PubMed

Molecular mechanism by which pioglitazone preserves pancreatic {beta} cells in obese diabetic mice: Evidence for acute and chronic actions as a PPAR{gamma} agonist.

Kanda Y, Shimoda M, Hamamoto S, Tawaramoto K, Kawasaki F, Hashiramoto M, Nakashima K, Matsuki M, Kaku K.

Am J Physiol Endocrinol Metab. 2009 Nov 17. [Epub ahead of print]PMID: 19920213 [PubMed - as supplied by publisher]Related articles

Long-term effects of pioglitazone in Japanese patients with type 2 diabetes without a recent history of macrovascular morbidity.

Kaku K, Daida H, Kashiwagi A, Yamashina A, Yamazaki T, Momomura S, Iwase T, Yamasaki Y, Nagatsuka K, Kitagawa K, Kawamori R.

Curr Med Res Opin. 2009 Dec;25(12):2925-32.PMID: 19835463 [PubMed - in process]Related articles

[Alpha-glucosidase inhibitor for the prevention of type 2 diabetes mellitus: a randomised, double-blind trial in Japanese subjects with impaired glucose tolerance]

Kawamori R, Tajima N, Iwamoto Y, Kashiwagi A, Shimamoto K, Kaku K.

Nippon Rinsho. 2009 Sep;67(9):1821-5. Japanese. PMID: 19768922 [PubMed - in process]Related articles

Gallbladder edema in type 1 diabetic patient due to delayed-type insulin allergy.

Kawasaki F, Kamei S, Tatsumi F, Hamamoto S, Shimoda M, Tawaramoto K, Shigeto M, Kanda Y, Hashiramoto M, Matsuki M, Kaku K.

Intern Med. 2009;48(17):1545-9. Epub 2009 Sep 1.PMID: 19721301 [PubMed - in process]Related articlesFree article

Molecular Analysis of db Gene-related Pancreatic beta Cell Dysfunction; Evidence for a Compensatory Mechanism Inhibiting Development of Diabetes in the db Gene Heterozygote.

Kanda Y, Shimoda M, Tawaramoto K, Hamamoto S, Tatsumi F, Kawasaki F, Hashiramoto M, Nakashima K, Matsuki M, Kaku K.

Endocr J. 2009 Aug 25. [Epub ahead of print]PMID: 19706988 [PubMed - as supplied by publisher]Related articlesFree article

[Regional infection control network in limited resource hospitals]

Kunishima H, Kitagawa M, Yamamoto N, Hiragata Y, Kaku K, Kaku M.

Rinsho Byori. 2009 May;57(5):471-3. Japanese. PMID: 19522255 [PubMed - indexed for MEDLINE]Related articles

Effect of mitiglinide on glycemic control over 52 weeks in Japanese type 2 diabetic patients insufficiently controlled with pioglitazone monotherapy.

Kaku K, Tanaka S, Origasa H, Kikuchi M, Akanuma Y.

Endocr J. 2009 Dec;56(6):739-46. Epub 2009 Jun 9.PMID: 19506328 [PubMed - in process]Related articlesFree article

[Progress in therapy for diabetes mellitus--insulin-resistance ameliorating agents]

Kaku K.

Nippon Naika Gakkai Zasshi. 2009 Apr 10;98(4):742-9. Review. Japanese. No abstract available. PMID: 19472525 [PubMed - indexed for MEDLINE]Related articles

Replication study for the association of new meta-analysis-derived risk loci with susceptibility to type 2 diabetes in 6,244 Japanese individuals.

Omori S, Tanaka Y, Horikoshi M, Takahashi A, Hara K, Hirose H, Kashiwagi A, Kaku K, Kawamori R, Kadowaki T, Nakamura Y, Maeda S.

Diabetologia. 2009 Aug;52(8):1554-60. Epub 2009 May 20.PMID: 19455301 [PubMed - indexed for MEDLINE]Related articles

Voglibose for prevention of type 2 diabetes mellitus: a randomised, double-blind trial in Japanese individuals with impaired glucose tolerance.

Kawamori R, Tajima N, Iwamoto Y, Kashiwagi A, Shimamoto K, Kaku K; Voglibose Ph-3 Study Group.

Lancet. 2009 May 9;373(9675):1607-14. Epub 2009 Apr 22.PMID: 19395079 [PubMed - indexed for MEDLINE]Related articles

Addition of mitiglinide to pioglitazone monotherapy improves overall glycemic control in Japanese patients with type 2 diabetes: a randomized double blind trial.

Kaku K, Tanaka S, Origasa H, Kikuchi M, Akanuma Y.

Endocr J. 2009 Oct;56(5):657-64. Epub 2009 Apr 7.PMID: 19352048 [PubMed - indexed for MEDLINE]Related articlesFree article

Efficacy and safety of therapy with metformin plus pioglitazone in the treatment of patients with type 2 diabetes: a double-blind, placebo-controlled, clinical trial.

Kaku K.

Curr Med Res Opin. 2009 May;25(5):1111-9.PMID: 19309251 [PubMed - indexed for MEDLINE]Related articles

Muscle-specific overexpression of heparin-binding epidermal growth factor-like growth factor increases peripheral glucose disposal and insulin sensitivity.

Fukatsu Y, Noguchi T, Hosooka T, Ogura T, Kotani K, Abe T, Shibakusa T, Inoue K, Sakai M, Tobimatsu K, Inagaki K, Yoshioka T, Matsuo M, Nakae J, Matsuki Y, Hiramatsu R, Kaku K, Okamura H, Fushiki T, Kasuga M.

Endocrinology. 2009 Jun;150(6):2683-91. Epub 2009 Mar 5.PMID: 19264873 [PubMed - indexed for MEDLINE]Related articles

The application of the mutated acetolactate synthase gene from rice as the selectable marker gene in the production of transgenic soybeans.

Tougou M, Yamagishi N, Furutani N, Kaku K, Shimizu T, Takahata Y, Sakai J, Kanematsu S, Hidaka S.

Plant Cell Rep. 2009 May;28(5):769-76. Epub 2009 Feb 15.PMID: 19219608 [PubMed - indexed for MEDLINE]Related articles

Measurement of (1-3)-beta-D-glucan derived from different gauze types.

Kanamori H, Kanemitsu K, Miyasaka T, Ameku K, Endo S, Aoyagi T, Inden K, Hatta M, Yamamoto N, Kunishima H, Yano H, Kaku K, Hirakata Y, Kaku M.

Tohoku J Exp Med. 2009 Feb;217(2):117-21.PMID: 19212104 [PubMed - indexed for MEDLINE]Related articlesFree article

Low, but physiological, concentration of GLP-1 stimulates insulin secretion independent of the cAMP-dependent protein kinase pathway.

Shigeto M, Katsura M, Matsuda M, Ohkuma S, Kaku K.

J Pharmacol Sci. 2008 Nov;108(3):274-9. Epub 2008 Nov 6.PMID: 18987435 [PubMed - indexed for MEDLINE]Related articlesFree article

MIN6 is not a pure beta cell line but a mixed cell line with other pancreatic endocrine hormones.

Nakashima K, Kanda Y, Hirokawa Y, Kawasaki F, Matsuki M, Kaku K.

Endocr J. 2009 Mar;56(1):45-53. Epub 2008 Oct 9.PMID: 18845907 [PubMed - indexed for MEDLINE]Related articlesFree article

SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations.

Unoki H, Takahashi A, Kawaguchi T, Hara K, Horikoshi M, Andersen G, Ng DP, Holmkvist J, Borch-Johnsen K, Jørgensen T, Sandbaek A, Lauritzen T, Hansen T, Nurbaya S, Tsunoda T, Kubo M, Babazono T, Hirose H, Hayashi M, Iwamoto Y, Kashiwagi A, Kaku K, Kawamori R, Tai ES, Pedersen O, Kamatani N, Kadowaki T, Kikkawa R, Nakamura Y, Maeda S.

Nat Genet. 2008 Sep;40(9):1098-102.PMID: 18711366 [PubMed - indexed for MEDLINE]Related articles

Dose-dependent improvement in glycemia with once-daily liraglutide without hypoglycemia or weight gain: A double-blind, randomized, controlled trial in Japanese patients with type 2 diabetes.

Seino Y, Rasmussen MF, Zdravkovic M, Kaku K.

Diabetes Res Clin Pract. 2008 Aug;81(2):161-8. Epub 2008 May 20.PMID: 18495285 [PubMed - indexed for MEDLINE]Related articles

The relationship between fasting hyperglycemia and insulin secretion in subjects with normal or impaired glucose tolerance.

Abdul-Ghani MA, Matsuda M, Jani R, Jenkinson CP, Coletta DK, Kaku K, DeFronzo RA.

Am J Physiol Endocrinol Metab. 2008 Aug;295(2):E401-6. Epub 2008 May 20.PMID: 18492770 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of sulfonylurea drugs on adiponectin production from 3T3-L1 adipocytes: implication of different mechanism from pioglitazone.

Kanda Y, Matsuda M, Tawaramoto K, Kawasaki F, Hashiramoto M, Matsuki M, Kaku K.

Diabetes Res Clin Pract. 2008 Jul;81(1):13-8. Epub 2008 May 2.PMID: 18455831 [PubMed - indexed for MEDLINE]Related articles

Association of CDKAL1, IGF2BP2, CDKN2A/B, HHEX, SLC30A8, and KCNJ11 with susceptibility to type 2 diabetes in a Japanese population.

Omori S, Tanaka Y, Takahashi A, Hirose H, Kashiwagi A, Kaku K, Kawamori R, Nakamura Y, Maeda S.

Diabetes. 2008 Mar;57(3):791-5. Epub 2007 Dec 27.PMID: 18162508 [PubMed - indexed for MEDLINE]Related articlesFree article

[Drug-induced hypoglycemia]

Hashiramoto M, Kaku K.

Nippon Rinsho. 2007 Oct 28;65 Suppl 8:575-83. Review. Japanese. No abstract available. PMID: 18074605 [PubMed - indexed for MEDLINE]Related articles

Hypogenetic lung syndrome with anomalous venous return to the left inferior pulmonary vein: multidetector row CT findings.

Furuya K, Kaku K, Yasumori K, Kometani T, Takeo S, Watanabe I, Muranaka T.

J Thorac Imaging. 2007 Nov;22(4):351-4.PMID: 18043392 [PubMed - indexed for MEDLINE]Related articles

A novel complex deletion-insertion mutation mediated by Alu repetitive elements leads to lipoprotein lipase deficiency.

Okubo M, Horinishi A, Saito M, Ebara T, Endo Y, Kaku K, Murase T, Eto M.

Mol Genet Metab. 2007 Nov;92(3):229-33. Epub 2007 Aug 13.PMID: 17706445 [PubMed - indexed for MEDLINE]Related articles

Polymorphisms in the 3' UTR in the neurocalcin delta gene affect mRNA stability, and confer susceptibility to diabetic nephropathy.

Kamiyama M, Kobayashi M, Araki S, Iida A, Tsunoda T, Kawai K, Imanishi M, Nomura M, Babazono T, Iwamoto Y, Kashiwagi A, Kaku K, Kawamori R, Ng DP, Hansen T, Gaede P, Pedersen O, Nakamura Y, Maeda S.

Hum Genet. 2007 Nov;122(3-4):397-407. Epub 2007 Aug 2.PMID: 17671797 [PubMed - indexed for MEDLINE]Related articles

Malaria and mefloquine prophylaxis use among Japan Ground Self-Defense Force personnel deployed in East Timor.

Fujii T, Kaku K, Jelinek T, Kimura M.

J Travel Med. 2007 Jul-Aug;14(4):226-32.PMID: 17617844 [PubMed - indexed for MEDLINE]Related articles

Pharmacokinetics and pharmacodynamics of glimepiride in type 2 diabetic patients: compared effects of once- versus twice-daily dosing.

Matsuki M, Matsuda M, Kohara K, Shimoda M, Kanda Y, Tawaramoto K, Shigetoh M, Kawasaki F, Kotani K, Kaku K.

Endocr J. 2007 Aug;54(4):571-6. Epub 2007 Jul 2.PMID: 17603225 [PubMed - indexed for MEDLINE]Related articlesFree article

Analysis of waist circumference in Japanese subjects with type 2 diabetes mellitus: lack of propriety to define the current criteria of metabolic syndrome.

Kanda Y, Matsuda M, Hamamoto S, Kawasaki F, Kotani K, Matsuki M, Kaku K.

Diabetes Res Clin Pract. 2007 Sep;77 Suppl 1:S220-3. Epub 2007 Apr 27.PMID: 17467108 [PubMed - indexed for MEDLINE]Related articles

[Progress in chemotherapy of type 2 diabetes mellitus]

Kaku K.

Nippon Naika Gakkai Zasshi. 2007 Mar 10;96(3):505-9. Review. Japanese. No abstract available. PMID: 17419417 [PubMed - indexed for MEDLINE]Related articles

Nateglinide and mitiglinide, but not sulfonylureas, induce insulin secretion through a mechanism mediated by calcium release from endoplasmic reticulum.

Shigeto M, Katsura M, Matsuda M, Ohkuma S, Kaku K.

J Pharmacol Exp Ther. 2007 Jul;322(1):1-7. Epub 2007 Apr 4.PMID: 17409272 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin-like growth factor 2 (IGF2) and IGF2 receptor gene variants are associated with fetal growth.

Kaku K, Osada H, Seki K, Sekiya S.

Acta Paediatr. 2007 Mar;96(3):363-7.PMID: 17407457 [PubMed - indexed for MEDLINE]Related articles

Replication study for the association of TCF7L2 with susceptibility to type 2 diabetes in a Japanese population.

Hayashi T, Iwamoto Y, Kaku K, Hirose H, Maeda S.

Diabetologia. 2007 May;50(5):980-4. Epub 2007 Mar 6.PMID: 17340123 [PubMed - indexed for MEDLINE]Related articles

A novel mutated acetolactate synthase gene conferring specific resistance to pyrimidinyl carboxy herbicides in rice.

Okuzaki A, Shimizu T, Kaku K, Kawai K, Toriyama K.

Plant Mol Biol. 2007 May;64(1-2):219-24. Epub 2007 Mar 3.PMID: 17334827 [PubMed - indexed for MEDLINE]Related articles

First phase of glucose-stimulated insulin secretion from MIN 6 cells does not always require extracellular calcium influx.

Shigeto M, Katsura M, Matsuda M, Ohkuma S, Kaku K.

J Pharmacol Sci. 2006 Aug;101(4):293-302. Epub 2006 Aug 5.PMID: 16891769 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanism behind augmentation in baroreflex sensitivity after acute exercise in spontaneously hypertensive rats.

Minami N, Mori N, Nagasaka M, Ito O, Kurosawa H, Kanazawa M, Kaku K, Lee E, Kohzuki M.

Hypertens Res. 2006 Feb;29(2):117-22.PMID: 16755145 [PubMed - indexed for MEDLINE]Related articles

Plasma lipid levels and nutritional intake in childhood- and adolescence-onset young type 1 diabetic patients in Japan.

Saito M, Kuratsune H, Nitta H, Kawahara K, Hamano M, Matsuda M, Kaku K, Eto M.

Diabetes Res Clin Pract. 2006 Jul;73(1):29-34. Epub 2006 Jan 26.PMID: 16442661 [PubMed - indexed for MEDLINE]Related articles

[The metabolic syndrome and insulin resistance]

Kotani K, Kaku K.

Nippon Rinsho. 2005 Aug;63(8):1485-91. Review. Japanese. PMID: 16101244 [PubMed - indexed for MEDLINE]Related articles

Genetic variations in the gene encoding TFAP2B are associated with type 2 diabetes mellitus.

Maeda S, Tsukada S, Kanazawa A, Sekine A, Tsunoda T, Koya D, Maegawa H, Kashiwagi A, Babazono T, Matsuda M, Tanaka Y, Fujioka T, Hirose H, Eguchi T, Ohno Y, Groves CJ, Hattersley AT, Hitman GA, Walker M, Kaku K, Iwamoto Y, Kawamori R, Kikkawa R, Kamatani N, McCarthy MI, Nakamura Y.

J Hum Genet. 2005;50(6):283-92. Epub 2005 Jun 7.PMID: 15940393 [PubMed - indexed for MEDLINE]Related articles

Single nucleotide polymorphisms in the gene encoding Krüppel-like factor 7 are associated with type 2 diabetes.

Kanazawa A, Kawamura Y, Sekine A, Iida A, Tsunoda T, Kashiwagi A, Tanaka Y, Babazono T, Matsuda M, Kawai K, Iiizumi T, Fujioka T, Imanishi M, Kaku K, Iwamoto Y, Kawamori R, Kikkawa R, Nakamura Y, Maeda S.

Diabetologia. 2005 Jul;48(7):1315-22. Epub 2005 Jun 4.PMID: 15937668 [PubMed - indexed for MEDLINE]Related articles

Genetic variations in the gene encoding ELMO1 are associated with susceptibility to diabetic nephropathy.

Shimazaki A, Kawamura Y, Kanazawa A, Sekine A, Saito S, Tsunoda T, Koya D, Babazono T, Tanaka Y, Matsuda M, Kawai K, Iiizumi T, Imanishi M, Shinosaki T, Yanagimoto T, Ikeda M, Omachi S, Kashiwagi A, Kaku K, Iwamoto Y, Kawamori R, Kikkawa R, Nakajima M, Nakamura Y, Maeda S.

Diabetes. 2005 Apr;54(4):1171-8.PMID: 15793258 [PubMed - indexed for MEDLINE]Related articlesFree article

[Treatment for patients with impaired glucose tolerance]

Tawaramoto K, Kaku K.

Nippon Rinsho. 2005 Feb;63 Suppl 2:423-7. Review. Japanese. No abstract available. PMID: 15779416 [PubMed - indexed for MEDLINE]Related articles

Possible contribution of adipocytokines on diabetic neuropathy.

Matsuda M, Kawasaki F, Inoue H, Kanda Y, Yamada K, Harada Y, Saito M, Eto M, Matsuki M, Kaku K.

Diabetes Res Clin Pract. 2004 Dec;66 Suppl 1:S121-3.PMID: 15563961 [PubMed - indexed for MEDLINE]Related articles

Structural and functional analysis of pancreatic islets preserved by pioglitazone in db/db mice.

Kawasaki F, Matsuda M, Kanda Y, Inoue H, Kaku K.

Am J Physiol Endocrinol Metab. 2005 Mar;288(3):E510-8. Epub 2004 Nov 2.PMID: 15522998 [PubMed - indexed for MEDLINE]Related articlesFree article

Association of the gene encoding wingless-type mammary tumor virus integration-site family member 5B (WNT5B) with type 2 diabetes.

Kanazawa A, Tsukada S, Sekine A, Tsunoda T, Takahashi A, Kashiwagi A, Tanaka Y, Babazono T, Matsuda M, Kaku K, Iwamoto Y, Kawamori R, Kikkawa R, Nakamura Y, Maeda S.

Am J Hum Genet. 2004 Nov;75(5):832-43. Epub 2004 Sep 21.PMID: 15386214 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanism of resistance to carpropamid in Magnaporthe grisea.

Takagaki M, Kaku K, Watanabe S, Kawai K, Shimizu T, Sawada H, Kumakura K, Nagayama K.

Pest Manag Sci. 2004 Sep;60(9):921-6.PMID: 15382507 [PubMed - indexed for MEDLINE]Related articles

Environmental impacts of the Japanese beef-fattening system with different feeding lengths as evaluated by a life-cycle assessment method.

Ogino A, Kaku K, Osada T, Shimada K.

J Anim Sci. 2004 Jul;82(7):2115-22.PMID: 15309959 [PubMed - indexed for MEDLINE]Related articlesFree article

Impact of adiposity and plasma adipocytokines on diabetic angiopathies in Japanese Type 2 diabetic subjects.

Matsuda M, Kawasaki F, Yamada K, Kanda Y, Saito M, Eto M, Matsuki M, Kaku K.

Diabet Med. 2004 Aug;21(8):881-8.PMID: 15270792 [PubMed - indexed for MEDLINE]Related articles

Effect of apolipoprotein E4 allele on plasma LDL cholesterol response to diet therapy in type 2 diabetic patients.

Saito M, Eto M, Nitta H, Kanda Y, Shigeto M, Nakayama K, Tawaramoto K, Kawasaki F, Kamei S, Kohara K, Matsuda M, Matsuki M, Kaku K.

Diabetes Care. 2004 Jun;27(6):1276-80.PMID: 15161775 [PubMed - indexed for MEDLINE]Related articlesFree article

Retained capacity of glucose-mediated insulin secretion in patients with type 2 diabetes mellitus inversely correlates with the duration of diabetes.

Kaku K, Kawasaki F, Kanda Y, Matsuda M.

Diabetes Res Clin Pract. 2004 Jun;64(3):221-3. No abstract available. PMID: 15126011 [PubMed - indexed for MEDLINE]Related articles