PubMed

Activation of PKC-delta and SHP-1 by hyperglycemia causes vascular cell apoptosis and diabetic retinopathy.

Geraldes P, Hiraoka-Yamamoto J, Matsumoto M, Clermont A, Leitges M, Marette A, Aiello LP, Kern TS, King GL.

Nat Med. 2009 Nov;15(11):1298-306. Epub 2009 Nov 1.PMID: 19881493 [PubMed - in process]Related articles

Identification of primary retinal cells and ex vivo detection of proinflammatory molecules using flow cytometry.

Portillo JA, Okenka G, Kern TS, Subauste CS.

Mol Vis. 2009 Jul 17;15:1383-9.PMID: 19626134 [PubMed - indexed for MEDLINE]Related articlesFree article

Therapies for hyperglycaemia-induced diabetic complications: from animal models to clinical trials.

Calcutt NA, Cooper ME, Kern TS, Schmidt AM.

Nat Rev Drug Discov. 2009 May;8(5):417-29. Review.PMID: 19404313 [PubMed - indexed for MEDLINE]Related articles

Pharmacologic intervention targeting glycolytic-related pathways protects against retinal injury due to ischemia and reperfusion.

Zheng L, Liu S, Sun MZ, Chang J, Chance MR, Kern TS.

Proteomics. 2009 Apr;9(7):1869-82.PMID: 19288518 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of nitric oxide, superoxide, peroxynitrite and PARP in diabetic retinopathy.

Zheng L, Kern TS.

Front Biosci. 2009 Jan 1;14:3974-87. Review.PMID: 19273327 [PubMed - indexed for MEDLINE]Related articles

Increased basement membrane thickness, pericyte ghosts, and loss of retinal thickness and cells in dopamine beta hydroxylase knockout mice.

Steinle JJ, Kern TS, Thomas SA, McFadyen-Ketchum LS, Smith CP.

Exp Eye Res. 2009 Jun;88(6):1014-9. Epub 2009 Jan 7.PMID: 19176214 [PubMed - indexed for MEDLINE]Related articles

Retinal ion regulation in a mouse model of diabetic retinopathy: natural history and the effect of Cu/Zn superoxide dismutase overexpression.

Berkowitz BA, Gradianu M, Bissig D, Kern TS, Roberts R.

Invest Ophthalmol Vis Sci. 2009 May;50(5):2351-8. Epub 2008 Dec 13.PMID: 19074809 [PubMed - indexed for MEDLINE]Related articlesFree article

Glutaredoxin regulates autocrine and paracrine proinflammatory responses in retinal glial (muller) cells.

Shelton MD, Distler AM, Kern TS, Mieyal JJ.

J Biol Chem. 2009 Feb 20;284(8):4760-6. Epub 2008 Dec 12.PMID: 19074435 [PubMed - indexed for MEDLINE]Related articles

CD40 mediates retinal inflammation and neurovascular degeneration.

Portillo JA, Van Grol J, Zheng L, Okenka G, Gentil K, Garland A, Carlson EC, Kern TS, Subauste CS.

J Immunol. 2008 Dec 15;181(12):8719-26.PMID: 19050292 [PubMed - indexed for MEDLINE]Related articles

Markers of glycemic control in the mouse: comparisons of 6-h- and overnight-fasted blood glucoses to Hb A1c.

Han BG, Hao CM, Tchekneva EE, Wang YY, Lee CA, Ebrahim B, Harris RC, Kern TS, Wasserman DH, Breyer MD, Qi Z.

Am J Physiol Endocrinol Metab. 2008 Oct;295(4):E981-6. Epub 2008 Jul 29.PMID: 18664598 [PubMed - indexed for MEDLINE]Related articlesFree article

Sulfasalazine blocks the development of tactile allodynia in diabetic rats.

Berti-Mattera LN, Kern TS, Siegel RE, Nemet I, Mitchell R.

Diabetes. 2008 Oct;57(10):2801-8. Epub 2008 Jul 15.PMID: 18633115 [PubMed - indexed for MEDLINE]Related articlesFree article

Retinal ganglion cells in diabetes.

Kern TS, Barber AJ.

J Physiol. 2008 Sep 15;586(Pt 18):4401-8. Epub 2008 Jun 19. Review.PMID: 18565995 [PubMed - indexed for MEDLINE]Related articlesFree article

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) meeting summary: Advances toward measuring diabetic retinopathy and neuropathy: from the bench to the clinic and back again (April 4-5, 2007, Baltimore, Maryland).

Kern TS, Berkowitz BA, Feldman EL.

J Diabetes Complications. 2009 May-Jun;23(3):219-23. Epub 2008 Apr 16.PMID: 18413183 [PubMed - indexed for MEDLINE]Related articles

5-Lipoxygenase, but not 12/15-lipoxygenase, contributes to degeneration of retinal capillaries in a mouse model of diabetic retinopathy.

Gubitosi-Klug RA, Talahalli R, Du Y, Nadler JL, Kern TS.

Diabetes. 2008 May;57(5):1387-93. Epub 2008 Mar 17.PMID: 18346986 [PubMed - indexed for MEDLINE]Related articlesFree article

Contributions of inflammatory processes to the development of the early stages of diabetic retinopathy.

Kern TS.

Exp Diabetes Res. 2007;2007:95103. Review.PMID: 18274606 [PubMed - indexed for MEDLINE]Related articlesFree article

Targets of tyrosine nitration in diabetic rat retina.

Zhan X, Du Y, Crabb JS, Gu X, Kern TS, Crabb JW.

Mol Cell Proteomics. 2008 May;7(5):864-74. Epub 2007 Dec 28. Erratum in: Mol Cell Proteomics. 2008 Jun;7(6):1188-9. PMID: 18165258 [PubMed - indexed for MEDLINE]Related articlesFree article

Long-term, topical insulin administration increases the severity of retinal vascular pathology in streptozotocin-induced diabetic rats.

Koevary SB, Nussey J, Kern TS.

Optometry. 2007 Nov;78(11):574-81.PMID: 17976619 [PubMed - indexed for MEDLINE]Related articles

Captopril inhibits capillary degeneration in the early stages of diabetic retinopathy.

Zhang JZ, Xi X, Gao L, Kern TS.

Curr Eye Res. 2007 Oct;32(10):883-9.PMID: 17963108 [PubMed - indexed for MEDLINE]Related articles

Oxidative damage in the retinal mitochondria of diabetic mice: possible protection by superoxide dismutase.

Kanwar M, Chan PS, Kern TS, Kowluru RA.

Invest Ophthalmol Vis Sci. 2007 Aug;48(8):3805-11.PMID: 17652755 [PubMed - indexed for MEDLINE]Related articlesFree article

Critical role of inducible nitric oxide synthase in degeneration of retinal capillaries in mice with streptozotocin-induced diabetes.

Zheng L, Du Y, Miller C, Gubitosi-Klug RA, Ball S, Berkowitz BA, Kern TS.

Diabetologia. 2007 Sep;50(9):1987-96. Epub 2007 Jun 22. Erratum in: Diabetologia. 2007 Oct;50(10):2228. PMID: 17583794 [PubMed - indexed for MEDLINE]Related articles

6-Fluoro-6-deoxy-D-glucose as a tracer of glucose transport.

Landau BR, Spring-Robinson CL, Muzic RF Jr, Rachdaoui N, Rubin D, Berridge MS, Schumann WC, Chandramouli V, Kern TS, Ismail-Beigi F.

Am J Physiol Endocrinol Metab. 2007 Jul;293(1):E237-45. Epub 2007 Apr 3.PMID: 17405828 [PubMed - indexed for MEDLINE]Related articlesFree article

Ischemic vascular damage can be repaired by healthy, but not diabetic, endothelial progenitor cells.

Caballero S, Sengupta N, Afzal A, Chang KH, Li Calzi S, Guberski DL, Kern TS, Grant MB.

Diabetes. 2007 Apr;56(4):960-7.PMID: 17395742 [PubMed - indexed for MEDLINE]Related articlesFree article

Glutaredoxin regulates nuclear factor kappa-B and intercellular adhesion molecule in Müller cells: model of diabetic retinopathy.

Shelton MD, Kern TS, Mieyal JJ.

J Biol Chem. 2007 Apr 27;282(17):12467-74. Epub 2007 Feb 26.PMID: 17324929 [PubMed - indexed for MEDLINE]Related articlesFree article

Topical administration of nepafenac inhibits diabetes-induced retinal microvascular disease and underlying abnormalities of retinal metabolism and physiology.

Kern TS, Miller CM, Du Y, Zheng L, Mohr S, Ball SL, Kim M, Jamison JA, Bingaman DP.

Diabetes. 2007 Feb;56(2):373-9.PMID: 17259381 [PubMed - indexed for MEDLINE]Related articlesFree article

Salicylate-based anti-inflammatory drugs inhibit the early lesion of diabetic retinopathy.

Zheng L, Howell SJ, Hatala DA, Huang K, Kern TS.

Diabetes. 2007 Feb;56(2):337-45. Erratum in: Diabetes. 2007 May;56(5):1486. PMID: 17259377 [PubMed - indexed for MEDLINE]Related articlesFree article

Retinal ischemia and reperfusion causes capillary degeneration: similarities to diabetes.

Zheng L, Gong B, Hatala DA, Kern TS.

Invest Ophthalmol Vis Sci. 2007 Jan;48(1):361-7.PMID: 17197555 [PubMed - indexed for MEDLINE]Related articlesFree article

Reduction of diabetes-induced oxidative stress, fibrotic cytokine expression, and renal dysfunction in protein kinase Cbeta-null mice.

Ohshiro Y, Ma RC, Yasuda Y, Hiraoka-Yamamoto J, Clermont AC, Isshiki K, Yagi K, Arikawa E, Kern TS, King GL.

Diabetes. 2006 Nov;55(11):3112-20.PMID: 17065350 [PubMed - indexed for MEDLINE]Related articlesFree article

Association between endothelin-1 and collagen deposition in db/db diabetic mouse kidneys.

Mishra R, Emancipator SN, Kern TS, Simonson MS.

Biochem Biophys Res Commun. 2006 Jan 6;339(1):65-70. Epub 2005 Nov 8.PMID: 16297859 [PubMed - indexed for MEDLINE]Related articles

Vascular damage in a mouse model of diabetic retinopathy: relation to neuronal and glial changes.

Feit-Leichman RA, Kinouchi R, Takeda M, Fan Z, Mohr S, Kern TS, Chen DF.

Invest Ophthalmol Vis Sci. 2005 Nov;46(11):4281-7.PMID: 16249509 [PubMed - indexed for MEDLINE]Related articlesFree article

The Ins2Akita mouse as a model of early retinal complications in diabetes.

Barber AJ, Antonetti DA, Kern TS, Reiter CE, Soans RS, Krady JK, Levison SW, Gardner TW, Bronson SK.

Invest Ophthalmol Vis Sci. 2005 Jun;46(6):2210-8.PMID: 15914643 [PubMed - indexed for MEDLINE]Related articlesFree article

Glycation of mitochondrial proteins from diabetic rat kidney is associated with excess superoxide formation.

Rosca MG, Mustata TG, Kinter MT, Ozdemir AM, Kern TS, Szweda LI, Brownlee M, Monnier VM, Weiss MF.

Am J Physiol Renal Physiol. 2005 Aug;289(2):F420-30. Epub 2005 Apr 5.PMID: 15814529 [PubMed - indexed for MEDLINE]Related articlesFree article

Paradoxical effects of green tea (Camellia sinensis) and antioxidant vitamins in diabetic rats: improved retinopathy and renal mitochondrial defects but deterioration of collagen matrix glycoxidation and cross-linking.

Mustata GT, Rosca M, Biemel KM, Reihl O, Smith MA, Viswanathan A, Strauch C, Du Y, Tang J, Kern TS, Lederer MO, Brownlee M, Weiss MF, Monnier VM.

Diabetes. 2005 Feb;54(2):517-26.PMID: 15677510 [PubMed - indexed for MEDLINE]Related articlesFree article

Chronically elevated glucose-induced apoptosis is mediated by inactivation of Akt in cultured Müller cells.

Xi X, Gao L, Hatala DA, Smith DG, Codispoti MC, Gong B, Kern TS, Zhang JZ.

Biochem Biophys Res Commun. 2005 Jan 21;326(3):548-53.PMID: 15596134 [PubMed - indexed for MEDLINE]Related articles

Poly(ADP-ribose) polymerase is involved in the development of diabetic retinopathy via regulation of nuclear factor-kappaB.

Zheng L, Szabó C, Kern TS.

Diabetes. 2004 Nov;53(11):2960-7.PMID: 15504977 [PubMed - indexed for MEDLINE]Related articlesFree article

Interaction between NO and COX pathways in retinal cells exposed to elevated glucose and retina of diabetic rats.

Du Y, Sarthy VP, Kern TS.

Am J Physiol Regul Integr Comp Physiol. 2004 Oct;287(4):R735-41.PMID: 15371279 [PubMed - indexed for MEDLINE]Related articles

A central role for inflammation in the pathogenesis of diabetic retinopathy.

Joussen AM, Poulaki V, Le ML, Koizumi K, Esser C, Janicki H, Schraermeyer U, Kociok N, Fauser S, Kirchhof B, Kern TS, Adamis AP.

FASEB J. 2004 Sep;18(12):1450-2. Epub 2004 Jul 1.PMID: 15231732 [PubMed - indexed for MEDLINE]Related articlesFree article

Comparison of glucose influx and blood flow in retina and brain of diabetic rats.

Puchowicz MA, Xu K, Magness D, Miller C, Lust WD, Kern TS, LaManna JC.

J Cereb Blood Flow Metab. 2004 Apr;24(4):449-57.PMID: 15087714 [PubMed - indexed for MEDLINE]Related articles

Regulation of the early subnormal retinal oxygenation response in experimental diabetes by inducible nitric oxide synthase.

Berkowitz BA, Luan H, Gupta RR, Pacheco D, Seidner A, Roberts R, Liggett J, Knoerzer DL, Connor JR, Du Y, Kern TS, Ito Y.

Diabetes. 2004 Jan;53(1):173-8.PMID: 14693712 [PubMed - indexed for MEDLINE]Related articlesFree article

Hyperglycemia increases mitochondrial superoxide in retina and retinal cells.

Du Y, Miller CM, Kern TS.

Free Radic Biol Med. 2003 Dec 1;35(11):1491-9.PMID: 14642397 [PubMed - indexed for MEDLINE]Related articles

A comprehensive analysis of the expression of crystallins in mouse retina.

Xi J, Farjo R, Yoshida S, Kern TS, Swaroop A, Andley UP.

Mol Vis. 2003 Aug 28;9:410-9.PMID: 12949468 [PubMed - indexed for MEDLINE]Related articlesFree article

Captopril inhibits glucose accumulation in retinal cells in diabetes.

Zhang JZ, Gao L, Widness M, Xi X, Kern TS.

Invest Ophthalmol Vis Sci. 2003 Sep;44(9):4001-5.PMID: 12939321 [PubMed - indexed for MEDLINE]Related articlesFree article

Non-enzymatic glycation in corneas from normal and diabetic donors and its effects on epithelial cell attachment in vitro.

McDermott AM, Xiao TL, Kern TS, Murphy CJ.

Optometry. 2003 Jul;74(7):443-52.PMID: 12877277 [PubMed - indexed for MEDLINE]Related articles

Non-uniform distribution of lesions and biochemical abnormalities within the retina of diabetic humans.

Tang J, Mohr S, Du YD, Kern TS.

Curr Eye Res. 2003 Jul;27(1):7-13.PMID: 12868004 [PubMed - indexed for MEDLINE]Related articles

Activation of nuclear factor-kappaB induced by diabetes and high glucose regulates a proapoptotic program in retinal pericytes.

Romeo G, Liu WH, Asnaghi V, Kern TS, Lorenzi M.

Diabetes. 2002 Jul;51(7):2241-8.PMID: 12086956 [PubMed - indexed for MEDLINE]Related articlesFree article

Diabetes-induced nitrative stress in the retina, and correction by aminoguanidine.

Du Y, Smith MA, Miller CM, Kern TS.

J Neurochem. 2002 Mar;80(5):771-9.PMID: 11948240 [PubMed - indexed for MEDLINE]Related articles

Caspase activation in retinas of diabetic and galactosemic mice and diabetic patients.

Mohr S, Xi X, Tang J, Kern TS.

Diabetes. 2002 Apr;51(4):1172-9.PMID: 11916941 [PubMed - indexed for MEDLINE]Related articlesFree article

Correction of early subnormal superior hemiretinal DeltaPO(2) predicts therapeutic efficacy in experimental diabetic retinopathy.

Berkowitz BA, Ito Y, Kern TS, McDonald C, Hawkins R.

Invest Ophthalmol Vis Sci. 2001 Nov;42(12):2964-9.PMID: 11687543 [PubMed - indexed for MEDLINE]Related articlesFree article

Abnormalities of retinal metabolism in diabetes and experimental galactosemia. VII. Effect of long-term administration of antioxidants on the development of retinopathy.

Kowluru RA, Tang J, Kern TS.

Diabetes. 2001 Aug;50(8):1938-42.PMID: 11473058 [PubMed - indexed for MEDLINE]Related articlesFree article

Pharmacological inhibition of diabetic retinopathy: aminoguanidine and aspirin.

Kern TS, Engerman RL.

Diabetes. 2001 Jul;50(7):1636-42.PMID: 11423486 [PubMed - indexed for MEDLINE]Related articlesFree article

Retinal glutamate in diabetes and effect of antioxidants.

Kowluru RA, Engerman RL, Case GL, Kern TS.

Neurochem Int. 2001 Apr;38(5):385-90.PMID: 11222918 [PubMed - indexed for MEDLINE]Related articles