PubMed

Medical antihyperglycaemic treatment of type 2 diabetes mellitus: update of the evidence-based guideline of the German Diabetes Association.

Matthaei S, Bierwirth R, Fritsche A, Gallwitz B, Häring HU, Joost HG, Kellerer M, Kloos Ch, Kunt T, Nauck M, Schernthaner G, Siegel E, Thienel F.

Exp Clin Endocrinol Diabetes. 2009 Oct;117(9):522-57. Epub 2009 Oct 29. No abstract available. PMID: 19876795 [PubMed - in process]Related articles

Protein kinase C iota mediates lipid-induced apoptosis of human coronary artery endothelial cells.

Staiger K, Schatz U, Staiger H, Weyrich P, Haas C, Guirguis A, Machicao F, Häring HU, Kellerer M.

Microvasc Res. 2009 Jun;78(1):40-4. Epub 2009 Mar 25.PMID: 19327373 [PubMed - indexed for MEDLINE]Related articles

Comparison of the mitogenic potency of regular human insulin and its analogue glargine in normal and transformed human breast epithelial cells.

Staiger K, Hennige AM, Staiger H, Häring HU, Kellerer M.

Horm Metab Res. 2007 Jan;39(1):65-7. No abstract available. PMID: 17226117 [PubMed - indexed for MEDLINE]Related articles

Saturated, but not unsaturated, fatty acids induce apoptosis of human coronary artery endothelial cells via nuclear factor-kappaB activation.

Staiger K, Staiger H, Weigert C, Haas C, Häring HU, Kellerer M.

Diabetes. 2006 Nov;55(11):3121-6.PMID: 17065351 [PubMed - indexed for MEDLINE]Related articlesFree article

Adiponectin is functionally active in human islets but does not affect insulin secretory function or beta-cell lipoapoptosis.

Staiger K, Stefan N, Staiger H, Brendel MD, Brandhorst D, Bretzel RG, Machicao F, Kellerer M, Stumvoll M, Fritsche A, Häring HU.

J Clin Endocrinol Metab. 2005 Dec;90(12):6707-13. Epub 2005 Oct 4.PMID: 16204361 [PubMed - indexed for MEDLINE]Related articlesFree article

[New concepts in blood glucose determination in insulin therapy]

Kellerer M.

Krankenpfl J. 2005;43(4-6):149. German. No abstract available. PMID: 16171092 [PubMed - indexed for MEDLINE]Related articles

Insulin and its analogue glargine do not affect viability and proliferation of human coronary artery endothelial and smooth muscle cells.

Staiger K, Staiger H, Schweitzer MA, Metzinger E, Balletshofer B, Häring HU, Kellerer M.

Diabetologia. 2005 Sep;48(9):1898-905. Epub 2005 Aug 3.PMID: 16078017 [PubMed - indexed for MEDLINE]Related articles

Shp2 is required for protein kinase C-dependent phosphorylation of serine 307 in insulin receptor substrate-1.

Müssig K, Staiger H, Fiedler H, Moeschel K, Beck A, Kellerer M, Häring HU.

J Biol Chem. 2005 Sep 23;280(38):32693-9. Epub 2005 Jul 29.PMID: 16055440 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of new insulin analogues HMR1964 (insulin glulisine) and HMR1423 on insulin receptors.

Hennige AM, Strack V, Metzinger E, Seipke G, Häring HU, Kellerer M.

Diabetologia. 2005 Sep;48(9):1891-7. Epub 2005 Jul 29.PMID: 16052329 [PubMed - indexed for MEDLINE]Related articles

Palmitate-induced interleukin-6 expression in human coronary artery endothelial cells.

Staiger H, Staiger K, Stefan N, Wahl HG, Machicao F, Kellerer M, Häring HU.

Diabetes. 2004 Dec;53(12):3209-16.PMID: 15561952 [PubMed - indexed for MEDLINE]Related articlesFree article

[Continuation 50. Type 2 diabetes: possibilities and limitations of pharmacological therapy]

Kellerer M, Jakob S, Linn T, Haslbeck M.

MMW Fortschr Med. 2003 Dec 18;145(51-52):I-X; quiz XI-XII. Review. German. No abstract available. PMID: 14974337 [PubMed - indexed for MEDLINE]Related articles

The protein tyrosine phosphatase alpha modifies insulin secretion in INS-1E cells.

Kapp K, Metzinger E, Kellerer M, Häring HU, Lammers R.

Biochem Biophys Res Commun. 2003 Nov 14;311(2):361-4.PMID: 14592422 [PubMed - indexed for MEDLINE]Related articles

[Apoptosis induced by free fatty acids]

Eitel K, Staiger H, Brendel MD, Brandhorst H, Bretzel RG, Häring HU, Kellerer M.

Med Klin (Munich). 2003 Apr 25;98(5):248-52. German. PMID: 12721668 [PubMed - indexed for MEDLINE]Related articles

Protein kinase C delta activation and translocation to the nucleus are required for fatty acid-induced apoptosis of insulin-secreting cells.

Eitel K, Staiger H, Rieger J, Mischak H, Brandhorst H, Brendel MD, Bretzel RG, Häring HU, Kellerer M.

Diabetes. 2003 Apr;52(4):991-7.PMID: 12663471 [PubMed - indexed for MEDLINE]Related articlesFree article

Different role of saturated and unsaturated fatty acids in beta-cell apoptosis.

Eitel K, Staiger H, Brendel MD, Brandhorst D, Bretzel RG, Häring HU, Kellerer M.

Biochem Biophys Res Commun. 2002 Dec 20;299(5):853-6.PMID: 12470657 [PubMed - indexed for MEDLINE]Related articles

Metabolic characterization of a woman homozygous for the Ser113Leu missense mutation in carnitine palmitoyl transferase II.

Haap M, Thamer C, Machann J, Tschritter O, Löblein K, Kellerer M, Schick F, Jacob S, Häring HU, Stumvoll M.

J Clin Endocrinol Metab. 2002 May;87(5):2139-43.PMID: 11994355 [PubMed - indexed for MEDLINE]Related articlesFree article

The Protein-tyrosine-phosphatase SHP2 is phosphorylated on serine residues 576 and 591 by protein kinase C isoforms alpha, beta 1, beta 2, and eta.

Strack V, Krützfeldt J, Kellerer M, Ullrich A, Lammers R, Häring HU.

Biochemistry. 2002 Jan 15;41(2):603-8.PMID: 11781100 [PubMed - indexed for MEDLINE]Related articles

PKC zeta enhances insulin-like growth factor 1-dependent mitogenic activity in the rat clonal beta cell line RIN 1046-38.

Hennige AM, Fritsche A, Strack V, Weigert C, Mischak H, Borboni P, Renn W, Häring HU, Kellerer M.

Biochem Biophys Res Commun. 2002 Jan 11;290(1):85-90.PMID: 11779137 [PubMed - indexed for MEDLINE]Related articles

Insulin inhibits leptin receptor signalling in HEK293 cells at the level of janus kinase-2: a potential mechanism for hyperinsulinaemia-associated leptin resistance.

Kellerer M, Lammers R, Fritsche A, Strack V, Machicao F, Borboni P, Ullrich A, Häring HU.

Diabetologia. 2001 Sep;44(9):1125-32.PMID: 11596667 [PubMed - indexed for MEDLINE]Related articles

Insulin analogues: impact of cell model characteristics on results and conclusions regarding mitogenic properties.

Kellerer M, Häring HU.

Exp Clin Endocrinol Diabetes. 2001;109(1):63-4. No abstract available. PMID: 11573144 [PubMed - indexed for MEDLINE]Related articles

Inhibition of Ret oncogene activity by the protein tyrosine phosphatase SHP1.

Hennige AM, Lammers R, Höppner W, Arlt D, Strack V, Teichmann R, Machicao F, Ullrich A, Häring HU, Kellerer M.

Endocrinology. 2001 Oct;142(10):4441-7.PMID: 11564708 [PubMed - indexed for MEDLINE]Related articlesFree article

Pathophysiology and pharmacological treatment of insulin resistance.

Matthaei S, Stumvoll M, Kellerer M, Häring HU.

Endocr Rev. 2000 Dec;21(6):585-618. Review.PMID: 11133066 [PubMed - indexed for MEDLINE]Related articlesFree article

Ret oncogene signal transduction via a IRS-2/PI 3-kinase/PKB and a SHC/Grb-2 dependent pathway: possible implication for transforming activity in NIH3T3 cells.

Hennige AM, Lammers R, Arlt D, Höppner W, Strack V, Niederfellner G, Seif FJ, Häring HU, Kellerer M.

Mol Cell Endocrinol. 2000 Sep 25;167(1-2):69-76.PMID: 11000521 [PubMed - indexed for MEDLINE]Related articles

Serine residues 1177/78/82 of the insulin receptor are required for substrate phosphorylation but not autophosphorylation.

Bossenmaier B, Strack V, Stoyanov B, Krützfeldt J, Beck A, Lehmann R, Kellerer M, Klein H, Ullrich A, Lammers R, Häring HU.

Diabetes. 2000 Jun;49(6):889-95.PMID: 10866039 [PubMed - indexed for MEDLINE]Related articlesFree article

Serine residues 994 and 1023/25 are important for insulin receptor kinase inhibition by protein kinase C isoforms beta2 and theta.

Strack V, Hennige AM, Krützfeldt J, Bossenmaier B, Klein HH, Kellerer M, Lammers R, Häring HU.

Diabetologia. 2000 Apr;43(4):443-9.PMID: 10819237 [PubMed - indexed for MEDLINE]Related articles

The inhibitory effect of 2-deoxyglucose on insulin receptor autophosphorylation does not depend on known serine phosphorylation sites or other conserved serine residues of the receptor beta-subunit.

Strack V, Bossenmaier B, Stoyanov B, Mosthaf L, Kellerer M, Lammers R, Häring HU.

FEBS Lett. 1999 Apr 23;449(2-3):111-4.PMID: 10338114 [PubMed - indexed for MEDLINE]Related articles

Insulin signal transduction: possible mechanisms for insulin resistance.

Kellerer M, Lammers R, Häring HU.

Exp Clin Endocrinol Diabetes. 1999;107(2):97-106. Review. No abstract available. PMID: 10320048 [PubMed - indexed for MEDLINE]Related articles

Evidence for inhibition of leptin secretion by catecholamines in man.

Fritsche A, Wahl HG, Metzinger E, Renn W, Kellerer M, Häring H, Stumvoll M.

Exp Clin Endocrinol Diabetes. 1998;106(5):415-8.PMID: 9831308 [PubMed - indexed for MEDLINE]Related articles

Protein kinase C isoforms alpha, delta and theta require insulin receptor substrate-1 to inhibit the tyrosine kinase activity of the insulin receptor in human kidney embryonic cells (HEK 293 cells).

Kellerer M, Mushack J, Seffer E, Mischak H, Ullrich A, Häring HU.

Diabetologia. 1998 Jul;41(7):833-8.PMID: 9686926 [PubMed - indexed for MEDLINE]Related articles

Increase in serum leptin concentrations in women undergoing controlled ovarian hyperstimulation for assisted reproduction.

Strowitzki T, Kellerer M, Capp E, Häring HU.

Gynecol Endocrinol. 1998 Jun;12(3):167-9.PMID: 9675562 [PubMed - indexed for MEDLINE]Related articles

The long acting human insulin analog HOE 901: characteristics of insulin signalling in comparison to Asp(B10) and regular insulin.

Berti L, Kellerer M, Bossenmaier B, Seffer E, Seipke G, Häring HU.

Horm Metab Res. 1998 Mar;30(3):123-9.PMID: 9566852 [PubMed - indexed for MEDLINE]Related articles

Protein kinase C (PKC) epsilon enhances the inhibitory effect of TNF alpha on insulin signaling in HEK293 cells.

Kellerer M, Mushack J, Mischak H, Häring HU.

FEBS Lett. 1997 Nov 24;418(1-2):119-22.PMID: 9414108 [PubMed - indexed for MEDLINE]Related articles

Leptin activates PI-3 kinase in C2C12 myotubes via janus kinase-2 (JAK-2) and insulin receptor substrate-2 (IRS-2) dependent pathways.

Kellerer M, Koch M, Metzinger E, Mushack J, Capp E, Häring HU.

Diabetologia. 1997 Nov;40(11):1358-62.PMID: 9389430 [PubMed - indexed for MEDLINE]Related articles

Impact of mutations at different serine residues on the tyrosine kinase activity of the insulin receptor.

Strack V, Stoyanov B, Bossenmaier B, Mosthaf L, Kellerer M, Häring HU.

Biochem Biophys Res Commun. 1997 Oct 9;239(1):235-9.PMID: 9345301 [PubMed - indexed for MEDLINE]Related articles

Leptin stimulates glucose transport and glycogen synthesis in C2C12 myotubes: evidence for a P13-kinase mediated effect.

Berti L, Kellerer M, Capp E, Häring HU.

Diabetologia. 1997 May;40(5):606-9.PMID: 9165231 [PubMed - indexed for MEDLINE]Related articles

Circulating TNF-alpha and leptin levels in offspring of NIDDM patients do not correlate to individual insulin sensitivity.

Kellerer M, Rett K, Renn W, Groop L, Häring HU.

Horm Metab Res. 1996 Dec;28(12):737-43.PMID: 9013754 [PubMed - indexed for MEDLINE]Related articles

Elevated venous glutamate levels in (pre)catabolic conditions result at least partly from a decreased glutamate transport activity.

Hack V, Stütz O, Kinscherf R, Schykowski M, Kellerer M, Holm E, Dröge W.

J Mol Med. 1996 Jun;74(6):337-43.PMID: 8862515 [PubMed - indexed for MEDLINE]Related articles

Tumor necrosis factor-alpha- and hyperglycemia-induced insulin resistance. Evidence for different mechanisms and different effects on insulin signaling.

Kroder G, Bossenmaier B, Kellerer M, Capp E, Stoyanov B, Mühlhöfer A, Berti L, Horikoshi H, Ullrich A, Häring H.

J Clin Invest. 1996 Mar 15;97(6):1471-7.PMID: 8617880 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin leads to a parallel translocation of PI-3-kinase and protein kinase C zeta.

Mosthaf L, Kellerer M, Mühlhöfer A, Mushack J, Seffer E, Häring HU.

Exp Clin Endocrinol Diabetes. 1996;104(1):19-24.PMID: 8750566 [PubMed - indexed for MEDLINE]Related articles

Modulation of insulin receptor signaling. Potential mechanisms of a cross talk between bradykinin and the insulin receptor.

Häring HU, Tippmer S, Kellerer M, Mosthaf L, Kroder G, Bossenmaier B, Berti L.

Diabetes. 1996 Jan;45 Suppl 1:S115-9. Review.PMID: 8529791 [PubMed - indexed for MEDLINE]Related articles

Insulin- and insulin-like growth-factor-I receptor tyrosine-kinase activities in human renal carcinoma.

Kellerer M, von Eye Corleta H, Mühlhöfer A, Capp E, Mosthaf L, Bock S, Petrides PE, Häring HU.

Int J Cancer. 1995 Sep 4;62(5):501-7.PMID: 7665217 [PubMed - indexed for MEDLINE]Related articles

Pathogenesis of insulin resistance: modulation of the insulin signal at receptor level.

Kellerer M, Häring HU.

Diabetes Res Clin Pract. 1995 Aug;28 Suppl:S173-7. Review.PMID: 8529511 [PubMed - indexed for MEDLINE]Related articles

Mechanism of insulin receptor kinase inhibition in non-insulin-dependent diabetes mellitus patients. Phosphorylation of serine 1327 or threonine 1348 is unaltered.

Kellerer M, Coghlan M, Capp E, Mühlhöfer A, Kroder G, Mosthaf L, Galante P, Siddle K, Häring HU.

J Clin Invest. 1995 Jul;96(1):6-11.PMID: 7615833 [PubMed - indexed for MEDLINE]Related articlesFree article

Acute hyperglycemia provides an insulin-independent inducer for GLUT4 translocation in C2C12 myotubes and rat skeletal muscle.

Galante P, Mosthaf L, Kellerer M, Berti L, Tippmer S, Bossenmaier B, Fujiwara T, Okuno A, Horikoshi H, Häring HU.

Diabetes. 1995 Jun;44(6):646-51.PMID: 7789629 [PubMed - indexed for MEDLINE]Related articles

C-terminus or juxtamembrane deletions in the insulin receptor do not affect the glucose-dependent inhibition of the tyrosine kinase activity.

Mosthaf L, Berti L, Kellerer M, Mushack J, Seffer E, Bossenmaier B, Coghlan M, Siddle K, Ullrich A, Häring HU.

Eur J Biochem. 1995 Feb 1;227(3):787-91.PMID: 7867639 [PubMed - indexed for MEDLINE]Related articlesFree article

Modulation of insulin receptor signalling: significance of altered receptor isoform patterns and mechanism of hyperglycaemia-induced receptor modulation.

Häring HU, Kellerer M, Mosthaf L.

Diabetologia. 1994 Sep;37 Suppl 2:S149-54. Review.PMID: 7821730 [PubMed - indexed for MEDLINE]Related articles

Troglitazone prevents glucose-induced insulin resistance of insulin receptor in rat-1 fibroblasts.

Kellerer M, Kroder G, Tippmer S, Berti L, Kiehn R, Mosthaf L, Häring H.

Diabetes. 1994 Mar;43(3):447-53.PMID: 7508875 [PubMed - indexed for MEDLINE]Related articles

Glucose-induced translocation of protein kinase C isoforms in rat-1 fibroblasts is paralleled by inhibition of the insulin receptor tyrosine kinase.

Berti L, Mosthaf L, Kroder G, Kellerer M, Tippmer S, Mushack J, Seffer E, Seedorf K, Häring H.

J Biol Chem. 1994 Feb 4;269(5):3381-6.PMID: 7508912 [PubMed - indexed for MEDLINE]Related articlesFree article

Modulation of insulin signalling in non-insulin-dependent diabetes mellitus: significance of altered receptor isoform patterns and mechanisms of glucose-induced receptor modulation.

Häring HU, Kellerer M, Mosthaf L.

Horm Res. 1994;41 Suppl 2:87-91; discussion 92. Review.PMID: 8088709 [PubMed - indexed for MEDLINE]Related articles

Inositol phospho-oligosaccharides from rat fibroblasts and adipocytes stimulate 3-O-methylglucose transport.

Kellerer M, Machicao F, Berti L, Sixt B, Mushack J, Seffer E, Mosthaf L, Ullrich A, Häring HU.

Biochem J. 1993 Nov 1;295 ( Pt 3):699-704.PMID: 8240280 [PubMed - indexed for MEDLINE]Related articlesFree article