PubMed

Diagnosis, management and prevention of drug-induced liver injury.

Verma S, Kaplowitz N.

Gut. 2009 Nov;58(11):1555-64.PMID: 19834119 [PubMed - in process]Related articles

Phenotypic characterization of idiosyncratic drug-induced liver injury: the influence of age and sex.

Lucena MI, Andrade RJ, Kaplowitz N, García-Cortes M, Fernández MC, Romero-Gomez M, Bruguera M, Hallal H, Robles-Diaz M, Rodriguez-González JF, Navarro JM, Salmeron J, Martinez-Odriozola P, Pérez-Alvarez R, Borraz Y, Hidalgo R; Spanish Group for the Study of Drug-Induced Liver Disease.

Hepatology. 2009 Jun;49(6):2001-9.PMID: 19475693 [PubMed - indexed for MEDLINE]Related articles

Redox regulation of tumor necrosis factor signaling.

Han D, Ybanez MD, Ahmadi S, Yeh K, Kaplowitz N.

Antioxid Redox Signal. 2009 Sep;11(9):2245-63.PMID: 19361274 [PubMed - in process]Related articles

Genetic risk factors for portopulmonary hypertension in patients with advanced liver disease.

Roberts KE, Fallon MB, Krowka MJ, Brown RS, Trotter JF, Peter I, Tighiouart H, Knowles JA, Rabinowitz D, Benza RL, Badesch DB, Taichman DB, Horn EM, Zacks S, Kaplowitz N, Kawut SM; Pulmonary Vascular Complications of Liver Disease Study Group.

Am J Respir Crit Care Med. 2009 May 1;179(9):835-42. Epub 2009 Feb 12.PMID: 19218192 [PubMed - indexed for MEDLINE]Related articles

Glutathione in liver diseases and hepatotoxicity.

Yuan L, Kaplowitz N.

Mol Aspects Med. 2009 Feb-Apr;30(1-2):29-41. Epub 2008 Aug 26. Review.PMID: 18786561 [PubMed - indexed for MEDLINE]Related articles

How to protect against acetaminophen: don't ask for JUNK.

Kaplowitz N, Shinohara M, Liu ZX, Han D.

Gastroenterology. 2008 Oct;135(4):1047-51. Epub 2008 Sep 7. No abstract available. PMID: 18782575 [PubMed - indexed for MEDLINE]Related articles

Impact of hepatopulmonary syndrome on quality of life and survival in liver transplant candidates.

Fallon MB, Krowka MJ, Brown RS, Trotter JF, Zacks S, Roberts KE, Shah VH, Kaplowitz N, Forman L, Wille K, Kawut SM; Pulmonary Vascular Complications of Liver Disease Study Group.

Gastroenterology. 2008 Oct;135(4):1168-75. Epub 2008 Jun 20.PMID: 18644373 [PubMed - indexed for MEDLINE]Related articles

Clinical risk factors for portopulmonary hypertension.

Kawut SM, Krowka MJ, Trotter JF, Roberts KE, Benza RL, Badesch DB, Taichman DB, Horn EM, Zacks S, Kaplowitz N, Brown RS Jr, Fallon MB; Pulmonary Vascular Complications of Liver Disease Study Group.

Hepatology. 2008 Jul;48(1):196-203.PMID: 18537192 [PubMed - indexed for MEDLINE]Related articles

Effect of transgenic extrahepatic expression of betaine-homocysteine methyltransferase on alcohol or homocysteine-induced fatty liver.

Ji C, Shinohara M, Vance D, Than TA, Ookhtens M, Chan C, Kaplowitz N.

Alcohol Clin Exp Res. 2008 Jun;32(6):1049-58.PMID: 18498552 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of H(2)O(2)-induced necrosis by PKC and AMP-activated kinase signaling in primary cultured hepatocytes.

Saberi B, Shinohara M, Ybanez MD, Hanawa N, Gaarde WA, Kaplowitz N, Han D.

Am J Physiol Cell Physiol. 2008 Jul;295(1):C50-63. Epub 2008 May 7.PMID: 18463227 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of JNK translocation to mitochondria leading to inhibition of mitochondria bioenergetics in acetaminophen-induced liver injury.

Hanawa N, Shinohara M, Saberi B, Gaarde WA, Han D, Kaplowitz N.

J Biol Chem. 2008 May 16;283(20):13565-77. Epub 2008 Mar 12.PMID: 18337250 [PubMed - indexed for MEDLINE]Related articlesFree article

Endoplasmic reticulum stress and liver injury.

Kaplowitz N, Than TA, Shinohara M, Ji C.

Semin Liver Dis. 2007 Nov;27(4):367-77. Review.PMID: 17979073 [PubMed - indexed for MEDLINE]Related articles

Mechanisms of drug-induced liver disease.

Gunawan BK, Kaplowitz N.

Clin Liver Dis. 2007 Aug;11(3):459-75, v. Review.PMID: 17723915 [PubMed - indexed for MEDLINE]Related articles

Mechanisms of protection by the betaine-homocysteine methyltransferase/betaine system in HepG2 cells and primary mouse hepatocytes.

Ji C, Shinohara M, Kuhlenkamp J, Chan C, Kaplowitz N.

Hepatology. 2007 Nov;46(5):1586-96.PMID: 17705221 [PubMed - indexed for MEDLINE]Related articlesFree article

Glutathione depletion down-regulates tumor necrosis factor alpha-induced NF-kappaB activity via IkappaB kinase-dependent and -independent mechanisms.

Lou H, Kaplowitz N.

J Biol Chem. 2007 Oct 5;282(40):29470-81. Epub 2007 Aug 9.PMID: 17690092 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of S-adenosylmethionine, folate, and betaine in the treatment of alcoholic liver disease: summary of a symposium.

Purohit V, Abdelmalek MF, Barve S, Benevenga NJ, Halsted CH, Kaplowitz N, Kharbanda KK, Liu QY, Lu SC, McClain CJ, Swanson C, Zakhari S.

Am J Clin Nutr. 2007 Jul;86(1):14-24. Review.PMID: 17616758 [PubMed - indexed for MEDLINE]Related articlesFree article

Drug-induced liver injury.

Abboud G, Kaplowitz N.

Drug Saf. 2007;30(4):277-94. Review.PMID: 17408305 [PubMed - indexed for MEDLINE]Related articles

Outcome of acute idiosyncratic drug-induced liver injury: Long-term follow-up in a hepatotoxicity registry.

Andrade RJ, Lucena MI, Kaplowitz N, García-Muņoz B, Borraz Y, Pachkoria K, García-Cortés M, Fernández MC, Pelaez G, Rodrigo L, Durán JA, Costa J, Planas R, Barriocanal A, Guarner C, Romero-Gomez M, Muņoz-Yagüe T, Salmerón J, Hidalgo R.

Hepatology. 2006 Dec;44(6):1581-8.PMID: 17133470 [PubMed - indexed for MEDLINE]Related articles

Current concepts and controversies in the treatment of alcoholic hepatitis.

Rongey C, Kaplowitz N.

World J Gastroenterol. 2006 Nov 21;12(43):6909-21. Review.PMID: 17109510 [PubMed - indexed for MEDLINE]Related articlesFree article

Drug hepatotoxicity.

Nathwani RA, Kaplowitz N.

Clin Liver Dis. 2006 May;10(2):207-17, vii. Review.PMID: 16971258 [PubMed - indexed for MEDLINE]Related articles

Unfolding new mechanisms of alcoholic liver disease in the endoplasmic reticulum.

Kaplowitz N, Ji C.

J Gastroenterol Hepatol. 2006 Oct;21 Suppl 3:S7-9. Review.PMID: 16958678 [PubMed - indexed for MEDLINE]Related articles

Predominant role of sterol response element binding proteins (SREBP) lipogenic pathways in hepatic steatosis in the murine intragastric ethanol feeding model.

Ji C, Chan C, Kaplowitz N.

J Hepatol. 2006 Nov;45(5):717-24. Epub 2006 Jun 21.PMID: 16879892 [PubMed - indexed for MEDLINE]Related articles

Hydrogen peroxide and redox modulation sensitize primary mouse hepatocytes to TNF-induced apoptosis.

Han D, Hanawa N, Saberi B, Kaplowitz N.

Free Radic Biol Med. 2006 Aug 15;41(4):627-39. Epub 2006 May 10.PMID: 16863996 [PubMed - indexed for MEDLINE]Related articles

Role of innate immunity in acetaminophen-induced hepatotoxicity.

Liu ZX, Kaplowitz N.

Expert Opin Drug Metab Toxicol. 2006 Aug;2(4):493-503. Review.PMID: 16859400 [PubMed - indexed for MEDLINE]Related articles

c-Jun N-terminal kinase plays a major role in murine acetaminophen hepatotoxicity.

Gunawan BK, Liu ZX, Han D, Hanawa N, Gaarde WA, Kaplowitz N.

Gastroenterology. 2006 Jul;131(1):165-78.PMID: 16831600 [PubMed - indexed for MEDLINE]Related articles

Aminotransferase elevations in healthy adults receiving 4 grams of acetaminophen daily: a randomized controlled trial.

Watkins PB, Kaplowitz N, Slattery JT, Colonese CR, Colucci SV, Stewart PW, Harris SC.

JAMA. 2006 Jul 5;296(1):87-93.PMID: 16820551 [PubMed - indexed for MEDLINE]Related articlesFree article

ER stress: can the liver cope?

Ji C, Kaplowitz N.

J Hepatol. 2006 Aug;45(2):321-33. Epub 2006 Jun 15. Review.PMID: 16797772 [PubMed - indexed for MEDLINE]Related articles

Neutrophil depletion protects against murine acetaminophen hepatotoxicity.

Liu ZX, Han D, Gunawan B, Kaplowitz N.

Hepatology. 2006 Jun;43(6):1220-30.PMID: 16729305 [PubMed - indexed for MEDLINE]Related articles

Rules and laws of drug hepatotoxicity.

Kaplowitz N.

Pharmacoepidemiol Drug Saf. 2006 Apr;15(4):231-3. No abstract available. PMID: 16552791 [PubMed - indexed for MEDLINE]Related articles

Mechanisms of liver injury. III. Role of glutathione redox status in liver injury.

Han D, Hanawa N, Saberi B, Kaplowitz N.

Am J Physiol Gastrointest Liver Physiol. 2006 Jul;291(1):G1-7. Epub 2006 Feb 23. Review.PMID: 16500922 [PubMed - indexed for MEDLINE]Related articlesFree article

Liver biology and pathobiology.

Kaplowitz N.

Hepatology. 2006 Feb;43(2 Suppl 1):S235-8. Review. No abstract available. Erratum in: Hepatology. 2006 Jul;44(1):282. PMID: 16447293 [PubMed - indexed for MEDLINE]Related articles

Role of CHOP in hepatic apoptosis in the murine model of intragastric ethanol feeding.

Ji C, Mehrian-Shai R, Chan C, Hsu YH, Kaplowitz N.

Alcohol Clin Exp Res. 2005 Aug;29(8):1496-503.PMID: 16131858 [PubMed - indexed for MEDLINE]Related articlesFree article

Idiosyncratic drug hepatotoxicity.

Kaplowitz N.

Nat Rev Drug Discov. 2005 Jun;4(6):489-99. Review.PMID: 15931258 [PubMed - indexed for MEDLINE]Related articles

Hepatic mitochondrial glutathione: transport and role in disease and toxicity.

Fernandez-Checa JC, Kaplowitz N.

Toxicol Appl Pharmacol. 2005 May 1;204(3):263-73. Review.PMID: 15845418 [PubMed - indexed for MEDLINE]Related articles

Marked elevation in serum transaminases: an atypical presentation of choledocholithiasis.

Nathwani RA, Kumar SR, Reynolds TB, Kaplowitz N.

Am J Gastroenterol. 2005 Feb;100(2):295-8.PMID: 15667485 [PubMed - indexed for MEDLINE]Related articles

Serum alanine aminotransferase in skeletal muscle diseases.

Nathwani RA, Pais S, Reynolds TB, Kaplowitz N.

Hepatology. 2005 Feb;41(2):380-2.PMID: 15660433 [PubMed - indexed for MEDLINE]Related articles

Severe hepatotoxicity associated with the use of weight loss diet supplements containing ma huang or usnic acid.

Neff GW, Reddy KR, Durazo FA, Meyer D, Marrero R, Kaplowitz N.

J Hepatol. 2004 Dec;41(6):1062-4. No abstract available. PMID: 15582145 [PubMed - indexed for MEDLINE]Related articles

Innate immune system plays a critical role in determining the progression and severity of acetaminophen hepatotoxicity.

Liu ZX, Govindarajan S, Kaplowitz N.

Gastroenterology. 2004 Dec;127(6):1760-74.PMID: 15578514 [PubMed - indexed for MEDLINE]Related articles

Statin-induced hepatotoxicity.

Kaplowitz N.

Gastroenterology. 2004 Oct;127(4):1278; author reply 1278-9. No abstract available. PMID: 15481021 [PubMed - indexed for MEDLINE]Related articles

Liver injury associated with the beta-interferons for MS.

Francis GS, Kaplowitz N, Alteri E.

Neurology. 2004 Sep 28;63(6):1142-3; author reply 1142-3. No abstract available. PMID: 15457586 [PubMed - indexed for MEDLINE]Related articles

Role of TNF-alpha in ethanol-induced hyperhomocysteinemia and murine alcoholic liver injury.

Ji C, Deng Q, Kaplowitz N.

Hepatology. 2004 Aug;40(2):442-51.PMID: 15368449 [PubMed - indexed for MEDLINE]Related articles

Acetaminophen hepatoxicity: what do we know, what don't we know, and what do we do next?

Kaplowitz N.

Hepatology. 2004 Jul;40(1):23-6. Review. No abstract available. PMID: 15239082 [PubMed - indexed for MEDLINE]Related articles

Clinical perspectives on xenobiotic-induced hepatotoxicity.

Gunawan B, Kaplowitz N.

Drug Metab Rev. 2004 May;36(2):301-12. Review.PMID: 15237856 [PubMed - indexed for MEDLINE]Related articles

Hyperhomocysteinemia, endoplasmic reticulum stress, and alcoholic liver injury.

Ji C, Kaplowitz N.

World J Gastroenterol. 2004 Jun 15;10(12):1699-708. Review.PMID: 15188490 [PubMed - indexed for MEDLINE]Related articlesFree article

Usnic acid-induced necrosis of cultured mouse hepatocytes: inhibition of mitochondrial function and oxidative stress.

Han D, Matsumaru K, Rettori D, Kaplowitz N.

Biochem Pharmacol. 2004 Feb 1;67(3):439-51.PMID: 15037196 [PubMed - indexed for MEDLINE]Related articles

Drug-induced liver injury.

Kaplowitz N.

Clin Infect Dis. 2004 Mar 1;38 Suppl 2:S44-8.PMID: 14986274 [PubMed - indexed for MEDLINE]Related articles

Effect of glutathione depletion on sites and topology of superoxide and hydrogen peroxide production in mitochondria.

Han D, Canali R, Rettori D, Kaplowitz N.

Mol Pharmacol. 2003 Nov;64(5):1136-44.PMID: 14573763 [PubMed - indexed for MEDLINE]Related articlesFree article

Sensitivity of the 2-oxoglutarate carrier to alcohol intake contributes to mitochondrial glutathione depletion.

Coll O, Colell A, García-Ruiz C, Kaplowitz N, Fernández-Checa JC.

Hepatology. 2003 Sep;38(3):692-702.PMID: 12939596 [PubMed - indexed for MEDLINE]Related articles

Hepatic reactions during treatment of multiple sclerosis with interferon-beta-1a: incidence and clinical significance.

Francis GS, Grumser Y, Alteri E, Micaleff A, O'Brien F, Alsop J, Stam Moraga M, Kaplowitz N.

Drug Saf. 2003;26(11):815-27.PMID: 12908850 [PubMed - indexed for MEDLINE]Related articles

Chelerythrine stimulates GSH transport by rat Mrp2 (Abcc2) expressed in canine kidney cells.

Lou H, Ookhtens M, Stolz A, Kaplowitz N.

Am J Physiol Gastrointest Liver Physiol. 2003 Dec;285(6):G1335-44. Epub 2003 Jul 31.PMID: 12893631 [PubMed - indexed for MEDLINE]Related articlesFree article