PubMed

Biomarker-Driven Early Clinical Trials in Oncology: A Paradigm Shift in Drug Development.

Tan DS, Thomas GV, Garrett MD, Banerji U, de Bono JS, Kaye SB, Workman P.

Cancer J. 2009 September/October;15(5):406-420.PMID: 19826361 [PubMed - as supplied by publisher]Related articles

Long-term Topical Steroid Treatment after Penetrating Keratoplasty in Patients with Pseudophakic Bullous Keratopathy.

Ross AH, Jones MN, Nguyen DQ, Jaycock PD, Armitage WJ, Cook SD, Kaye SB, Tole DM; National Health Service Blood and Transplant Ocular Tissue Advisory Group and Contributing Ophthalmologists.

Ophthalmology. 2009 Oct 6. [Epub ahead of print]PMID: 19815284 [PubMed - as supplied by publisher]Related articles

Capsular distention syndrome: sine anterior chamber shallowing?

Karri B, Sebastian RT, Kaye SB.

Can J Ophthalmol. 2009 Oct;44(5):e45. No abstract available. PMID: 19798816 [PubMed - indexed for MEDLINE]Related articles

Bacterial susceptibility to topical antimicrobials and clinical outcome in bacterial keratitis.

Kaye SB, Tuft S, Neal T, Tole D, Leeming J, Figueiredo F, Armstrong M, McDonnell P, Tullo A, Parry C.

Invest Ophthalmol Vis Sci. 2009 Aug 13. [Epub ahead of print]PMID: 19684005 [PubMed - as supplied by publisher]Related articles

Conjunctival-corneal melt in association with carotid artery stenosis.

Stewart RM, Quah SA, Nguyen DQ, Kaye SB.

Clin Ophthalmol. 2008 Sep;2(3):649-55.PMID: 19668768 [PubMed - in process]Related articlesFree article

Penetrating and Deep Anterior Lamellar Keratoplasty for keratoconus: a comparison of graft outcomes in the UK.

Jones MN, Armitage J, Ayliffe W, Larkin DF, Kaye SB.

Invest Ophthalmol Vis Sci. 2009 Aug 6. [Epub ahead of print]PMID: 19661238 [PubMed - as supplied by publisher]Related articles

Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers.

Fong PC, Boss DS, Yap TA, Tutt A, Wu P, Mergui-Roelvink M, Mortimer P, Swaisland H, Lau A, O'Connor MJ, Ashworth A, Carmichael J, Kaye SB, Schellens JH, de Bono JS.

N Engl J Med. 2009 Jul 9;361(2):123-34. Epub 2009 Jun 24.PMID: 19553641 [PubMed - indexed for MEDLINE]Related articles

A feasibility study of sequential doublet chemotherapy comprising carboplatin-doxorubicin and carboplatin-paclitaxel for advanced endometrial adenocarcinoma and carcinosarcoma.

Ang JE, Shah RN, Everard M, Keyzor C, Coombes I, Jenkins A, Thomas K, A'Hern R, Jones RL, Blake P, Gabra H, Hall G, Gore ME, Kaye SB.

Ann Oncol. 2009 Nov;20(11):1787-93. Epub 2009 Jun 19.PMID: 19542250 [PubMed - in process]Related articles

Phase I safety, pharmacokinetic, and pharmacogenomic trial of ES-285, a novel marine cytotoxic agent, administered to adult patients with advanced solid tumors.

Baird RD, Kitzen J, Clarke PA, Planting A, Reade S, Reid A, Welsh L, López Lázaro L, de las Heras B, Judson IR, Kaye SB, Eskens F, Workman P, deBono JS, Verweij J.

Mol Cancer Ther. 2009 Jun;8(6):1430-7. Epub 2009 Jun 9.PMID: 19509256 [PubMed - indexed for MEDLINE]Related articles

Selective inhibition of CYP17 with abiraterone acetate is highly active in the treatment of castration-resistant prostate cancer.

Attard G, Reid AH, A'Hern R, Parker C, Oommen NB, Folkerd E, Messiou C, Molife LR, Maier G, Thompson E, Olmos D, Sinha R, Lee G, Dowsett M, Kaye SB, Dearnaley D, Kheoh T, Molina A, de Bono JS.

J Clin Oncol. 2009 Aug 10;27(23):3742-8. Epub 2009 May 26.PMID: 19470933 [PubMed - indexed for MEDLINE]Related articles

Characterization of ERG, AR and PTEN gene status in circulating tumor cells from patients with castration-resistant prostate cancer.

Attard G, Swennenhuis JF, Olmos D, Reid AH, Vickers E, A'Hern R, Levink R, Coumans F, Moreira J, Riisnaes R, Oommen NB, Hawche G, Jameson C, Thompson E, Sipkema R, Carden CP, Parker C, Dearnaley D, Kaye SB, Cooper CS, Molina A, Cox ME, Terstappen LW, de Bono JS.

Cancer Res. 2009 Apr 1;69(7):2912-8.PMID: 19339269 [PubMed - indexed for MEDLINE]Related articles

PPM1D is a potential therapeutic target in ovarian clear cell carcinomas.

Tan DS, Lambros MB, Rayter S, Natrajan R, Vatcheva R, Gao Q, Marchiò C, Geyer FC, Savage K, Parry S, Fenwick K, Tamber N, Mackay A, Dexter T, Jameson C, McCluggage WG, Williams A, Graham A, Faratian D, El-Bahrawy M, Paige AJ, Gabra H, Gore ME, Zvelebil M, Lord CJ, Kaye SB, Ashworth A, Reis-Filho JS.

Clin Cancer Res. 2009 Apr 1;15(7):2269-80. Epub 2009 Mar 17.PMID: 19293255 [PubMed - indexed for MEDLINE]Related articles

Approximating lens power.

Kaye SB.

Optom Vis Sci. 2009 Apr;86(4):382-94.PMID: 19258914 [PubMed - indexed for MEDLINE]Related articles

Beyond chemotherapy: targeted therapies in ovarian cancer.

Yap TA, Carden CP, Kaye SB.

Nat Rev Cancer. 2009 Mar;9(3):167-81. Review.PMID: 19238149 [PubMed - indexed for MEDLINE]Related articles

Concentration and bioavailability of ciprofloxacin and teicoplanin in the cornea.

Kaye SB, Neal T, Nicholson S, Szkurlat J, Bamber S, Baddon AC, Anderson S, Seddon K, Dwyer N, Lovering AM, Smith G.

Invest Ophthalmol Vis Sci. 2009 Jul;50(7):3176-84. Epub 2009 Feb 14.PMID: 19218614 [PubMed - indexed for MEDLINE]Related articles

The promises and pitfalls of epigenetic therapies in solid tumours.

Graham JS, Kaye SB, Brown R.

Eur J Cancer. 2009 May;45(7):1129-36. Epub 2009 Feb 11. Review.PMID: 19211243 [PubMed - indexed for MEDLINE]Related articles

From darkness to light with biomarkers in early clinical trials of cancer drugs.

Carden CP, Banerji U, Kaye SB, Workman P, de Bono JS.

Clin Pharmacol Ther. 2009 Feb;85(2):131-3. Review.PMID: 19151637 [PubMed - indexed for MEDLINE]Related articles

Localized bullous keratopathy secondary to posterior polymorphous dystrophy.

Srinivasan S, Skarmoutsos P, O'Donnell C, Kaye SB.

Clin Experiment Ophthalmol. 2008 Nov;36(8):800-1. No abstract available. PMID: 19128391 [PubMed - indexed for MEDLINE]Related articles

"BRCAness" syndrome in ovarian cancer: a case-control study describing the clinical features and outcome of patients with epithelial ovarian cancer associated with BRCA1 and BRCA2 mutations.

Tan DS, Rothermundt C, Thomas K, Bancroft E, Eeles R, Shanley S, Ardern-Jones A, Norman A, Kaye SB, Gore ME.

J Clin Oncol. 2008 Dec 1;26(34):5530-6. Epub 2008 Oct 27.PMID: 18955455 [PubMed - indexed for MEDLINE]Related articles

The visual and refractive outcomes of combined and sequential penetrating keratoplasty, cataract extraction, and intraocular lens insertion.

Nguyen DQ, Mumford LL, Jones MN, Armitage WJ, Cook SD, Kaye SB, Tole DM.

Eye (Lond). 2009 Jun;23(6):1295-301. Epub 2008 Oct 3.PMID: 18836407 [PubMed - in process]Related articles

Phase I clinical trial of a selective inhibitor of CYP17, abiraterone acetate, confirms that castration-resistant prostate cancer commonly remains hormone driven.

Attard G, Reid AH, Yap TA, Raynaud F, Dowsett M, Settatree S, Barrett M, Parker C, Martins V, Folkerd E, Clark J, Cooper CS, Kaye SB, Dearnaley D, Lee G, de Bono JS.

J Clin Oncol. 2008 Oct 1;26(28):4563-71. Epub 2008 Jul 21.PMID: 18645193 [PubMed - indexed for MEDLINE]Related articles

Ovarian cancer: can we reverse drug resistance?

Tan DS, Ang JE, Kaye SB.

Adv Exp Med Biol. 2008;622:153-67. Review. No abstract available. PMID: 18546626 [PubMed - indexed for MEDLINE]Related articles

Reversal of drug resistance in ovarian cancer: where do we go from here?

Kaye SB.

J Clin Oncol. 2008 Jun 1;26(16):2616-8. No abstract available. PMID: 18509172 [PubMed - indexed for MEDLINE]Related articles

New drugs for ovarian cancer.

Kaye SB.

Clin Adv Hematol Oncol. 2008 Feb;6(2):91-3. No abstract available. PMID: 18347558 [PubMed - indexed for MEDLINE]Related articles

Transient ectopic expression as a method to detect genes conferring drug resistance.

Witham J, Vidot S, Agarwal R, Kaye SB, Richardson A.

Int J Cancer. 2008 Jun 1;122(11):2641-5.PMID: 18324624 [PubMed - indexed for MEDLINE]Related articles

Does body mass index affect progression-free or overall survival in patients with ovarian cancer? Results from SCOTROC I trial.

Barrett SV, Paul J, Hay A, Vasey PA, Kaye SB, Glasspool RM; Scottish Gynaecological Cancer Trials Group.

Ann Oncol. 2008 May;19(5):898-902. Epub 2008 Feb 13.PMID: 18272913 [PubMed - indexed for MEDLINE]Related articlesFree article

Experience in a UK cancer centre of weekly paclitaxel in the treatment of relapsed ovarian and primary peritoneal cancer.

Linch M, Stavridi F, Hook J, Barbachano Y, Gore M, Kaye SB.

Gynecol Oncol. 2008 Apr;109(1):27-32. Epub 2008 Feb 8.PMID: 18262259 [PubMed - indexed for MEDLINE]Related articles

Outcomes of same-sizing versus oversizing donor trephines in keratoconic patients undergoing first penetrating keratoplasty.

Jaycock PD, Jones MN, Males J, Armitage WJ, Cook SD, Tole DM, Kaye SB; UK Transplant Ocular Tissue Advisory Group and Contributing Ophthalmologists.

Ophthalmology. 2008 Feb;115(2):268-75.PMID: 18164404 [PubMed - indexed for MEDLINE]Related articles

The Bcl-2/Bcl-XL family inhibitor ABT-737 sensitizes ovarian cancer cells to carboplatin.

Witham J, Valenti MR, De-Haven-Brandon AK, Vidot S, Eccles SA, Kaye SB, Richardson A.

Clin Cancer Res. 2007 Dec 1;13(23):7191-8.PMID: 18056200 [PubMed - indexed for MEDLINE]Related articlesFree article

Cyclosporin-A associated malignancy.

Durnian JM, Stewart RM, Tatham R, Batterbury M, Kaye SB.

Clin Ophthalmol. 2007 Dec;1(4):421-30.PMID: 19668519 [PubMed - in process]Related articlesFree article

Bevacizumab for the treatment of epithelial ovarian cancer: will this be its finest hour?

Kaye SB.

J Clin Oncol. 2007 Nov 20;25(33):5150-2. No abstract available. PMID: 18024860 [PubMed - indexed for MEDLINE]Related articles

In-vivo scanning of Ascher intrastromal corneal ring opacity.

Nguyen DQ, Quah SA, Kumar N, Jacob A, Kaye SB.

Br J Ophthalmol. 2007 Dec;91(12):1710-1. No abstract available. PMID: 18024816 [PubMed - indexed for MEDLINE]Related articles

Bleomycin and scuba diving: where is the harm?

de Wit R, Sleijfer S, Kaye SB, Horwich A, Mead B, Sleijfer DT, Stoter G.

Lancet Oncol. 2007 Nov;8(11):954-5. No abstract available. PMID: 17976605 [PubMed - indexed for MEDLINE]Related articles

Potential clinical applications of epothilones: a review of phase II studies.

Larkin JM, Kaye SB.

Ann Oncol. 2007 Jul;18 Suppl 5:v28-34. Review.PMID: 17656559 [PubMed - indexed for MEDLINE]Related articlesFree article

Phase I and pharmacodynamic trial of the DNA methyltransferase inhibitor decitabine and carboplatin in solid tumors.

Appleton K, Mackay HJ, Judson I, Plumb JA, McCormick C, Strathdee G, Lee C, Barrett S, Reade S, Jadayel D, Tang A, Bellenger K, Mackay L, Setanoians A, Schätzlein A, Twelves C, Kaye SB, Brown R.

J Clin Oncol. 2007 Oct 10;25(29):4603-9.PMID: 17925555 [PubMed - indexed for MEDLINE]Related articles

Flow cytometric method for determining folate receptor expression on ovarian carcinoma cells.

Forster MD, Ormerod MG, Agarwal R, Kaye SB, Jackman AL.

Cytometry A. 2007 Nov;71(11):945-50.PMID: 17712798 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of intraocular surgery and ketamine on aqueous and serum cytokines.

Tu KL, Kaye SB, Sidaras G, Taylor W, Shenkin A.

Mol Vis. 2007 Jul 12;13:1130-7.PMID: 17653058 [PubMed - indexed for MEDLINE]Related articlesFree article

Bilateral cloudy corneas in an adult.

Srinivasan S, Hiscott P, Kaye SB.

Compr Ophthalmol Update. 2007 May-Jun;8(3):171-2. No abstract available. PMID: 17651547 [PubMed - indexed for MEDLINE]Related articles

Pre-treatment white blood cell subtypes as prognostic indicators in ovarian cancer.

Bishara S, Griffin M, Cargill A, Bali A, Gore ME, Kaye SB, Shepherd JH, Van Trappen PO.

Eur J Obstet Gynecol Reprod Biol. 2008 May;138(1):71-5. Epub 2007 Jul 17.PMID: 17644243 [PubMed - indexed for MEDLINE]Related articles

Gliomatosis peritonei: MRI appearances and its potential role in follow up.

England RA, deSouza NM, Kaye SB.

Br J Radiol. 2007 May;80(953):e101-4.PMID: 17638834 [PubMed - indexed for MEDLINE]Related articlesFree article

The use of voriconazole in the treatment of Aspergillus fumigatus keratitis.

Stewart RM, Quah SA, Neal TJ, Kaye SB.

Br J Ophthalmol. 2007 Aug;91(8):1094-6. No abstract available. PMID: 17638830 [PubMed - indexed for MEDLINE]Related articles

Thimerosal-induced limbal stem cell failure: report of a case and review of the literature.

Nguyen DQ, Srinivasan S, Hiscott P, Kaye SB.

Eye Contact Lens. 2007 Jul;33(4):196-8.PMID: 17630628 [PubMed - indexed for MEDLINE]Related articles

Pharmacokinetics of vancomycin following intracameral bolus injection in patients undergoing phacoemulsification cataract surgery.

Murphy CC, Nicholson S, Quah SA, Batterbury M, Neal T, Kaye SB.

Br J Ophthalmol. 2007 Oct;91(10):1350-3. Epub 2007 Mar 27.PMID: 17389745 [PubMed - indexed for MEDLINE]Related articles

Keratoconus associated with CSNB1.

Nguyen DQ, Hemmerdinger C, Hagan RP, Brown MC, Quah SA, Kaye SB.

Br J Ophthalmol. 2007 Jan;91(1):116-7. No abstract available. PMID: 17179126 [PubMed - indexed for MEDLINE]Related articles

Terrien marginal degeneration presenting with spontaneous corneal perforation.

Srinivasan S, Murphy CC, Fisher AC, Freeman LB, Kaye SB.

Cornea. 2006 Sep;25(8):977-80.PMID: 17102680 [PubMed - indexed for MEDLINE]Related articles

Mechanisms of transcoelomic metastasis in ovarian cancer.

Tan DS, Agarwal R, Kaye SB.

Lancet Oncol. 2006 Nov;7(11):925-34. Review.PMID: 17081918 [PubMed - indexed for MEDLINE]Related articles

Corneal topographic features in a family with nanophthalmos.

Srinivasan S, Batterbury M, Marsh IB, Fisher AC, Willoughby C, Kaye SB.

Cornea. 2006 Jul;25(6):750-6.PMID: 17077675 [PubMed - indexed for MEDLINE]Related articles

Treatment of refractory vernal ulcers with large-diameter bandage contact lenses.

Quah SA, Hemmerdinger C, Nicholson S, Kaye SB.

Eye Contact Lens. 2006 Sep;32(5):245-7.PMID: 16974158 [PubMed - indexed for MEDLINE]Related articles

Congenital absence of optic chiasm: demonstration of an uncrossed visual pathway using monocular flash visual evoked potentials.

Brown MC, Southern CL, Anbarasu A, Kaye SB, Fisher AC, Hagan RP, Newman WD.

Doc Ophthalmol. 2006 Jul;113(1):1-4. Epub 2006 Aug 12.PMID: 16906412 [PubMed - indexed for MEDLINE]Related articles

The significance of cicatricial conjunctivitis in Wegener's granulomatosis.

Nguyen DQ, Harper J, Hiscott P, Quah SA, Jacob A, Kaye SB.

Nephrol Dial Transplant. 2006 Nov;21(11):3342-3. Epub 2006 Jul 5. No abstract available. PMID: 16822788 [PubMed - indexed for MEDLINE]Related articlesFree article