PubMed

Circulating CD52 and CD20 levels at end of treatment predict for progression and survival in patients with chronic lymphocytic leukaemia treated with fludarabine, cyclophosphamide and rituximab (FCR).

Alatrash G, Albitar M, O'Brien S, Wang X, Manshouri T, Faderl S, Ferrajoli A, Burger J, Garcia-Manero G, Kantarjian HM, Lerner S, Keating MJ, Wierda WG.

Br J Haematol. 2009 Nov 6. [Epub ahead of print]PMID: 19895616 [PubMed - as supplied by publisher]Related articles

p53 expression by immunohistochemistry is an important determinant of survival in patients with chronic lymphocytic leukemia receiving frontline chemo-immunotherapy.

Schlette EJ, Schlette EJ, Admirand J, Wierda W, Abruzzo L, Lin KI, O'Brien S, Lerner S, Keating MJ, Tam C.

Leuk Lymphoma. 2009 Oct;50(10):1597-605.PMID: 19863337 [PubMed - in process]Related articles

Dynamic model for predicting death within 12 months in patients with primary or post-polycythemia vera/essential thrombocythemia myelofibrosis.

Tam CS, Kantarjian H, Cortes J, Lynn A, Pierce S, Zhou L, Keating MJ, Thomas DA, Verstovsek S.

J Clin Oncol. 2009 Nov 20;27(33):5587-93. Epub 2009 Sep 28.PMID: 19786661 [PubMed - in process]Related articles

Leukemia research, 2008.

Freireich EJ, Kantarjian H, Keating MJ.

Clin Lymphoma Myeloma. 2009;9 Suppl 3:S178. No abstract available. PMID: 19778837 [PubMed - in process]Related articles

High TCL1 levels are a marker of B-cell receptor pathway responsiveness and adverse outcome in chronic lymphocytic leukemia.

Herling M, Patel KA, Weit N, Lilienthal N, Hallek M, Keating MJ, Jones D.

Blood. 2009 Nov 19;114(21):4675-86. Epub 2009 Sep 21.PMID: 19770358 [PubMed - in process]Related articles

Diverse marrow stromal cells protect CLL cells from spontaneous and drug-induced apoptosis: development of a reliable and reproducible system to assess stromal cell adhesion-mediated drug resistance.

Kurtova AV, Balakrishnan K, Chen R, Ding W, Schnabl S, Quiroga MP, Sivina M, Wierda WG, Estrov Z, Keating MJ, Shehata M, Jäger U, Gandhi V, Kay NE, Plunkett W, Burger JA.

Blood. 2009 Nov 12;114(20):4441-50. Epub 2009 Sep 17.PMID: 19762485 [PubMed - in process]Related articles

Fludarabine, cyclophosphamide, mitoxantrone plus rituximab (FCM-R) in frontline CLL <70 Years.

Faderl S, Wierda W, O'Brien S, Ferrajoli A, Lerner S, Keating MJ.

Leuk Res. 2009 Jul 29. [Epub ahead of print]PMID: 19646755 [PubMed - as supplied by publisher]Related articles

B-cell antigen receptor signaling enhances chronic lymphocytic leukemia cell migration and survival: specific targeting with a novel spleen tyrosine kinase inhibitor, R406.

Quiroga MP, Balakrishnan K, Kurtova AV, Sivina M, Keating MJ, Wierda WG, Gandhi V, Burger JA.

Blood. 2009 Jul 30;114(5):1029-37. Epub 2009 Jun 2.PMID: 19491390 [PubMed - indexed for MEDLINE]Related articles

Targeting DNA repair in chronic lymphocytic leukemia cells with a novel acyclic nucleotide analogue, GS-9219.

Tsai CY, Ray AS, Tumas DB, Keating MJ, Reiser H, Plunkett W.

Clin Cancer Res. 2009 Jun 1;15(11):3760-9. Epub 2009 May 12.PMID: 19435836 [PubMed - indexed for MEDLINE]Related articles

De novo deletion 17p13.1 chronic lymphocytic leukemia shows significant clinical heterogeneity: the M. D. Anderson and Mayo Clinic experience.

Tam CS, Shanafelt TD, Wierda WG, Abruzzo LV, Van Dyke DL, O'Brien S, Ferrajoli A, Lerner SA, Lynn A, Kay NE, Keating MJ.

Blood. 2009 Jul 30;114(5):957-64. Epub 2009 May 4.PMID: 19414856 [PubMed - indexed for MEDLINE]Related articles

Treatment of fludarabine-refractory chronic lymphocytic leukemia.

Tsimberidou AM, Keating MJ.

Cancer. 2009 Jul 1;115(13):2824-36. Review.PMID: 19402170 [PubMed - indexed for MEDLINE]Related articles

Chronic lymphocytic leukemia With t(2;14)(p16;q32) involves the BCL11A and IgH genes and is associated with atypical morphologic features and unmutated IgVH genes.

Yin CC, Lin KI, Ketterling RP, Knudson RA, Medeiros LJ, Barron LL, Huh YO, Luthra R, Keating MJ, Abruzzo LV.

Am J Clin Pathol. 2009 May;131(5):663-70.PMID: 19369625 [PubMed - indexed for MEDLINE]Related articles

Isoform-selective phosphoinositide 3'-kinase inhibitors inhibit CXCR4 signaling and overcome stromal cell-mediated drug resistance in chronic lymphocytic leukemia: a novel therapeutic approach.

Niedermeier M, Hennessy BT, Knight ZA, Henneberg M, Hu J, Kurtova AV, Wierda WG, Keating MJ, Shokat KM, Burger JA.

Blood. 2009 May 28;113(22):5549-57. Epub 2009 Mar 24.PMID: 19318683 [PubMed - indexed for MEDLINE]Related articles

Mechanism of action of SNS-032, a novel cyclin-dependent kinase inhibitor, in chronic lymphocytic leukemia.

Chen R, Wierda WG, Chubb S, Hawtin RE, Fox JA, Keating MJ, Gandhi V, Plunkett W.

Blood. 2009 May 7;113(19):4637-45. Epub 2009 Feb 20.PMID: 19234140 [PubMed - indexed for MEDLINE]Related articles

Caspase-8 dependent histone acetylation by a novel proteasome inhibitor, NPI-0052: a mechanism for synergy in leukemia cells.

Miller CP, Rudra S, Keating MJ, Wierda WG, Palladino M, Chandra J.

Blood. 2009 Apr 30;113(18):4289-99. Epub 2009 Jan 30.PMID: 19182209 [PubMed - indexed for MEDLINE]Related articles

The role of cytogenetic abnormalities as a prognostic marker in primary myelofibrosis: applicability at the time of diagnosis and later during disease course.

Tam CS, Abruzzo LV, Lin KI, Cortes J, Lynn A, Keating MJ, Thomas DA, Pierce S, Kantarjian H, Verstovsek S.

Blood. 2009 Apr 30;113(18):4171-8. Epub 2009 Jan 8.PMID: 19131547 [PubMed - indexed for MEDLINE]Related articles

Chemoimmunotherapy may overcome the adverse prognostic significance of 11q deletion in previously untreated patients with chronic lymphocytic leukemia.

Tsimberidou AM, Tam C, Abruzzo LV, O'Brien S, Wierda WG, Lerner S, Kantarjian HM, Keating MJ.

Cancer. 2009 Jan 15;115(2):373-80.PMID: 19117034 [PubMed - indexed for MEDLINE]Related articles

Other malignancies in chronic lymphocytic leukemia/small lymphocytic lymphoma.

Tsimberidou AM, Wen S, McLaughlin P, O'Brien S, Wierda WG, Lerner S, Strom S, Freireich EJ, Medeiros LJ, Kantarjian HM, Keating MJ.

J Clin Oncol. 2009 Feb 20;27(6):904-10. Epub 2008 Dec 29.PMID: 19114699 [PubMed - indexed for MEDLINE]Related articles

Specific activation of microRNA106b enables the p73 apoptotic response in chronic lymphocytic leukemia by targeting the ubiquitin ligase Itch for degradation.

Sampath D, Calin GA, Puduvalli VK, Gopisetty G, Taccioli C, Liu CG, Ewald B, Liu C, Keating MJ, Plunkett W.

Blood. 2009 Apr 16;113(16):3744-53. Epub 2008 Dec 18.PMID: 19096009 [PubMed - indexed for MEDLINE]Related articles

High-level expression of the T-cell chemokines CCL3 and CCL4 by chronic lymphocytic leukemia B cells in nurselike cell cocultures and after BCR stimulation.

Burger JA, Quiroga MP, Hartmann E, Bürkle A, Wierda WG, Keating MJ, Rosenwald A.

Blood. 2009 Mar 26;113(13):3050-8. Epub 2008 Dec 12.PMID: 19074730 [PubMed - indexed for MEDLINE]Related articles

Customized oligonucleotide array-based comparative genomic hybridization as a clinical assay for genomic profiling of chronic lymphocytic leukemia.

Sargent R, Jones D, Abruzzo LV, Yao H, Bonderover J, Cisneros M, Wierda WG, Keating MJ, Luthra R.

J Mol Diagn. 2009 Jan;11(1):25-34. Epub 2008 Dec 12.PMID: 19074592 [PubMed - indexed for MEDLINE]Related articles

Relevance of the immunoglobulin VH somatic mutation status in patients with chronic lymphocytic leukemia treated with fludarabine, cyclophosphamide, and rituximab (FCR) or related chemoimmunotherapy regimens.

Lin KI, Tam CS, Keating MJ, Wierda WG, O'Brien S, Lerner S, Coombes KR, Schlette E, Ferrajoli A, Barron LL, Kipps TJ, Rassenti L, Faderl S, Kantarjian H, Abruzzo LV.

Blood. 2009 Apr 2;113(14):3168-71. Epub 2008 Dec 2.PMID: 19050308 [PubMed - indexed for MEDLINE]Related articles

Array CGH analysis of chronic lymphocytic leukemia reveals frequent cryptic monoallelic and biallelic deletions of chromosome 22q11 that include the PRAME gene.

Gunn SR, Bolla AR, Barron LL, Gorre ME, Mohammed MS, Bahler DW, Mellink CH, van Oers MH, Keating MJ, Ferrajoli A, Coombes KR, Abruzzo LV, Robetorye RS.

Leuk Res. 2009 Sep;33(9):1276-81. Epub 2008 Nov 21.PMID: 19027161 [PubMed - indexed for MEDLINE]Related articles

Phase I study of obatoclax mesylate (GX15-070), a small molecule pan-Bcl-2 family antagonist, in patients with advanced chronic lymphocytic leukemia.

O'Brien SM, Claxton DF, Crump M, Faderl S, Kipps T, Keating MJ, Viallet J, Cheson BD.

Blood. 2009 Jan 8;113(2):299-305. Epub 2008 Oct 17.PMID: 18931344 [PubMed - indexed for MEDLINE]Related articles

Prognostic significance of CD20 expression in adults with de novo precursor B-lineage acute lymphoblastic leukemia.

Thomas DA, O'Brien S, Jorgensen JL, Cortes J, Faderl S, Garcia-Manero G, Verstovsek S, Koller C, Pierce S, Huh Y, Wierda W, Keating MJ, Kantarjian HM.

Blood. 2009 Jun 18;113(25):6330-7. Epub 2008 Aug 14.PMID: 18703706 [PubMed - indexed for MEDLINE]Related articles

Whole-genome scanning by array comparative genomic hybridization as a clinical tool for risk assessment in chronic lymphocytic leukemia.

Gunn SR, Mohammed MS, Gorre ME, Cotter PD, Kim J, Bahler DW, Preobrazhensky SN, Higgins RA, Bolla AR, Ismail SH, de Jong D, Eldering E, van Oers MH, Mellink CH, Keating MJ, Schlette EJ, Abruzzo LV, Robetorye RS.

J Mol Diagn. 2008 Sep;10(5):442-51. Epub 2008 Aug 7.PMID: 18687794 [PubMed - indexed for MEDLINE]Related articlesFree article

Chromosomal abnormalities detected by multicolor fluorescence in situ hybridization in fine-needle aspirates from patients with small lymphocytic lymphoma are useful for predicting survival.

Caraway NP, Thomas E, Khanna A, Payne L, Zhang HZ, Lin E, Keating MJ, Katz RL.

Cancer. 2008 Oct 25;114(5):315-22.PMID: 18683215 [PubMed - indexed for MEDLINE]Related articlesFree article

Myeloid sarcoma is associated with superior event-free survival and overall survival compared with acute myeloid leukemia.

Tsimberidou AM, Kantarjian HM, Wen S, Keating MJ, O'Brien S, Brandt M, Pierce S, Freireich EJ, Medeiros LJ, Estey E.

Cancer. 2008 Sep 15;113(6):1370-8.PMID: 18623376 [PubMed - indexed for MEDLINE]Related articlesFree article

Relative value of ZAP-70, CD38, and immunoglobulin mutation status in predicting aggressive disease in chronic lymphocytic leukemia.

Rassenti LZ, Jain S, Keating MJ, Wierda WG, Grever MR, Byrd JC, Kay NE, Brown JR, Gribben JG, Neuberg DS, He F, Greaves AW, Rai KR, Kipps TJ.

Blood. 2008 Sep 1;112(5):1923-30. Epub 2008 Jun 24.PMID: 18577710 [PubMed - indexed for MEDLINE]Related articlesFree article

Effective elimination of fludarabine-resistant CLL cells by PEITC through a redox-mediated mechanism.

Trachootham D, Zhang H, Zhang W, Feng L, Du M, Zhou Y, Chen Z, Pelicano H, Plunkett W, Wierda WG, Keating MJ, Huang P.

Blood. 2008 Sep 1;112(5):1912-22. Epub 2008 Jun 23.PMID: 18574029 [PubMed - indexed for MEDLINE]Related articlesFree article

Gossypol, a BH3 mimetic, induces apoptosis in chronic lymphocytic leukemia cells.

Balakrishnan K, Wierda WG, Keating MJ, Gandhi V.

Blood. 2008 Sep 1;112(5):1971-80. Epub 2008 Jun 19.PMID: 18566329 [PubMed - indexed for MEDLINE]Related articlesFree article

Bendamustine.

Keating MJ, Bach C, Yasothan U, Kirkpatrick P.

Nat Rev Drug Discov. 2008 Jun;7(6):473-4. No abstract available. PMID: 18511926 [PubMed - indexed for MEDLINE]Related articles

MYC translocation in chronic lymphocytic leukaemia is associated with increased prolymphocytes and a poor prognosis.

Huh YO, Lin KI, Vega F, Schlette E, Yin CC, Keating MJ, Luthra R, Medeiros LJ, Abruzzo LV.

Br J Haematol. 2008 Jul;142(1):36-44. Epub 2008 May 8.PMID: 18477041 [PubMed - indexed for MEDLINE]Related articles

Multiple-dose granulocyte-macrophage-colony-stimulating factor plus 23-valent polysaccharide pneumococcal vaccine in patients with chronic lymphocytic leukemia: a prospective, randomized trial of safety and immunogenicity.

Safdar A, Rodriguez GH, Rueda AM, Wierda WG, Ferrajoli A, Musher DM, O'Brien S, Koller CA, Bodey GP, Keating MJ.

Cancer. 2008 Jul 15;113(2):383-7.PMID: 18470901 [PubMed - indexed for MEDLINE]Related articlesFree article

Rapid resolution of Mycobacterium marinum chronic skin infection during lenalidomide therapy for chronic lymphocytic leukemia.

Awais A, Tam CS, Kontoyiannis D, Ferrajoli A, Duvic M, Cortes J, Keating MJ.

Clin Infect Dis. 2008 Apr 1;46(7):e69-71.PMID: 18444808 [PubMed - indexed for MEDLINE]Related articles

Long-term results of the fludarabine, cyclophosphamide, and rituximab regimen as initial therapy of chronic lymphocytic leukemia.

Tam CS, O'Brien S, Wierda W, Kantarjian H, Wen S, Do KA, Thomas DA, Cortes J, Lerner S, Keating MJ.

Blood. 2008 Aug 15;112(4):975-80. Epub 2008 Apr 14.PMID: 18411418 [PubMed - indexed for MEDLINE]Related articlesFree article

Protein expression profiling of cytokines and cytokine receptors on purified chronic lymphocytic leukemia cells from patients with favourable prognostic indicators.

Yu Z, Sun B, Kantarjian HM, Keating MJ, Amin HM, Sun X.

Leuk Lymphoma. 2008 Apr;49(4):751-6.PMID: 18398743 [PubMed - indexed for MEDLINE]Related articles

Effective killing of Gleevec-resistant CML cells with T315I mutation by a natural compound PEITC through redox-mediated mechanism.

Zhang H, Trachootham D, Lu W, Carew J, Giles FJ, Keating MJ, Arlinghaus RB, Huang P.

Leukemia. 2008 Jun;22(6):1191-9. Epub 2008 Apr 3.PMID: 18385754 [PubMed - indexed for MEDLINE]Related articlesFree article

Lenalidomide induces complete and partial remissions in patients with relapsed and refractory chronic lymphocytic leukemia.

Ferrajoli A, Lee BN, Schlette EJ, O'Brien SM, Gao H, Wen S, Wierda WG, Estrov Z, Faderl S, Cohen EN, Li C, Reuben JM, Keating MJ.

Blood. 2008 Jun 1;111(11):5291-7. Epub 2008 Mar 11.PMID: 18334676 [PubMed - indexed for MEDLINE]Related articlesFree article

Use of IGHV3-21 in chronic lymphocytic leukemia is associated with high-risk disease and reflects antigen-driven, post-germinal center leukemogenic selection.

Ghia EM, Jain S, Widhopf GF 2nd, Rassenti LZ, Keating MJ, Wierda WG, Gribben JG, Brown JR, Rai KR, Byrd JC, Kay NE, Greaves AW, Kipps TJ.

Blood. 2008 May 15;111(10):5101-8. Epub 2008 Mar 7.PMID: 18326815 [PubMed - indexed for MEDLINE]Related articlesFree article

Chronic lymphocytic leukaemia CD20 expression is dependent on the genetic subtype: a study of quantitative flow cytometry and fluorescent in-situ hybridization in 510 patients.

Tam CS, Otero-Palacios J, Abruzzo LV, Jorgensen JL, Ferrajoli A, Wierda WG, Lerner S, O'Brien S, Keating MJ.

Br J Haematol. 2008 Apr;141(1):36-40.PMID: 18324964 [PubMed - indexed for MEDLINE]Related articles

Phase I trial of nelarabine in indolent leukemias.

Gandhi V, Tam C, O'Brien S, Jewell RC, Rodriguez CO Jr, Lerner S, Plunkett W, Keating MJ.

J Clin Oncol. 2008 Mar 1;26(7):1098-105.PMID: 18309944 [PubMed - indexed for MEDLINE]Related articles

The prognostic significance of serum beta2 microglobulin levels in acute myeloid leukemia and prognostic scores predicting survival: analysis of 1,180 patients.

Tsimberidou AM, Kantarjian HM, Wen S, O'Brien S, Cortes J, Wierda WG, Koller C, Pierce S, Brandt M, Freireich EJ, Keating MJ, Estey EH.

Clin Cancer Res. 2008 Feb 1;14(3):721-30.PMID: 18245532 [PubMed - indexed for MEDLINE]Related articlesFree article

Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines.

Hallek M, Cheson BD, Catovsky D, Caligaris-Cappio F, Dighiero G, Döhner H, Hillmen P, Keating MJ, Montserrat E, Rai KR, Kipps TJ; International Workshop on Chronic Lymphocytic Leukemia.

Blood. 2008 Jun 15;111(12):5446-56. Epub 2008 Jan 23. Erratum in: Blood. 2008 Dec 15;112(13):5259. PMID: 18216293 [PubMed - indexed for MEDLINE]Related articlesFree article

Phase I-II study of oxaliplatin, fludarabine, cytarabine, and rituximab combination therapy in patients with Richter's syndrome or fludarabine-refractory chronic lymphocytic leukemia.

Tsimberidou AM, Wierda WG, Plunkett W, Kurzrock R, O'Brien S, Wen S, Ferrajoli A, Ravandi-Kashani F, Garcia-Manero G, Estrov Z, Kipps TJ, Brown JR, Fiorentino A, Lerner S, Kantarjian HM, Keating MJ.

J Clin Oncol. 2008 Jan 10;26(2):196-203.PMID: 18182662 [PubMed - indexed for MEDLINE]Related articles

Pilot experience with continuous infusion alemtuzumab in patients with fludarabine-refractory chronic lymphocytic leukemia.

Ferrajoli A, Wierda WG, LaPushin R, O'Brien SM, Faderl S, Browning ML, Keating MJ.

Eur J Haematol. 2008 Apr;80(4):296-8. Epub 2007 Dec 21.PMID: 18182081 [PubMed - indexed for MEDLINE]Related articles

Assessment of chronic lymphocytic leukemia and small lymphocytic lymphoma by absolute lymphocyte counts in 2,126 patients: 20 years of experience at the University of Texas M.D. Anderson Cancer Center.

Tsimberidou AM, Wen S, O'Brien S, McLaughlin P, Wierda WG, Ferrajoli A, Faderl S, Manning J, Lerner S, Mai CV, Rodriguez AM, Hess M, Do KA, Freireich EJ, Kantarjian HM, Medeiros LJ, Keating MJ.

J Clin Oncol. 2007 Oct 10;25(29):4648-56.PMID: 17925562 [PubMed - indexed for MEDLINE]Related articles

Fine-needle aspiration biopsy findings in patients with small lymphocytic lymphoma transformed to hodgkin lymphoma.

Catrina Reading F, Schlette EJ, Stewart JM, Keating MJ, Katz RL, Caraway NP.

Am J Clin Pathol. 2007 Oct;128(4):571-8.PMID: 17875507 [PubMed - indexed for MEDLINE]Related articlesFree article

Chemoimmunotherapy of chronic lymphocytic leukemia.

Tam CS, Keating MJ.

Best Pract Res Clin Haematol. 2007 Sep;20(3):479-98. Review.PMID: 17707835 [PubMed - indexed for MEDLINE]Related articles

Identification and validation of biomarkers of IgV(H) mutation status in chronic lymphocytic leukemia using microfluidics quantitative real-time polymerase chain reaction technology.

Abruzzo LV, Barron LL, Anderson K, Newman RJ, Wierda WG, O'brien S, Ferrajoli A, Luthra M, Talwalkar S, Luthra R, Jones D, Keating MJ, Coombes KR.

J Mol Diagn. 2007 Sep;9(4):546-55. Epub 2007 Aug 9.PMID: 17690214 [PubMed - indexed for MEDLINE]Related articlesFree article