PubMed

Deletion of GPR40 impairs glucose-induced insulin secretion in vivo in mice without affecting intracellular fuel metabolism in islets.

Alquier T, Peyot ML, Latour MG, Kebede M, Sorensen CM, Gesta S, Ronald Kahn C, Smith RD, Jetton TL, Metz TO, Prentki M, Poitout V.

Diabetes. 2009 Nov;58(11):2607-15. Epub 2009 Aug 31.PMID: 19720802 [PubMed - in process]Related articles

Islet beta cell failure in the 60% pancreatectomised obese hyperlipidaemic Zucker fatty rat: severe dysfunction with altered glycerolipid metabolism without steatosis or a falling beta cell mass.

Delghingaro-Augusto V, Nolan CJ, Gupta D, Jetton TL, Latour MG, Peshavaria M, Madiraju SR, Joly E, Peyot ML, Prentki M, Leahy J.

Diabetologia. 2009 Jun;52(6):1122-32. Epub 2009 Mar 18.PMID: 19294363 [PubMed - indexed for MEDLINE]Related articles

In vivo and in vitro studies of a functional peroxisome proliferator-activated receptor gamma response element in the mouse pdx-1 promoter.

Gupta D, Jetton TL, Mortensen RM, Duan SZ, Peshavaria M, Leahy JL.

J Biol Chem. 2008 Nov 21;283(47):32462-70. Epub 2008 Aug 21.PMID: 18718916 [PubMed - indexed for MEDLINE]Related articles

Enhanced beta-cell mass without increased proliferation following chronic mild glucose infusion.

Jetton TL, Everill B, Lausier J, Roskens V, Habibovic A, LaRock K, Gokin A, Peshavaria M, Leahy JL.

Am J Physiol Endocrinol Metab. 2008 Apr;294(4):E679-87. Epub 2008 Jan 29.PMID: 18230696 [PubMed - indexed for MEDLINE]Related articlesFree article

Cyclical and alternating infusions of glucose and intralipid in rats inhibit insulin gene expression and Pdx-1 binding in islets.

Hagman DK, Latour MG, Chakrabarti SK, Fontes G, Amyot J, Tremblay C, Semache M, Lausier JA, Roskens V, Mirmira RG, Jetton TL, Poitout V.

Diabetes. 2008 Feb;57(2):424-31. Epub 2007 Nov 8.PMID: 17991758 [PubMed - indexed for MEDLINE]Related articlesFree article

GPR40 is necessary but not sufficient for fatty acid stimulation of insulin secretion in vivo.

Latour MG, Alquier T, Oseid E, Tremblay C, Jetton TL, Luo J, Lin DC, Poitout V.

Diabetes. 2007 Apr;56(4):1087-94.PMID: 17395749 [PubMed - indexed for MEDLINE]Related articlesFree article

Cecal infusion of butyrate increases intestinal cell proliferation in piglets.

Kien CL, Blauwiekel R, Bunn JY, Jetton TL, Frankel WL, Holst JJ.

J Nutr. 2007 Apr;137(4):916-22.PMID: 17374654 [PubMed - indexed for MEDLINE]Related articlesFree article

Immunohistochemical evidence for the presence of glucokinase in the gonadotropes and thyrotropes of the anterior pituitary gland of rat and monkey.

Sorenson RL, Stout LE, Brelje TC, Jetton TL, Matschinsky FM.

J Histochem Cytochem. 2007 Jun;55(6):555-66. Epub 2007 Feb 5.PMID: 17283370 [PubMed - indexed for MEDLINE]Related articlesFree article

Peroxisome proliferator-activated receptor-gamma regulates expression of PDX-1 and NKX6.1 in INS-1 cells.

Moibi JA, Gupta D, Jetton TL, Peshavaria M, Desai R, Leahy JL.

Diabetes. 2007 Jan;56(1):88-95.PMID: 17192469 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of pancreatic beta-cell regeneration in the normoglycemic 60% partial-pancreatectomy mouse.

Peshavaria M, Larmie BL, Lausier J, Satish B, Habibovic A, Roskens V, Larock K, Everill B, Leahy JL, Jetton TL.

Diabetes. 2006 Dec;55(12):3289-98.PMID: 17130472 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression and shifting subcellular localization of the transcription factor, Foxd3, in embryonic and adult pancreas.

Perera HK, Caldwell ME, Hayes-Patterson D, Teng L, Peshavaria M, Jetton TL, Labosky PA.

Gene Expr Patterns. 2006 Oct;6(8):971-7. Epub 2006 Apr 22.PMID: 16750430 [PubMed - indexed for MEDLINE]Related articles

The network of glucokinase-expressing cells in glucose homeostasis and the potential of glucokinase activators for diabetes therapy.

Matschinsky FM, Magnuson MA, Zelent D, Jetton TL, Doliba N, Han Y, Taub R, Grimsby J.

Diabetes. 2006 Jan;55(1):1-12. Review.PMID: 16380470 [PubMed - indexed for MEDLINE]Related articlesFree article

Cre recombinase-dependent expression of a constitutively active mutant allele of the catalytic subunit of protein kinase A.

Niswender CM, Willis BS, Wallen A, Sweet IR, Jetton TL, Thompson BR, Wu C, Lange AJ, McKnight GS.

Genesis. 2005 Nov;43(3):109-19.PMID: 16155866 [PubMed - indexed for MEDLINE]Related articles

Mechanisms of compensatory beta-cell growth in insulin-resistant rats: roles of Akt kinase.

Jetton TL, Lausier J, LaRock K, Trotman WE, Larmie B, Habibovic A, Peshavaria M, Leahy JL.

Diabetes. 2005 Aug;54(8):2294-304.PMID: 16046294 [PubMed - indexed for MEDLINE]Related articlesFree article

Topiramate ameliorates hyperglycaemia and improves glucose-stimulated insulin release in ZDF rats and db/db mice.

Liang Y, Chen X, Osborne M, DeCarlo SO, Jetton TL, Demarest K.

Diabetes Obes Metab. 2005 Jul;7(4):360-9.PMID: 15955122 [PubMed - indexed for MEDLINE]Related articles

CAI is a potent inhibitor of neovascularization and imparts neuroprotection in a mouse model of ischemic retinopathy.

Franklin AJ, Jetton TL, Kuchemann CL, Russell SR, Kohn EC.

Invest Ophthalmol Vis Sci. 2004 Oct;45(10):3756-66.PMID: 15452087 [PubMed - indexed for MEDLINE]Related articlesFree article

Reduction in glucagon receptor expression by an antisense oligonucleotide ameliorates diabetic syndrome in db/db mice.

Liang Y, Osborne MC, Monia BP, Bhanot S, Gaarde WA, Reed C, She P, Jetton TL, Demarest KT.

Diabetes. 2004 Feb;53(2):410-7.PMID: 14747292 [PubMed - indexed for MEDLINE]Related articlesFree article

Substrate-induced nuclear export and peripheral compartmentalization of hepatic glucokinase correlates with glycogen deposition.

Jetton TL, Shiota M, Knobel SM, Piston DW, Cherrington AD, Magnuson MA.

Int J Exp Diabetes Res. 2001;2(3):173-86.PMID: 12369705 [PubMed - indexed for MEDLINE]Related articlesFree article

beta-Cell adaptation to insulin resistance. Increased pyruvate carboxylase and malate-pyruvate shuttle activity in islets of nondiabetic Zucker fatty rats.

Liu YQ, Jetton TL, Leahy JL.

J Biol Chem. 2002 Oct 18;277(42):39163-8. Epub 2002 Jul 29.PMID: 12147706 [PubMed - indexed for MEDLINE]Related articlesFree article

In vivo phosphorylation of insulin receptor substrate 1 at serine 789 by a novel serine kinase in insulin-resistant rodents.

Qiao LY, Zhande R, Jetton TL, Zhou G, Sun XJ.

J Biol Chem. 2002 Jul 19;277(29):26530-9. Epub 2002 May 2.PMID: 12006586 [PubMed - indexed for MEDLINE]Related articlesFree article

Enhanced expression of insulin receptor substrate-2 and activation of protein kinase B/Akt in regenerating pancreatic duct epithelium of 60 %-partial pancreatectomy rats.

Jetton TL, Liu YQ, Trotman WE, Nevin PW, Sun XJ, Leahy JL.

Diabetologia. 2001 Nov;44(11):2056-65.PMID: 11719838 [PubMed - indexed for MEDLINE]Related articles

Systemic treatment with sympatholytic dopamine agonists improves aberrant beta-cell hyperplasia and GLUT2, glucokinase, and insulin immunoreactive levels in ob/ob mice.

Jetton TL, Liang Y, Cincotta AH.

Metabolism. 2001 Nov;50(11):1377-84.PMID: 11699060 [PubMed - indexed for MEDLINE]Related articles

Glucokinase gene locus transgenic mice are resistant to the development of obesity-induced type 2 diabetes.

Shiota M, Postic C, Fujimoto Y, Jetton TL, Dixon K, Pan D, Grimsby J, Grippo JF, Magnuson MA, Cherrington AD.

Diabetes. 2001 Mar;50(3):622-9.PMID: 11246883 [PubMed - indexed for MEDLINE]Related articlesFree article

Chronic infusion of norepinephrine into the VMH of normal rats induces the obese glucose-intolerant state.

Cincotta AH, Luo S, Zhang Y, Liang Y, Bina KG, Jetton TL, Scislowski PW.

Am J Physiol Regul Integr Comp Physiol. 2000 Feb;278(2):R435-44.PMID: 10666145 [PubMed - indexed for MEDLINE]Related articles

Mice lacking alpha-calcitonin gene-related peptide exhibit normal cardiovascular regulation and neuromuscular development.

Lu JT, Son YJ, Lee J, Jetton TL, Shiota M, Moscoso L, Niswender KD, Loewy AD, Magnuson MA, Sanes JR, Emeson RB.

Mol Cell Neurosci. 1999 Aug;14(2):99-120.PMID: 10532808 [PubMed - indexed for MEDLINE]Related articles

Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase.

Postic C, Shiota M, Niswender KD, Jetton TL, Chen Y, Moates JM, Shelton KD, Lindner J, Cherrington AD, Magnuson MA.

J Biol Chem. 1999 Jan 1;274(1):305-15.PMID: 9867845 [PubMed - indexed for MEDLINE]Related articlesFree article

Bromocriptine/SKF38393 ameliorates islet dysfunction in the diabetic (db/db) mouse.

Liang Y, Jetton TL, Lubkin M, Meier AH, Cincotta AH.

Cell Mol Life Sci. 1998 Jul;54(7):703-11.PMID: 9711236 [PubMed - indexed for MEDLINE]Related articles

Targeted oncogenesis of hormone-negative pancreatic islet progenitor cells.

Jetton TL, Moates JM, Lindner J, Wright CV, Magnuson MA.

Proc Natl Acad Sci U S A. 1998 Jul 21;95(15):8654-9.PMID: 9671733 [PubMed - indexed for MEDLINE]Related articlesFree article

Cell-specific expression and regulation of a glucokinase gene locus transgene.

Niswender KD, Postic C, Jetton TL, Bennett BD, Piston DW, Efrat S, Magnuson MA.

J Biol Chem. 1997 Sep 5;272(36):22564-9.PMID: 9278410 [PubMed - indexed for MEDLINE]Related articlesFree article

The winged helix gene, Mf3, is required for normal development of the diencephalon and midbrain, postnatal growth and the milk-ejection reflex.

Labosky PA, Winnier GE, Jetton TL, Hargett L, Ryan AK, Rosenfeld MG, Parlow AF, Hogan BL.

Development. 1997 Apr;124(7):1263-74.PMID: 9118797 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of altered glucokinase gene copy number on blood glucose homoeostasis.

Niswender KD, Postic C, Shiota M, Jetton TL, Magnuson MA.

Biochem Soc Trans. 1997 Feb;25(1):113-7. Review. No abstract available. PMID: 9056854 [PubMed - indexed for MEDLINE]Related articles

Epidermal growth factor receptor activation induces nuclear targeting of cyclooxygenase-2, basolateral release of prostaglandins, and mitogenesis in polarizing colon cancer cells.

Coffey RJ, Hawkey CJ, Damstrup L, Graves-Deal R, Daniel VC, Dempsey PJ, Chinery R, Kirkland SC, DuBois RN, Jetton TL, Morrow JD.

Proc Natl Acad Sci U S A. 1997 Jan 21;94(2):657-62.PMID: 9012840 [PubMed - indexed for MEDLINE]Related articlesFree article

PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum.

Offield MF, Jetton TL, Labosky PA, Ray M, Stein RW, Magnuson MA, Hogan BL, Wright CV.

Development. 1996 Mar;122(3):983-95.PMID: 8631275 [PubMed - indexed for MEDLINE]Related articlesFree article

BRCA1 is secreted and exhibits properties of a granin.

Jensen RA, Thompson ME, Jetton TL, Szabo CI, van der Meer R, Helou B, Tronick SR, Page DL, King MC, Holt JT.

Nat Genet. 1996 Mar;12(3):303-8.PMID: 8589722 [PubMed - indexed for MEDLINE]Related articles

Quantitative subcellular imaging of glucose metabolism within intact pancreatic islets.

Bennett BD, Jetton TL, Ying G, Magnuson MA, Piston DW.

J Biol Chem. 1996 Feb 16;271(7):3647-51.PMID: 8631975 [PubMed - indexed for MEDLINE]Related articlesFree article

BZP, a novel serum-responsive zinc finger protein that inhibits gene transcription.

Franklin AJ, Jetton TL, Shelton KD, Magnuson MA.

Mol Cell Biol. 1994 Oct;14(10):6773-88.PMID: 7935395 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of glucose on insulin secretion, glucokinase activity, and transgene expression in transgenic mouse islets containing an upstream glucokinase promoter-human growth hormone fusion gene.

Liang Y, Jetton TL, Zimmerman EC, Najafi H, Berner DK, Matschinsky FM, Magnuson MA.

Diabetes. 1994 Sep;43(9):1138-45.PMID: 8070614 [PubMed - indexed for MEDLINE]Related articles

Ribozyme-mediated attenuation of pancreatic beta-cell glucokinase expression in transgenic mice results in impaired glucose-induced insulin secretion.

Efrat S, Leiser M, Wu YJ, Fusco-DeMane D, Emran OA, Surana M, Jetton TL, Magnuson MA, Weir G, Fleischer N.

Proc Natl Acad Sci U S A. 1994 Mar 15;91(6):2051-5.PMID: 7510884 [PubMed - indexed for MEDLINE]Related articlesFree article

Analysis of upstream glucokinase promoter activity in transgenic mice and identification of glucokinase in rare neuroendocrine cells in the brain and gut.

Jetton TL, Liang Y, Pettepher CC, Zimmerman EC, Cox FG, Horvath K, Matschinsky FM, Magnuson MA.

J Biol Chem. 1994 Feb 4;269(5):3641-54.PMID: 8106409 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucokinase as pancreatic beta cell glucose sensor and diabetes gene.

Matschinsky F, Liang Y, Kesavan P, Wang L, Froguel P, Velho G, Cohen D, Permutt MA, Tanizawa Y, Jetton TL, et al.

J Clin Invest. 1993 Nov;92(5):2092-8. Review. No abstract available. PMID: 8227324 [PubMed - indexed for MEDLINE]Related articlesFree article

Different intracellular localization of inositol 1,4,5-trisphosphate and ryanodine receptors in cardiomyocytes.

Kijima Y, Saito A, Jetton TL, Magnuson MA, Fleischer S.

J Biol Chem. 1993 Feb 15;268(5):3499-506.PMID: 8381433 [PubMed - indexed for MEDLINE]Related articlesFree article

Evolutionary conservation of elements in the upstream glucokinase promoter.

Magnuson MA, Jetton TL.

Biochem Soc Trans. 1993 Feb;21(1):160-3. Review. No abstract available. PMID: 8449284 [PubMed - indexed for MEDLINE]Related articles

Heterogeneous expression of glucokinase among pancreatic beta cells.

Jetton TL, Magnuson MA.

Proc Natl Acad Sci U S A. 1992 Apr 1;89(7):2619-23.PMID: 1557365 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of alternate RNA splicing on glucokinase isoform activities in the pancreatic islet, liver, and pituitary.

Liang Y, Jetton TL, Zimmerman EC, Najafi H, Matschinsky FM, Magnuson MA.

J Biol Chem. 1991 Apr 15;266(11):6999-7007.PMID: 2016311 [PubMed - indexed for MEDLINE]Related articlesFree article