PubMed

Transgenically Induced GAD Tolerance Curtails the Development of Early {beta}-Cell Autoreactivities but Causes the Subsequent Development of Supernormal Autoreactivities to Other {beta}-Cell Antigens.

Tian J, Dang H, von Boehmer H, Jaeckel E, Kaufman DL.

Diabetes. 2009 Dec;58(12):2843-50. Epub 2009 Sep 9.PMID: 19741165 [PubMed - in process]Related articles

Antigen-based therapy for the treatment of type 1 diabetes.

Tian J, Kaufman DL.

Diabetes. 2009 Sep;58(9):1939-46. No abstract available. PMID: 19720821 [PubMed - indexed for MEDLINE]Related articles

Design, synthesis, and antihepatocellular carcinoma activity of nitric oxide releasing derivatives of oleanolic acid.

Chen L, Zhang Y, Kong X, Lan E, Huang Z, Peng S, Kaufman DL, Tian J.

J Med Chem. 2008 Aug 14;51(15):4834-8. Epub 2008 Jul 4.PMID: 18598019 [PubMed - indexed for MEDLINE]Related articles

The postnatal maternal environment influences diabetes development in nonobese diabetic mice.

Washburn LR, Dang H, Tian J, Kaufman DL.

J Autoimmun. 2007 Feb;28(1):19-23. Epub 2007 Jan 4.PMID: 17207966 [PubMed - indexed for MEDLINE]Related articlesFree article

Long-term monitoring of transplanted islets using positron emission tomography.

Lu Y, Dang H, Middleton B, Campbell-Thompson M, Atkinson MA, Gambhir SS, Tian J, Kaufman DL.

Mol Ther. 2006 Dec;14(6):851-6. Epub 2006 Sep 18.PMID: 16982215 [PubMed - indexed for MEDLINE]Related articles

Noninvasive imaging of islet grafts using positron-emission tomography.

Lu Y, Dang H, Middleton B, Zhang Z, Washburn L, Stout DB, Campbell-Thompson M, Atkinson MA, Phelps M, Gambhir SS, Tian J, Kaufman DL.

Proc Natl Acad Sci U S A. 2006 Jul 25;103(30):11294-9.PMID: 16868090 [PubMed - indexed for MEDLINE]Related articlesFree article

B cells are crucial for determinant spreading of T cell autoimmunity among beta cell antigens in diabetes-prone nonobese diabetic mice.

Tian J, Zekzer D, Lu Y, Dang H, Kaufman DL.

J Immunol. 2006 Feb 15;176(4):2654-61.PMID: 16456028 [PubMed - indexed for MEDLINE]Related articlesFree article

Antigen-based therapies using ignored determinants of beta cell antigens can more effectively inhibit late-stage autoimmune disease in diabetes-prone mice.

Olcott AP, Tian J, Walker V, Dang H, Middleton B, Adorini L, Washburn L, Kaufman DL.

J Immunol. 2005 Aug 1;175(3):1991-9.PMID: 16034144 [PubMed - indexed for MEDLINE]Related articlesFree article

Gamma-aminobutyric acid inhibits T cell autoimmunity and the development of inflammatory responses in a mouse type 1 diabetes model.

Tian J, Lu Y, Zhang H, Chau CH, Dang HN, Kaufman DL.

J Immunol. 2004 Oct 15;173(8):5298-304.PMID: 15470076 [PubMed - indexed for MEDLINE]Related articlesFree article

A salen-manganese catalytic free radical scavenger inhibits type 1 diabetes and islet allograft rejection.

Olcott AP, Tocco G, Tian J, Zekzer D, Fukuto J, Ignarro L, Kaufman DL.

Diabetes. 2004 Oct;53(10):2574-80.PMID: 15448086 [PubMed - indexed for MEDLINE]Related articlesFree article

Bioluminescent monitoring of islet graft survival after transplantation.

Lu Y, Dang H, Middleton B, Zhang Z, Washburn L, Campbell-Thompson M, Atkinson MA, Gambhir SS, Tian J, Kaufman DL.

Mol Ther. 2004 Mar;9(3):428-35.PMID: 15006610 [PubMed - indexed for MEDLINE]Related articles

Memory and effector T cells modulate subsequently primed immune responses to unrelated antigens.

Tian J, Lu Y, Hanssen L, Dang H, Kaufman DL.

Cell Immunol. 2003 Aug;224(2):74-85.PMID: 14609573 [PubMed - indexed for MEDLINE]Related articles

Somatic instability of the NF2 gene in schwannomatosis.

Kaufman DL, Heinrich BS, Willett C, Perry A, Finseth F, Sobel RA, MacCollin M.

Arch Neurol. 2003 Sep;60(9):1317-20.PMID: 12975302 [PubMed - indexed for MEDLINE]Related articlesFree article

Murder mysteries in type 1 diabetes.

Kaufman DL.

Nat Med. 2003 Feb;9(2):161-2. No abstract available. PMID: 12563331 [PubMed - indexed for MEDLINE]Related articles

Antigen-based immunotherapy drives the precocious development of autoimmunity.

Tian J, Olcott AP, Kaufman DL.

J Immunol. 2002 Dec 1;169(11):6564-9.PMID: 12444168 [PubMed - indexed for MEDLINE]Related articlesFree article

Report from the 1st International NOD Mouse T-Cell Workshop and the follow-up mini-workshop.

Kaufman DL, Tisch R, Sarvetnick N, Chatenoud L, Harrison LC, Haskins K, Quinn A, Sercarz E, Singh B, von Herrath M, Wegmann D, Wen L, Zekzer D.

Diabetes. 2001 Nov;50(11):2459-63. Review.PMID: 11679422 [PubMed - indexed for MEDLINE]Related articlesFree article

Lipopolysaccharide-activated B cells down-regulate Th1 immunity and prevent autoimmune diabetes in nonobese diabetic mice.

Tian J, Zekzer D, Hanssen L, Lu Y, Olcott A, Kaufman DL.

J Immunol. 2001 Jul 15;167(2):1081-9.PMID: 11441119 [PubMed - indexed for MEDLINE]Related articlesFree article

The frequency of high avidity T cells determines the hierarchy of determinant spreading.

Tian J, Gregori S, Adorini L, Kaufman DL.

J Immunol. 2001 Jun 15;166(12):7144-50.PMID: 11390460 [PubMed - indexed for MEDLINE]Related articlesFree article

Antisense oligonucleotides to C-fos reduce postictal seizure susceptibility following fully kindled seizures in rats.

Rocha L, Ondarza R, Kaufman DL.

Neurosci Lett. 1999 Jun 25;268(3):143-6.PMID: 10406025 [PubMed - indexed for MEDLINE]Related articles

GABA(A) receptors mediate inhibition of T cell responses.

Tian J, Chau C, Hales TG, Kaufman DL.

J Neuroimmunol. 1999 Apr 1;96(1):21-8.PMID: 10227421 [PubMed - indexed for MEDLINE]Related articles

Antigen-based immunotherapy for autoimmune disease: from animal models to humans?

Tian J, Olcott A, Hanssen L, Zekzer D, Kaufman DL.

Immunol Today. 1999 Apr;20(4):190-5. Review.PMID: 10203718 [PubMed - indexed for MEDLINE]Related articles

Attenuation of inducible Th2 immunity with autoimmune disease progression.

Tian J, Kaufman DL.

J Immunol. 1998 Nov 15;161(10):5399-403.PMID: 9820514 [PubMed - indexed for MEDLINE]Related articlesFree article

Infectious Th1 and Th2 autoimmunity in diabetes-prone mice.

Tian J, Olcott AP, Hanssen LR, Zekzer D, Middleton B, Kaufman DL.

Immunol Rev. 1998 Aug;164:119-27. Review.PMID: 9795770 [PubMed - indexed for MEDLINE]Related articles

In vivo administration of c-Fos antisense oligonucleotides accelerates amygdala kindling.

Rocha L, Kaufman DL.

Neurosci Lett. 1998 Jan 30;241(2-3):111-4.PMID: 9507933 [PubMed - indexed for MEDLINE]Related articles

Insulin selectively primes Th2 responses and induces regulatory tolerance to insulin in pre-diabetic mice.

Tian J, Chau C, Kaufman DL.

Diabetologia. 1998 Feb;41(2):237-40.PMID: 9498660 [PubMed - indexed for MEDLINE]Related articles

Determinant spreading of T helper cell 2 (Th2) responses to pancreatic islet autoantigens.

Tian J, Lehmann PV, Kaufman DL.

J Exp Med. 1997 Dec 15;186(12):2039-43.PMID: 9396773 [PubMed - indexed for MEDLINE]Related articlesFree article

Modulating autoimmune responses to GAD inhibits disease progression and prolongs islet graft survival in diabetes-prone mice.

Tian J, Clare-Salzler M, Herschenfeld A, Middleton B, Newman D, Mueller R, Arita S, Evans C, Atkinson MA, Mullen Y, Sarvetnick N, Tobin AJ, Lehmann PV, Kaufman DL.

Nat Med. 1996 Dec;2(12):1348-53.PMID: 8946834 [PubMed - indexed for MEDLINE]Related articles

Nasal administration of glutamate decarboxylase (GAD65) peptides induces Th2 responses and prevents murine insulin-dependent diabetes.

Tian J, Atkinson MA, Clare-Salzler M, Herschenfeld A, Forsthuber T, Lehmann PV, Kaufman DL.

J Exp Med. 1996 Apr 1;183(4):1561-7.PMID: 8666914 [PubMed - indexed for MEDLINE]Related articlesFree article

Characterization of the murine mu opioid receptor gene.

Kaufman DL, Keith DE Jr, Anton B, Tian J, Magendzo K, Newman D, Tran TH, Lee DS, Wen C, Xia YR, et al.

J Biol Chem. 1995 Jun 30;270(26):15877-83.PMID: 7797593 [PubMed - indexed for MEDLINE]Related articlesFree article

T cell cross-reactivity between coxsackievirus and glutamate decarboxylase is associated with a murine diabetes susceptibility allele.

Tian J, Lehmann PV, Kaufman DL.

J Exp Med. 1994 Nov 1;180(5):1979-84.PMID: 7964474 [PubMed - indexed for MEDLINE]Related articlesFree article

Cellular immunity to a determinant common to glutamate decarboxylase and coxsackie virus in insulin-dependent diabetes.

Atkinson MA, Bowman MA, Campbell L, Darrow BL, Kaufman DL, Maclaren NK.

J Clin Invest. 1994 Nov;94(5):2125-9.PMID: 7962558 [PubMed - indexed for MEDLINE]Related articlesFree article

Intrauterine oxygen tension during the oestrous cycle in the hamster: patterns of change.

Kaufman DL, Mitchell JA.

Comp Biochem Physiol Comp Physiol. 1994 Apr;107(4):673-8.PMID: 7911412 [PubMed - indexed for MEDLINE]Related articles

Comparative localization of two forms of glutamic acid decarboxylase and their mRNAs in rat brain supports the concept of functional differences between the forms.

Esclapez M, Tillakaratne NJ, Kaufman DL, Tobin AJ, Houser CR.

J Neurosci. 1994 Mar;14(3 Pt 2):1834-55.PMID: 8126575 [PubMed - indexed for MEDLINE]Related articlesFree article

Localization of the delta-opioid receptor gene to mouse chromosome 4 by linkage analysis.

Kaufman DL, Xia YR, Keith DE Jr, Newman D, Evans CJ, Lusis AJ.

Genomics. 1994 Jan 15;19(2):405-6. No abstract available. PMID: 8188281 [PubMed - indexed for MEDLINE]Related articles

Horizontal cells in cat and monkey retina express different isoforms of glutamic acid decarboxylase.

Vardi N, Kaufman DL, Sterling P.

Vis Neurosci. 1994 Jan-Feb;11(1):135-42.PMID: 8011576 [PubMed - indexed for MEDLINE]Related articles

Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes.

Kaufman DL, Clare-Salzler M, Tian J, Forsthuber T, Ting GS, Robinson P, Atkinson MA, Sercarz EE, Tobin AJ, Lehmann PV.

Nature. 1993 Nov 4;366(6450):69-72.PMID: 7694152 [PubMed - indexed for MEDLINE]Related articles

Cloning and sequence analysis of a murine cDNA encoding glutamate decarboxylase (GAD65).

Lee DS, Tian J, Phan T, Kaufman DL.

Biochim Biophys Acta. 1993 Oct 19;1216(1):157-60.PMID: 8218409 [PubMed - indexed for MEDLINE]Related articles

Two controlled trials of rifabutin prophylaxis against Mycobacterium avium complex infection in AIDS.

Nightingale SD, Cameron DW, Gordin FM, Sullam PM, Cohn DL, Chaisson RE, Eron LJ, Sparti PD, Bihari B, Kaufman DL, et al.

N Engl J Med. 1993 Sep 16;329(12):828-33.PMID: 8179648 [PubMed - indexed for MEDLINE]Related articlesFree article

Permanent diabetes developing after transient neonatal diabetes.

Geffner ME, Clare-Salzler M, Kaufman DL, Ting GS, Gottschalk ME, Schatz DA.

Lancet. 1993 Apr 24;341(8852):1095. No abstract available. PMID: 8096989 [PubMed - indexed for MEDLINE]Related articles

Glutamate decarboxylases and autoimmunity in insulin-dependent diabetes.

Kaufman DL, Tobin AJ.

Trends Pharmacol Sci. 1993 Apr;14(4):107-9. Review. No abstract available. PMID: 8516952 [PubMed - indexed for MEDLINE]Related articles

Islet cell cytoplasmic autoantibody reactivity to glutamate decarboxylase in insulin-dependent diabetes.

Atkinson MA, Kaufman DL, Newman D, Tobin AJ, Maclaren NK.

J Clin Invest. 1993 Jan;91(1):350-6.PMID: 8423231 [PubMed - indexed for MEDLINE]Related articlesFree article

Permanent diabetes without serological evidence of autoimmunity after transient neonatal diabetes.

Gottschalk ME, Schatz DA, Clare-Salzler M, Kaufman DL, Ting GS, Geffner ME.

Diabetes Care. 1992 Oct;15(10):1273-6. Review.PMID: 1425088 [PubMed - indexed for MEDLINE]Related articles

Two human glutamate decarboxylases, 65-kDa GAD and 67-kDa GAD, are each encoded by a single gene.

Bu DF, Erlander MG, Hitz BC, Tillakaratne NJ, Kaufman DL, Wagner-McPherson CB, Evans GA, Tobin AJ.

Proc Natl Acad Sci U S A. 1992 Mar 15;89(6):2115-9.PMID: 1549570 [PubMed - indexed for MEDLINE]Related articlesFree article

Response of peripheral-blood mononuclear cells to glutamate decarboxylase in insulin-dependent diabetes.

Atkinson MA, Kaufman DL, Campbell L, Gibbs KA, Shah SC, Bu DF, Erlander MG, Tobin AJ, Maclaren NK.

Lancet. 1992 Feb 22;339(8791):458-9.PMID: 1346821 [PubMed - indexed for MEDLINE]Related articles

Glutamate decarboxylase: an autoantigen in IDDM.

Clare-Salzler MJ, Tobin AJ, Kaufman DL.

Diabetes Care. 1992 Jan;15(1):132-5. No abstract available. PMID: 1737532 [PubMed - indexed for MEDLINE]Related articles

Autoimmunity to two forms of glutamate decarboxylase in insulin-dependent diabetes mellitus.

Kaufman DL, Erlander MG, Clare-Salzler M, Atkinson MA, Maclaren NK, Tobin AJ.

J Clin Invest. 1992 Jan;89(1):283-92.PMID: 1370298 [PubMed - indexed for MEDLINE]Related articlesFree article

Alternative forms of GAD and GABAA receptors.

Tobin AJ, Brecha N, Chiang MY, Endo S, Erlander MG, Feldblum S, Houser CR, Kaufman DL, Khrestchatistky M, MacLennan AJ, et al.

Adv Biochem Psychopharmacol. 1992;47:55-66. Review. No abstract available. PMID: 1324588 [PubMed - indexed for MEDLINE]Related articles

Distribution of glutamic acid decarboxylase (Mr 67,000) in the basal ganglia of the rat: an immunohistochemical study with a selective cDNA-generated polyclonal antibody.

Gonzales C, Kaufman DL, Tobin AJ, Chesselet MF.

J Neurocytol. 1991 Dec;20(12):953-61.PMID: 1783943 [PubMed - indexed for MEDLINE]Related articles

Two forms of the gamma-aminobutyric acid synthetic enzyme glutamate decarboxylase have distinct intraneuronal distributions and cofactor interactions.

Kaufman DL, Houser CR, Tobin AJ.

J Neurochem. 1991 Feb;56(2):720-3.PMID: 1988566 [PubMed - indexed for MEDLINE]Related articles

Detection of point mutations associated with genetic diseases by an exon scanning technique.

Kaufman DL, Ramesh V, McClatchey AI, Menkes JH, Tobin AJ.

Genomics. 1990 Dec;8(4):656-63.PMID: 2276738 [PubMed - indexed for MEDLINE]Related articles