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    Results: 1 to 50 of 155

    1.

    Crystal structure of albaflavenone monooxygenase containing a moonlighting terpene synthase active site.

    Zhao B, Lei L, Vassylyev DG, Lin X, Cane DE, Kelly SL, Yuan H, Lamb DC, Waterman MR.

    J Biol Chem. 2009 Oct 26. [Epub ahead of print]PMID: 19858213 [PubMed - as supplied by publisher]Related articlesFree article

    2.

    Characterization of mutant serine palmitoyltransferase 1 in LY-B cells.

    Momin AA, Park H, Allegood JC, Leipelt M, Kelly SL, Merrill AH Jr, Hanada K.

    Lipids. 2009 Aug;44(8):725-32. Epub 2009 Jun 18.PMID: 19536577 [PubMed - indexed for MEDLINE]Related articles

    3.

    The first virally encoded cytochrome p450.

    Lamb DC, Lei L, Warrilow AG, Lepesheva GI, Mullins JG, Waterman MR, Kelly SL.

    J Virol. 2009 Aug;83(16):8266-9. Epub 2009 Jun 10.PMID: 19515774 [PubMed - indexed for MEDLINE]Related articles

    4.

    Successful management of an aortoesophageal fistula caused by a fish bone--case report and review of literature.

    Kelly SL, Peters P, Ogg MJ, Li A, Smithers BM.

    J Cardiothorac Surg. 2009 May 8;4:21. Review.PMID: 19422725 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    Identification, characterization, and azole-binding properties of Mycobacterium smegmatis CYP164A2, a homolog of ML2088, the sole cytochrome P450 gene of Mycobacterium leprae.

    Warrilow AG, Jackson CJ, Parker JE, Marczylo TH, Kelly DE, Lamb DC, Kelly SL.

    Antimicrob Agents Chemother. 2009 Mar;53(3):1157-64. Epub 2008 Dec 15.PMID: 19075057 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    Molecular characterization of a subgroup IE intron with wide distribution in the large subunit rRNA genes of dermatophyte fungi.

    Jackson CJ, Barton RC, Clark CG, Kelly SL.

    Med Mycol. 2009;47(6):609-17.PMID: 18949625 [PubMed - in process]Related articles

    7.

    Differential azole antifungal efficacies contrasted using a Saccharomyces cerevisiae strain humanized for sterol 14 alpha-demethylase at the homologous locus.

    Parker JE, Merkamm M, Manning NJ, Pompon D, Kelly SL, Kelly DE.

    Antimicrob Agents Chemother. 2008 Oct;52(10):3597-603. Epub 2008 Aug 11.PMID: 18694951 [PubMed - indexed for MEDLINE]Related articlesFree article

    8.

    CYP56 (Dit2p) in Candida albicans: characterization and investigation of its role in growth and antifungal drug susceptibility.

    Melo NR, Moran GP, Warrilow AG, Dudley E, Smith SN, Sullivan DJ, Lamb DC, Kelly DE, Coleman DC, Kelly SL.

    Antimicrob Agents Chemother. 2008 Oct;52(10):3718-24. Epub 2008 Jul 28.PMID: 18663031 [PubMed - indexed for MEDLINE]Related articlesFree article

    9.

    Human cytomegalovirus regulates bioactive sphingolipids.

    Machesky NJ, Zhang G, Raghavan B, Zimmerman P, Kelly SL, Merrill AH Jr, Waldman WJ, Van Brocklyn JR, Trgovcich J.

    J Biol Chem. 2008 Sep 19;283(38):26148-60. Epub 2008 Jul 20.PMID: 18644793 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    Genome-wide generation of yeast gene deletion strains.

    Kelly DE, Lamb DC, Kelly SL.

    Comp Funct Genomics. 2001;2(4):236-42.PMID: 18628917 [PubMed - in process]Related articlesFree article

    11.

    1-[(3-Aryloxy-3-aryl)propyl]-1H-imidazoles, new imidazoles with potent activity against Candida albicans and dermatophytes. Synthesis, structure-activity relationship, and molecular modeling studies.

    La Regina G, D'Auria FD, Tafi A, Piscitelli F, Olla S, Caporuscio F, Nencioni L, Cirilli R, La Torre F, De Melo NR, Kelly SL, Lamb DC, Artico M, Botta M, Palamara AT, Silvestri R.

    J Med Chem. 2008 Jul 10;51(13):3841-55. Epub 2008 Jun 5.PMID: 18529046 [PubMed - indexed for MEDLINE]Related articles

    12.

    Biosynthesis of the sesquiterpene antibiotic albaflavenone in Streptomyces coelicolor A3(2).

    Zhao B, Lin X, Lei L, Lamb DC, Kelly SL, Waterman MR, Cane DE.

    J Biol Chem. 2008 Mar 28;283(13):8183-9. Epub 2008 Jan 30.PMID: 18234666 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    Cytochromes P450 and drug discovery.

    Lamb DC, Waterman MR, Kelly SL, Guengerich FP.

    Curr Opin Biotechnol. 2007 Dec;18(6):504-12. Epub 2007 Nov 19. Review.PMID: 18006294 [PubMed - indexed for MEDLINE]Related articles

    14.

    Different binding modes of two flaviolin substrate molecules in cytochrome P450 158A1 (CYP158A1) compared to CYP158A2.

    Zhao B, Lamb DC, Lei L, Kelly SL, Yuan H, Hachey DL, Waterman MR.

    Biochemistry. 2007 Jul 31;46(30):8725-33. Epub 2007 Jul 6.PMID: 17614370 [PubMed - indexed for MEDLINE]Related articles

    15.

    Lanosterol biosynthesis in the prokaryote Methylococcus capsulatus: insight into the evolution of sterol biosynthesis.

    Lamb DC, Jackson CJ, Warrilow AG, Manning NJ, Kelly DE, Kelly SL.

    Mol Biol Evol. 2007 Aug;24(8):1714-21. Epub 2007 Jun 13.PMID: 17567593 [PubMed - indexed for MEDLINE]Related articlesFree article

    16.

    Electron transport pathway for a Streptomyces cytochrome P450: cytochrome P450 105D5-catalyzed fatty acid hydroxylation in Streptomyces coelicolor A3(2).

    Chun YJ, Shimada T, Sanchez-Ponce R, Martin MV, Lei L, Zhao B, Kelly SL, Waterman MR, Lamb DC, Guengerich FP.

    J Biol Chem. 2007 Jun 15;282(24):17486-500. Epub 2007 Apr 19.PMID: 17446171 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    The cytochrome P450 gene family CYP157 does not contain EXXR in the K-helix reducing the absolute conserved P450 residues to a single cysteine.

    Rupasinghe S, Schuler MA, Kagawa N, Yuan H, Lei L, Zhao B, Kelly SL, Waterman MR, Lamb DC.

    FEBS Lett. 2006 Nov 27;580(27):6338-42. Epub 2006 Oct 30.PMID: 17092500 [PubMed - indexed for MEDLINE]Related articles

    18.

    Towards engineered topogenesis of cytochrome b(5) and P450 for in vivo transformation of xenobiotics.

    Kaderbhai MA, Kelly SL, Kaderbhai NN.

    Biochem Soc Trans. 2006 Dec;34(Pt 6):1231-5.PMID: 17073792 [PubMed - indexed for MEDLINE]Related articles

    19.

    Cytochrome P450 biodiversity and biotechnology.

    Kelly SL, Lamb DC, Kelly DE.

    Biochem Soc Trans. 2006 Dec;34(Pt 6):1159-60.PMID: 17073775 [PubMed - indexed for MEDLINE]Related articles

    20.

    Exploiting Streptomyces coelicolor A3(2) P450s as a model for application in drug discovery.

    Lamb DC, Guengerich FP, Kelly SL, Waterman MR.

    Expert Opin Drug Metab Toxicol. 2006 Feb;2(1):27-40. Review.PMID: 16863466 [PubMed - indexed for MEDLINE]Related articles

    21.

    Evaluation of corneal sensitivity to mechanical and chemical stimuli after LASIK: a pilot study.

    Stapleton F, Hayward KB, Bachand N, Trong PH, Teh DW, Deng KM, Yang EI, Kelly SL, Lette M, Robinson D.

    Eye Contact Lens. 2006 Mar;32(2):88-93.PMID: 16538130 [PubMed - indexed for MEDLINE]Related articles

    22.

    Characterization of Acanthamoeba-microsphere association by multiparameter flow cytometry and confocal microscopy.

    Elloway EA, Bird RA, Hewitt CJ, Kelly SL, Smith SN.

    Cytometry A. 2006 Apr;69(4):266-72.PMID: 16498687 [PubMed - indexed for MEDLINE]Related articlesFree article

    23.

    A second FMN binding site in yeast NADPH-cytochrome P450 reductase suggests a mechanism of electron transfer by diflavin reductases.

    Lamb DC, Kim Y, Yermalitskaya LV, Yermalitsky VN, Lepesheva GI, Kelly SL, Waterman MR, Podust LM.

    Structure. 2006 Jan;14(1):51-61.PMID: 16407065 [PubMed - indexed for MEDLINE]Related articles

    24.

    Cytochrome b(5) modulation of 17{alpha} hydroxylase and 17-20 lyase (CYP17) activities in steroidogenesis.

    Akhtar MK, Kelly SL, Kaderbhai MA.

    J Endocrinol. 2005 Nov;187(2):267-74. Review.PMID: 16293774 [PubMed - indexed for MEDLINE]Related articlesFree article

    25.

    Reduced azole susceptibility in genotype 3 Candida dubliniensis isolates associated with increased CdCDR1 and CdCDR2 expression.

    Pinjon E, Jackson CJ, Kelly SL, Sanglard D, Moran G, Coleman DC, Sullivan DJ.

    Antimicrob Agents Chemother. 2005 Apr;49(4):1312-8.PMID: 15793103 [PubMed - indexed for MEDLINE]Related articlesFree article

    26.

    Binding of two flaviolin substrate molecules, oxidative coupling, and crystal structure of Streptomyces coelicolor A3(2) cytochrome P450 158A2.

    Zhao B, Guengerich FP, Bellamine A, Lamb DC, Izumikawa M, Lei L, Podust LM, Sundaramoorthy M, Kalaitzis JA, Reddy LM, Kelly SL, Moore BS, Stec D, Voehler M, Falck JR, Shimada T, Waterman MR.

    J Biol Chem. 2005 Mar 25;280(12):11599-607. Epub 2005 Jan 19.PMID: 15659395 [PubMed - indexed for MEDLINE]Related articlesFree article

    27.

    Analysis of Acanthamoeba polyphaga surface carbohydrate exposure by FITC-lectin binding and fluorescence evaluation.

    Elloway EA, Armstrong RA, Bird RA, Kelly SL, Smith SN.

    J Appl Microbiol. 2004;97(6):1319-25.PMID: 15546423 [PubMed - indexed for MEDLINE]Related articles

    28.

    Cloning and characterization of the lanosterol 14alpha-demethylase (ERG11) gene in Cryptococcus neoformans.

    Revankar SG, Fu J, Rinaldi MG, Kelly SL, Kelly DE, Lamb DC, Keller SM, Wickes BL.

    Biochem Biophys Res Commun. 2004 Nov 12;324(2):719-28.PMID: 15474487 [PubMed - indexed for MEDLINE]Related articles

    29.

    Availability of specific reductases controls the temporal activity of the cytochrome P450 complement of Streptomyces coelicolor A3(2).

    Lei L, Waterman MR, Fulco AJ, Kelly SL, Lamb DC.

    Proc Natl Acad Sci U S A. 2004 Jan 13;101(2):494-9. Epub 2004 Jan 2.PMID: 14704268 [PubMed - indexed for MEDLINE]Related articlesFree article

    30.

    Comparison of the 1.85 A structure of CYP154A1 from Streptomyces coelicolor A3(2) with the closely related CYP154C1 and CYPs from antibiotic biosynthetic pathways.

    Podust LM, Bach H, Kim Y, Lamb DC, Arase M, Sherman DH, Kelly SL, Waterman MR.

    Protein Sci. 2004 Jan;13(1):255-68.PMID: 14691240 [PubMed - indexed for MEDLINE]Related articlesFree article

    31.

    The biodiversity of microbial cytochromes P450.

    Kelly SL, Lamb DC, Jackson CJ, Warrilow AG, Kelly DE.

    Adv Microb Physiol. 2003;47:131-86. Review.PMID: 14560664 [PubMed - indexed for MEDLINE]Related articles

    32.

    Restriction fragment length polymorphism analysis of ribosomal DNA intergenic regions is useful for differentiating strains of Trichophyton mentagrophytes.

    Mochizuki T, Ishizaki H, Barton RC, Moore MK, Jackson CJ, Kelly SL, Evans EG.

    J Clin Microbiol. 2003 Oct;41(10):4583-8.PMID: 14532186 [PubMed - indexed for MEDLINE]Related articlesFree article

    33.

    Mutations in Saccharomyces cerevisiae sterol C5-desaturase conferring resistance to the CYP51 inhibitor fluconazole.

    Jackson CJ, Lamb DC, Manning NJ, Kelly DE, Kelly SL.

    Biochem Biophys Res Commun. 2003 Oct 3;309(4):999-1004.PMID: 13679073 [PubMed - indexed for MEDLINE]Related articles

    34.

    Export of a heterologous cytochrome P450 (CYP105D1) in Escherichia coli is associated with periplasmic accumulation of uroporphyrin.

    Akhtar MK, Kaderbhai NN, Hopper DJ, Kelly SL, Kaderbhai MA.

    J Biol Chem. 2003 Nov 14;278(46):45555-62. Epub 2003 Aug 20.PMID: 12930844 [PubMed - indexed for MEDLINE]Related articlesFree article

    35.

    Cytochrome p450 complement (CYPome) of the avermectin-producer Streptomyces avermitilis and comparison to that of Streptomyces coelicolor A3(2).

    Lamb DC, Ikeda H, Nelson DR, Ishikawa J, Skaug T, Jackson C, Omura S, Waterman MR, Kelly SL.

    Biochem Biophys Res Commun. 2003 Aug 1;307(3):610-9.PMID: 12893267 [PubMed - indexed for MEDLINE]Related articles

    36.

    Molecular mechanisms of itraconazole resistance in Candida dubliniensis.

    Pinjon E, Moran GP, Jackson CJ, Kelly SL, Sanglard D, Coleman DC, Sullivan DJ.

    Antimicrob Agents Chemother. 2003 Aug;47(8):2424-37.PMID: 12878500 [PubMed - indexed for MEDLINE]Related articlesFree article

    37.

    Conservation and cloning of CYP51: a sterol 14 alpha-demethylase from Mycobacterium smegmatis.

    Jackson CJ, Lamb DC, Marczylo TH, Parker JE, Manning NL, Kelly DE, Kelly SL.

    Biochem Biophys Res Commun. 2003 Feb 7;301(2):558-63.PMID: 12565899 [PubMed - indexed for MEDLINE]Related articles

    38.

    The 1.92-A structure of Streptomyces coelicolor A3(2) CYP154C1. A new monooxygenase that functionalizes macrolide ring systems.

    Podust LM, Kim Y, Arase M, Neely BA, Beck BJ, Bach H, Sherman DH, Lamb DC, Kelly SL, Waterman MR.

    J Biol Chem. 2003 Apr 4;278(14):12214-21. Epub 2003 Jan 7.PMID: 12519772 [PubMed - indexed for MEDLINE]Related articlesFree article

    39.

    Phanerochaete chrysosporium NADPH-cytochrome P450 reductase kinetic mechanism.

    Warrilow AG, Lamb DC, Kelly DE, Kelly SL.

    Biochem Biophys Res Commun. 2002 Nov 29;299(2):189-95.PMID: 12437968 [PubMed - indexed for MEDLINE]Related articles

    40.

    Metabolic control analysis and engineering of the yeast sterol biosynthetic pathway.

    Groeneveld P, Rolley N, Kell DB, Kelly SL, Kelly DE.

    Mol Biol Rep. 2002;29(1-2):27-9. No abstract available. PMID: 12241069 [PubMed - indexed for MEDLINE]Related articles

    41.

    A novel sterol 14alpha-demethylase/ferredoxin fusion protein (MCCYP51FX) from Methylococcus capsulatus represents a new class of the cytochrome P450 superfamily.

    Jackson CJ, Lamb DC, Marczylo TH, Warrilow AG, Manning NJ, Lowe DJ, Kelly DE, Kelly SL.

    J Biol Chem. 2002 Dec 6;277(49):46959-65. Epub 2002 Sep 13.PMID: 12235134 [PubMed - indexed for MEDLINE]Related articlesFree article

    42.

    Functional profiling of the Saccharomyces cerevisiae genome.

    Giaever G, Chu AM, Ni L, Connelly C, Riles L, Véronneau S, Dow S, Lucau-Danila A, Anderson K, André B, Arkin AP, Astromoff A, El-Bakkoury M, Bangham R, Benito R, Brachat S, Campanaro S, Curtiss M, Davis K, Deutschbauer A, Entian KD, Flaherty P, Foury F, Garfinkel DJ, Gerstein M, Gotte D, Güldener U, Hegemann JH, Hempel S, Herman Z, Jaramillo DF, Kelly DE, Kelly SL, Kötter P, LaBonte D, Lamb DC, Lan N, Liang H, Liao H, Liu L, Luo C, Lussier M, Mao R, Menard P, Ooi SL, Revuelta JL, Roberts CJ, Rose M, Ross-Macdonald P, Scherens B, Schimmack G, Shafer B, Shoemaker DD, Sookhai-Mahadeo S, Storms RK, Strathern JN, Valle G, Voet M, Volckaert G, Wang CY, Ward TR, Wilhelmy J, Winzeler EA, Yang Y, Yen G, Youngman E, Yu K, Bussey H, Boeke JD, Snyder M, Philippsen P, Davis RW, Johnston M.

    Nature. 2002 Jul 25;418(6896):387-91.PMID: 12140549 [PubMed - indexed for MEDLINE]Related articles

    43.

    Sterol 14alpha-demethylase activity in Streptomyces coelicolor A3(2) is associated with an unusual member of the CYP51 gene family.

    Lamb DC, Fowler K, Kieser T, Manning N, Podust LM, Waterman MR, Kelly DE, Kelly SL.

    Biochem J. 2002 Jun 1;364(Pt 2):555-62.PMID: 12023899 [PubMed - indexed for MEDLINE]Related articlesFree article

    44.

    Fibrinogen is degraded and internalized during incubation with neutrophils, and fibrinogen products localize to electron lucent vesicles.

    Kirsch R, Jaffer MA, Woodburne VE, Sewell T, Kelly SL, Kirsch RE, Shephard EG.

    Biochem J. 2002 Jun 1;364(Pt 2):403-12.PMID: 12023883 [PubMed - indexed for MEDLINE]Related articlesFree article

    45.

    The cytochrome P450 complement (CYPome) of Streptomyces coelicolor A3(2).

    Lamb DC, Skaug T, Song HL, Jackson CJ, Podust LM, Waterman MR, Kell DB, Kelly DE, Kelly SL.

    J Biol Chem. 2002 Jul 5;277(27):24000-5. Epub 2002 Apr 9.PMID: 11943767 [PubMed - indexed for MEDLINE]Related articlesFree article

    46.

    HNF-1alpha G319S, a transactivation-deficient mutant, is associated with altered dynamics of diabetes onset in an Oji-Cree community.

    Triggs-Raine BL, Kirkpatrick RD, Kelly SL, Norquay LD, Cattini PA, Yamagata K, Hanley AJ, Zinman B, Harris SB, Barrett PH, Hegele RA.

    Proc Natl Acad Sci U S A. 2002 Apr 2;99(7):4614-9. Epub 2002 Mar 19.PMID: 11904371 [PubMed - indexed for MEDLINE]Related articlesFree article

    47.

    Human sterol 14alpha-demethylase activity is enhanced by the membrane-bound state of cytochrome b(5).

    Lamb DC, Kaderbhai NN, Venkateswarlu K, Kelly DE, Kelly SL, Kaderbhai MA.

    Arch Biochem Biophys. 2001 Nov 1;395(1):78-84.PMID: 11673868 [PubMed - indexed for MEDLINE]Related articles

    48.

    Activities and kinetic mechanisms of native and soluble NADPH-cytochrome P450 reductase.

    Lamb DC, Warrilow AG, Venkateswarlu K, Kelly DE, Kelly SL.

    Biochem Biophys Res Commun. 2001 Aug 10;286(1):48-54.PMID: 11485306 [PubMed - indexed for MEDLINE]Related articles

    49.

    Plant sterol 14 alpha-demethylase affinity for azole fungicides.

    Lamb DC, Cannieux M, Warrilow AG, Bak S, Kahn RA, Manning NJ, Kelly DE, Kelly SL.

    Biochem Biophys Res Commun. 2001 Jun 15;284(3):845-9.PMID: 11396979 [PubMed - indexed for MEDLINE]Related articles

    50.

    An old activity in the cytochrome P450 superfamily (CYP51) and a new story of drugs and resistance.

    Kelly SL, Lamb DC, Cannieux M, Greetham D, Jackson CJ, Marczylo T, Ugochukwu C, Kelly DE.

    Biochem Soc Trans. 2001 May;29(Pt 2):122-8. Review.PMID: 11356139 [PubMed - indexed for MEDLINE]Related articles

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