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The role of perforin and granzymes in diabetes.

Thomas HE, Trapani JA, Kay TW.

Cell Death Differ. 2009 Nov 20. [Epub ahead of print]PMID: 19927156 [PubMed - as supplied by publisher]Related articles

Insulin teaches a new lesson in tolerance.

Kay TW, Krishnamurthy B, Brodnicki TC, Mannering SI.

EMBO J. 2009 Sep 16;28(18):2687-8. No abstract available. PMID: 19759522 [PubMed - indexed for MEDLINE]Related articlesFree article

Islet beta-cells deficient in Bcl-xL develop but are abnormally sensitive to apoptotic stimuli.

Carrington EM, McKenzie MD, Jansen E, Myers M, Fynch S, Kos C, Strasser A, Kay TW, Scott CL, Allison J.

Diabetes. 2009 Oct;58(10):2316-23. Epub 2009 Jul 6.PMID: 19581414 [PubMed - indexed for MEDLINE]Related articles

SOCS1 negatively regulates the production of Foxp3+ CD4+ T cells in the thymus.

Zhan Y, Davey GM, Graham KL, Kiu H, Dudek NL, Kay TW, Lew AM.

Immunol Cell Biol. 2009 Aug-Sep;87(6):473-80. Epub 2009 Apr 21.PMID: 19381159 [PubMed - in process]Related articles

Beta cell apoptosis in diabetes.

Thomas HE, McKenzie MD, Angstetra E, Campbell PD, Kay TW.

Apoptosis. 2009 Dec;14(12):1389-404.PMID: 19322660 [PubMed - in process]Related articles

Interferon signalling in pancreatic beta cells.

Thomas HE, Graham KL, Angstetra E, McKenzie MD, Dudek NL, Kay TW.

Front Biosci. 2009 Jan 1;14:644-56. Review.PMID: 19273092 [PubMed - indexed for MEDLINE]Related articles

Cytotoxic T cell mechanisms of beta cell destruction in non-obese diabetic mice.

Kay TW, Dudek NL, Graham K, Estella E, Angstetra E, McKenzie MD, Allison J, Thomas HE.

Novartis Found Symp. 2008;292:68-78; discussion 78-84, 122-9, 202-3.PMID: 19203093 [PubMed - indexed for MEDLINE]Related articles

In vivo effects of cytokines on pancreatic beta-cells in models of type I diabetes dependent on CD4(+) T lymphocytes.

Angstetra E, Graham KL, Emmett S, Dudek NL, Darwiche R, Ayala-Perez R, Allison J, Santamaria P, Kay TW, Thomas HE.

Immunol Cell Biol. 2009 Feb;87(2):178-85. Epub 2008 Nov 18.PMID: 19015667 [PubMed - indexed for MEDLINE]Related articles

Cytotoxic T-lymphocyte-mediated killing of human pancreatic islet cells in vitro.

Campbell PD, Estella E, Dudek NL, Jhala G, Thomas HE, Kay TW, Mannering SI.

Hum Immunol. 2008 Sep;69(9):543-51. Epub 2008 Jul 17.PMID: 18639598 [PubMed - indexed for MEDLINE]Related articles

Rotavirus infection accelerates type 1 diabetes in mice with established insulitis.

Graham KL, Sanders N, Tan Y, Allison J, Kay TW, Coulson BS.

J Virol. 2008 Jul;82(13):6139-49. Epub 2008 Apr 16.PMID: 18417562 [PubMed - indexed for MEDLINE]Related articlesFree article

Autoimmunity to both proinsulin and IGRP is required for diabetes in nonobese diabetic 8.3 TCR transgenic mice.

Krishnamurthy B, Mariana L, Gellert SA, Colman PG, Harrison LC, Lew AM, Santamaria P, Thomas HE, Kay TW.

J Immunol. 2008 Apr 1;180(7):4458-64.PMID: 18354167 [PubMed - indexed for MEDLINE]Related articlesFree article

Perturbed thymopoiesis in vitro in the absence of suppressor of cytokine signalling 1 and 3.

Croom HA, Izon DJ, Chong MM, Curtis DJ, Roberts AW, Kay TW, Hilton DJ, Alexander WS, Starr R.

Mol Immunol. 2008 May;45(10):2888-96. Epub 2008 Mar 5.PMID: 18321577 [PubMed - indexed for MEDLINE]Related articles

Proapoptotic BH3-only protein Bid is essential for death receptor-induced apoptosis of pancreatic beta-cells.

McKenzie MD, Carrington EM, Kaufmann T, Strasser A, Huang DC, Kay TW, Allison J, Thomas HE.

Diabetes. 2008 May;57(5):1284-92. Epub 2008 Feb 5.PMID: 18252892 [PubMed - indexed for MEDLINE]Related articlesFree article

Evaluation of promoters for driving efficient transgene expression in neonatal porcine islets.

Londrigan SL, Brady JL, Sutherland RM, Hawthorne WJ, Thomas HE, Jhala G, Cowan PJ, Kay TW, O'Connell PJ, Lew AM.

Xenotransplantation. 2007 Mar;14(2):119-25.PMID: 17381686 [PubMed - indexed for MEDLINE]Related articles

Responses against islet antigens in NOD mice are prevented by tolerance to proinsulin but not IGRP.

Krishnamurthy B, Dudek NL, McKenzie MD, Purcell AW, Brooks AG, Gellert S, Colman PG, Harrison LC, Lew AM, Thomas HE, Kay TW.

J Clin Invest. 2006 Dec;116(12):3258-65.PMID: 17143333 [PubMed - indexed for MEDLINE]Related articlesFree article

Tumor necrosis factor alpha-induced skeletal muscle insulin resistance involves suppression of AMP-kinase signaling.

Steinberg GR, Michell BJ, van Denderen BJ, Watt MJ, Carey AL, Fam BC, Andrikopoulos S, Proietto J, Görgün CZ, Carling D, Hotamisligil GS, Febbraio MA, Kay TW, Kemp BE.

Cell Metab. 2006 Dec;4(6):465-74.PMID: 17141630 [PubMed - indexed for MEDLINE]Related articles

SOCS-1 protects from virally-induced CD8 T cell mediated type 1 diabetes.

Barral AM, Thomas HE, Ling EM, Darwiche R, Rodrigo E, Christen U, Ejrnaes M, Wolfe T, Kay TW, von Herrath MG.

J Autoimmun. 2006 Nov;27(3):166-73. Epub 2006 Oct 10.PMID: 17045460 [PubMed - indexed for MEDLINE]Related articles

Cytotoxic T-cells from T-cell receptor transgenic NOD8.3 mice destroy beta-cells via the perforin and Fas pathways.

Dudek NL, Thomas HE, Mariana L, Sutherland RM, Allison J, Estella E, Angstetra E, Trapani JA, Santamaria P, Lew AM, Kay TW.

Diabetes. 2006 Sep;55(9):2412-8.PMID: 16936188 [PubMed - indexed for MEDLINE]Related articlesFree article

Granzyme B-mediated death of pancreatic beta-cells requires the proapoptotic BH3-only molecule bid.

Estella E, McKenzie MD, Catterall T, Sutton VR, Bird PI, Trapani JA, Kay TW, Thomas HE.

Diabetes. 2006 Aug;55(8):2212-9.PMID: 16873683 [PubMed - indexed for MEDLINE]Related articlesFree article

IL-1 beta breaks tolerance through expansion of CD25+ effector T cells.

O'Sullivan BJ, Thomas HE, Pai S, Santamaria P, Iwakura Y, Steptoe RJ, Kay TW, Thomas R.

J Immunol. 2006 Jun 15;176(12):7278-87.PMID: 16751371 [PubMed - indexed for MEDLINE]Related articlesFree article

Perforin and Fas induced by IFNgamma and TNFalpha mediate beta cell death by OT-I CTL.

McKenzie MD, Dudek NL, Mariana L, Chong MM, Trapani JA, Kay TW, Thomas HE.

Int Immunol. 2006 Jun;18(6):837-46. Epub 2006 Mar 30.PMID: 16574667 [PubMed - indexed for MEDLINE]Related articlesFree article

A critical role for granzyme B, in addition to perforin and TNFalpha, in alloreactive CTL-induced mouse pancreatic beta cell death.

Sutton VR, Estella E, Li C, Chen M, Thomas HE, Kay TW, Trapani JA.

Transplantation. 2006 Jan 27;81(2):146-54.PMID: 16436955 [PubMed - indexed for MEDLINE]Related articles

Perturbations in nuclear factor-kappaB or c-Jun N-terminal kinase pathways in pancreatic beta cells confer susceptibility to cytokine-induced cell death.

Thomas HE, Angstetra E, Fernandes RV, Mariana L, Irawaty W, Jamieson EL, Dudek NL, Kay TW.

Immunol Cell Biol. 2006 Feb;84(1):20-7. Epub 2005 Nov 7.PMID: 16277639 [PubMed - indexed for MEDLINE]Related articles

The insulin A-chain epitope recognized by human T cells is posttranslationally modified.

Mannering SI, Harrison LC, Williamson NA, Morris JS, Thearle DJ, Jensen KP, Kay TW, Rossjohn J, Falk BA, Nepom GT, Purcell AW.

J Exp Med. 2005 Nov 7;202(9):1191-7. Epub 2005 Oct 31.PMID: 16260488 [PubMed - indexed for MEDLINE]Related articlesFree article

Prolonged local expression of anti-CD4 antibody by adenovirally transduced allografts can promote long-term graft survival.

Londrigan SL, Sutherland RM, Brady JL, Zhan Y, Li R, Estella E, Kay TW, Lew AM.

J Gene Med. 2006 Jan;8(1):42-52.PMID: 16075436 [PubMed - indexed for MEDLINE]Related articles

Socs1 deficiency enhances hepatic insulin signaling.

Jamieson E, Chong MM, Steinberg GR, Jovanovska V, Fam BC, Bullen DV, Chen Y, Kemp BE, Proietto J, Kay TW, Andrikopoulos S.

J Biol Chem. 2005 Sep 9;280(36):31516-21. Epub 2005 Jun 27.PMID: 15983045 [PubMed - indexed for MEDLINE]Related articlesFree article

Transgenic expression of dominant-negative Fas-associated death domain protein in beta cells protects against Fas ligand-induced apoptosis and reduces spontaneous diabetes in nonobese diabetic mice.

Allison J, Thomas HE, Catterall T, Kay TW, Strasser A.

J Immunol. 2005 Jul 1;175(1):293-301.PMID: 15972661 [PubMed - indexed for MEDLINE]Related articlesFree article

Suppressor of cytokine signaling-1 in T cells and macrophages is critical for preventing lethal inflammation.

Chong MM, Metcalf D, Jamieson E, Alexander WS, Kay TW.

Blood. 2005 Sep 1;106(5):1668-75. Epub 2005 May 17.PMID: 15899915 [PubMed - indexed for MEDLINE]Related articlesFree article

Severe pancreatitis with exocrine destruction and increased islet neogenesis in mice with suppressor of cytokine signaling-1 deficiency.

Chen Y, Chong MM, Darwiche R, Thomas HE, Kay TW.

Am J Pathol. 2004 Sep;165(3):913-21.PMID: 15331415 [PubMed - indexed for MEDLINE]Related articlesFree article

Bcl-2 protection of islet allografts is unmasked by costimulation blockade.

Sutherland RM, Allison J, Thomas HE, Brady JL, Kay TW, Lew AM.

Transplantation. 2004 May 27;77(10):1610-3.PMID: 15239630 [PubMed - indexed for MEDLINE]Related articles

Suppressor of cytokine signaling-1 overexpression protects pancreatic beta cells from CD8+ T cell-mediated autoimmune destruction.

Chong MM, Chen Y, Darwiche R, Dudek NL, Irawaty W, Santamaria P, Allison J, Kay TW, Thomas HE.

J Immunol. 2004 May 1;172(9):5714-21.PMID: 15100317 [PubMed - indexed for MEDLINE]Related articlesFree article

IL-1 receptor deficiency slows progression to diabetes in the NOD mouse.

Thomas HE, Irawaty W, Darwiche R, Brodnicki TC, Santamaria P, Allison J, Kay TW.

Diabetes. 2004 Jan;53(1):113-21.PMID: 14693705 [PubMed - indexed for MEDLINE]Related articlesFree article

Activated macrophages require T cells for xenograft rejection under the kidney capsule.

Zhan Y, Brady JL, Irawaty W, Thomas HE, Kay TW, Lew AM.

Immunol Cell Biol. 2003 Dec;81(6):451-8.PMID: 14636242 [PubMed - indexed for MEDLINE]Related articlesFree article

Fas is detectable on beta cells in accelerated, but not spontaneous, diabetes in nonobese diabetic mice.

Darwiche R, Chong MM, Santamaria P, Thomas HE, Kay TW.

J Immunol. 2003 Jun 15;170(12):6292-7.PMID: 12794162 [PubMed - indexed for MEDLINE]Related articlesFree article

Suppressor of cytokine signaling-1 is a critical regulator of interleukin-7-dependent CD8+ T cell differentiation.

Chong MM, Cornish AL, Darwiche R, Stanley EG, Purton JF, Godfrey DI, Hilton DJ, Starr R, Alexander WS, Kay TW.

Immunity. 2003 Apr;18(4):475-87.PMID: 12705851 [PubMed - indexed for MEDLINE]Related articles

Suppressor of cytokine signaling-1 regulates signaling in response to interleukin-2 and other gamma c-dependent cytokines in peripheral T cells.

Cornish AL, Chong MM, Davey GM, Darwiche R, Nicola NA, Hilton DJ, Kay TW, Starr R, Alexander WS.

J Biol Chem. 2003 Jun 20;278(25):22755-61. Epub 2003 Mar 28.PMID: 12665516 [PubMed - indexed for MEDLINE]Related articlesFree article

The role of cytokines as effectors of tissue destruction in autoimmunity.

Kay TW, Darwiche R, Irawaty W, Chong MM, Pennington HL, Thomas HE.

Adv Exp Med Biol. 2003;520:73-86. No abstract available. PMID: 12613573 [PubMed - indexed for MEDLINE]Related articles

Transmembrane TNF and IFNgamma induce caspase-independent death of primary mouse pancreatic beta cells.

Irawaty W, Kay TW, Thomas HE.

Autoimmunity. 2002 Sep;35(6):369-75.PMID: 12568116 [PubMed - indexed for MEDLINE]Related articles

Suppressor of cytokine signaling-1 regulates the sensitivity of pancreatic beta cells to tumor necrosis factor.

Chong MM, Thomas HE, Kay TW.

J Biol Chem. 2002 Aug 2;277(31):27945-52. Epub 2002 May 24.PMID: 12032139 [PubMed - indexed for MEDLINE]Related articlesFree article

Comparison of insulin secretory function in two mouse models with different susceptibility to beta-cell failure.

Kooptiwut S, Zraika S, Thorburn AW, Dunlop ME, Darwiche R, Kay TW, Proietto J, Andrikopoulos S.

Endocrinology. 2002 Jun;143(6):2085-92.PMID: 12021173 [PubMed - indexed for MEDLINE]Related articlesFree article

International Workshop on Lessons from Animal Models for Human Type 1 Diabetes: analyzing target autoantigens of humoral immunity in nonobese diabetic mice.

Bonifacio E, Atkinson M, Eisenbarth G, Serreze D, Kay TW, Lee-Chan E, Singh B.

Ann N Y Acad Sci. 2002 Apr;958:1-2.PMID: 12021078 [PubMed - indexed for MEDLINE]Related articles

Interleukin-1 plus gamma-interferon-induced pancreatic beta-cell dysfunction is mediated by beta-cell nitric oxide production.

Thomas HE, Darwiche R, Corbett JA, Kay TW.

Diabetes. 2002 Feb;51(2):311-6.PMID: 11812737 [PubMed - indexed for MEDLINE]Related articlesFree article

Behçet's disease with cerebral vasculitis.

Scardamaglia L, Desmond PM, Gonzales MF, Bendrups A, Brodtmann A, Kay TW.

Intern Med J. 2001 Dec;31(9):560-1. No abstract available. PMID: 11767874 [PubMed - indexed for MEDLINE]Related articles

gamma-Interferon signaling in pancreatic beta-cells is persistent but can be terminated by overexpression of suppressor of cytokine signaling-1.

Chong MM, Thomas HE, Kay TW.

Diabetes. 2001 Dec;50(12):2744-51.PMID: 11723057 [PubMed - indexed for MEDLINE]Related articlesFree article

International Workshop on Lessons From Animal Models for Human Type 1 Diabetes: identification of insulin but not glutamic acid decarboxylase or IA-2 as specific autoantigens of humoral autoimmunity in nonobese diabetic mice.

Bonifacio E, Atkinson M, Eisenbarth G, Serreze D, Kay TW, Lee-Chan E, Singh B.

Diabetes. 2001 Nov;50(11):2451-8. Review.PMID: 11679421 [PubMed - indexed for MEDLINE]Related articlesFree article

Granulocyte macrophage colony-stimulating factor: a new putative therapeutic target in multiple sclerosis.

McQualter JL, Darwiche R, Ewing C, Onuki M, Kay TW, Hamilton JA, Reid HH, Bernard CC.

J Exp Med. 2001 Oct 1;194(7):873-82.PMID: 11581310 [PubMed - indexed for MEDLINE]Related articlesFree article

How beta cells die in type 1 diabetes.

Thomas HE, Kay TW.

Curr Dir Autoimmun. 2001;4:144-70. Review. No abstract available. PMID: 11569401 [PubMed - indexed for MEDLINE]Related articles

Lack of expression of Gp-130 makes pancreatic beta cell lines unresponsive to the IL-6 family of cytokines.

Naselli G, Deaizpurua HJ, Thomas HE, Johnston AM, Kay TW.

Int J Exp Diabetes Res. 2001;1(4):239-48.PMID: 11467415 [PubMed - indexed for MEDLINE]Related articlesFree article

Virus-induced autoimmune diabetes: most beta-cells die through inflammatory cytokines and not perforin from autoreactive (anti-viral) cytotoxic T-lymphocytes.

Seewaldt S, Thomas HE, Ejrnaes M, Christen U, Wolfe T, Rodrigo E, Coon B, Michelsen B, Kay TW, von Herrath MG.

Diabetes. 2000 Nov;49(11):1801-9.PMID: 11078446 [PubMed - indexed for MEDLINE]Related articlesFree article

Beta cell destruction in the development of autoimmune diabetes in the non-obese diabetic (NOD) mouse.

Thomas HE, Kay TW.

Diabetes Metab Res Rev. 2000 Jul-Aug;16(4):251-61. Review.PMID: 10934453 [PubMed - indexed for MEDLINE]Related articles