PubMed

A comprehensive evaluation of the prognostic significance of 13q deletions in patients with B-chronic lymphocytic leukaemia.

Van Dyke DL, Shanafelt TD, Call TG, Zent CS, Smoley SA, Rabe KG, Schwager SM, Sonbert JC, Slager SL, Kay NE.

Br J Haematol. 2009 Nov 6. [Epub ahead of print]PMID: 19895615 [PubMed - as supplied by publisher]Related articles

Autoimmune cytopenia in chronic lymphocytic leukemia/small lymphocytic lymphoma: changes in clinical presentation and prognosis.

Zent CS, Ding W, Reinalda MS, Schwager SM, Hoyer JD, Bowen DA, Jelinek DF, Tschumper RC, Call TG, Shanafelt TD, Kay NE, Slager SL.

Leuk Lymphoma. 2009 Aug;50(8):1261-8.PMID: 19811329 [PubMed - in process]Related articles

Familial chronic lymphocytic leukemia: what does it mean to me?

Slager SL, Kay NE.

Clin Lymphoma Myeloma. 2009;9 Suppl 3:S194-7.PMID: 19778840 [PubMed - in process]Related articles

Diverse marrow stromal cells protect CLL cells from spontaneous and drug-induced apoptosis: development of a reliable and reproducible system to assess stromal cell adhesion-mediated drug resistance.

Kurtova AV, Balakrishnan K, Chen R, Ding W, Schnabl S, Quiroga MP, Sivina M, Wierda WG, Estrov Z, Keating MJ, Shehata M, Jager U, Gandhi V, Kay NE, Plunkett W, Burger JA.

Blood. 2009 Sep 17. [Epub ahead of print]PMID: 19762485 [PubMed - as supplied by publisher]Related articles

Bi-directional activation between mesenchymal stem cells and CLL B-cells: implication for CLL disease progression.

Ding W, Nowakowski GS, Knox TR, Boysen JC, Maas ML, Schwager SM, Wu W, Wellik LE, Dietz AB, Ghosh AK, Secreto CR, Medina KL, Shanafelt TD, Zent CS, Call TG, Kay NE.

Br J Haematol. 2009 Nov;147(4):471-83. Epub 2009 Sep 8.PMID: 19751240 [PubMed - in process]Related articles

Brief report: natural history of individuals with clinically recognized monoclonal B-cell lymphocytosis compared with patients with Rai 0 chronic lymphocytic leukemia.

Shanafelt TD, Kay NE, Rabe KG, Call TG, Zent CS, Maddocks K, Jenkins G, Jelinek DF, Morice WG, Boysen J, Schwager S, Bowen D, Slager SL, Hanson CA.

J Clin Oncol. 2009 Aug 20;27(24):3959-63. Epub 2009 Jul 20.PMID: 19620484 [PubMed - indexed for MEDLINE]Related articles

Pentostatin treatment combinations in chronic lymphocytic leukemia.

Lamanna N, Kay NE.

Clin Adv Hematol Oncol. 2009 Jun;7(6):386-92. Review.PMID: 19606074 [PubMed - indexed for MEDLINE]Related articles

Pretreatment angiogenic cytokines predict response to chemoimmunotherapy in patients with chronic lymphocytic leukaemia.

Shanafelt TD, Byrd JC, LaPLant B, Zent CS, Call T, Secreto C, Grever MR, Lin TS, Kay NE.

Br J Haematol. 2009 Sep;146(6):660-4. Epub 2009 Jul 10.PMID: 19604237 [PubMed - in process]Related articles

Phase I trial of daily oral Polyphenon E in patients with asymptomatic Rai stage 0 to II chronic lymphocytic leukemia.

Shanafelt TD, Call TG, Zent CS, LaPlant B, Bowen DA, Roos M, Secreto CR, Ghosh AK, Kabat BF, Lee MJ, Yang CS, Jelinek DF, Erlichman C, Kay NE.

J Clin Oncol. 2009 Aug 10;27(23):3808-14. Epub 2009 May 26.PMID: 19470922 [PubMed - indexed for MEDLINE]Related articles

De novo deletion 17p13.1 chronic lymphocytic leukemia shows significant clinical heterogeneity: the M. D. Anderson and Mayo Clinic experience.

Tam CS, Shanafelt TD, Wierda WG, Abruzzo LV, Van Dyke DL, O'Brien S, Ferrajoli A, Lerner SA, Lynn A, Kay NE, Keating MJ.

Blood. 2009 Jul 30;114(5):957-64. Epub 2009 May 4.PMID: 19414856 [PubMed - indexed for MEDLINE]Related articles

N9986: a phase II trial of thalidomide in patients with relapsed chronic lymphocytic leukemia.

Kay NE, Shanafelt TD, Call TG, Wu W, Laplant BR.

Leuk Lymphoma. 2009 Apr;50(4):588-92.PMID: 19373657 [PubMed - indexed for MEDLINE]Related articles

Risk of non-Hodgkin lymphoma in association with germline variation in complement genes.

Cerhan JR, Novak AJ, Fredericksen ZS, Wang AH, Liebow M, Call TG, Dogan A, Witzig TE, Ansell SM, Habermann TM, Kay NE, Slager SL.

Br J Haematol. 2009 Jun;145(5):614-23. Epub 2009 Mar 30.PMID: 19344414 [PubMed - indexed for MEDLINE]Related articles

Aberrant regulation of pVHL levels by microRNA promotes the HIF/VEGF axis in CLL B cells.

Ghosh AK, Shanafelt TD, Cimmino A, Taccioli C, Volinia S, Liu CG, Calin GA, Croce CM, Chan DA, Giaccia AJ, Secreto C, Wellik LE, Lee YK, Mukhopadhyay D, Kay NE.

Blood. 2009 May 28;113(22):5568-74. Epub 2009 Mar 31.PMID: 19336759 [PubMed - indexed for MEDLINE]Related articles

Percentage of smudge cells on routine blood smear predicts survival in chronic lymphocytic leukemia.

Nowakowski GS, Hoyer JD, Shanafelt TD, Zent CS, Call TG, Bone ND, Laplant B, Dewald GW, Tschumper RC, Jelinek DF, Witzig TE, Kay NE.

J Clin Oncol. 2009 Apr 10;27(11):1844-9. Epub 2009 Mar 2.PMID: 19255329 [PubMed - indexed for MEDLINE]Related articles

Phase II study of interleukin-12 for treatment of plateau phase multiple myeloma (E1A96): a trial of the Eastern Cooperative Oncology Group.

Lacy MQ, Jacobus S, Blood EA, Kay NE, Rajkumar SV, Greipp PR.

Leuk Res. 2009 Nov;33(11):1485-9. Epub 2009 Feb 24.PMID: 19243818 [PubMed - indexed for MEDLINE]Related articles

Curcumin inhibits prosurvival pathways in chronic lymphocytic leukemia B cells and may overcome their stromal protection in combination with EGCG.

Ghosh AK, Kay NE, Secreto CR, Shanafelt TD.

Clin Cancer Res. 2009 Feb 15;15(4):1250-8.PMID: 19228728 [PubMed - indexed for MEDLINE]Related articles

Circulating endothelial cells in chronic lymphocytic leukemia: more evidence of disturbed angiogenesis.

Kay NE.

Leuk Lymphoma. 2009 Jan;50(1):8-9. No abstract available. PMID: 19172495 [PubMed - indexed for MEDLINE]Related articles

Validation of a new prognostic index for patients with chronic lymphocytic leukemia.

Shanafelt TD, Jenkins G, Call TG, Zent CS, Slager S, Bowen DA, Schwager S, Hanson CA, Jelinek DF, Kay NE.

Cancer. 2009 Jan 15;115(2):363-72.PMID: 19090008 [PubMed - indexed for MEDLINE]Related articles

The yin and yang of lenalidomide.

Kay NE.

Blood. 2008 Dec 15;112(13):4785-6. No abstract available. PMID: 19064733 [PubMed]Related articles

B-cell count and survival: differentiating chronic lymphocytic leukemia from monoclonal B-cell lymphocytosis based on clinical outcome.

Shanafelt TD, Kay NE, Jenkins G, Call TG, Zent CS, Jelinek DF, Morice WG, Boysen J, Zakko L, Schwager S, Slager SL, Hanson CA.

Blood. 2009 Apr 30;113(18):4188-96. Epub 2008 Nov 17.PMID: 19015397 [PubMed - indexed for MEDLINE]Related articles

Mcl-1 expression predicts progression-free survival in chronic lymphocytic leukemia patients treated with pentostatin, cyclophosphamide, and rituximab.

Awan FT, Kay NE, Davis ME, Wu W, Geyer SM, Leung N, Jelinek DF, Tschumper RC, Secreto CR, Lin TS, Grever MR, Shanafelt TD, Zent CS, Call TG, Heerema NA, Lozanski G, Byrd JC, Lucas DM.

Blood. 2009 Jan 15;113(3):535-7. Epub 2008 Nov 13.PMID: 19008456 [PubMed - indexed for MEDLINE]Related articles

Benefits of minimal residual disease negativity in the therapy of chronic lymphocytic leukemia.

Kay NE.

Clin Adv Hematol Oncol. 2008 Oct;6(10):727-9. No abstract available. PMID: 18997661 [PubMed - indexed for MEDLINE]Related articles

Genetic variation in tumor necrosis factor and the nuclear factor-kappaB canonical pathway and risk of non-Hodgkin's lymphoma.

Cerhan JR, Liu-Mares W, Fredericksen ZS, Novak AJ, Cunningham JM, Kay NE, Dogan A, Liebow M, Wang AH, Call TG, Habermann TM, Ansell SM, Slager SL.

Cancer Epidemiol Biomarkers Prev. 2008 Nov;17(11):3161-9.PMID: 18990758 [PubMed - indexed for MEDLINE]Related articlesFree article

Early treatment of high-risk chronic lymphocytic leukemia with alemtuzumab and rituximab.

Zent CS, Call TG, Shanafelt TD, Tschumper RC, Jelinek DF, Bowen DA, Secreto CR, Laplant BR, Kabat BF, Kay NE.

Cancer. 2008 Oct 15;113(8):2110-8.PMID: 18759253 [PubMed - indexed for MEDLINE]Related articlesFree article

The physician-patient relationship and quality of life: lessons from chronic lymphocytic leukemia.

Shanafelt TD, Bowen DA, Venkat C, Slager SL, Zent CS, Kay NE, Reinalda M, Tun H, Sloan JA, Call TG.

Leuk Res. 2009 Feb;33(2):263-70. Epub 2008 Jul 25.PMID: 18656259 [PubMed - indexed for MEDLINE]Related articles

Computational identification of CDR3 sequence archetypes among immunoglobulin sequences in chronic lymphocytic leukemia.

Messmer BT, Raphael BJ, Aerni SJ, Widhopf GF, Rassenti LZ, Gribben JG, Kay NE, Kipps TJ.

Leuk Res. 2009 Mar;33(3):368-76. Epub 2008 Jul 21.PMID: 18640719 [PubMed - indexed for MEDLINE]Related articles

Direct and complement dependent cytotoxicity in CLL cells from patients with high-risk early-intermediate stage chronic lymphocytic leukemia (CLL) treated with alemtuzumab and rituximab.

Zent CS, Secreto CR, LaPlant BR, Bone ND, Call TG, Shanafelt TD, Jelinek DF, Tschumper RC, Kay NE.

Leuk Res. 2008 Dec;32(12):1849-56. Epub 2008 Jun 27.PMID: 18584865 [PubMed - indexed for MEDLINE]Related articles

Relative value of ZAP-70, CD38, and immunoglobulin mutation status in predicting aggressive disease in chronic lymphocytic leukemia.

Rassenti LZ, Jain S, Keating MJ, Wierda WG, Grever MR, Byrd JC, Kay NE, Brown JR, Gribben JG, Neuberg DS, He F, Greaves AW, Rai KR, Kipps TJ.

Blood. 2008 Sep 1;112(5):1923-30. Epub 2008 Jun 24.PMID: 18577710 [PubMed - indexed for MEDLINE]Related articlesFree article

Karyotype evolution on fluorescent in situ hybridization analysis is associated with short survival in patients with chronic lymphocytic leukemia and is related to CD49d expression.

Shanafelt TD, Hanson C, Dewald GW, Witzig TE, LaPlant B, Abrahamzon J, Jelinek DF, Kay NE.

J Clin Oncol. 2008 May 10;26(14):e5-6. No abstract available. PMID: 18467710 [PubMed - indexed for MEDLINE]Related articles

Dysregulated angiogenesis in B-chronic lymphocytic leukemia: Morphologic, immunohistochemical, and flow cytometric evidence.

Frater JL, Kay NE, Goolsby CL, Crawford SE, Dewald GW, Peterson LC.

Diagn Pathol. 2008 Apr 18;3:16.PMID: 18423023 [PubMed - in process]Related articlesFree article

Neuropilin-1 is expressed by chronic lymphocytic leukemia B cells.

Nowakowski GS, Mukhopadhyay D, Wu X, Kay NE.

Leuk Res. 2008 Oct;32(10):1634-6. Epub 2008 Apr 9. No abstract available. PMID: 18403014 [PubMed - indexed for MEDLINE]Related articles

Prognostic importance of T and NK-cells in a consecutive series of newly diagnosed patients with chronic lymphocytic leukaemia.

Palmer S, Hanson CA, Zent CS, Porrata LF, Laplant B, Geyer SM, Markovic SN, Call TG, Bowen DA, Jelinek DF, Kay NE, Shanafelt TD.

Br J Haematol. 2008 May;141(5):607-14. Epub 2008 Apr 1.PMID: 18384436 [PubMed - indexed for MEDLINE]Related articles

The prognostic significance of cytopenia in chronic lymphocytic leukaemia/small lymphocytic lymphoma.

Zent CS, Ding W, Schwager SM, Reinalda MS, Hoyer JD, Jelinek DF, Tschumper RC, Bowen DA, Call TG, Shanafelt TD, Kay NE, Slager SL.

Br J Haematol. 2008 May;141(5):615-21. Epub 2008 Mar 27.PMID: 18373706 [PubMed - indexed for MEDLINE]Related articlesFree article

Use of IGHV3-21 in chronic lymphocytic leukemia is associated with high-risk disease and reflects antigen-driven, post-germinal center leukemogenic selection.

Ghia EM, Jain S, Widhopf GF 2nd, Rassenti LZ, Keating MJ, Wierda WG, Gribben JG, Brown JR, Rai KR, Byrd JC, Kay NE, Greaves AW, Kipps TJ.

Blood. 2008 May 15;111(10):5101-8. Epub 2008 Mar 7.PMID: 18326815 [PubMed - indexed for MEDLINE]Related articlesFree article

Marker rescue mapping of the combined Condit/Dales collection of temperature-sensitive vaccinia virus mutants.

Kato SE, Moussatche N, D'Costa SM, Bainbridge TW, Prins C, Strahl AL, Shatzer AN, Brinker AJ, Kay NE, Condit RC.

Virology. 2008 May 25;375(1):213-22. Epub 2008 Mar 7.PMID: 18314155 [PubMed - indexed for MEDLINE]Related articlesFree article

CD49d expression is an independent predictor of overall survival in patients with chronic lymphocytic leukaemia: a prognostic parameter with therapeutic potential.

Shanafelt TD, Geyer SM, Bone ND, Tschumper RC, Witzig TE, Nowakowski GS, Zent CS, Call TG, Laplant B, Dewald GW, Jelinek DF, Kay NE.

Br J Haematol. 2008 Mar;140(5):537-46.PMID: 18275431 [PubMed - indexed for MEDLINE]Related articles

Controversies in the front-line management of chronic lymphocytic leukemia.

Nabhan C, Shanafelt TD, Kay NE.

Leuk Res. 2008 May;32(5):679-88. Epub 2008 Jan 11. Review.PMID: 18191201 [PubMed - indexed for MEDLINE]Related articles

MBL or CLL: which classification best categorizes the clinical course of patients with an absolute lymphocyte count >or= 5 x 10(9) L(-1) but a B-cell lymphocyte count <5 x 10(9) L(-1)?

Shanafelt TD, Kay NE, Call TG, Zent CS, Jelinek DF, LaPlant B, Morice WG, Hanson CA.

Leuk Res. 2008 Sep;32(9):1458-61. Epub 2008 Jan 7.PMID: 18179821 [PubMed - indexed for MEDLINE]Related articlesFree article

Methylprednisolone-rituximab is an effective salvage therapy for patients with relapsed chronic lymphocytic leukemia including those with unfavorable cytogenetic features.

Bowen DA, Call TG, Jenkins GD, Zent CS, Schwager SM, Van Dyke DL, Jelinek DF, Kay NE, Shanafelt TD.

Leuk Lymphoma. 2007 Dec;48(12):2412-7.PMID: 18067017 [PubMed - indexed for MEDLINE]Related articles

Immunoglobulin diversity gene usage predicts unfavorable outcome in a subset of chronic lymphocytic leukemia patients.

Tschumper RC, Geyer SM, Campbell ME, Kay NE, Shanafelt TD, Zent CS, Nowakowski GS, Call TG, Dewald GW, Jelinek DF.

J Clin Invest. 2008 Jan;118(1):306-15.PMID: 18064298 [PubMed - indexed for MEDLINE]Related articlesFree article

Comprehensive management of the CLL patient: a holistic approach.

Shanafelt TD, Kay NE.

Hematology Am Soc Hematol Educ Program. 2007:324-31. Review.PMID: 18024647 [PubMed - indexed for MEDLINE]Related articlesFree article

Susceptibility genes and B-chronic lymphocytic leukaemia.

Slager SL, Kay NE, Fredericksen ZS, Wang AH, Liebow M, Cunningham JM, Vachon CM, Call TG, Cerhan JR.

Br J Haematol. 2007 Dec;139(5):762-71. Review.PMID: 18021089 [PubMed - indexed for MEDLINE]Related articles

Community-based phase II trial of PCR for CLL/SLL patients.

Kay NE, Shanafelt TD, Byrd JC, Grever MR.

Cancer Biother Radiopharm. 2007 Oct;22(5):713-4; author reply 715-7. No abstract available. PMID: 17979574 [PubMed - indexed for MEDLINE]Related articles

Risk factors for development of a second lymphoid malignancy in patients with chronic lymphocytic leukaemia.

Maddocks-Christianson K, Slager SL, Zent CS, Reinalda M, Call TG, Habermann TM, Bowen DA, Hoyer JD, Schwager S, Jelinek DF, Kay NE, Shanafelt TD.

Br J Haematol. 2007 Nov;139(3):398-404.PMID: 17910629 [PubMed - indexed for MEDLINE]Related articles

Quality of life in chronic lymphocytic leukemia: an international survey of 1482 patients.

Shanafelt TD, Bowen D, Venkat C, Slager SL, Zent CS, Kay NE, Reinalda M, Sloan JA, Call TG.

Br J Haematol. 2007 Oct;139(2):255-64.PMID: 17897301 [PubMed - indexed for MEDLINE]Related articles

Genetic variation in 1253 immune and inflammation genes and risk of non-Hodgkin lymphoma.

Cerhan JR, Ansell SM, Fredericksen ZS, Kay NE, Liebow M, Call TG, Dogan A, Cunningham JM, Wang AH, Liu-Mares W, Macon WR, Jelinek D, Witzig TE, Habermann TM, Slager SL.

Blood. 2007 Dec 15;110(13):4455-63. Epub 2007 Sep 7.PMID: 17827388 [PubMed - indexed for MEDLINE]Related articlesFree article

Chronic lymphocytic leukemia: biology and current treatment.

Zent CS, Kay NE.

Curr Oncol Rep. 2007 Sep;9(5):345-52. Review.PMID: 17706162 [PubMed - indexed for MEDLINE]Related articles

Expression of TCL-1 as a potential prognostic factor for treatment outcome in B-cell chronic lymphocytic leukemia.

Browning RL, Geyer SM, Johnson AJ, Jelinek DF, Tschumper RC, Call TG, Shanafelt TD, Zent CS, Bone ND, Dewald GW, Lin TS, Heerema NA, Grever MR, Kay NE, Byrd JC, Lucas DM.

Leuk Res. 2007 Dec;31(12):1737-40. Epub 2007 Jul 19.PMID: 17659340 [PubMed - indexed for MEDLINE]Related articlesFree article

Combination therapies for previously untreated CLL.

Shanafelt TD, Kay NE.

Lancet. 2007 Jul 21;370(9583):197-8. No abstract available. PMID: 17658375 [PubMed - indexed for MEDLINE]Related articles

The role of prognostic factors in assessing 'high-risk' subgroups of patients with chronic lymphocytic leukemia.

Kay NE, O'Brien SM, Pettitt AR, Stilgenbauer S.

Leukemia. 2007 Sep;21(9):1885-91. Epub 2007 Jun 14. Review.PMID: 17568813 [PubMed - indexed for MEDLINE]Related articles