PubMed

Early-onset and robust amyloid pathology in a new homozygous mouse model of Alzheimer's disease.

Willuweit A, Velden J, Godemann R, Manook A, Jetzek F, Tintrup H, Kauselmann G, Zevnik B, Henriksen G, Drzezga A, Pohlner J, Schoor M, Kemp JA, von der Kammer H.

PLoS One. 2009 Nov 20;4(11):e7931.PMID: 19936202 [PubMed - in process]Related articlesFree article

Outcomes of laparoscopic and open colectomy: a national population-based comparison.

Kemp JA, Finlayson SR.

Surg Innov. 2008 Dec;15(4):277-83.PMID: 19036732 [PubMed - indexed for MEDLINE]Related articles

Nationwide trends in laparoscopic colectomy from 2000 to 2004.

Kemp JA, Finlayson SR.

Surg Endosc. 2008 May;22(5):1181-7. Epub 2008 Feb 1.PMID: 18246394 [PubMed - indexed for MEDLINE]Related articles

Trends in adoption of laparoscopic cholecystectomy in rural versus urban hospitals.

Kemp JA, Zuckerman RS, Finlayson SR.

J Am Coll Surg. 2008 Jan;206(1):28-32. Epub 2007 Sep 17.PMID: 18155565 [PubMed - indexed for MEDLINE]Related articles

Asymmetric synthesis and receptor pharmacology of the group II mGlu receptor ligand (1S,2R,3R,5R,6S)-2-amino-3-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid-HYDIA.

Woltering TJ, Adam G, Huguenin P, Wichmann J, Kolczewski S, Gatti S, Bourson A, Kew JN, Richards G, Kemp JA, Mutel V, Knoflach F.

ChemMedChem. 2008 Feb;3(2):323-35.PMID: 18058780 [PubMed - indexed for MEDLINE]Related articles

Familial risk and colorectal cancer screening health beliefs and attitudes in an insured population.

Palmer RC, Emmons KM, Fletcher RH, Lobb R, Miroshnik I, Kemp JA, Bauer M.

Prev Med. 2007 Nov;45(5):336-41. Epub 2007 Jul 26.PMID: 17804048 [PubMed - indexed for MEDLINE]Related articles

Screening patients with a family history of colorectal cancer.

Fletcher RH, Lobb R, Bauer MR, Kemp JA, Palmer RC, Kleinman KP, Miroshnik I, Emmons KM.

J Gen Intern Med. 2007 Apr;22(4):508-13.PMID: 17372801 [PubMed - indexed for MEDLINE]Related articlesFree article

Life expectancy benefits of gastric bypass surgery.

Pope GD, Finlayson SR, Kemp JA, Birkmeyer JD.

Surg Innov. 2006 Dec;13(4):265-73.PMID: 17227925 [PubMed - indexed for MEDLINE]Related articles

[The South African Dental Association and dentists in the field]

Kemp JA.

SADJ. 2001 Jan;56(1):10-1; author reply. Afrikaans. No abstract available. PMID: 16894678 [PubMed - indexed for MEDLINE]Related articles

Glutamate- and GABA-based CNS therapeutics.

Foster AC, Kemp JA.

Curr Opin Pharmacol. 2006 Feb;6(1):7-17. Epub 2005 Dec 22. Review.PMID: 16377242 [PubMed - indexed for MEDLINE]Related articles

Controlled trial of interventions to increase testing and treatment for Helicobacter pylori and reduce medication use in patients with chronic acid-related symptoms.

Majumdar SR, Ross-Degnan D, Farraye FA, Lee M, Kemp JA, Lecates RF, Henning JM, Tunis SR, Schrammel P, Soumerai SB.

Aliment Pharmacol Ther. 2005 Apr 15;21(8):1029-39.PMID: 15813839 [PubMed - indexed for MEDLINE]Related articlesFree article

Evidence for improved performance in cognitive tasks following selective NR2B NMDA receptor antagonist pre-treatment in the rat.

Higgins GA, Ballard TM, Enderlin M, Haman M, Kemp JA.

Psychopharmacology (Berl). 2005 Apr;179(1):85-98. Epub 2005 Mar 10.PMID: 15759152 [PubMed - indexed for MEDLINE]Related articles

Ionotropic and metabotropic glutamate receptor structure and pharmacology.

Kew JN, Kemp JA.

Psychopharmacology (Berl). 2005 Apr;179(1):4-29. Epub 2005 Feb 25. Review. Erratum in: Psychopharmacology (Berl). 2005 Oct;182(2):320. PMID: 15731895 [PubMed - indexed for MEDLINE]Related articles

Human C-reactive protein increases cerebral infarct size after middle cerebral artery occlusion in adult rats.

Gill R, Kemp JA, Sabin C, Pepys MB.

J Cereb Blood Flow Metab. 2004 Nov;24(11):1214-8.PMID: 15545914 [PubMed - indexed for MEDLINE]Related articles

Pharmacological manipulation of mGlu2 receptors influences cognitive performance in the rodent.

Higgins GA, Ballard TM, Kew JN, Richards JG, Kemp JA, Adam G, Woltering T, Nakanishi S, Mutel V.

Neuropharmacology. 2004 Jun;46(7):907-17.PMID: 15081787 [PubMed - indexed for MEDLINE]Related articles

Antiparkinsonian activity of Ro 25-6981, a NR2B subunit specific NMDA receptor antagonist, in animal models of Parkinson's disease.

Löschmann PA, De Groote C, Smith L, Wüllner U, Fischer G, Kemp JA, Jenner P, Klockgether T.

Exp Neurol. 2004 May;187(1):86-93.PMID: 15081591 [PubMed - indexed for MEDLINE]Related articles

Pharmacological and genetic evidence indicates that combined inhibition of NR2A and NR2B subunit containing NMDA receptors is required to disrupt prepulse inhibition.

Spooren W, Mombereau C, Maco M, Gill R, Kemp JA, Ozmen L, Nakanishi S, Higgins GA.

Psychopharmacology (Berl). 2004 Aug;175(1):99-105. Epub 2004 Feb 20.PMID: 14985927 [PubMed - indexed for MEDLINE]Related articles

Chronic acid-related disorders are common and underinvestigated.

Majumdar SR, Soumerai SB, Farraye FA, Lee M, Kemp JA, Henning JM, Schrammel P, LeCates RF, Ross-Degnan D.

Am J Gastroenterol. 2003 Nov;98(11):2409-14.PMID: 14638341 [PubMed - indexed for MEDLINE]Related articles

Identification of critical residues in the amino terminal domain of the human NR2B subunit involved in the RO 25-6981 binding pocket.

Malherbe P, Mutel V, Broger C, Perin-Dureau F, Kemp JA, Neyton J, Paoletti P, Kew JN.

J Pharmacol Exp Ther. 2003 Dec;307(3):897-905. Epub 2003 Oct 8.PMID: 14534359 [PubMed - indexed for MEDLINE]Related articlesFree article

PS2APP transgenic mice, coexpressing hPS2mut and hAPPswe, show age-related cognitive deficits associated with discrete brain amyloid deposition and inflammation.

Richards JG, Higgins GA, Ouagazzal AM, Ozmen L, Kew JN, Bohrmann B, Malherbe P, Brockhaus M, Loetscher H, Czech C, Huber G, Bluethmann H, Jacobsen H, Kemp JA.

J Neurosci. 2003 Oct 1;23(26):8989-9003.PMID: 14523101 [PubMed - indexed for MEDLINE]Related articlesFree article

The voltage-dependent anion channel is the target for a new class of inhibitors of the mitochondrial permeability transition pore.

Cesura AM, Pinard E, Schubenel R, Goetschy V, Friedlein A, Langen H, Polcic P, Forte MA, Bernardi P, Kemp JA.

J Biol Chem. 2003 Dec 12;278(50):49812-8. Epub 2003 Sep 2.PMID: 12952973 [PubMed - indexed for MEDLINE]Related articlesFree article

Evaluation of the NR2B-selective NMDA receptor antagonist Ro 63-1908 on rodent behaviour: evidence for an involvement of NR2B NMDA receptors in response inhibition.

Higgins GA, Ballard TM, Huwyler J, Kemp JA, Gill R.

Neuropharmacology. 2003 Mar;44(3):324-41.PMID: 12604092 [PubMed - indexed for MEDLINE]Related articles

Identification and characterization of a novel splice variant of the metabotropic glutamate receptor 5 gene in human hippocampus and cerebellum.

Malherbe P, Kew JN, Richards JG, Knoflach F, Kratzeisen C, Zenner MT, Faull RL, Kemp JA, Mutel V.

Brain Res Mol Brain Res. 2002 Dec 30;109(1-2):168-78.PMID: 12531526 [PubMed - indexed for MEDLINE]Related articles

NMDA receptor pathways as drug targets.

Kemp JA, McKernan RM.

Nat Neurosci. 2002 Nov;5 Suppl:1039-42. Review.PMID: 12403981 [PubMed - indexed for MEDLINE]Related articles

Differential regulation of synaptic transmission by mGlu2 and mGlu3 at the perforant path inputs to the dentate gyrus and CA1 revealed in mGlu2 -/- mice.

Kew JN, Pflimlin MC, Kemp JA, Mutel V.

Neuropharmacology. 2002 Aug;43(2):215-21.PMID: 12213275 [PubMed - indexed for MEDLINE]Related articles

Pharmacological characterization of Ro 63-1908 (1-[2-(4-hydroxy-phenoxy)-ethyl]-4-(4-methyl-benzyl)-piperidin-4-ol), a novel subtype-selective N-methyl-D-aspartate antagonist.

Gill R, Alanine A, Bourson A, Buttelmann B, Fischer G, Heitz MP, Kew JN, Levet-Trafit B, Lorez HP, Malherbe P, Miss MT, Mutel V, Pinard E, Roever S, Schmitt M, Trube G, Wybrecht R, Wyler R, Kemp JA.

J Pharmacol Exp Ther. 2002 Sep;302(3):940-8.PMID: 12183650 [PubMed - indexed for MEDLINE]Related articlesFree article

Severe impairment of NMDA receptor function in mice carrying targeted point mutations in the glycine binding site results in drug-resistant nonhabituating hyperactivity.

Ballard TM, Pauly-Evers M, Higgins GA, Ouagazzal AM, Mutel V, Borroni E, Kemp JA, Bluethmann H, Kew JN.

J Neurosci. 2002 Aug 1;22(15):6713-23.PMID: 12151550 [PubMed - indexed for MEDLINE]Related articlesFree article

Donepezil reverses a mnemonic deficit produced by scopolamine but not by perforant path lesion or transient cerebral ischaemia.

Higgins GA, Enderlin M, Fimbel R, Haman M, Grottick AJ, Soriano M, Richards JG, Kemp JA, Gill R.

Eur J Neurosci. 2002 Jun;15(11):1827-40.PMID: 12081663 [PubMed - indexed for MEDLINE]Related articles

Targeted pharmacological depletion of serum amyloid P component for treatment of human amyloidosis.

Pepys MB, Herbert J, Hutchinson WL, Tennent GA, Lachmann HJ, Gallimore JR, Lovat LB, Bartfai T, Alanine A, Hertel C, Hoffmann T, Jakob-Roetne R, Norcross RD, Kemp JA, Yamamura K, Suzuki M, Taylor GW, Murray S, Thompson D, Purvis A, Kolstoe S, Wood SP, Hawkins PN.

Nature. 2002 May 16;417(6886):254-9.PMID: 12015594 [PubMed - indexed for MEDLINE]Related articles

Role of caspase-3 activation in cerebral ischemia-induced neurodegeneration in adult and neonatal brain.

Gill R, Soriano M, Blomgren K, Hagberg H, Wybrecht R, Miss MT, Hoefer S, Adam G, Niederhauser O, Kemp JA, Loetscher H.

J Cereb Blood Flow Metab. 2002 Apr;22(4):420-30.PMID: 11919513 [PubMed - indexed for MEDLINE]Related articlesFree article

A combined pharmacological and genetic approach to investigate the role of orphanin FQ in learning and memory.

Higgins GA, Kew JN, Richards JG, Takeshima H, Jenck F, Adam G, Wichmann J, Kemp JA, Grottick AJ.

Eur J Neurosci. 2002 Mar;15(5):911-22.PMID: 11906533 [PubMed - indexed for MEDLINE]Related articles

Clinical course and visual function in a family with mutations in the RPE65 gene.

Felius J, Thompson DA, Khan NW, Bingham EL, Jamison JA, Kemp JA, Sieving PA.

Arch Ophthalmol. 2002 Jan;120(1):55-61.PMID: 11786058 [PubMed - indexed for MEDLINE]Related articlesFree article

Analysis of photoreceptor function and inner retinal activity in juvenile X-linked retinoschisis.

Khan NW, Jamison JA, Kemp JA, Sieving PA.

Vision Res. 2001 Dec;41(28):3931-42.PMID: 11738458 [PubMed - indexed for MEDLINE]Related articles

Identification of essential residues involved in the glutamate binding pocket of the group II metabotropic glutamate receptor.

Malherbe P, Knoflach F, Broger C, Ohresser S, Kratzeisen C, Adam G, Stadler H, Kemp JA, Mutel V.

Mol Pharmacol. 2001 Nov;60(5):944-54.PMID: 11641422 [PubMed - indexed for MEDLINE]Related articlesFree article

Positive allosteric modulators of metabotropic glutamate 1 receptor: characterization, mechanism of action, and binding site.

Knoflach F, Mutel V, Jolidon S, Kew JN, Malherbe P, Vieira E, Wichmann J, Kemp JA.

Proc Natl Acad Sci U S A. 2001 Nov 6;98(23):13402-7. Epub 2001 Oct 23. Erratum in: Proc Natl Acad Sci U S A 2001 Dec 18;98(26):15393. PMID: 11606768 [PubMed - indexed for MEDLINE]Related articlesFree article

Management of asthma in children.

Kemp JP, Kemp JA.

Am Fam Physician. 2001 Apr 1;63(7):1341-8, 1353-4. Review. Erratum in: Am Fam Physician 2002 Feb 1;65(3):386. PMID: 11310649 [PubMed - indexed for MEDLINE]Related articles

Pharmacological properties of native metabotropic glutamate receptors in freshly dissociated Golgi cells of the rat cerebellum.

Knoflach F, Woltering T, Adam G, Mutel V, Kemp JA.

Neuropharmacology. 2001;40(2):163-9.PMID: 11114394 [PubMed - indexed for MEDLINE]Related articles

Activity-dependent presynaptic autoinhibition by group II metabotropic glutamate receptors at the perforant path inputs to the dentate gyrus and CA1.

Kew JN, Ducarre JM, Pflimlin MC, Mutel V, Kemp JA.

Neuropharmacology. 2001;40(1):20-7.PMID: 11077067 [PubMed - indexed for MEDLINE]Related articles

Functional consequences of reduction in NMDA receptor glycine affinity in mice carrying targeted point mutations in the glycine binding site.

Kew JN, Koester A, Moreau JL, Jenck F, Ouagazzal AM, Mutel V, Richards JG, Trube G, Fischer G, Montkowski A, Hundt W, Reinscheid RK, Pauly-Evers M, Kemp JA, Bluethmann H.

J Neurosci. 2000 Jun 1;20(11):4037-49.PMID: 10818139 [PubMed - indexed for MEDLINE]Related articlesFree article

Controlling polymerization of beta-amyloid and prion-derived peptides with synthetic small molecule ligands.

Kuner P, Bohrmann B, Tjernberg LO, Näslund J, Huber G, Celenk S, Grüninger-Leitch F, Richards JG, Jakob-Roetne R, Kemp JA, Nordstedt C.

J Biol Chem. 2000 Jan 21;275(3):1673-8.PMID: 10636861 [PubMed - indexed for MEDLINE]Related articlesFree article

A randomized controlled trial of an enhanced patient compliance program for Helicobacter pylori therapy.

Lee M, Kemp JA, Canning A, Egan C, Tataronis G, Farraye FA.

Arch Intern Med. 1999 Oct 25;159(19):2312-6.PMID: 10547171 [PubMed - indexed for MEDLINE]Related articlesFree article

Screening for colorectal cancer with flexible sigmoidoscopy by nonphysician endoscopists.

Wallace MB, Kemp JA, Meyer F, Horton K, Reffel A, Christiansen CL, Farraye FA.

Am J Med. 1999 Sep;107(3):214-8.PMID: 10492313 [PubMed - indexed for MEDLINE]Related articles

Methotrexate in Crohn's disease: results of a randomized, double-blind, placebo-controlled trial.

Arora S, Katkov W, Cooley J, Kemp JA, Johnston DE, Schapiro RH, Podolsky D.

Hepatogastroenterology. 1999 May-Jun;46(27):1724-9.PMID: 10430331 [PubMed - indexed for MEDLINE]Related articles

Colonoscopy for small adenomas.

Wallace MB, Farraye FA, Kemp JA.

Ann Intern Med. 1999 Apr 20;130(8):701. No abstract available. PMID: 10215574 [PubMed - indexed for MEDLINE]Related articlesFree article

Cholecystectomy and colon cancer.

Kemp JA.

Am J Gastroenterol. 1999 Jan;94(1):1-2. No abstract available. PMID: 9934719 [PubMed - indexed for MEDLINE]Related articles

Characterization of (2S,2'R,3'R)-2-(2',3'-[3H]-dicarboxycyclopropyl)glycine binding in rat brain.

Mutel V, Adam G, Chaboz S, Kemp JA, Klingelschmidt A, Messer J, Wichmann J, Woltering T, Richards JG.

J Neurochem. 1998 Dec;71(6):2558-64.PMID: 9832156 [PubMed - indexed for MEDLINE]Related articles

L-687,414, a low efficacy NMDA receptor glycine site partial agonist in vitro, does not prevent hippocampal LTP in vivo at plasma levels known to be neuroprotective.

Priestley T, Marshall GR, Hill RG, Kemp JA.

Br J Pharmacol. 1998 Aug;124(8):1767-73.PMID: 9756395 [PubMed - indexed for MEDLINE]Related articlesFree article

An allosteric interaction between the NMDA receptor polyamine and ifenprodil sites in rat cultured cortical neurones.

Kew JN, Kemp JA.

J Physiol. 1998 Oct 1;512 ( Pt 1):17-28.PMID: 9729614 [PubMed - indexed for MEDLINE]Related articlesFree article

Is colonoscopy indicated for small adenomas found by screening flexible sigmoidoscopy?

Wallace MB, Kemp JA, Trnka YM, Donovan JM, Farraye FA.

Ann Intern Med. 1998 Aug 15;129(4):273-8.PMID: 9729179 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of metabotropic glutamate receptor activation on receptor-mediated cyclic AMP responses in primary cultures of rat striatal neurones.

Cartmell J, Goepfert F, Knoflach F, Pink JR, Bleuel Z, Richards JG, Schaffhauser H, Kemp JA, Wichmann J, Mutel V.

Brain Res. 1998 Apr 27;791(1-2):191-9.PMID: 9593890 [PubMed - indexed for MEDLINE]Related articles