PubMed

MicroRNA-125a is over-expressed in insulin target tissues in a spontaneous rat model of Type 2 Diabetes.

Herrera BM, Lockstone HE, Taylor JM, Wills QF, Kaisaki PJ, Barrett A, Camps C, Fernandez C, Ragoussis J, Gauguier D, McCarthy MI, Lindgren CM.

BMC Med Genomics. 2009 Aug 18;2:54.PMID: 19689793 [PubMed - in process]Related articlesFree article

Functional annotations of diabetes nephropathy susceptibility loci through analysis of genome-wide renal gene expression in rat models of diabetes mellitus.

Hu Y, Kaisaki PJ, Argoud K, Wilder SP, Wallace KJ, Woon PY, Blancher C, Tarnow L, Groop PH, Hadjadj S, Marre M, Parving HH, Farrall M, Cox RD, Lathrop M, Vionnet N, Bihoreau MT, Gauguier D.

BMC Med Genomics. 2009 Jul 9;2:41.PMID: 19586551 [PubMed - in process]Related articlesFree article

Comparative analysis of methods for gene transcription profiling data derived from different microarray technologies in rat and mouse models of diabetes.

Wilder SP, Kaisaki PJ, Argoud K, Salhan A, Ragoussis J, Bihoreau MT, Gauguier D.

BMC Genomics. 2009 Feb 5;10:63.PMID: 19196459 [PubMed - indexed for MEDLINE]Related articlesFree article

Pathophysiological, genetic and gene expression features of a novel rodent model of the cardio-metabolic syndrome.

Wallis RH, Collins SC, Kaisaki PJ, Argoud K, Wilder SP, Wallace KJ, Ria M, Ktorza A, Rorsman P, Bihoreau MT, Gauguier D.

PLoS One. 2008 Aug 13;3(8):e2962.PMID: 18698428 [PubMed - indexed for MEDLINE]Related articlesFree article

Genomic organization and mutation screening of the human ortholog of Pkdr1 associated with polycystic kidney disease in the rat.

Kaisaki PJ, Bergmann C, Brown JH, Outeda P, Lens XM, Peters DJ, Gretz N, Gauguier D, Bihoreau MT.

Eur J Med Genet. 2008 Jul-Aug;51(4):325-31. Epub 2008 Mar 16.PMID: 18434273 [PubMed - indexed for MEDLINE]Related articles

Aryl hydrocarbon receptor nuclear translocator-like (BMAL1) is associated with susceptibility to hypertension and type 2 diabetes.

Woon PY, Kaisaki PJ, Bragança J, Bihoreau MT, Levy JC, Farrall M, Gauguier D.

Proc Natl Acad Sci U S A. 2007 Sep 4;104(36):14412-7. Epub 2007 Aug 29.PMID: 17728404 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic association analysis of inositol polyphosphate phosphatase-like 1 (INPPL1, SHIP2) variants with essential hypertension.

Marçano AC, Burke B, Gungadoo J, Wallace C, Kaisaki PJ, Woon PY, Farrall M, Clayton D, Brown M, Dominiczak A, Connell JM, Webster J, Lathrop M, Caulfield M, Samani N, Gauguier D, Munroe PB.

J Med Genet. 2007 Sep;44(9):603-5. Epub 2007 Jun 8.PMID: 17557929 [PubMed - indexed for MEDLINE]Related articles

Mapping diabetes QTL in an intercross derived from a congenic strain of the Brown Norway and Goto-Kakizaki rats.

Collins SC, Wallis RH, Wilder SP, Wallace KJ, Argoud K, Kaisaki PJ, Bihoreau MT, Gauguier D.

Mamm Genome. 2006 Jun;17(6):538-47. Epub 2006 Jun 12.PMID: 16783636 [PubMed - indexed for MEDLINE]Related articles

Genomic organization of the rat Clock gene and sequence analysis in inbred rat strains.

Woon PY, Curtis AM, Kaisaki PJ, Argoud K, Wallace KJ, Bihoreau MT, FitzGerald GA, Gauguier D.

Genomics. 2006 Feb;87(2):208-17. Epub 2006 Jan 11.PMID: 16376516 [PubMed - indexed for MEDLINE]Related articles

Missense mutation in sterile alpha motif of novel protein SamCystin is associated with polycystic kidney disease in (cy/+) rat.

Brown JH, Bihoreau MT, Hoffmann S, Kränzlin B, Tychinskaya I, Obermüller N, Podlich D, Boehn SN, Kaisaki PJ, Megel N, Danoy P, Copley RR, Broxholme J, Witzgall R, Lathrop M, Gretz N, Gauguier D.

J Am Soc Nephrol. 2005 Dec;16(12):3517-26. Epub 2005 Oct 5.PMID: 16207829 [PubMed - indexed for MEDLINE]Related articlesFree article

Medical Genetics: revenge of the thrift.

Kaisaki PJ, Gauguier D.

Heredity. 2005 Nov;95(5):337-8. No abstract available. PMID: 15999140 [PubMed - indexed for MEDLINE]Related articlesFree article

Quantitative trait locus dissection in congenic strains of the Goto-Kakizaki rat identifies a region conserved with diabetes loci in human chromosome 1q.

Wallace KJ, Wallis RH, Collins SC, Argoud K, Kaisaki PJ, Ktorza A, Woon PY, Bihoreau MT, Gauguier D.

Physiol Genomics. 2004 Sep 16;19(1):1-10. Epub 2004 Jul 20.PMID: 15266047 [PubMed - indexed for MEDLINE]Related articlesFree article

Polymorphisms in type II SH2 domain-containing inositol 5-phosphatase (INPPL1, SHIP2) are associated with physiological abnormalities of the metabolic syndrome.

Kaisaki PJ, Delépine M, Woon PY, Sebag-Montefiore L, Wilder SP, Menzel S, Vionnet N, Marion E, Riveline JP, Charpentier G, Schurmans S, Levy JC, Lathrop M, Farrall M, Gauguier D.

Diabetes. 2004 Jul;53(7):1900-4.PMID: 15220217 [PubMed - indexed for MEDLINE]Related articlesFree article

Enhanced insulin secretion and cholesterol metabolism in congenic strains of the spontaneously diabetic (Type 2) Goto Kakizaki rat are controlled by independent genetic loci in rat chromosome 8.

Wallis RH, Wallace KJ, Collins SC, McAteer M, Argoud K, Bihoreau MT, Kaisaki PJ, Gauguier D.

Diabetologia. 2004 Jun;47(6):1096-106. Epub 2004 May 26.PMID: 15164172 [PubMed - indexed for MEDLINE]Related articles

Localization, cDNA sequence and genomic organization of the rat seipin gene (Bscl2) and sequence analysis in inbred rat models of Type 2 diabetes mellitus.

Kaisaki PJ, Sebag-Montefiore LM, Brown JH, Magre J, Lathrop M, Capeau J, Gauguier D.

Cytogenet Genome Res. 2002;98(1):71-4.PMID: 12584444 [PubMed - indexed for MEDLINE]Related articles

The gene INPPL1, encoding the lipid phosphatase SHIP2, is a candidate for type 2 diabetes in rat and man.

Marion E, Kaisaki PJ, Pouillon V, Gueydan C, Levy JC, Bodson A, Krzentowski G, Daubresse JC, Mockel J, Behrends J, Servais G, Szpirer C, Kruys V, Gauguier D, Schurmans S.

Diabetes. 2002 Jul;51(7):2012-7.PMID: 12086927 [PubMed - indexed for MEDLINE]Related articlesFree article

A high-resolution consensus linkage map of the rat, integrating radiation hybrid and genetic maps.

Bihoreau MT, Sebag-Montefiore L, Godfrey RF, Wallis RH, Brown JH, Danoy PA, Collins SC, Rouard M, Kaisaki PJ, Lathrop M, Gauguier D.

Genomics. 2001 Jul;75(1-3):57-69.PMID: 11472068 [PubMed - indexed for MEDLINE]Related articles

Detailed comparative gene map of rat chromosome 1 with mouse and human genomes and physical mapping of an evolutionary chromosomal breakpoint.

Kaisaki PJ, Rouard M, Danoy PA, Wallis RH, Collins SC, Rice M, Levy ER, Lathrop M, Bihoreau MT, Gauguier D.

Genomics. 2000 Feb 15;64(1):32-43.PMID: 10708516 [PubMed - indexed for MEDLINE]Related articles

A gene map of the rat derived from linkage analysis and related regions in the mouse and human genomes.

Gauguier D, Kaisaki PJ, Rouard M, Wallis RH, Browne J, Rapp JP, Bihoreau MT.

Mamm Genome. 1999 Jul;10(7):675-86.PMID: 10384039 [PubMed - indexed for MEDLINE]Related articles

Linkage and physical mapping of rat microsatellites derived from minisatellite loci.

Giraudeau F, Apiou F, Amarger V, Kaisaki PJ, Bihoreau MT, Lathrop M, Vergnaud G, Gauguier D.

Mamm Genome. 1999 Apr;10(4):405-9. No abstract available. PMID: 10087303 [PubMed - indexed for MEDLINE]Related articles

Localization of tub and uncoupling proteins (Ucp) 2 and 3 to a region of rat chromosome 1 linked to glucose intolerance and adiposity in the Goto-Kakizaki (GK) type 2 diabetic rat.

Kaisaki PJ, Woon PY, Wallis RH, Monaco AP, Lathrop M, Gauguier D.

Mamm Genome. 1998 Nov;9(11):910-2. No abstract available. PMID: 9799845 [PubMed - indexed for MEDLINE]Related articles

A low renal threshold for glucose in diabetic patients with a mutation in the hepatocyte nuclear factor-1alpha (HNF-1alpha) gene.

Menzel R, Kaisaki PJ, Rjasanowski I, Heinke P, Kerner W, Menzel S.

Diabet Med. 1998 Oct;15(10):816-20.PMID: 9796880 [PubMed - indexed for MEDLINE]Related articles

Construction and characterization of a 10-fold genome equivalent rat P1-derived artificial chromosome library.

Woon PY, Osoegawa K, Kaisaki PJ, Zhao B, Catanese JJ, Gauguier D, Cox R, Levy ER, Lathrop GM, Monaco AP, de Jong PJ.

Genomics. 1998 Jun 15;50(3):306-16.PMID: 9676425 [PubMed - indexed for MEDLINE]Related articles

Maturity-onset diabetes of the young due to a mutation in the hepatocyte nuclear factor-4 alpha binding site in the promoter of the hepatocyte nuclear factor-1 alpha gene.

Gragnoli C, Lindner T, Cockburn BN, Kaisaki PJ, Gragnoli F, Marozzi G, Bell GI.

Diabetes. 1997 Oct;46(10):1648-51.PMID: 9313764 [PubMed - indexed for MEDLINE]Related articles

Genetic variation in the hepatocyte nuclear factor-1 alpha gene in Danish Caucasians with late-onset NIDDM.

Urhammer SA, Rasmussen SK, Kaisaki PJ, Oda N, Yamagata K, Møller AM, Fridberg M, Hansen L, Hansen T, Bell GI, Pedersen O.

Diabetologia. 1997 Apr;40(4):473-5.PMID: 9112026 [PubMed - indexed for MEDLINE]Related articles

Identification of nine novel mutations in the hepatocyte nuclear factor 1 alpha gene associated with maturity-onset diabetes of the young (MODY3).

Vaxillaire M, Rouard M, Yamagata K, Oda N, Kaisaki PJ, Boriraj VV, Chevre JC, Boccio V, Cox RD, Lathrop GM, Dussoix P, Philippe J, Timsit J, Charpentier G, Velho G, Bell GI, Froguel P.

Hum Mol Genet. 1997 Apr;6(4):583-6.PMID: 9097962 [PubMed - indexed for MEDLINE]Related articlesFree article

Mutations in the hepatocyte nuclear factor-1alpha gene are a common cause of maturity-onset diabetes of the young in the U.K.

Frayling TM, Bulamn MP, Ellard S, Appleton M, Dronsfield MJ, Mackie AD, Baird JD, Kaisaki PJ, Yamagata K, Bell GI, Bain SC, Hattersley AT.

Diabetes. 1997 Apr;46(4):720-5.PMID: 9075818 [PubMed - indexed for MEDLINE]Related articles

Mutations in the hepatocyte nuclear factor-1alpha gene in MODY and early-onset NIDDM: evidence for a mutational hotspot in exon 4.

Kaisaki PJ, Menzel S, Lindner T, Oda N, Rjasanowski I, Sahm J, Meincke G, Schulze J, Schmechel H, Petzold C, Ledermann HM, Sachse G, Boriraj VV, Menzel R, Kerner W, Turner RC, Yamagata K, Bell GI.

Diabetes. 1997 Mar;46(3):528-35. Erratum in: Diabetes 1997 Jul;46(7):1239. PMID: 9032114 [PubMed - indexed for MEDLINE]Related articles

Mutations in the hepatocyte nuclear factor-4alpha gene in maturity-onset diabetes of the young (MODY1)

Yamagata K, Furuta H, Oda N, Kaisaki PJ, Menzel S, Cox NJ, Fajans SS, Signorini S, Stoffel M, Bell GI.

Nature. 1996 Dec 5;384(6608):458-60.PMID: 8945471 [PubMed - indexed for MEDLINE]Related articles

Mutations in the hepatocyte nuclear factor-1alpha gene in maturity-onset diabetes of the young (MODY3)

Yamagata K, Oda N, Kaisaki PJ, Menzel S, Furuta H, Vaxillaire M, Southam L, Cox RD, Lathrop GM, Boriraj VV, Chen X, Cox NJ, Oda Y, Yano H, Le Beau MM, Yamada S, Nishigori H, Takeda J, Fajans SS, Hattersley AT, Iwasaki N, Hansen T, Pedersen O, Polonsky KS, Bell GI, et al.

Nature. 1996 Dec 5;384(6608):455-8.PMID: 8945470 [PubMed - indexed for MEDLINE]Related articles

Human gastric inhibitory polypeptide receptor: cloning of the gene (GIPR) and cDNA.

Yamada Y, Hayami T, Nakamura K, Kaisaki PJ, Someya Y, Wang CZ, Seino S, Seino Y.

Genomics. 1995 Oct 10;29(3):773-6.PMID: 8575774 [PubMed - indexed for MEDLINE]Related articles

Cloning and characterization of rat cysteine sulfinic acid decarboxylase.

Kaisaki PJ, Jerkins AA, Goodspeed DC, Steele RD, Kaisakia PJ.

Biochim Biophys Acta. 1995 May 17;1262(1):79-82. Erratum in: Biochim Biophys Acta 1995 Aug 22;1263(2):179. PMID: 7772604 [PubMed - indexed for MEDLINE]Related articles

A cloned rat CD38-homologous protein and its expression in pancreatic islets.

Li Q, Yamada Y, Yasuda K, Ihara Y, Okamoto Y, Kaisaki PJ, Watanabe R, Ikeda H, Tsuda K, Seino Y.

Biochem Biophys Res Commun. 1994 Jul 15;202(1):629-36. Erratum in: Biochem Biophys Res Commun 1994 Oct 28;204(2):1001. PMID: 8037769 [PubMed - indexed for MEDLINE]Related articles

Resolution of rat liver 10-formyltetrahydrofolate dehydrogenase/hydrolase activities.

Case GL, Kaisaki PJ, Steele RD.

J Biol Chem. 1988 Jul 25;263(21):10204-7.PMID: 3392008 [PubMed - indexed for MEDLINE]Related articlesFree article