PubMed

AICAR and metformin, but not exercise, increase muscle glucose transport through AMPK- , ERK- and PDK1-dependent activation of atypical PKC.

Sajan MP, Bandyopadhyay G, Miura A, Standaert M, Nimal S, Longnus SL, Van Obberghen E, Hainault I, Foufelle F, Kahn CR, Braun U, Leitges M, Farese RV.

Am J Physiol Endocrinol Metab. 2009 Nov 3. [Epub ahead of print]PMID: 19887597 [PubMed - as supplied by publisher]Related articles

Interaction of myocardial insulin receptor and IGF receptor signaling in exercise-induced cardiac hypertrophy.

Ikeda H, Shiojima I, Ozasa Y, Yoshida M, Holzenberger M, Kahn CR, Walsh K, Igarashi T, Abel ED, Komuro I.

J Mol Cell Cardiol. 2009 Nov;47(5):664-75. Epub 2009 Sep 8.PMID: 19744489 [PubMed - in process]Related articles

Antioxidants prevent health-promoting effects of physical exercise in humans.

Ristow M, Zarse K, Oberbach A, Klöting N, Birringer M, Kiehntopf M, Stumvoll M, Kahn CR, Blüher M.

Proc Natl Acad Sci U S A. 2009 May 26;106(21):8665-70. Epub 2009 May 11.PMID: 19433800 [PubMed - indexed for MEDLINE]Related articlesFree article

Ablation of ARNT/HIF1beta in liver alters gluconeogenesis, lipogenic gene expression, and serum ketones.

Wang XL, Suzuki R, Lee K, Tran T, Gunton JE, Saha AK, Patti ME, Goldfine A, Ruderman NB, Gonzalez FJ, Kahn CR.

Cell Metab. 2009 May;9(5):428-39. Erratum in: Cell Metab. 2009 Jun;9(6):565. PMID: 19416713 [PubMed - indexed for MEDLINE]Related articles

Role of atypical protein kinase C in activation of sterol regulatory element binding protein-1c and nuclear factor kappa B (NFkappaB) in liver of rodents used as a model of diabetes, and relationships to hyperlipidaemia and insulin resistance.

Sajan MP, Standaert ML, Rivas J, Miura A, Kanoh Y, Soto J, Taniguchi CM, Kahn CR, Farese RV.

Diabetologia. 2009 Jun;52(6):1197-207. Epub 2009 Apr 9.PMID: 19357831 [PubMed - indexed for MEDLINE]Related articles

Identification and importance of brown adipose tissue in adult humans.

Cypess AM, Lehman S, Williams G, Tal I, Rodman D, Goldfine AB, Kuo FC, Palmer EL, Tseng YH, Doria A, Kolodny GM, Kahn CR.

N Engl J Med. 2009 Apr 9;360(15):1509-17.PMID: 19357406 [PubMed - indexed for MEDLINE]Related articlesFree article

Beta-Cell hyperplasia induced by hepatic insulin resistance: role of a liver-pancreas endocrine axis through insulin receptor A isoform.

Escribano O, Guillén C, Nevado C, Gómez-Hernández A, Kahn CR, Benito M.

Diabetes. 2009 Apr;58(4):820-8. Epub 2009 Jan 9.PMID: 19136656 [PubMed - indexed for MEDLINE]Related articlesFree article

Sex and depot differences in adipocyte insulin sensitivity and glucose metabolism.

Macotela Y, Boucher J, Tran TT, Kahn CR.

Diabetes. 2009 Apr;58(4):803-12. Epub 2009 Jan 9.PMID: 19136652 [PubMed - indexed for MEDLINE]Related articlesFree article

Deletion of Shp2 tyrosine phosphatase in muscle leads to dilated cardiomyopathy, insulin resistance, and premature death.

Princen F, Bard E, Sheikh F, Zhang SS, Wang J, Zago WM, Wu D, Trelles RD, Bailly-Maitre B, Kahn CR, Chen Y, Reed JC, Tong GG, Mercola M, Chen J, Feng GS.

Mol Cell Biol. 2009 Jan;29(2):378-88. Epub 2008 Nov 10.PMID: 19001090 [PubMed - indexed for MEDLINE]Related articlesFree article

Medicine. Can we nip obesity in its vascular bud?

Kahn CR.

Science. 2008 Oct 24;322(5901):542-3. No abstract available. PMID: 18948531 [PubMed - indexed for MEDLINE]Related articles

The emerging genetic architecture of type 2 diabetes.

Doria A, Patti ME, Kahn CR.

Cell Metab. 2008 Sep;8(3):186-200. Review.PMID: 18762020 [PubMed - indexed for MEDLINE]Related articles

New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure.

Tseng YH, Kokkotou E, Schulz TJ, Huang TL, Winnay JN, Taniguchi CM, Tran TT, Suzuki R, Espinoza DO, Yamamoto Y, Ahrens MJ, Dudley AT, Norris AW, Kulkarni RN, Kahn CR.

Nature. 2008 Aug 21;454(7207):1000-4.PMID: 18719589 [PubMed - indexed for MEDLINE]Related articlesFree article

Endogenous peroxisome proliferator-activated receptor-gamma augments fatty acid uptake in oxidative muscle.

Norris AW, Hirshman MF, Yao J, Jessen N, Musi N, Chen L, Sivitz WI, Goodyear LJ, Kahn CR.

Endocrinology. 2008 Nov;149(11):5374-83. Epub 2008 Jul 24.PMID: 18653710 [PubMed - indexed for MEDLINE]Related articlesFree article

Hepatic insulin resistance directly promotes formation of cholesterol gallstones.

Biddinger SB, Haas JT, Yu BB, Bezy O, Jing E, Zhang W, Unterman TG, Carey MC, Kahn CR.

Nat Med. 2008 Jul;14(7):778-82. Epub 2008 Jun 29.PMID: 18587407 [PubMed - indexed for MEDLINE]Related articlesFree article

Loss of neuroprotective survival signal in mice lacking insulin receptor gene in rod photoreceptor cells.

Rajala A, Tanito M, Le YZ, Kahn CR, Rajala RV.

J Biol Chem. 2008 Jul 11;283(28):19781-92. Epub 2008 May 14.PMID: 18480052 [PubMed - indexed for MEDLINE]Related articlesFree article

Beneficial effects of subcutaneous fat transplantation on metabolism.

Tran TT, Yamamoto Y, Gesta S, Kahn CR.

Cell Metab. 2008 May;7(5):410-20.PMID: 18460332 [PubMed - indexed for MEDLINE]Related articles

Central insulin action regulates peripheral glucose and fat metabolism in mice.

Koch L, Wunderlich FT, Seibler J, Könner AC, Hampel B, Irlenbusch S, Brabant G, Kahn CR, Schwenk F, Brüning JC.

J Clin Invest. 2008 Jun;118(6):2132-47.PMID: 18451994 [PubMed - indexed for MEDLINE]Related articlesFree article

Impaired sodium excretion and increased blood pressure in mice with targeted deletion of renal epithelial insulin receptor.

Tiwari S, Sharma N, Gill PS, Igarashi P, Kahn CR, Wade JB, Ecelbarger CM.

Proc Natl Acad Sci U S A. 2008 Apr 29;105(17):6469-74. Epub 2008 Apr 18.PMID: 18424559 [PubMed - indexed for MEDLINE]Related articlesFree article

Overexpression of the dual-specificity phosphatase MKP-4/DUSP-9 protects against stress-induced insulin resistance.

Emanuelli B, Eberlé D, Suzuki R, Kahn CR.

Proc Natl Acad Sci U S A. 2008 Mar 4;105(9):3545-50. Epub 2008 Feb 22.PMID: 18296638 [PubMed - indexed for MEDLINE]Related articlesFree article

Dissection of the insulin signaling pathway via quantitative phosphoproteomics.

Krüger M, Kratchmarova I, Blagoev B, Tseng YH, Kahn CR, Mann M.

Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2451-6. Epub 2008 Feb 11.PMID: 18268350 [PubMed - indexed for MEDLINE]Related articlesFree article

Hepatic insulin resistance is sufficient to produce dyslipidemia and susceptibility to atherosclerosis.

Biddinger SB, Hernandez-Ono A, Rask-Madsen C, Haas JT, Alemán JO, Suzuki R, Scapa EF, Agarwal C, Carey MC, Stephanopoulos G, Cohen DE, King GL, Ginsberg HN, Kahn CR.

Cell Metab. 2008 Feb;7(2):125-34.PMID: 18249172 [PubMed - indexed for MEDLINE]Related articles

Rad GTPase deficiency leads to cardiac hypertrophy.

Chang L, Zhang J, Tseng YH, Xie CQ, Ilany J, Brüning JC, Sun Z, Zhu X, Cui T, Youker KA, Yang Q, Day SM, Kahn CR, Chen YE.

Circulation. 2007 Dec 18;116(25):2976-83. Epub 2007 Dec 3.PMID: 18056528 [PubMed - indexed for MEDLINE]Related articlesFree article

A patient with type B insulin resistance syndrome, responsive to immune therapy.

Page KA, Dejardin S, Kahn CR, Kulkarni RN, Herold KC, Inzucchi SE.

Nat Clin Pract Endocrinol Metab. 2007 Dec;3(12):835-40.PMID: 18026162 [PubMed - indexed for MEDLINE]Related articles

Mitochondrial gene expression and increased oxidative metabolism: role in increased lifespan of fat-specific insulin receptor knock-out mice.

Katic M, Kennedy AR, Leykin I, Norris A, McGettrick A, Gesta S, Russell SJ, Bluher M, Maratos-Flier E, Kahn CR.

Aging Cell. 2007 Dec;6(6):827-39.PMID: 18001293 [PubMed - indexed for MEDLINE]Related articles

Targeted deletion of AIF decreases mitochondrial oxidative phosphorylation and protects from obesity and diabetes.

Pospisilik JA, Knauf C, Joza N, Benit P, Orthofer M, Cani PD, Ebersberger I, Nakashima T, Sarao R, Neely G, Esterbauer H, Kozlov A, Kahn CR, Kroemer G, Rustin P, Burcelin R, Penninger JM.

Cell. 2007 Nov 2;131(3):476-91.PMID: 17981116 [PubMed - indexed for MEDLINE]Related articles

Developmental origin of fat: tracking obesity to its source.

Gesta S, Tseng YH, Kahn CR.

Cell. 2007 Oct 19;131(2):242-56. Review. Erratum in: Cell. 2008 Oct 17;135(2):366. PMID: 17956727 [PubMed - indexed for MEDLINE]Related articles

IRS-1 transgenic mice show increased epididymal fat mass and insulin resistance.

Murata Y, Tsuruzoe K, Kawashima J, Furukawa N, Kondo T, Motoshima H, Igata M, Taketa K, Sasaki K, Kishikawa H, Kahn CR, Toyonaga T, Araki E.

Biochem Biophys Res Commun. 2007 Dec 14;364(2):301-7. Epub 2007 Oct 12.PMID: 17950694 [PubMed - indexed for MEDLINE]Related articles

Mitochondrial proton leak in obesity-resistant and obesity-prone mice.

Fink BD, Herlein JA, Almind K, Cinti S, Kahn CR, Sivitz WI.

Am J Physiol Regul Integr Comp Physiol. 2007 Nov;293(5):R1773-80. Epub 2007 Aug 29.PMID: 17761507 [PubMed - indexed for MEDLINE]Related articles

Endocrine regulation of ageing.

Russell SJ, Kahn CR.

Nat Rev Mol Cell Biol. 2007 Sep;8(9):681-91. Review.PMID: 17684529 [PubMed - indexed for MEDLINE]Related articles

SIRT2 regulates adipocyte differentiation through FoxO1 acetylation/deacetylation.

Jing E, Gesta S, Kahn CR.

Cell Metab. 2007 Aug;6(2):105-14.PMID: 17681146 [PubMed - indexed for MEDLINE]Related articlesFree article

TRB3 blocks adipocyte differentiation through the inhibition of C/EBPbeta transcriptional activity.

Bezy O, Vernochet C, Gesta S, Farmer SR, Kahn CR.

Mol Cell Biol. 2007 Oct;27(19):6818-31. Epub 2007 Jul 23.PMID: 17646392 [PubMed - indexed for MEDLINE]Related articlesFree article

Muscle-specific knockout of PKC-lambda impairs glucose transport and induces metabolic and diabetic syndromes.

Farese RV, Sajan MP, Yang H, Li P, Mastorides S, Gower WR Jr, Nimal S, Choi CS, Kim S, Shulman GI, Kahn CR, Braun U, Leitges M.

J Clin Invest. 2007 Aug;117(8):2289-301. Erratum in: J Clin Invest. 2007 Oct;117(10):3141. PMID: 17641777 [PubMed - indexed for MEDLINE]Related articlesFree article

High circulating leptin receptors with normal leptin sensitivity in liver-specific insulin receptor knock-out (LIRKO) mice.

Cohen SE, Kokkotou E, Biddinger SB, Kondo T, Gebhardt R, Kratzsch J, Mantzoros CS, Kahn CR.

J Biol Chem. 2007 Aug 10;282(32):23672-8. Epub 2007 Jun 7.PMID: 17556363 [PubMed - indexed for MEDLINE]Related articlesFree article

Reduced expression of the NADPH oxidase NOX4 is a hallmark of adipocyte differentiation.

Mouche S, Mkaddem SB, Wang W, Katic M, Tseng YH, Carnesecchi S, Steger K, Foti M, Meier CA, Muzzin P, Kahn CR, Ogier-Denis E, Szanto I.

Biochim Biophys Acta. 2007 Jul;1773(7):1015-27. Epub 2007 Mar 19.PMID: 17553579 [PubMed - indexed for MEDLINE]Related articles

Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production.

Könner AC, Janoschek R, Plum L, Jordan SD, Rother E, Ma X, Xu C, Enriori P, Hampel B, Barsh GS, Kahn CR, Cowley MA, Ashcroft FM, Brüning JC.

Cell Metab. 2007 Jun;5(6):438-49.PMID: 17550779 [PubMed - indexed for MEDLINE]Related articles

Protein-tyrosine phosphatase 1B deficiency reduces insulin resistance and the diabetic phenotype in mice with polygenic insulin resistance.

Xue B, Kim YB, Lee A, Toschi E, Bonner-Weir S, Kahn CR, Neel BG, Kahn BB.

J Biol Chem. 2007 Aug 17;282(33):23829-40. Epub 2007 Jun 1.PMID: 17545163 [PubMed - indexed for MEDLINE]Related articlesFree article

Ephs and ephrins keep pancreatic Beta cells connected.

Kulkarni RN, Kahn CR.

Cell. 2007 Apr 20;129(2):241-3.PMID: 17448984 [PubMed - indexed for MEDLINE]Related articles

Ectopic brown adipose tissue in muscle provides a mechanism for differences in risk of metabolic syndrome in mice.

Almind K, Manieri M, Sivitz WI, Cinti S, Kahn CR.

Proc Natl Acad Sci U S A. 2007 Feb 13;104(7):2366-71. Epub 2007 Feb 5.PMID: 17283342 [PubMed - indexed for MEDLINE]Related articlesFree article

The p85alpha regulatory subunit of phosphoinositide 3-kinase potentiates c-Jun N-terminal kinase-mediated insulin resistance.

Taniguchi CM, Aleman JO, Ueki K, Luo J, Asano T, Kaneto H, Stephanopoulos G, Cantley LC, Kahn CR.

Mol Cell Biol. 2007 Apr;27(8):2830-40. Epub 2007 Feb 5.PMID: 17283057 [PubMed - indexed for MEDLINE]Related articlesFree article

Essential role of insulin and insulin-like growth factor 1 receptor signaling in cardiac development and function.

Laustsen PG, Russell SJ, Cui L, Entingh-Pearsall A, Holzenberger M, Liao R, Kahn CR.

Mol Cell Biol. 2007 Mar;27(5):1649-64. Epub 2006 Dec 22.PMID: 17189427 [PubMed - indexed for MEDLINE]Related articlesFree article

Skeletal muscle-selective knockout of LKB1 increases insulin sensitivity, improves glucose homeostasis, and decreases TRB3.

Koh HJ, Arnolds DE, Fujii N, Tran TT, Rogers MJ, Jessen N, Li Y, Liew CW, Ho RC, Hirshman MF, Kulkarni RN, Kahn CR, Goodyear LJ.

Mol Cell Biol. 2006 Nov;26(22):8217-27. Epub 2006 Sep 11.PMID: 16966378 [PubMed - indexed for MEDLINE]Related articlesFree article

Phosphoinositide 3-kinase regulatory subunit p85alpha suppresses insulin action via positive regulation of PTEN.

Taniguchi CM, Tran TT, Kondo T, Luo J, Ueki K, Cantley LC, Kahn CR.

Proc Natl Acad Sci U S A. 2006 Aug 8;103(32):12093-7. Epub 2006 Jul 31.PMID: 16880400 [PubMed - indexed for MEDLINE]Related articlesFree article

Leptin suppresses stearoyl-CoA desaturase 1 by mechanisms independent of insulin and sterol regulatory element-binding protein-1c.

Biddinger SB, Miyazaki M, Boucher J, Ntambi JM, Kahn CR.

Diabetes. 2006 Jul;55(7):2032-41.PMID: 16804073 [PubMed - indexed for MEDLINE]Related articlesFree article

Divergent regulation of hepatic glucose and lipid metabolism by phosphoinositide 3-kinase via Akt and PKClambda/zeta.

Taniguchi CM, Kondo T, Sajan M, Luo J, Bronson R, Asano T, Farese R, Cantley LC, Kahn CR.

Cell Metab. 2006 May;3(5):343-53.PMID: 16679292 [PubMed - indexed for MEDLINE]Related articles

Total insulin and IGF-I resistance in pancreatic beta cells causes overt diabetes.

Ueki K, Okada T, Hu J, Liew CW, Assmann A, Dahlgren GM, Peters JL, Shackman JG, Zhang M, Artner I, Satin LS, Stein R, Holzenberger M, Kennedy RT, Kahn CR, Kulkarni RN.

Nat Genet. 2006 May;38(5):583-8. Epub 2006 Apr 23.PMID: 16642022 [PubMed - indexed for MEDLINE]Related articles

Evidence for a role of developmental genes in the origin of obesity and body fat distribution.

Gesta S, Blüher M, Yamamoto Y, Norris AW, Berndt J, Kralisch S, Boucher J, Lewis C, Kahn CR.

Proc Natl Acad Sci U S A. 2006 Apr 25;103(17):6676-81. Epub 2006 Apr 14.PMID: 16617105 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of hepatic STAT3 in brain-insulin action on hepatic glucose production.

Inoue H, Ogawa W, Asakawa A, Okamoto Y, Nishizawa A, Matsumoto M, Teshigawara K, Matsuki Y, Watanabe E, Hiramatsu R, Notohara K, Katayose K, Okamura H, Kahn CR, Noda T, Takeda K, Akira S, Inui A, Kasuga M.

Cell Metab. 2006 Apr;3(4):267-75.PMID: 16581004 [PubMed - indexed for MEDLINE]Related articles

Myeloid lineage cell-restricted insulin resistance protects apolipoproteinE-deficient mice against atherosclerosis.

Baumgartl J, Baudler S, Scherner M, Babaev V, Makowski L, Suttles J, McDuffie M, Tobe K, Kadowaki T, Fazio S, Kahn CR, Hotamisligil GS, Krone W, Linton M, Brüning JC.

Cell Metab. 2006 Apr;3(4):247-56. Erratum in: Cell Metab. 2006 Jun;3(6):469. Tobe, Kazuyuki [added]; Kadowaki, Takashi [added]. PMID: 16581002 [PubMed - indexed for MEDLINE]Related articles

Overexpression of Rad in muscle worsens diet-induced insulin resistance and glucose intolerance and lowers plasma triglyceride level.

Ilany J, Bilan PJ, Kapur S, Caldwell JS, Patti ME, Marette A, Kahn CR.

Proc Natl Acad Sci U S A. 2006 Mar 21;103(12):4481-6. Epub 2006 Mar 14.PMID: 16537411 [PubMed - indexed for MEDLINE]Related articlesFree article

Critical nodes in signalling pathways: insights into insulin action.

Taniguchi CM, Emanuelli B, Kahn CR.

Nat Rev Mol Cell Biol. 2006 Feb;7(2):85-96. Review.PMID: 16493415 [PubMed - indexed for MEDLINE]Related articles