PubMed

Phase I trial of a combination of the multikinase inhibitor sorafenib and the farnesyltransferase inhibitor tipifarnib in advanced malignancies.

Hong DS, Sebti SM, Newman RA, Blaskovich MA, Ye L, Gagel RF, Moulder S, Wheler JJ, Naing A, Tannir NM, Ng CS, Sherman SI, El Naggar AK, Khan R, Trent J, Wright JJ, Kurzrock R.

Clin Cancer Res. 2009 Nov 15;15(22):7061-8. Epub 2009 Nov 10.PMID: 19903778 [PubMed - in process]Related articles

Sulforaphane inhibits angiogenesis through activation of FOXO transcription factors.

Davis R, Singh KP, Kurzrock R, Shankar S.

Oncol Rep. 2009 Dec;22(6):1473-8.PMID: 19885601 [PubMed - in process]Related articles

Ultimate Fate of Oncology Drugs Approved by the US Food and Drug Administration Without a Randomized Trial.

Tsimberidou AM, Braiteh F, Stewart DJ, Kurzrock R.

J Clin Oncol. 2009 Oct 13. [Epub ahead of print]PMID: 19826112 [PubMed - as supplied by publisher]Related articles

Molecular imaging of gefitinib activity in an epidermal growth factor receptor (EGFR)-bearing xenograft model.

Gong J, Yang DJ, Kohanim S, Angelo LS, Kurzrock R.

Cancer Biol Ther. 2009 Dec 2;8(23). [Epub ahead of print]PMID: 19823028 [PubMed - as supplied by publisher]Related articles

Phase I clinical trials in 56 patients with thyroid cancer: the M. D. Anderson Cancer Center experience.

Tsimberidou AM, Vaklavas C, Wen S, Hong D, Wheler J, Ng C, Naing A, Tse S, Busaidy N, Markman M, Sherman SI, Kurzrock R.

J Clin Endocrinol Metab. 2009 Nov;94(11):4423-32. Epub 2009 Oct 9.PMID: 19820016 [PubMed - in process]Related articles

Pilot study of huachansu in patients with hepatocellular carcinoma, nonsmall-cell lung cancer, or pancreatic cancer.

Meng Z, Yang P, Shen Y, Bei W, Zhang Y, Ge Y, Newman RA, Cohen L, Liu L, Thornton B, Chang DZ, Liao Z, Kurzrock R.

Cancer. 2009 Nov 15;115(22):5309-18.PMID: 19701908 [PubMed - in process]Related articles

Genetic and Nongenetic Covariates of Pain Severity in Patients with Adenocarcinoma of the Pancreas: Assessing the Influence of Cytokine Genes.

Reyes-Gibby CC, Shete S, Yennurajalingam S, Frazier M, Bruera E, Kurzrock R, Crane CH, Abbruzzese J, Evans D, Spitz MR.

J Pain Symptom Manage. 2009 Aug 17. [Epub ahead of print]PMID: 19692203 [PubMed - as supplied by publisher]Related articles

Consensus recommendations to accelerate clinical trials for neurofibromatosis type 2.

Evans DG, Kalamarides M, Hunter-Schaedle K, Blakeley J, Allen J, Babovic-Vuskanovic D, Belzberg A, Bollag G, Chen R, DiTomaso E, Golfinos J, Harris G, Jacob A, Kalpana G, Karajannis M, Korf B, Kurzrock R, Law M, McClatchey A, Packer R, Roehm P, Rubenstein A, Slattery W 3rd, Tonsgard JH, Welling DB, Widemann B, Yohay K, Giovannini M.

Clin Cancer Res. 2009 Aug 15;15(16):5032-9. Epub 2009 Aug 11.PMID: 19671848 [PubMed - in process]Related articles

Project Zero Delay: a process for accelerating the activation of cancer clinical trials.

Kurzrock R, Pilat S, Bartolazzi M, Sanders D, Van Wart Hood J, Tucker SD, Webster K, Mallamaci MA, Strand S, Babcock E, Bast RC Jr.

J Clin Oncol. 2009 Sep 10;27(26):4433-40. Epub 2009 Aug 3.PMID: 19652061 [PubMed - indexed for MEDLINE]Related articles

A phase I clinical trial of darinaparsin in patients with refractory solid tumors.

Tsimberidou AM, Camacho LH, Verstovsek S, Ng C, Hong DS, Uehara CK, Gutierrez C, Daring S, Stevens J, Komarnitsky PB, Schwartz B, Kurzrock R.

Clin Cancer Res. 2009 Jul 15;15(14):4769-76. Epub 2009 Jul 7.PMID: 19584162 [PubMed - indexed for MEDLINE]Related articles

Safety, pharmacokinetics, and antitumor activity of AMG 386, a selective angiopoietin inhibitor, in adult patients with advanced solid tumors.

Herbst RS, Hong D, Chap L, Kurzrock R, Jackson E, Silverman JM, Rasmussen E, Sun YN, Zhong D, Hwang YC, Evelhoch JL, Oliner JD, Le N, Rosen LS.

J Clin Oncol. 2009 Jul 20;27(21):3557-65. Epub 2009 Jun 22.PMID: 19546406 [PubMed - indexed for MEDLINE]Related articles

Determination of minimum effective dose and optimal dosing schedule for liposomal curcumin in a xenograft human pancreatic cancer model.

Mach CM, Mathew L, Mosley SA, Kurzrock R, Smith JA.

Anticancer Res. 2009 Jun;29(6):1895-9.PMID: 19528445 [PubMed - indexed for MEDLINE]Related articles

Suberoylanilide hydroxamic acid (Zolinza/vorinostat) sensitizes TRAIL-resistant breast cancer cells orthotopically implanted in BALB/c nude mice.

Shankar S, Davis R, Singh KP, Kurzrock R, Ross DD, Srivastava RK.

Mol Cancer Ther. 2009 Jun;8(6):1596-605. Epub 2009 Jun 9.PMID: 19509267 [PubMed - indexed for MEDLINE]Related articles

A phase I trial of imexon, a pro-oxidant, in combination with docetaxel for the treatment of patients with advanced breast, non-small cell lung and prostate cancer.

Moulder S, Dhillon N, Ng C, Hong D, Wheler J, Naing A, Tse S, La Paglia A, Dorr R, Hersh E, Boytim M, Kurzrock R.

Invest New Drugs. 2009 Jun 6. [Epub ahead of print]PMID: 19499186 [PubMed - as supplied by publisher]Related articles

Phase 1 first-in-human clinical study of S-trans, trans-farnesylthiosalicylic acid (salirasib) in patients with solid tumors.

Tsimberidou AM, Rudek MA, Hong D, Ng CS, Blair J, Goldsweig H, Kurzrock R.

Cancer Chemother Pharmacol. 2009 May 31. [Epub ahead of print]PMID: 19484470 [PubMed - as supplied by publisher]Related articles

Decitabine effect on tumor global DNA methylation and other parameters in a phase I trial in refractory solid tumors and lymphomas.

Stewart DJ, Issa JP, Kurzrock R, Nunez MI, Jelinek J, Hong D, Oki Y, Guo Z, Gupta S, Wistuba II.

Clin Cancer Res. 2009 Jun 1;15(11):3881-8. Epub 2009 May 26.PMID: 19470736 [PubMed - indexed for MEDLINE]Related articles

Clinical outcomes and factors predicting development of venous thromboembolic complications in patients with advanced refractory cancer in a Phase I Clinic: the M. D. Anderson Cancer Center experience.

Vemulapalli S, Chintala L, Tsimberidou AM, Dhillon N, Lei X, Hong D, Kurzrock R.

Am J Hematol. 2009 Jul;84(7):408-13.PMID: 19437507 [PubMed - indexed for MEDLINE]Related articles

Electronic clinical challenges and images in GI. Image 2. Extensive bilateral extracranial subcutaneous fluid collection.

Braiteh F, Kurzrock R.

Gastroenterology. 2009 Jun;136(7):e3-6. Epub 2009 May 8. No abstract available. PMID: 19427926 [PubMed - indexed for MEDLINE]Related articles

Molecular imaging of Bcr-Abl phosphokinase in a xenograft model.

Wu JY, Yang DJ, Angelo LS, Kohanim S, Kurzrock R.

Mol Cancer Ther. 2009 Mar;8(3):703-10. Epub 2009 Mar 3.PMID: 19258427 [PubMed - indexed for MEDLINE]Related articles

Turmeric and green tea: a recipe for the treatment of B-chronic lymphocytic leukemia.

Angelo LS, Kurzrock R.

Clin Cancer Res. 2009 Feb 15;15(4):1123-5.PMID: 19228716 [PubMed - indexed for MEDLINE]Related articles

The changing face of phase 1 cancer clinical trials: new challenges in study requirements.

Craft BS, Kurzrock R, Lei X, Herbst R, Lippman S, Fu S, Karp DD.

Cancer. 2009 Apr 15;115(8):1592-7.PMID: 19165808 [PubMed - indexed for MEDLINE]Related articles

Survival of patients in a Phase 1 Clinic: the M. D. Anderson Cancer Center experience.

Wheler J, Tsimberidou AM, Hong D, Naing A, Jackson T, Liu S, Feng L, Kurzrock R.

Cancer. 2009 Mar 1;115(5):1091-9. Erratum in: Cancer. 2009 Apr 1;115(7):1588. PMID: 19165805 [PubMed - indexed for MEDLINE]Related articles

Cancer: the road to Amiens.

Stewart DJ, Kurzrock R.

J Clin Oncol. 2009 Jan 20;27(3):328-33. Epub 2008 Dec 8. No abstract available. PMID: 19064964 [PubMed - indexed for MEDLINE]Related articles

The role of investigational therapy in management of patients with advanced metastatic malignancy.

Freireich EJ, Kurzrock R.

J Clin Oncol. 2009 Jan 10;27(2):304-6. Epub 2008 Dec 8. No abstract available. PMID: 19064962 [PubMed - indexed for MEDLINE]Related articles

Poor prognosis in non-Caucasian patients with early-onset mycosis fungoides.

Sun G, Berthelot C, Li Y, Glass DA 2nd, George D, Pandya A, Kurzrock R, Duvic M.

J Am Acad Dermatol. 2009 Feb;60(2):231-5. Epub 2008 Nov 20.PMID: 19026464 [PubMed - indexed for MEDLINE]Related articles

The influence of tumor necrosis factor-alpha -308 G/A and IL-6 -174 G/C on pain and analgesia response in lung cancer patients receiving supportive care.

Reyes-Gibby CC, El Osta B, Spitz MR, Parsons H, Kurzrock R, Wu X, Shete S, Bruera E.

Cancer Epidemiol Biomarkers Prev. 2008 Nov;17(11):3262-7.PMID: 18990769 [PubMed - indexed for MEDLINE]Related articlesFree article

Phase I study of epigenetic modulation with 5-azacytidine and valproic acid in patients with advanced cancers.

Braiteh F, Soriano AO, Garcia-Manero G, Hong D, Johnson MM, Silva Lde P, Yang H, Alexander S, Wolff J, Kurzrock R.

Clin Cancer Res. 2008 Oct 1;14(19):6296-301.PMID: 18829512 [PubMed - indexed for MEDLINE]Related articlesFree article

Early drug development of inhibitors of the insulin-like growth factor-I receptor pathway: lessons from the first clinical trials.

Rodon J, DeSantos V, Ferry RJ Jr, Kurzrock R.

Mol Cancer Ther. 2008 Sep;7(9):2575-88. Review.PMID: 18790742 [PubMed - indexed for MEDLINE]Related articlesFree article

The prognostic significance of cytokine levels in newly diagnosed acute myeloid leukemia and high-risk myelodysplastic syndromes.

Tsimberidou AM, Estey E, Wen S, Pierce S, Kantarjian H, Albitar M, Kurzrock R.

Cancer. 2008 Oct 1;113(7):1605-13.PMID: 18683214 [PubMed - indexed for MEDLINE]Related articlesFree article

Molecular epidemiology, cancer-related symptoms, and cytokines pathway.

Reyes-Gibby CC, Wu X, Spitz M, Kurzrock R, Fisch M, Bruera E, Shete S.

Lancet Oncol. 2008 Aug;9(8):777-85. Review.PMID: 18672213 [PubMed - indexed for MEDLINE]Related articles

Phase II trial of curcumin in patients with advanced pancreatic cancer.

Dhillon N, Aggarwal BB, Newman RA, Wolff RA, Kunnumakkara AB, Abbruzzese JL, Ng CS, Badmaev V, Kurzrock R.

Clin Cancer Res. 2008 Jul 15;14(14):4491-9.PMID: 18628464 [PubMed - indexed for MEDLINE]Related articlesFree article

Trichomegaly of the eyelashes after lung cancer treatment with the epidermal growth factor receptor inhibitor erlotinib.

Braiteh F, Kurzrock R, Johnson FM.

J Clin Oncol. 2008 Jul 10;26(20):3460-2. No abstract available. PMID: 18612164 [PubMed - indexed for MEDLINE]Related articles

Multiple squamous cell carcinomas of the skin after therapy with sorafenib combined with tipifarnib.

Hong DS, Reddy SB, Prieto VG, Wright JJ, Tannir NM, Cohen PR, Diwan AH, Evans HL, Kurzrock R.

Arch Dermatol. 2008 Jun;144(6):779-82.PMID: 18559769 [PubMed - indexed for MEDLINE]Related articlesFree article

Medullary thyroid cancer: targeting the RET kinase pathway with sorafenib/tipifarnib.

Hong D, Ye L, Gagel R, Chintala L, El Naggar AK, Wright J, Kurzrock R.

Mol Cancer Ther. 2008 May;7(5):1001-6. Epub 2008 Apr 29.PMID: 18445656 [PubMed - indexed for MEDLINE]Related articlesFree article

Curcumin (diferuloylmethane) alters the expression profiles of microRNAs in human pancreatic cancer cells.

Sun M, Estrov Z, Ji Y, Coombes KR, Harris DH, Kurzrock R.

Mol Cancer Ther. 2008 Mar;7(3):464-73.PMID: 18347134 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased cancer antigen 27.29 (CA27.29) level in patients with mycosis fungoides.

Cen P, Duvic M, Cohen PR, Kurzrock R.

J Am Acad Dermatol. 2008 Mar;58(3):382-6.PMID: 18280334 [PubMed - indexed for MEDLINE]Related articles

Phase I study of alternate-week administration of tipifarnib in patients with myelodysplastic syndrome.

Kurzrock R, Kantarjian HM, Blascovich MA, Bucher C, Verstovsek S, Wright JJ, Pilat SR, Cortes JE, Estey EH, Giles FJ, Beran M, Sebti SM.

Clin Cancer Res. 2008 Jan 15;14(2):509-14.PMID: 18223226 [PubMed - indexed for MEDLINE]Related articlesFree article

Phase I-II study of oxaliplatin, fludarabine, cytarabine, and rituximab combination therapy in patients with Richter's syndrome or fludarabine-refractory chronic lymphocytic leukemia.

Tsimberidou AM, Wierda WG, Plunkett W, Kurzrock R, O'Brien S, Wen S, Ferrajoli A, Ravandi-Kashani F, Garcia-Manero G, Estrov Z, Kipps TJ, Brown JR, Fiorentino A, Lerner S, Kantarjian HM, Keating MJ.

J Clin Oncol. 2008 Jan 10;26(2):196-203.PMID: 18182662 [PubMed - indexed for MEDLINE]Related articles

Cytokine genes and pain severity in lung cancer: exploring the influence of TNF-alpha-308 G/A IL6-174G/C and IL8-251T/A.

Reyes-Gibby CC, Spitz M, Wu X, Merriman K, Etzel C, Bruera E, Kurzrock R, Shete S.

Cancer Epidemiol Biomarkers Prev. 2007 Dec;16(12):2745-51.PMID: 18086782 [PubMed - indexed for MEDLINE]Related articlesFree article

The immunocytokine scFv23/TNF targeting HER-2/neu induces synergistic cytotoxic effects with 5-fluorouracil in TNF-resistant pancreatic cancer cell lines.

Lyu MA, Kurzrock R, Rosenblum MG.

Biochem Pharmacol. 2008 Feb 15;75(4):836-46. Epub 2007 Oct 22.PMID: 18082672 [PubMed - indexed for MEDLINE]Related articles

Interleukin-6 and its receptor in cancer: implications for Translational Therapeutics.

Hong DS, Angelo LS, Kurzrock R.

Cancer. 2007 Nov 1;110(9):1911-28. Review.PMID: 17849470 [PubMed - indexed for MEDLINE]Related articlesFree article

Studies in target-based treatment.

Kurzrock R.

Mol Cancer Ther. 2007 Sep;6(9):2385. Epub 2007 Sep 10. No abstract available. PMID: 17846118 [PubMed - indexed for MEDLINE]Related articlesFree article

Cutaneous castleman's disease responds to anti interleukin-6 treatment.

Ahmed B, Tschen JA, Cohen PR, Zaki MH, Rady PL, Tyring SK, Corringham RE, Kurzrock R.

Mol Cancer Ther. 2007 Sep;6(9):2386-90. Epub 2007 Aug 31.PMID: 17766835 [PubMed - indexed for MEDLINE]Related articlesFree article

I have good news! You have leukemia.

Kurzrock R.

Clin Dermatol. 2007 May-Jun;25(3):350-2. No abstract available. PMID: 17560314 [PubMed - indexed for MEDLINE]Related articles

Sarcoidosis and malignancy.

Cohen PR, Kurzrock R.

Clin Dermatol. 2007 May-Jun;25(3):326-33. Review.PMID: 17560310 [PubMed - indexed for MEDLINE]Related articles

Safety, pharmacokinetics, and efficacy of AMG 706, an oral multikinase inhibitor, in patients with advanced solid tumors.

Rosen LS, Kurzrock R, Mulay M, Van Vugt A, Purdom M, Ng C, Silverman J, Koutsoukos A, Sun YN, Bass MB, Xu RY, Polverino A, Wiezorek JS, Chang DD, Benjamin R, Herbst RS.

J Clin Oncol. 2007 Jun 10;25(17):2369-76.PMID: 17557949 [PubMed - indexed for MEDLINE]Related articles

Vascular endothelial growth factor and its relationship to inflammatory mediators.

Angelo LS, Kurzrock R.

Clin Cancer Res. 2007 May 15;13(10):2825-30. Review.PMID: 17504979 [PubMed - indexed for MEDLINE]Related articlesFree article

Studies in target-based treatment.

Kurzrock R.

Mol Cancer Ther. 2007 May;6(5):1477. Epub 2007 May 4.PMID: 17483434 [PubMed - indexed for MEDLINE]Related articlesFree article

Pilot study of regional, hepatic intra-arterial paclitaxel in patients with breast carcinoma metastatic to the liver.

Camacho LH, Kurzrock R, Cheung A, Barber DF, Gupta S, Madoff DC, Wallace MJ, Kim EE, Curley SA, Hortobagyi GN, Mavligit G.

Cancer. 2007 Jun 1;109(11):2190-6.PMID: 17464952 [PubMed - indexed for MEDLINE]Related articlesFree article

Improving the institutional submission and approval process for clinical research protocols in oncology.

Camacho LH, Marubio L, Purdom MA, Leonard D, Hong DS, Moulder S, Pilat SR, Kurzrock R.

J Clin Oncol. 2007 Apr 20;25(12):1632-3. No abstract available. PMID: 17443009 [PubMed - indexed for MEDLINE]Related articles