PubMed

The active site of an algal prolyl 4-hydroxylase has a large structural plasticity.

Koski MK, Hieta R, Böllner C, Kivirikko KI, Myllyharju J, Wierenga RK.

J Biol Chem. 2007 Dec 21;282(51):37112-23. Epub 2007 Oct 16.PMID: 17940281 [PubMed - indexed for MEDLINE]Related articlesFree article

An endoplasmic reticulum transmembrane prolyl 4-hydroxylase is induced by hypoxia and acts on hypoxia-inducible factor alpha.

Koivunen P, Tiainen P, Hyvärinen J, Williams KE, Sormunen R, Klaus SJ, Kivirikko KI, Myllyharju J.

J Biol Chem. 2007 Oct 19;282(42):30544-52. Epub 2007 Aug 27.PMID: 17726031 [PubMed - indexed for MEDLINE]Related articlesFree article

LOXL1 and LOXL4 are epigenetically silenced and can inhibit ras/extracellular signal-regulated kinase signaling pathway in human bladder cancer.

Wu G, Guo Z, Chang X, Kim MS, Nagpal JK, Liu J, Maki JM, Kivirikko KI, Ethier SP, Trink B, Sidransky D.

Cancer Res. 2007 May 1;67(9):4123-9. Epub 2007 Apr 24.PMID: 17456585 [PubMed - indexed for MEDLINE]Related articlesFree article

Tissue-specific changes in the hydroxylysine content and cross-links of collagens and alterations in fibril morphology in lysyl hydroxylase 1 knock-out mice.

Takaluoma K, Hyry M, Lantto J, Sormunen R, Bank RA, Kivirikko KI, Myllyharju J, Soininen R.

J Biol Chem. 2007 Mar 2;282(9):6588-96. Epub 2006 Dec 29.PMID: 17197443 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of hypoxia-inducible factor (HIF) hydroxylases by citric acid cycle intermediates: possible links between cell metabolism and stabilization of HIF.

Koivunen P, Hirsilä M, Remes AM, Hassinen IE, Kivirikko KI, Myllyharju J.

J Biol Chem. 2007 Feb 16;282(7):4524-32. Epub 2006 Dec 19.PMID: 17182618 [PubMed - indexed for MEDLINE]Related articlesFree article

Loss of assembly of the main basement membrane collagen, type IV, but not fibril-forming collagens and embryonic death in collagen prolyl 4-hydroxylase I null mice.

Holster T, Pakkanen O, Soininen R, Sormunen R, Nokelainen M, Kivirikko KI, Myllyharju J.

J Biol Chem. 2007 Jan 26;282(4):2512-9. Epub 2006 Nov 29.PMID: 17135260 [PubMed - indexed for MEDLINE]Related articlesFree article

The length of peptide substrates has a marked effect on hydroxylation by the hypoxia-inducible factor prolyl 4-hydroxylases.

Koivunen P, Hirsilä M, Kivirikko KI, Myllyharju J.

J Biol Chem. 2006 Sep 29;281(39):28712-20. Epub 2006 Aug 1.PMID: 16885164 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of desferrioxamine and metals on the hydroxylases in the oxygen sensing pathway.

Hirsilä M, Koivunen P, Xu L, Seeley T, Kivirikko KI, Myllyharju J.

FASEB J. 2005 Aug;19(10):1308-10. Epub 2005 Jun 7.PMID: 15941769 [PubMed - indexed for MEDLINE]Related articlesFree article

Many amino acid substitutions in a hypoxia-inducible transcription factor (HIF)-1alpha-like peptide cause only minor changes in its hydroxylation by the HIF prolyl 4-hydroxylases: substitution of 3,4-dehydroproline or azetidine-2-carboxylic acid for the proline leads to a high rate of uncoupled 2-oxoglutarate decarboxylation.

Li D, Hirsilä M, Koivunen P, Brenner MC, Xu L, Yang C, Kivirikko KI, Myllyharju J.

J Biol Chem. 2004 Dec 31;279(53):55051-9. Epub 2004 Oct 12.PMID: 15485863 [PubMed - indexed for MEDLINE]Related articlesFree article

The peptide-substrate-binding domain of collagen prolyl 4-hydroxylases is a tetratricopeptide repeat domain with functional aromatic residues.

Pekkala M, Hieta R, Bergmann U, Kivirikko KI, Wierenga RK, Myllyharju J.

J Biol Chem. 2004 Dec 10;279(50):52255-61. Epub 2004 Sep 28.PMID: 15456751 [PubMed - indexed for MEDLINE]Related articlesFree article

Premature aggregation of type IV collagen and early lethality in lysyl hydroxylase 3 null mice.

Rautavuoma K, Takaluoma K, Sormunen R, Myllyharju J, Kivirikko KI, Soininen R.

Proc Natl Acad Sci U S A. 2004 Sep 28;101(39):14120-5. Epub 2004 Sep 17.PMID: 15377789 [PubMed - indexed for MEDLINE]Related articlesFree article

Relevance of posttranslational modifications for the arthritogenicity of type II collagen.

Myers LK, Myllyharju J, Nokelainen M, Brand DD, Cremer MA, Stuart JM, Bodo M, Kivirikko KI, Kang AH.

J Immunol. 2004 Mar 1;172(5):2970-5.PMID: 14978100 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification and characterization of structural domains of human ERp57: association with calreticulin requires several domains.

Silvennoinen L, Myllyharju J, Ruoppolo M, Orrù S, Caterino M, Kivirikko KI, Koivunen P.

J Biol Chem. 2004 Apr 2;279(14):13607-15. Epub 2004 Jan 19.PMID: 14732712 [PubMed - indexed for MEDLINE]Related articlesFree article

Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases.

Koivunen P, Hirsilä M, Günzler V, Kivirikko KI, Myllyharju J.

J Biol Chem. 2004 Mar 12;279(11):9899-904. Epub 2003 Dec 29.PMID: 14701857 [PubMed - indexed for MEDLINE]Related articlesFree article

Collagens, modifying enzymes and their mutations in humans, flies and worms.

Myllyharju J, Kivirikko KI.

Trends Genet. 2004 Jan;20(1):33-43. Review.PMID: 14698617 [PubMed - indexed for MEDLINE]Related articles

Molecular characterization of the principal substrate binding site of the ubiquitous folding catalyst protein disulfide isomerase.

Pirneskoski A, Klappa P, Lobell M, Williamson RA, Byrne L, Alanen HI, Salo KE, Kivirikko KI, Freedman RB, Ruddock LW.

J Biol Chem. 2004 Mar 12;279(11):10374-81. Epub 2003 Dec 18.PMID: 14684740 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification and characterization of a third human, rat, and mouse collagen prolyl 4-hydroxylase isoenzyme.

Kukkola L, Hieta R, Kivirikko KI, Myllyharju J.

J Biol Chem. 2003 Nov 28;278(48):47685-93. Epub 2003 Sep 18.PMID: 14500733 [PubMed - indexed for MEDLINE]Related articlesFree article

The peptide-substrate-binding domain of human collagen prolyl 4-hydroxylases. Backbone assignments, secondary structure, and binding of proline-rich peptides.

Hieta R, Kukkola L, Permi P, Pirilä P, Kivirikko KI, Kilpeläinen I, Myllyharju J.

J Biol Chem. 2003 Sep 12;278(37):34966-74. Epub 2003 Jun 24.PMID: 12824157 [PubMed - indexed for MEDLINE]Related articlesFree article

Assembly of stable human type I and III collagen molecules from hydroxylated recombinant chains in the yeast Pichia pastoris. Effect of an engineered C-terminal oligomerization domain foldon.

Pakkanen O, Hämäläinen ER, Kivirikko KI, Myllyharju J.

J Biol Chem. 2003 Aug 22;278(34):32478-83. Epub 2003 Jun 12.PMID: 12805365 [PubMed - indexed for MEDLINE]Related articlesFree article

Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor.

Hirsilä M, Koivunen P, Günzler V, Kivirikko KI, Myllyharju J.

J Biol Chem. 2003 Aug 15;278(33):30772-80. Epub 2003 Jun 3.PMID: 12788921 [PubMed - indexed for MEDLINE]Related articlesFree article

Crystallization of the proline-rich-peptide binding domain of human type I collagen prolyl 4-hydroxylase.

Pekkala M, Hieta R, Kursula P, Kivirikko KI, Wierenga RK, Myllyharju J.

Acta Crystallogr D Biol Crystallogr. 2003 May;59(Pt 5):940-2. Epub 2003 Apr 25.PMID: 12777818 [PubMed - indexed for MEDLINE]Related articles

Mutations in domain a' of protein disulfide isomerase affect the folding pathway of bovine pancreatic ribonuclease A.

Ruoppolo M, Orrù S, Talamo F, Ljung J, Pirneskoski A, Kivirikko KI, Marino G, Koivunen P.

Protein Sci. 2003 May;12(5):939-52.PMID: 12717017 [PubMed - indexed for MEDLINE]Related articlesFree article

Inactivation of the lysyl oxidase gene Lox leads to aortic aneurysms, cardiovascular dysfunction, and perinatal death in mice.

Mäki JM, Räsänen J, Tikkanen H, Sormunen R, Mäkikallio K, Kivirikko KI, Soininen R.

Circulation. 2002 Nov 5;106(19):2503-9.PMID: 12417550 [PubMed - indexed for MEDLINE]Related articlesFree article

Characterization of three fragments that constitute the monomers of the human lysyl hydroxylase isoenzymes 1-3. The 30-kDa N-terminal fragment is not required for lysyl hydroxylase activity.

Rautavuoma K, Takaluoma K, Passoja K, Pirskanen A, Kvist AP, Kivirikko KI, Myllyharju J.

J Biol Chem. 2002 Jun 21;277(25):23084-91. Epub 2002 Apr 15.PMID: 11956192 [PubMed - indexed for MEDLINE]Related articlesFree article

Egg shell collagen formation in Caenorhabditis elegans involves a novel prolyl 4-hydroxylase expressed in spermatheca and embryos and possessing many unique properties.

Riihimaa P, Nissi R, Page AP, Winter AD, Keskiaho K, Kivirikko KI, Myllyharju J.

J Biol Chem. 2002 May 17;277(20):18238-43. Epub 2002 Mar 12.PMID: 11891226 [PubMed - indexed for MEDLINE]Related articlesFree article

Cloning and characterization of a fifth human lysyl oxidase isoenzyme: the third member of the lysyl oxidase-related subfamily with four scavenger receptor cysteine-rich domains.

Mäki JM, Tikkanen H, Kivirikko KI.

Matrix Biol. 2001 Nov;20(7):493-6.PMID: 11691589 [PubMed - indexed for MEDLINE]Related articles

Prolyl 4-hydroxylase isoenzymes I and II have different expression patterns in several human tissues.

Nissi R, Autio-Harmainen H, Marttila P, Sormunen R, Kivirikko KI.

J Histochem Cytochem. 2001 Sep;49(9):1143-53.PMID: 11511683 [PubMed - indexed for MEDLINE]Related articlesFree article

High-level production of human type I collagen in the yeast Pichia pastoris.

Nokelainen M, Tu H, Vuorela A, Notbohm H, Kivirikko KI, Myllyharju J.

Yeast. 2001 Jun 30;18(9):797-806.PMID: 11427962 [PubMed - indexed for MEDLINE]Related articles

Collagens and collagen-related diseases.

Myllyharju J, Kivirikko KI.

Ann Med. 2001 Feb;33(1):7-21. Review.PMID: 11310942 [PubMed - indexed for MEDLINE]Related articles

Cloning and characterization of a fourth human lysyl oxidase isoenzyme.

Mäki JM, Kivirikko KI.

Biochem J. 2001 Apr 15;355(Pt 2):381-7.PMID: 11284725 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanistic Studies on Prolyl-4-Hydroxylase: Demonstration That the Ferryl Intermediate Does Not Exchange with Water.

Min W, Begley TP, Myllyharju J, Kivirikko KI.

Bioorg Chem. 2000 Oct;28(5):261-265.PMID: 11133144 [PubMed - as supplied by publisher]Related articles

Domains b' and a' of protein disulfide isomerase fulfill the minimum requirement for function as a subunit of prolyl 4-hydroxylase. The N-terminal domains a and b enhances this function and can be substituted in part by those of ERp57.

Pirneskoski A, Ruddock LW, Klappa P, Freedman RB, Kivirikko KI, Koivunen P.

J Biol Chem. 2001 Apr 6;276(14):11287-93. Epub 2000 Dec 29.PMID: 11134056 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression of recombinant human type I-III collagens in the yeast pichia pastoris.

Myllyharju J, Nokelainen M, Vuorela A, Kivirikko KI.

Biochem Soc Trans. 2000;28(4):353-7. Review.PMID: 10961918 [PubMed - indexed for MEDLINE]Related articles

Mechanistic studies on prolyl-4-hydroxylase: the vitamin C requiring uncoupled oxidation.

Wu M, Moon HS, Pirskanen A, Myllyharju J, Kivirikko KI, Begley TP.

Bioorg Med Chem Lett. 2000 Jul 17;10(14):1511-4.PMID: 10915038 [PubMed - indexed for MEDLINE]Related articles

Mutations that destabilize the a' domain of human protein-disulfide isomerase indirectly affect peptide binding.

Klappa P, Koivunen P, Pirneskoski A, Karvonen P, Ruddock LW, Kivirikko KI, Freedman RB.

J Biol Chem. 2000 May 5;275(18):13213-8.PMID: 10788425 [PubMed - indexed for MEDLINE]Related articlesFree article

Type XIII collagen forms homotrimers with three triple helical collagenous domains and its association into disulfide-bonded trimers is enhanced by prolyl 4-hydroxylase.

Snellman A, Keränen MR, Hägg PO, Lamberg A, Hiltunen JK, Kivirikko KI, Pihlajaniemi T.

J Biol Chem. 2000 Mar 24;275(12):8936-44.PMID: 10722741 [PubMed - indexed for MEDLINE]Related articlesFree article

Complete exon-intron organization of the gene for human lysyl hydroxylase 3 (LH3).

Rautavuoma K, Passoja K, Helaakoski T, Kivirikko KI.

Matrix Biol. 2000 Feb;19(1):73-9.PMID: 10686427 [PubMed - indexed for MEDLINE]Related articles

Accumulation of properly folded human type III procollagen molecules in specific intracellular membranous compartments in the yeast Pichia pastoris.

Keizer-Gunnink I, Vuorela A, Myllyharju J, Pihlajaniemi T, Kivirikko KI, Veenhuis M.

Matrix Biol. 2000 Feb;19(1):29-36.PMID: 10686423 [PubMed - indexed for MEDLINE]Related articles

Coexpression with collagen markedly increases the half-life of the recombinant human prolyl 4-hydroxylase tetramer in the yeast Pichia pastoris.

Vuorela A, Myllyharju J, Pihlajaniemi T, Kivirikko KI.

Matrix Biol. 1999 Oct;18(5):519-22.PMID: 10601739 [PubMed - indexed for MEDLINE]Related articles

Evidence for 4-hydroxyproline in viral proteins. Characterization of a viral prolyl 4-hydroxylase and its peptide substrates.

Eriksson M, Myllyharju J, Tu H, Hellman M, Kivirikko KI.

J Biol Chem. 1999 Aug 6;274(32):22131-4.PMID: 10428773 [PubMed - indexed for MEDLINE]Related articlesFree article

Assignment of 1H, 13C and 15N resonances of the a' domain of protein disulfide isomerase.

Dijkstra K, Karvonen P, Pirneskoski A, Koivunen P, Kivirikko KI, Darby NJ, van Straaten M, Scheek RM, Kemmink J.

J Biomol NMR. 1999 Jun;14(2):195-6. No abstract available. PMID: 10427749 [PubMed - indexed for MEDLINE]Related articles

Recombinant human type II collagens with low and high levels of hydroxylysine and its glycosylated forms show marked differences in fibrillogenesis in vitro.

Notbohm H, Nokelainen M, Myllyharju J, Fietzek PP, Müller PK, Kivirikko KI.

J Biol Chem. 1999 Mar 26;274(13):8988-92.PMID: 10085145 [PubMed - indexed for MEDLINE]Related articlesFree article

Cloning of the alpha subunit of prolyl 4-hydroxylase from Drosophila and expression and characterization of the corresponding enzyme tetramer with some unique properties.

Annunen P, Koivunen P, Kivirikko KI.

J Biol Chem. 1999 Mar 5;274(10):6790-6.PMID: 10037780 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of a novel proline-rich peptide-binding domain in prolyl 4-hydroxylase.

Myllyharju J, Kivirikko KI.

EMBO J. 1999 Jan 15;18(2):306-12.PMID: 9889187 [PubMed - indexed for MEDLINE]Related articlesFree article

The acidic C-terminal domain of protein disulfide isomerase is not critical for the enzyme subunit function or for the chaperone or disulfide isomerase activities of the polypeptide.

Koivunen P, Pirneskoski A, Karvonen P, Ljung J, Helaakoski T, Notbohm H, Kivirikko KI.

EMBO J. 1999 Jan 4;18(1):65-74.PMID: 9878051 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of arginine-700 as the residue that binds the C-5 carboxyl group of 2-oxoglutarate in human lysyl hydroxylase 1.

Passoja K, Myllyharju J, Pirskanen A, Kivirikko KI.

FEBS Lett. 1998 Aug 28;434(1-2):145-8.PMID: 9738467 [PubMed - indexed for MEDLINE]Related articles

Cloning and characterization of a third human lysyl hydroxylase isoform.

Passoja K, Rautavuoma K, Ala-Kokko L, Kosonen T, Kivirikko KI.

Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10482-6.PMID: 9724729 [PubMed - indexed for MEDLINE]Related articlesFree article

Collagen hydroxylases and the protein disulfide isomerase subunit of prolyl 4-hydroxylases.

Kivirikko KI, Pihlajaniemi T.

Adv Enzymol Relat Areas Mol Biol. 1998;72:325-98. Review.PMID: 9559057 [PubMed - indexed for MEDLINE]Related articles

The novel type II prolyl 4-hydroxylase is the main enzyme form in chondrocytes and capillary endothelial cells, whereas the type I enzyme predominates in most cells.

Annunen P, Autio-Harmainen H, Kivirikko KI.

J Biol Chem. 1998 Mar 13;273(11):5989-92.PMID: 9497309 [PubMed - indexed for MEDLINE]Related articlesFree article

Prolyl 4-hydroxylases and their protein disulfide isomerase subunit.

Kivirikko KI, Myllyharju J.

Matrix Biol. 1998 Feb;16(7):357-68. Review.PMID: 9524356 [PubMed - indexed for MEDLINE]Related articles