PubMed

Deficiency of Electron Transport Chain in Human Skeletal Muscle Mitochondria in Type 2 Diabetes Mellitus and Obesity.

Ritov VB, Menshikova EV, Azuma K, Wood RJ, Toledo FG, Goodpaster BH, Ruderman NB, Kelley DE.

Am J Physiol Endocrinol Metab. 2009 Nov 3. [Epub ahead of print]PMID: 19887598 [PubMed - as supplied by publisher]Related articles

Differential effect of weight loss on adipocyte size subfractions in patients with type 2 diabetes.

Pasarica M, Tchoukalova YD, Heilbronn LK, Fang X, Albu JB, Kelley DE, Smith SR, Ravussin E; Look AHEAD Adipose Research Group.

Obesity (Silver Spring). 2009 Oct;17(10):1976-8. Epub 2009 Jul 23.PMID: 19629054 [PubMed - in process]Related articles

Mechanisms of insulin resistance assessed by dynamic in-vivo positron emission tomography imaging.

Ng JM, Kelley DE, Goodpaster BH.

Curr Opin Clin Nutr Metab Care. 2009 Sep;12(5):508-12. Review.PMID: 19550312 [PubMed - indexed for MEDLINE]Related articles

Higher liver fat content among Japanese in Japan compared with non-Hispanic whites in the United States.

Azuma K, Kadowaki T, Cetinel C, Kadota A, El-Saed A, Kadowaki S, Edmundowicz D, Nishio Y, Sutton-Tyrrell K, Okamura T, Evans RW, Takamiya T, Ueshima H, Curb JD, Abbott RD, Kuller LH, Kelley DE, Sekikawa A; ERA JUMP study group.

Metabolism. 2009 Aug;58(8):1200-7. Epub 2009 Jun 18.PMID: 19428036 [PubMed - indexed for MEDLINE]Related articles

Adipose tissue distribution is different in type 2 diabetes.

Gallagher D, Kelley DE, Yim JE, Spence N, Albu J, Boxt L, Pi-Sunyer FX, Heshka S; MRI Ancillary Study Group of the Look AHEAD Research Group.

Am J Clin Nutr. 2009 Mar;89(3):807-14. Epub 2009 Jan 21.PMID: 19158213 [PubMed - indexed for MEDLINE]Related articles

New method for GC/FID and GC-C-IRMS analysis of plasma free fatty acid concentration and isotopic enrichment.

Kangani CO, Kelley DE, Delany JP.

J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Sep 15;873(1):95-101. Epub 2008 Aug 19.PMID: 18757250 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of vildagliptin on glucagon concentration during meals in patients with type 1 diabetes.

Foley JE, Ligueros-Saylan M, He YL, Holst JJ, Deacon CF, Dunning BE, Leone-Jones A, Yu T, Kelley DE.

Horm Metab Res. 2008 Oct;40(10):727-30. Epub 2008 Jul 2. No abstract available. PMID: 18597213 [PubMed - indexed for MEDLINE]Related articles

Metabolic flexibility in response to glucose is not impaired in people with type 2 diabetes after controlling for glucose disposal rate.

Galgani JE, Heilbronn LK, Azuma K, Kelley DE, Albu JB, Pi-Sunyer X, Smith SR, Ravussin E; Look AHEAD Adipose Research Group.

Diabetes. 2008 Apr;57(4):841-5. Epub 2008 Feb 19.PMID: 18285553 [PubMed - indexed for MEDLINE]Related articlesFree article

Mitochondrial capacity in skeletal muscle is not stimulated by weight loss despite increases in insulin action and decreases in intramyocellular lipid content.

Toledo FG, Menshikova EV, Azuma K, Radiková Z, Kelley CA, Ritov VB, Kelley DE.

Diabetes. 2008 Apr;57(4):987-94. Epub 2008 Feb 5.PMID: 18252894 [PubMed - indexed for MEDLINE]Related articlesFree article

Estimates of hepatic glyceroneogenesis in type 2 diabetes mellitus in humans.

Kalhan SC, Bugianesi E, McCullough AJ, Hanson RW, Kelley DE.

Metabolism. 2008 Mar;57(3):305-12.PMID: 18249200 [PubMed - indexed for MEDLINE]Related articlesFree article

Potential role of increased matrix metalloproteinase-2 (MMP2) transcription in impaired adipogenesis in type 2 diabetes mellitus.

Dubois SG, Tchoukalova YD, Heilbronn LK, Albu JB, Kelley DE, Smith SR, Fang X, Ravussin E; Look AHEAD Adipose Research Group.

Biochem Biophys Res Commun. 2008 Mar 21;367(4):725-8. Epub 2008 Jan 7.PMID: 18182154 [PubMed - indexed for MEDLINE]Related articlesFree article

Measurements of islet function and glucose metabolism with the dipeptidyl peptidase 4 inhibitor vildagliptin in patients with type 2 diabetes.

Azuma K, Rádiková Z, Mancino J, Toledo FG, Thomas E, Kangani C, Dalla Man C, Cobelli C, Holst JJ, Deacon CF, He Y, Ligueros-Saylan M, Serra D, Foley JE, Kelley DE.

J Clin Endocrinol Metab. 2008 Feb;93(2):459-64. Epub 2007 Nov 27.PMID: 18042650 [PubMed - indexed for MEDLINE]Related articlesFree article

Synthesis and mass spectrometry of benzoxazoline, dimethyloxazoline and 4-phenyloxazoline derivatives of polyunsaturated fatty acids.

Kangani CO, Kelley DE, Evans RW.

Rapid Commun Mass Spectrom. 2007;21(13):2129-36.PMID: 17551993 [PubMed - indexed for MEDLINE]Related articles

Effects of physical activity and weight loss on skeletal muscle mitochondria and relationship with glucose control in type 2 diabetes.

Toledo FG, Menshikova EV, Ritov VB, Azuma K, Radikova Z, DeLany J, Kelley DE.

Diabetes. 2007 Aug;56(8):2142-7. Epub 2007 May 29.PMID: 17536063 [PubMed - indexed for MEDLINE]Related articlesFree article

Waist Circumference and Cardiometabolic Risk: a Consensus Statement from Shaping America's Health: Association for Weight Management and Obesity Prevention; NAASO, the Obesity Society; the American Society for Nutrition; and the American Diabetes Association.

Klein S, Allison DB, Heymsfield SB, Kelley DE, Leibel RL, Nonas C, Kahn R.

Obesity (Silver Spring). 2007 May;15(5):1061-7. Review. No abstract available. PMID: 17495180 [PubMed - indexed for MEDLINE]Related articles

Waist circumference and cardiometabolic risk: a consensus statement from Shaping America's Health: Association for Weight Management and Obesity Prevention; NAASO, The Obesity Society; the American Society for Nutrition; and the American Diabetes Association.

Klein S, Allison DB, Heymsfield SB, Kelley DE, Leibel RL, Nonas C, Kahn R; Association for Weight Management and Obesity Prevention; NAASO, The Obesity Society; American Society for Nutrition; American Diabetes Association.

Am J Clin Nutr. 2007 May;85(5):1197-202. No abstract available. PMID: 17490953 [PubMed - indexed for MEDLINE]Related articlesFree article

Adipose tissue distribution in relation to insulin resistance in type 2 diabetes mellitus.

Azuma K, Heilbronn LK, Albu JB, Smith SR, Ravussin E, Kelley DE; and the Look AHEAD Adipose Research Group.

Am J Physiol Endocrinol Metab. 2007 Jul;293(1):E435-42. Epub 2007 Apr 17.PMID: 17440034 [PubMed - indexed for MEDLINE]Related articlesFree article

Reduction in weight and cardiovascular disease risk factors in individuals with type 2 diabetes: one-year results of the look AHEAD trial.

Look AHEAD Research Group, Pi-Sunyer X, Blackburn G, Brancati FL, Bray GA, Bright R, Clark JM, Curtis JM, Espeland MA, Foreyt JP, Graves K, Haffner SM, Harrison B, Hill JO, Horton ES, Jakicic J, Jeffery RW, Johnson KC, Kahn S, Kelley DE, Kitabchi AE, Knowler WC, Lewis CE, Maschak-Carey BJ, Montgomery B, Nathan DM, Patricio J, Peters A, Redmon JB, Reeves RS, Ryan DH, Safford M, Van Dorsten B, Wadden TA, Wagenknecht L, Wesche-Thobaben J, Wing RR, Yanovski SZ.

Diabetes Care. 2007 Jun;30(6):1374-83. Epub 2007 Mar 15.PMID: 17363746 [PubMed - indexed for MEDLINE]Related articlesFree article

Waist circumference and cardiometabolic risk: a consensus statement from shaping America's health: Association for Weight Management and Obesity Prevention; NAASO, the Obesity Society; the American Society for Nutrition; and the American Diabetes Association.

Klein S, Allison DB, Heymsfield SB, Kelley DE, Leibel RL, Nonas C, Kahn R; Association for Weight Management and Obesity Prevention; NAASO; Obesity Society; American Society for Nutrition; American Diabetes Association.

Diabetes Care. 2007 Jun;30(6):1647-52. Epub 2007 Mar 14. No abstract available. PMID: 17360974 [PubMed - indexed for MEDLINE]Related articlesFree article

Characteristics of skeletal muscle mitochondrial biogenesis induced by moderate-intensity exercise and weight loss in obesity.

Menshikova EV, Ritov VB, Ferrell RE, Azuma K, Goodpaster BH, Kelley DE.

J Appl Physiol. 2007 Jul;103(1):21-7. Epub 2007 Mar 1.PMID: 17332268 [PubMed - indexed for MEDLINE]Related articlesFree article

Interleukin-6 regulation of AMP-activated protein kinase. Potential role in the systemic response to exercise and prevention of the metabolic syndrome.

Ruderman NB, Keller C, Richard AM, Saha AK, Luo Z, Xiang X, Giralt M, Ritov VB, Menshikova EV, Kelley DE, Hidalgo J, Pedersen BK, Kelly M.

Diabetes. 2006 Dec;55 Suppl 2:S48-54. Review.PMID: 17130644 [PubMed - indexed for MEDLINE]Related articlesFree article

Interactions between delivery, transport, and phosphorylation of glucose in governing uptake into human skeletal muscle.

Bertoldo A, Pencek RR, Azuma K, Price JC, Kelley C, Cobelli C, Kelley DE.

Diabetes. 2006 Nov;55(11):3028-37.PMID: 17065339 [PubMed - indexed for MEDLINE]Related articlesFree article

Decreased expression of adipogenic genes in obese subjects with type 2 diabetes.

Dubois SG, Heilbronn LK, Smith SR, Albu JB, Kelley DE, Ravussin E; Look AHEAD Adipose Research Group.

Obesity (Silver Spring). 2006 Sep;14(9):1543-52.PMID: 17030965 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of weight loss and nutritional intervention on arterial stiffness in type 2 diabetes.

Barinas-Mitchell E, Kuller LH, Sutton-Tyrrell K, Hegazi R, Harper P, Mancino J, Kelley DE.

Diabetes Care. 2006 Oct;29(10):2218-22.PMID: 17003296 [PubMed - indexed for MEDLINE]Related articlesFree article

Influence of hepatic steatosis (fatty liver) on severity and composition of dyslipidemia in type 2 diabetes.

Toledo FG, Sniderman AD, Kelley DE.

Diabetes Care. 2006 Aug;29(8):1845-50.PMID: 16873790 [PubMed - indexed for MEDLINE]Related articlesFree article

The Look AHEAD study: a description of the lifestyle intervention and the evidence supporting it.

Look AHEAD Research Group, Wadden TA, West DS, Delahanty L, Jakicic J, Rejeski J, Williamson D, Berkowitz RI, Kelley DE, Tomchee C, Hill JO, Kumanyika S.

Obesity (Silver Spring). 2006 May;14(5):737-52. Review. Erratum in: Obesity (Silver Spring). 2007 May;15(5):1339. Wadden, Thomas A [added]; West, Delia Smith [added]; Delahanty, Linda [added]; Jakicic, John [added]; Rejeski, Jack [added]; Williamson, Don [added]; Berkowitz, Robert I [added]; Kelley, David E [added]; Tomchee, Christine [added]; Hill, James O [added]; Kumanyika, Shiriki [added]. PMID: 16855180 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of exercise on mitochondrial content and function in aging human skeletal muscle.

Menshikova EV, Ritov VB, Fairfull L, Ferrell RE, Kelley DE, Goodpaster BH.

J Gerontol A Biol Sci Med Sci. 2006 Jun;61(6):534-40.PMID: 16799133 [PubMed - indexed for MEDLINE]Related articlesFree article

One pot direct synthesis of amides or oxazolines from carboxylic acids using Deoxo-Fluor reagent.

Kangani CO, Kelley DE.

Tetrahedron Lett. 2005 Dec 19;46(51):8917-8920.PMID: 16755305 [PubMed]Related articlesFree article

Changes induced by physical activity and weight loss in the morphology of intermyofibrillar mitochondria in obese men and women.

Toledo FG, Watkins S, Kelley DE.

J Clin Endocrinol Metab. 2006 Aug;91(8):3224-7. Epub 2006 May 9.PMID: 16684829 [PubMed - indexed for MEDLINE]Related articlesFree article

Induction of leptin resistance through direct interaction of C-reactive protein with leptin.

Chen K, Li F, Li J, Cai H, Strom S, Bisello A, Kelley DE, Friedman-Einat M, Skibinski GA, McCrory MA, Szalai AJ, Zhao AZ.

Nat Med. 2006 Apr;12(4):425-32. Epub 2006 Apr 2.PMID: 16582918 [PubMed - indexed for MEDLINE]Related articles

Muscle-associated triglyceride measured by computed tomography and magnetic resonance spectroscopy.

Larson-Meyer DE, Smith SR, Heilbronn LK, Kelley DE, Ravussin E, Newcomer BR; Look AHEAD Adipose Research Group.

Obesity (Silver Spring). 2006 Jan;14(1):73-87.PMID: 16493125 [PubMed - indexed for MEDLINE]Related articlesFree article

Dose-responsive insulin regulation of glucose transport in human skeletal muscle.

Pencek RR, Bertoldo A, Price J, Kelley C, Cobelli C, Kelley DE.

Am J Physiol Endocrinol Metab. 2006 Jun;290(6):E1124-30. Epub 2006 Jan 3.PMID: 16390860 [PubMed - indexed for MEDLINE]Related articlesFree article

Analysis of cardiolipin in human muscle biopsy.

Ritov VB, Menshikova EV, Kelley DE.

J Chromatogr B Analyt Technol Biomed Life Sci. 2006 Feb 2;831(1-2):63-71. Epub 2005 Dec 6.PMID: 16337440 [PubMed - indexed for MEDLINE]Related articles

Pulling in more fat.

Kelley DE.

Cell Metab. 2005 Nov;2(5):275-6.PMID: 16271525 [PubMed - indexed for MEDLINE]Related articles

Skeletal muscle fat oxidation: timing and flexibility are everything.

Kelley DE.

J Clin Invest. 2005 Jul;115(7):1699-702. Review.PMID: 16007246 [PubMed - indexed for MEDLINE]Related articlesFree article

Deficiency of subsarcolemmal mitochondria in obesity and type 2 diabetes.

Ritov VB, Menshikova EV, He J, Ferrell RE, Goodpaster BH, Kelley DE.

Diabetes. 2005 Jan;54(1):8-14.PMID: 15616005 [PubMed - indexed for MEDLINE]Related articlesFree article

Quantitative assessment of glucose transport in human skeletal muscle: dynamic positron emission tomography imaging of [O-methyl-11C]3-O-methyl-D-glucose.

Bertoldo A, Price J, Mathis C, Mason S, Holt D, Kelley C, Cobelli C, Kelley DE.

J Clin Endocrinol Metab. 2005 Mar;90(3):1752-9. Epub 2004 Dec 21.PMID: 15613423 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of weight loss and physical activity on skeletal muscle mitochondrial function in obesity.

Menshikova EV, Ritov VB, Toledo FG, Ferrell RE, Goodpaster BH, Kelley DE.

Am J Physiol Endocrinol Metab. 2005 Apr;288(4):E818-25. Epub 2004 Dec 7.PMID: 15585590 [PubMed - indexed for MEDLINE]Related articlesFree article

Hypoglycemic potential of nateglinide versus glyburide in patients with type 2 diabetes mellitus.

Fonseca VA, Kelley DE, Cefalu W, Baron MA, Purkayastha D, Nestler JE, Hsia S, Gerich JE.

Metabolism. 2004 Oct;53(10):1331-5. Erratum in: Metabolism. 2005 May;54(5):698. PMID: 15375790 [PubMed - indexed for MEDLINE]Related articles

High-performance liquid chromatography-based methods of enzymatic analysis: electron transport chain activity in mitochondria from human skeletal muscle.

Ritov VB, Menshikova EV, Kelley DE.

Anal Biochem. 2004 Oct 1;333(1):27-38.PMID: 15351277 [PubMed - indexed for MEDLINE]Related articles

Metabolic flexibility.

Storlien L, Oakes ND, Kelley DE.

Proc Nutr Soc. 2004 May;63(2):363-8. Review.PMID: 15294056 [PubMed - indexed for MEDLINE]Related articles

Muscle glycogen content in type 2 diabetes mellitus.

He J, Kelley DE.

Am J Physiol Endocrinol Metab. 2004 Nov;287(5):E1002-7. Epub 2004 Jul 13.PMID: 15251866 [PubMed - indexed for MEDLINE]Related articlesFree article

Exercise training increases intramyocellular lipid and oxidative capacity in older adults.

Pruchnic R, Katsiaras A, He J, Kelley DE, Winters C, Goodpaster BH.

Am J Physiol Endocrinol Metab. 2004 Nov;287(5):E857-62. Epub 2004 Jun 29.PMID: 15226098 [PubMed - indexed for MEDLINE]Related articlesFree article

Thermodynamics, liposuction, and metabolism.

Kelley DE.

N Engl J Med. 2004 Jun 17;350(25):2542-4. No abstract available. PMID: 15201408 [PubMed - indexed for MEDLINE]Related articles

The chronic inflammatory hypothesis for the morbidity associated with morbid obesity: implications and effects of weight loss.

Cottam DR, Mattar SG, Barinas-Mitchell E, Eid G, Kuller L, Kelley DE, Schauer PR.

Obes Surg. 2004 May;14(5):589-600. Review.PMID: 15186624 [PubMed - indexed for MEDLINE]Related articles

Effects of weight loss and physical activity on muscle lipid content and droplet size.

He J, Goodpaster BH, Kelley DE.

Obes Res. 2004 May;12(5):761-9.PMID: 15166296 [PubMed - indexed for MEDLINE]Related articles

Influence of weight loss and physical activity interventions upon muscle lipid content in relation to insulin resistance.

Kelley DE.

Curr Diab Rep. 2004 Jun;4(3):165-8. Review.PMID: 15132879 [PubMed - indexed for MEDLINE]Related articles

Skeletal muscle lipid concentration quantified by magnetic resonance imaging.

Goodpaster BH, Stenger VA, Boada F, McKolanis T, Davis D, Ross R, Kelley DE.

Am J Clin Nutr. 2004 May;79(5):748-54.PMID: 15113711 [PubMed - indexed for MEDLINE]Related articlesFree article

Relationship between serum resistin concentrations and insulin resistance in nonobese, obese, and obese diabetic subjects.

Heilbronn LK, Rood J, Janderova L, Albu JB, Kelley DE, Ravussin E, Smith SR.

J Clin Endocrinol Metab. 2004 Apr;89(4):1844-8.PMID: 15070954 [PubMed - indexed for MEDLINE]Related articlesFree article

Metabolic syndrome modifies the cardiovascular risk associated with angiographic coronary artery disease in women: a report from the Women's Ischemia Syndrome Evaluation.

Marroquin OC, Kip KE, Kelley DE, Johnson BD, Shaw LJ, Bairey Merz CN, Sharaf BL, Pepine CJ, Sopko G, Reis SE; Women's Ischemia Syndrome Evaluation Investigators.

Circulation. 2004 Feb 17;109(6):714-21.PMID: 14970105 [PubMed - indexed for MEDLINE]Related articlesFree article