PubMed

Effect of cancer on platelets.

Green DL, Karpatkin S.

Cancer Treat Res. 2009;148:17-30. No abstract available. PMID: 19377916 [PubMed - in process]Related articles

Thrombin induces tumor cell cycle activation and spontaneous growth by down-regulation of p27Kip1, in association with the up-regulation of Skp2 and MiR-222.

Hu L, Ibrahim S, Liu C, Skaar J, Pagano M, Karpatkin S.

Cancer Res. 2009 Apr 15;69(8):3374-81. Epub 2009 Apr 7.PMID: 19351827 [PubMed - indexed for MEDLINE]Related articlesFree article

C-terminal ADAMTS-18 fragment induces oxidative platelet fragmentation, dissolves platelet aggregates, and protects against carotid artery occlusion and cerebral stroke.

Li Z, Nardi MA, Li YS, Zhang W, Pan R, Dang S, Yee H, Quartermain D, Jonas S, Karpatkin S.

Blood. 2009 Jun 11;113(24):6051-60. Epub 2009 Feb 13.PMID: 19218546 [PubMed - indexed for MEDLINE]Related articles

Role of molecular mimicry of hepatitis C virus protein with platelet GPIIIa in hepatitis C-related immunologic thrombocytopenia.

Zhang W, Nardi MA, Borkowsky W, Li Z, Karpatkin S.

Blood. 2009 Apr 23;113(17):4086-93. Epub 2008 Nov 20.PMID: 19023115 [PubMed - indexed for MEDLINE]Related articles

Thrombin up-regulates cathepsin D which enhances angiogenesis, growth, and metastasis.

Hu L, Roth JM, Brooks P, Luty J, Karpatkin S.

Cancer Res. 2008 Jun 15;68(12):4666-73.PMID: 18559512 [PubMed - indexed for MEDLINE]Related articlesFree article

Twist is required for thrombin-induced tumor angiogenesis and growth.

Hu L, Roth JM, Brooks P, Ibrahim S, Karpatkin S.

Cancer Res. 2008 Jun 1;68(11):4296-302.PMID: 18519689 [PubMed - indexed for MEDLINE]Related articlesFree article

Platelet fragmentation requires a specific structural conformation of human monoclonal antibody against beta3 integrin.

Li Z, Nardi MA, Wu J, Pan R, Zhang W, Karpatkin S.

J Biol Chem. 2008 Feb 8;283(6):3224-30. Epub 2007 Dec 3.PMID: 18056258 [PubMed - indexed for MEDLINE]Related articlesFree article

Growth regulated oncogene is pivotal in thrombin-induced angiogenesis.

Karpatkin S.

Thromb Res. 2007;120 Suppl 2:S71-4. Review. No abstract available. Erratum in: Thromb Res. 2008;123(1):187-90. PMID: 18023717 [PubMed - indexed for MEDLINE]Related articles

Platelet particle formation by anti GPIIIa49-66 Ab, Ca2+ ionophore A23187, and phorbol myristate acetate is induced by reactive oxygen species and inhibited by dexamethasone blockade of platelet phospholipase A2, 12-lipoxygenase, and NADPH oxidase.

Nardi MA, Gor Y, Feinmark SJ, Xu F, Karpatkin S.

Blood. 2007 Sep 15;110(6):1989-96. Epub 2007 Jun 1.PMID: 17545506 [PubMed - indexed for MEDLINE]Related articlesFree article

Thrombin induces tumor growth, metastasis, and angiogenesis: Evidence for a thrombin-regulated dormant tumor phenotype.

Nierodzik ML, Karpatkin S.

Cancer Cell. 2006 Nov;10(5):355-62. Review.PMID: 17097558 [PubMed - indexed for MEDLINE]Related articles

Growth-regulated oncogene is pivotal in thrombin-induced angiogenesis.

Caunt M, Hu L, Tang T, Brooks PC, Ibrahim S, Karpatkin S.

Cancer Res. 2006 Apr 15;66(8):4125-32.PMID: 16618733 [PubMed - indexed for MEDLINE]Related articlesFree article

Hematopoiesis and stem cell renewal in long-term bone marrow cultures containing catalase.

Gupta R, Karpatkin S, Basch RS.

Blood. 2006 Mar 1;107(5):1837-46. Epub 2005 Nov 8.PMID: 16278309 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of molecular mimicry to HIV-1 peptides in HIV-1-related immunologic thrombocytopenia.

Li Z, Nardi MA, Karpatkin S.

Blood. 2005 Jul 15;106(2):572-6. Epub 2005 Mar 17.PMID: 15774614 [PubMed - indexed for MEDLINE]Related articlesFree article

Hypercoagulability preceding cancer. Does hypercoagulability awaken dormant tumor cells in the host?

Nierodzik M, Karpatkin S.

J Thromb Haemost. 2005 Mar;3(3):577-80. No abstract available. PMID: 15748252 [PubMed - indexed for MEDLINE]Related articles

Does hypercoagulability awaken dormant tumor cells in the host?

Karpatkin S.

J Thromb Haemost. 2004 Dec;2(12):2103-6. No abstract available. PMID: 15613013 [PubMed - indexed for MEDLINE]Related articles

Autoimmune thrombocytopenias.

Karpatkin S.

Autoimmunity. 2004 Jun;37(4):363-8. Review. No abstract available. PMID: 15518060 [PubMed - indexed for MEDLINE]Related articles

Role of endogenous thrombin in tumor implantation, seeding, and spontaneous metastasis.

Hu L, Lee M, Campbell W, Perez-Soler R, Karpatkin S.

Blood. 2004 Nov 1;104(9):2746-51. Epub 2004 Jul 20.PMID: 15265791 [PubMed - indexed for MEDLINE]Related articlesFree article

Complement-independent Ab-induced peroxide lysis of platelets requires 12-lipoxygenase and a platelet NADPH oxidase pathway.

Nardi M, Feinmark SJ, Hu L, Li Z, Karpatkin S.

J Clin Invest. 2004 Apr;113(7):973-80.PMID: 15057303 [PubMed - indexed for MEDLINE]Related articlesFree article

Thrombin induces neoangiogenesis in the chick chorioallantoic membrane.

Caunt M, Huang YQ, Brooks PC, Karpatkin S.

J Thromb Haemost. 2003 Oct;1(10):2097-102.PMID: 14521590 [PubMed - indexed for MEDLINE]Related articles

Role of thrombin in tumor angiogenesis, implantation, and metastasis.

Karpatkin S.

Pathophysiol Haemost Thromb. 2003;33 Suppl 1:54-5. No abstract available. PMID: 12955005 [PubMed - indexed for MEDLINE]Related articles

Platelet and coagulation defects associated with HIV-1-infection.

Karpatkin S, Nardi M, Green D.

Thromb Haemost. 2002 Sep;88(3):389-401. Review. No abstract available. PMID: 12353066 [PubMed - indexed for MEDLINE]Related articles

Thrombin induces increased expression and secretion of angiopoietin-2 from human umbilical vein endothelial cells.

Huang YQ, Li JJ, Hu L, Lee M, Karpatkin S.

Blood. 2002 Mar 1;99(5):1646-50.PMID: 11861279 [PubMed - indexed for MEDLINE]Related articlesFree article

Thrombin induces increased expression and secretion of VEGF from human FS4 fibroblasts, DU145 prostate cells and CHRF megakaryocytes.

Huang YQ, Li JJ, Hu L, Lee M, Karpatkin S.

Thromb Haemost. 2001 Oct;86(4):1094-8.PMID: 11686329 [PubMed - indexed for MEDLINE]Related articles

Complement-independent, peroxide-induced antibody lysis of platelets in HIV-1-related immune thrombocytopenia.

Nardi M, Tomlinson S, Greco MA, Karpatkin S.

Cell. 2001 Sep 7;106(5):551-61.PMID: 11551503 [PubMed - indexed for MEDLINE]Related articles

Thrombin induces the release of angiopoietin-1 from platelets.

Li JJ, Huang YQ, Basch R, Karpatkin S.

Thromb Haemost. 2001 Feb;85(2):204-6.PMID: 11246533 [PubMed - indexed for MEDLINE]Related articles

Antiidiotype antibody against platelet anti-GPIIIa contributes to the regulation of thrombocytopenia in HIV-1-ITP patients.

Nardi M, Karpatkin S.

J Exp Med. 2000 Jun 19;191(12):2093-100.PMID: 10859334 [PubMed - indexed for MEDLINE]Related articlesFree article

Concentration-dependent dual effect of thrombin on impaired growth/apoptosis or mitogenesis in tumor cells.

Zain J, Huang YQ, Feng X, Nierodzik ML, Li JJ, Karpatkin S.

Blood. 2000 May 15;95(10):3133-8.PMID: 10807779 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of a family of alternatively spliced mRNA species of angiopoietin-1.

Huang YQ, Li JJ, Karpatkin S.

Blood. 2000 Mar 15;95(6):1993-9.PMID: 10706866 [PubMed - indexed for MEDLINE]Related articlesFree article

Thrombin inhibits tumor cell growth in association with up-regulation of p21(waf/cip1) and caspases via a p53-independent, STAT-1-dependent pathway.

Huang YQ, Li JJ, Karpatkin S.

J Biol Chem. 2000 Mar 3;275(9):6462-8.PMID: 10692450 [PubMed - indexed for MEDLINE]Related articlesFree article

Differentiation of autoimmune thrombocytopenia from thrombocytopenia associated with immune complex disease: systemic lupus erythematosus, hepatitis-cirrhosis, and HIV-1 infection by platelet and serum immunological measurements.

Samuel H, Nardi M, Karpatkin M, Hart D, Belmont M, Karpatkin S.

Br J Haematol. 1999 Jun;105(4):1086-91.PMID: 10554825 [PubMed - indexed for MEDLINE]Related articles

Expression of CD41 and c-mpl does not indicate commitment to the megakaryocyte lineage during haemopoietic development.

Basch RS, Zhang XM, Dolzhanskiy A, Karpatkin S.

Br J Haematol. 1999 Jun;105(4):1044-54.PMID: 10554819 [PubMed - indexed for MEDLINE]Related articles

Protease-activated receptor 1 (PAR-1) is required and rate-limiting for thrombin-enhanced experimental pulmonary metastasis.

Nierodzik ML, Chen K, Takeshita K, Li JJ, Huang YQ, Feng XS, D'Andrea MR, Andrade-Gordon P, Karpatkin S.

Blood. 1998 Nov 15;92(10):3694-700.PMID: 9808563 [PubMed - indexed for MEDLINE]Related articlesFree article

Treatment of thrombocytopenia in chimpanzees infected with human immunodeficiency virus by pegylated recombinant human megakaryocyte growth and development factor.

Harker LA, Marzec UM, Novembre F, Sundell IB, Waller EK, Karpatkin S, McClure HM, Kelly AB, Stead RB.

Blood. 1998 Jun 15;91(12):4427-33.PMID: 9616135 [PubMed - indexed for MEDLINE]Related articlesFree article

Ineffective platelet production in thrombocytopenic human immunodeficiency virus-infected patients.

Cole JL, Marzec UM, Gunthel CJ, Karpatkin S, Worford L, Sundell IB, Lennox JL, Nichol JL, Harker LA.

Blood. 1998 May 1;91(9):3239-46.PMID: 9558379 [PubMed - indexed for MEDLINE]Related articlesFree article

Complementary and antagonistic effects of IL-3 in the early development of human megakaryocytes in culture.

Dolzhanskiy A, Hirst J, Basch RS, Karpatkin S.

Br J Haematol. 1998 Feb;100(2):415-26.PMID: 9488638 [PubMed - indexed for MEDLINE]Related articles

GPIIIa-(49-66) is a major pathophysiologically relevant antigenic determinant for anti-platelet GPIIIa of HIV-1-related immunologic thrombocytopenia.

Nardi MA, Liu LX, Karpatkin S.

Proc Natl Acad Sci U S A. 1997 Jul 8;94(14):7589-94.PMID: 9207136 [PubMed - indexed for MEDLINE]Related articlesFree article

Autoimmune (idiopathic) thrombocytopenic purpura.

Karpatkin S.

Lancet. 1997 May 24;349(9064):1531-6. Review. No abstract available. PMID: 9167472 [PubMed - indexed for MEDLINE]Related articles

Human immunodeficiency virus infection and thrombotic microangiopathy.

Hymes KB, Karpatkin S.

Semin Hematol. 1997 Apr;34(2):117-25. Review. No abstract available. PMID: 9109213 [PubMed - indexed for MEDLINE]Related articles

The development of human megakaryocytes: III. Development of mature megakaryocytes from highly purified committed progenitors in synthetic culture media and inhibition of thrombopoietin-induced polyploidization by interleukin-3.

Dolzhanskiy A, Basch RS, Karpatkin S.

Blood. 1997 Jan 15;89(2):426-34.PMID: 9002944 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of binding of anti-PLA1 antibodies to platelets with monoclonal antibody LK-4. Evidence for multiple PLA1 receptor sites on platelet GPIIIa.

Liu LX, Nardi MA, Casella JF, Karpatkin S.

Blood. 1996 Nov 1;88(9):3601-7.PMID: 8896429 [PubMed - indexed for MEDLINE]Related articlesFree article

The development of human megakaryocytes. II. CD4 expression occurs during haemopoietic differentiation and is an early step in megakaryocyte maturation.

Basch RS, Dolzhanskiy A, Zhang XM, Karpatkin S.

Br J Haematol. 1996 Sep;94(3):433-42.PMID: 8790138 [PubMed - indexed for MEDLINE]Related articles

Development of human megakaryocytes: I. Hematopoietic progenitors (CD34+ bone marrow cells) are enriched with megakaryocytes expressing CD4.

Dolzhanskiy A, Basch RS, Karpatkin S.

Blood. 1996 Feb 15;87(4):1353-60.PMID: 8608224 [PubMed - indexed for MEDLINE]Related articlesFree article

Presence of the seven transmembrane thrombin receptor on human tumour cells: effect of activation on tumour adhesion to platelets and tumor tyrosine phosphorylation.

Nierodzik ML, Bain RM, Liu LX, Shivji M, Takeshita K, Karpatkin S.

Br J Haematol. 1996 Feb;92(2):452-7.PMID: 8603016 [PubMed - indexed for MEDLINE]Related articles

Heterogenous inhibition of platelet aggregation by monoclonal antibodies binding to multiple sites on GPIIIa.

Liu LX, Nardi MA, Nierodzik ML, Karpatkin S.

Br J Haematol. 1995 Dec;91(4):976-82.PMID: 8547151 [PubMed - indexed for MEDLINE]Related articles

Role of platelets, thrombin, integrin IIb-IIIa, fibronectin and von Willebrand factor on tumor adhesion in vitro and metastasis in vivo.

Nierodzik ML, Klepfish A, Karpatkin S.

Thromb Haemost. 1995 Jul;74(1):282-90. Review.PMID: 8578473 [PubMed - indexed for MEDLINE]Related articles

Production of a human anti-CD4 monoclonal antibody with antiidiotype to anti-HIV type 1 glycoprotein 120.

Karpatkin S, Nardi MA, Liu LX, Kouri YH, Borkowsky W.

AIDS Res Hum Retroviruses. 1995 Apr;11(4):509-15.PMID: 7632465 [PubMed - indexed for MEDLINE]Related articles

Sequestration of anti-platelet GPIIIa antibody in rheumatoid factor immune complexes of human immunodeficiency virus 1 thrombocytopenic patients.

Karpatkin S, Nardi MA, Hymes KB.

Proc Natl Acad Sci U S A. 1995 Mar 14;92(6):2263-7.PMID: 7892259 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of platelet integrin GPIIb-GPIIIa, fibronectin, von Willebrand factor, and thrombin in platelet-tumor interaction in vitro and metastasis in vivo.

Nierodzik ML, Klepfish A, Karpatkin S.

Semin Hematol. 1994 Oct;31(4):278-88. Review. No abstract available. PMID: 7831573 [PubMed - indexed for MEDLINE]Related articles

Should all pregnant women be tested for their platelet PLA (Zw, HPA-1) phenotype?

Flug F, Karpatkin M, Karpatkin S.

Br J Haematol. 1994 Jan;86(1):1-5. Review. No abstract available. PMID: 7872969 [PubMed - indexed for MEDLINE]Related articles

Human megakaryocytes have a CD4 molecule capable of binding human immunodeficiency virus-1.

Kouri YH, Borkowsky W, Nardi M, Karpatkin S, Basch RS.

Blood. 1993 May 15;81(10):2664-70.PMID: 8490176 [PubMed - indexed for MEDLINE]Related articlesFree article