190262 [PubMed - indexed for MEDLINE]Related articles

Incretin release from gut is acutely enhanced by sugar but not by sweeteners in vivo.

Fujita Y, Wideman RD, Speck M, Asadi A, King DS, Webber TD, Haneda M, Kieffer TJ.

Am J Physiol Endocrinol Metab. 2009 Mar;296(3):E473-9. Epub 2008 Dec 23.PMID: 19106249 [PubMed - indexed for MEDLINE]Related articles

Transplantation of PC1/3-Expressing alpha-cells improves glucose handling and cold tolerance in leptin-resistant mice.

Wideman RD, Gray SL, Covey SD, Webb GC, Kieffer TJ.

Mol Ther. 2009 Jan;17(1):191-8. Epub 2008 Oct 21.PMID: 18941442 [PubMed - indexed for MEDLINE]Related articles

Ontogeny of ghrelin, obestatin, preproghrelin, and prohormone convertases in rat pancreas and stomach.

Walia P, Asadi A, Kieffer TJ, Johnson JD, Chanoine JP.

Pediatr Res. 2009 Jan;65(1):39-44.PMID: 18784614 [PubMed - indexed for MEDLINE]Related articles

Pax6 and Pdx1 are required for production of glucose-dependent insulinotropic polypeptide in proglucagon-expressing L cells.

Fujita Y, Chui JW, King DS, Zhang T, Seufert J, Pownall S, Cheung AT, Kieffer TJ.

Am J Physiol Endocrinol Metab. 2008 Sep;295(3):E648-57. Epub 2008 Jul 1.PMID: 18593849 [PubMed - indexed for MEDLINE]Related articlesFree article

Metabolic effects of chronic obestatin infusion in rats.

Unniappan S, Speck M, Kieffer TJ.

Peptides. 2008 Aug;29(8):1354-61. Epub 2008 Apr 16.PMID: 18508160 [PubMed - indexed for MEDLINE]Related articles

Exercise restores endothelial function independently of weight loss or hyperglycaemic status in db/db mice.

Moien-Afshari F, Ghosh S, Elmi S, Rahman MM, Sallam N, Khazaei M, Kieffer TJ, Brownsey RW, Laher I.

Diabetologia. 2008 Jul;51(7):1327-37. Epub 2008 Apr 25. Erratum in: Diabetologia. 2009 Jan;52(1):181. Elmi, S [added]; Rahman, M M [added]; Sallam, N [added]. PMID: 18437348 [PubMed - indexed for MEDLINE]Related articles

Leptin extends the anorectic effects of chronic PYY(3-36) administration in ad libitum-fed rats.

Unniappan S, Kieffer TJ.

Am J Physiol Regul Integr Comp Physiol. 2008 Jul;295(1):R51-8. Epub 2008 Apr 16.PMID: 18417649 [PubMed - indexed for MEDLINE]Related articlesFree article

Treatment of obesity and diabetes in mice by transplant of gut cells engineered to produce leptin.

Oosman SN, Lam AW, Harb G, Unniappan S, Lam NT, Webber T, Bruch D, Zhang QX, Korbutt GS, Kieffer TJ.

Mol Ther. 2008 Jun;16(6):1138-45. Epub 2008 Apr 15.PMID: 18414479 [PubMed - indexed for MEDLINE]Related articles

Effect of exercise on augmented aortic vasoconstriction in the db/db mouse model of type-II diabetes.

Khazaei M, Moien-Afshari F, Kieffer TJ, Laher I.

Physiol Res. 2008;57(6):847-56. Epub 2007 Nov 30.PMID: 18052681 [PubMed - indexed for MEDLINE]Related articlesFree article

A switch from prohormone convertase (PC)-2 to PC1/3 expression in transplanted alpha-cells is accompanied by differential processing of proglucagon and improved glucose homeostasis in mice.

Wideman RD, Covey SD, Webb GC, Drucker DJ, Kieffer TJ.

Diabetes. 2007 Nov;56(11):2744-52. Epub 2007 Aug 13.PMID: 17698597 [PubMed - indexed for MEDLINE]Related articlesFree article

Enriched human pancreatic ductal cultures obtained from selective death of acinar cells express pancreatic and duodenal homeobox gene-1 age-dependently.

Street CN, Lakey JR, Rajotte RV, Shapiro AM, Kieffer TJ, Lyon JG, Kin T, Korbutt GS.

Rev Diabet Stud. 2004 Summer;1(2):66-79. Epub 2004 Aug 10.PMID: 17491668 [PubMed]Related articlesFree article

The pancreatic beta cell is a key site for mediating the effects of leptin on glucose homeostasis.

Covey SD, Wideman RD, McDonald C, Unniappan S, Huynh F, Asadi A, Speck M, Webber T, Chua SC, Kieffer TJ.

Cell Metab. 2006 Oct;4(4):291-302.PMID: 17011502 [PubMed - indexed for MEDLINE]Related articles

Improving function and survival of pancreatic islets by endogenous production of glucagon-like peptide 1 (GLP-1).

Wideman RD, Yu IL, Webber TD, Verchere CB, Johnson JD, Cheung AT, Kieffer TJ.

Proc Natl Acad Sci U S A. 2006 Sep 5;103(36):13468-73. Epub 2006 Aug 28.PMID: 16938896 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of dipeptidyl peptidase IV on the satiety actions of peptide YY.

Unniappan S, McIntosh CH, Demuth HU, Heiser U, Wolf R, Kieffer TJ.

Diabetologia. 2006 Aug;49(8):1915-23. Epub 2006 Jun 27.PMID: 16802131 [PubMed - indexed for MEDLINE]Related articles

Leptin resistance following over-expression of protein tyrosine phosphatase 1B in liver.

Lam NT, Covey SD, Lewis JT, Oosman S, Webber T, Hsu EC, Cheung AT, Kieffer TJ.

J Mol Endocrinol. 2006 Feb;36(1):163-74.PMID: 16461936 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of preproinsulin gene expression by leptin induction of suppressor of cytokine signaling 3 in pancreatic beta-cells.

Laubner K, Kieffer TJ, Lam NT, Niu X, Jakob F, Seufert J.

Diabetes. 2005 Dec;54(12):3410-7.PMID: 16306356 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose-dependent insulinotropic polypeptide is expressed in adult hippocampus and induces progenitor cell proliferation.

Nyberg J, Anderson MF, Meister B, Alborn AM, Ström AK, Brederlau A, Illerskog AC, Nilsson O, Kieffer TJ, Hietala MA, Ricksten A, Eriksson PS.

J Neurosci. 2005 Feb 16;25(7):1816-25.PMID: 15716418 [PubMed - indexed for MEDLINE]Related articlesFree article

Ghrelin, peptide YY, glucose-dependent insulinotropic polypeptide, and hunger responses to a mixed meal in anorexic, obese, and control female adolescents.

Stock S, Leichner P, Wong AC, Ghatei MA, Kieffer TJ, Bloom SR, Chanoine JP.

J Clin Endocrinol Metab. 2005 Apr;90(4):2161-8. Epub 2005 Jan 18.PMID: 15657373 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose-dependent insulinotropic polypeptide as a regulator of beta cell function and fate.

Wideman RD, Kieffer TJ.

Horm Metab Res. 2004 Nov-Dec;36(11-12):782-6. Review.PMID: 15655709 [PubMed - indexed for MEDLINE]Related articles

Harnessing the gut to treat diabetes.

Fujita Y, Cheung AT, Kieffer TJ.

Pediatr Diabetes. 2004;5 Suppl 2:57-69. Review.PMID: 15601375 [PubMed - indexed for MEDLINE]Related articles

Clonal identification of multipotent precursors from adult mouse pancreas that generate neural and pancreatic lineages.

Seaberg RM, Smukler SR, Kieffer TJ, Enikolopov G, Asghar Z, Wheeler MB, Korbutt G, van der Kooy D.

Nat Biotechnol. 2004 Sep;22(9):1115-24. Epub 2004 Aug 22.PMID: 15322557 [PubMed - indexed for MEDLINE]Related articles

Dietary fructose reduces circulating insulin and leptin, attenuates postprandial suppression of ghrelin, and increases triglycerides in women.

Teff KL, Elliott SS, Tschöp M, Kieffer TJ, Rader D, Heiman M, Townsend RR, Keim NL, D'Alessio D, Havel PJ.

J Clin Endocrinol Metab. 2004 Jun;89(6):2963-72.PMID: 15181085 [PubMed - indexed for MEDLINE]Related articlesFree article

Gastro-intestinal hormones GIP and GLP-1.

Kieffer TJ.

Ann Endocrinol (Paris). 2004 Feb;65(1):13-21. Review. No abstract available. PMID: 15122087 [PubMed - indexed for MEDLINE]Related articles

Leptin reduces glucose transport and cellular ATP levels in INS-1 beta-cells.

Lam NT, Cheung AT, Riedel MJ, Light PE, Cheeseman CI, Kieffer TJ.

J Mol Endocrinol. 2004 Apr;32(2):415-24.PMID: 15072548 [PubMed - indexed for MEDLINE]Related articlesFree article

Leptin increases hepatic insulin sensitivity and protein tyrosine phosphatase 1B expression.

Lam NT, Lewis JT, Cheung AT, Luk CT, Tse J, Wang J, Bryer-Ash M, Kolls JK, Kieffer TJ.

Mol Endocrinol. 2004 Jun;18(6):1333-45. Epub 2004 Feb 19.PMID: 14976221 [PubMed - indexed for MEDLINE]Related articlesFree article

GIP or not GIP? That is the question.

Kieffer TJ.

Trends Pharmacol Sci. 2003 Mar;24(3):110-2. Review.PMID: 12628351 [PubMed - indexed for MEDLINE]Related articles

The multifaceted potential of glucagon-like peptide-1 as a therapeutic agent.

Lam NT, Kieffer TJ.

Minerva Endocrinol. 2002 Jun;27(2):79-93. Review.PMID: 11961501 [PubMed - indexed for MEDLINE]Related articles

Defective glucose-dependent insulinotropic polypeptide receptor expression in diabetic fatty Zucker rats.

Lynn FC, Pamir N, Ng EH, McIntosh CH, Kieffer TJ, Pederson RA.

Diabetes. 2001 May;50(5):1004-11.PMID: 11334402 [PubMed - indexed for MEDLINE]Related articlesFree article

Novel alternatively spliced exon in the extracellular ligand-binding domain of the pituitary adenylate cyclase-activating polypeptide (PACAP) type 1 receptor (PAC1R) selectively increases ligand affinity and alters signal transduction coupling during spermatogenesis.

Daniel PB, Kieffer TJ, Leech CA, Habener JF.

J Biol Chem. 2001 Apr 20;276(16):12938-44. Epub 2001 Jan 29.PMID: 11278585 [PubMed - indexed for MEDLINE]Related articlesFree article

Activation of the parasympathetic nervous system is necessary for normal meal-induced insulin secretion in rhesus macaques.

D'Alessio DA, Kieffer TJ, Taborsky GJ Jr, Havel PJ.

J Clin Endocrinol Metab. 2001 Mar;86(3):1253-9.PMID: 11238517 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose-dependent insulin release from genetically engineered K cells.

Cheung AT, Dayanandan B, Lewis JT, Korbutt GS, Rajotte RV, Bryer-Ash M, Boylan MO, Wolfe MM, Kieffer TJ.

Science. 2000 Dec 8;290(5498):1959-62.PMID: 11110661 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose-dependent insulinotropic polypeptide confers early phase insulin release to oral glucose in rats: demonstration by a receptor antagonist.

Lewis JT, Dayanandan B, Habener JF, Kieffer TJ.

Endocrinology. 2000 Oct;141(10):3710-6.PMID: 11014226 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucagon-like peptide-1, but not glucose-dependent insulinotropic peptide, regulates fasting glycemia and nonenteral glucose clearance in mice.

Baggio L, Kieffer TJ, Drucker DJ.

Endocrinology. 2000 Oct;141(10):3703-9.PMID: 11014225 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas.

Stoffers DA, Kieffer TJ, Hussain MA, Drucker DJ, Bonner-Weir S, Habener JF, Egan JM.

Diabetes. 2000 May;49(5):741-8.PMID: 10905482 [PubMed - indexed for MEDLINE]Related articlesFree article

The adipoinsular axis: effects of leptin on pancreatic beta-cells.

Kieffer TJ, Habener JF.

Am J Physiol Endocrinol Metab. 2000 Jan;278(1):E1-E14. Review.PMID: 10644531 [PubMed - indexed for MEDLINE]Related articlesFree article

The glucagon-like peptides.

Kieffer TJ, Habener JF.

Endocr Rev. 1999 Dec;20(6):876-913. Review. No abstract available. PMID: 10605628 [PubMed - indexed for MEDLINE]Related articlesFree article

Leptin suppression of insulin secretion and gene expression in human pancreatic islets: implications for the development of adipogenic diabetes mellitus.

Seufert J, Kieffer TJ, Leech CA, Holz GG, Moritz W, Ricordi C, Habener JF.

J Clin Endocrinol Metab. 1999 Feb;84(2):670-6.PMID: 10022436 [PubMed - indexed for MEDLINE]Related articlesFree article

Leptin inhibits insulin gene transcription and reverses hyperinsulinemia in leptin-deficient ob/ob mice.

Seufert J, Kieffer TJ, Habener JF.

Proc Natl Acad Sci U S A. 1999 Jan 19;96(2):674-9.PMID: 9892692 [PubMed - indexed for MEDLINE]Related articlesFree article

Functional GIP receptors are present on adipocytes.

Yip RG, Boylan MO, Kieffer TJ, Wolfe MM.

Endocrinology. 1998 Sep;139(9):4004-7.PMID: 9724057 [PubMed - indexed for MEDLINE]Related articlesFree article

Leptin suppression of insulin secretion by the activation of ATP-sensitive K+ channels in pancreatic beta-cells.

Kieffer TJ, Heller RS, Leech CA, Holz GG, Habener JF.

Diabetes. 1997 Jun;46(6):1087-93.PMID: 9166685 [PubMed - indexed for MEDLINE]Related articles

Insulinotropic glucagon-like peptide I receptor expression in glucagon-producing alpha-cells of the rat endocrine pancreas.

Heller RS, Kieffer TJ, Habener JF.

Diabetes. 1997 May;46(5):785-91.PMID: 9133545 [PubMed - indexed for MEDLINE]Related articles

Postprandial stimulation of insulin release by glucose-dependent insulinotropic polypeptide (GIP). Effect of a specific glucose-dependent insulinotropic polypeptide receptor antagonist in the rat.

Tseng CC, Kieffer TJ, Jarboe LA, Usdin TB, Wolfe MM.

J Clin Invest. 1996 Dec 1;98(11):2440-5.PMID: 8958204 [PubMed - indexed for MEDLINE]Related articlesFree article

The enteroinsular axis in dipeptidyl peptidase IV-negative rats.

Pederson RA, Kieffer TJ, Pauly R, Kofod H, Kwong J, McIntosh CH.

Metabolism. 1996 Nov;45(11):1335-41.PMID: 8931636 [PubMed - indexed for MEDLINE]Related articles