PubMed

Clinical outcome in 520 consecutive Danish rectal cancer patients treated with short course preoperative radiotherapy.

Jensen LH, Altaf R, Harling H, Jensen M, Laurberg S, Lindegaard JC, Muhic A, Vestermark L, Jakobsen A, Bülow S; on behalf of the Danish Colorectal Cancer Group.

Eur J Surg Oncol. 2009 Oct 30. [Epub ahead of print]PMID: 19880268 [PubMed - as supplied by publisher]Related articles

Molecular screening for Lynch syndrome: from bench to bedside.

Jensen LH, Lindebjerg J, Kølvraa S, Crüger DG.

J Clin Oncol. 2009 Dec 1;27(34):e224; author reply e225. Epub 2009 Oct 26. No abstract available. PMID: 19858372 [PubMed - in process]Related articles

EGF61A>G polymorphism as predictive marker of clinical outcome to first-line capecitabine and oxaliplatin in metastatic colorectal cancer.

Spindler KL, Andersen RF, Jensen LH, Ploen J, Jakobsen A.

Ann Oncol. 2009 Oct 22. [Epub ahead of print]PMID: 19850635 [PubMed - as supplied by publisher]Related articles

A national cohort study of long course preoperative radiotherapy in primary fixed rectal cancer in Denmark.

Bülow S, Jensen LH, Altaf R, Harling H, Jensen M, Laurberg S, Lindegaard JC, Muhic A, Vestermark L; on behalf of the Danish Colorectal Cancer Group.

Colorectal Dis. 2009 Apr 13. [Epub ahead of print]PMID: 19508538 [PubMed - as supplied by publisher]Related articles

Evaluation of the topoisomerase II-inactive bisdioxopiperazine ICRF-161 as a protectant against doxorubicin-induced cardiomyopathy.

Martin E, Thougaard AV, Grauslund M, Jensen PB, Bjorkling F, Hasinoff BB, Tjørnelund J, Sehested M, Jensen LH.

Toxicology. 2009 Jan 8;255(1-2):72-9. Epub 2008 Oct 25.PMID: 19010377 [PubMed - indexed for MEDLINE]Related articles

The prognostic importance of thymidylate gene polymorphism in colon cancer stage II.

Dysager L, Jensen LH, Lindebjerg J, Jakobsen A.

Int J Colorectal Dis. 2008 Dec;23(12):1267. Epub 2008 Jul 16. No abstract available. PMID: 18629514 [PubMed - indexed for MEDLINE]Related articles

Microsatellite instability and the association with plasma homocysteine and thymidylate synthase in colorectal cancer.

Jensen LH, Lindebjerg J, Crüger DG, Brandslund I, Jakobsen A, Kolvraa S, Nielsen JN.

Cancer Invest. 2008 Jul;26(6):583-9.PMID: 18584349 [PubMed - indexed for MEDLINE]Related articles

Comparison of two point-of-care lipid analyzers for use in global cardiovascular risk assessments.

Dale RA, Jensen LH, Krantz MJ.

Ann Pharmacother. 2008 May;42(5):633-9. Epub 2008 Apr 15.PMID: 18413684 [PubMed - indexed for MEDLINE]Related articles

Randomized cross-over study of patient preference for oral or intravenous vinorelbine in combination with carboplatin in the treatment of advanced NSCLC.

Jensen LH, Osterlind K, Rytter C.

Lung Cancer. 2008 Oct;62(1):85-91. Epub 2008 Mar 26.PMID: 18372075 [PubMed - indexed for MEDLINE]Related articles

Strategy in clinical practice for classification of unselected colorectal tumours based on mismatch repair deficiency.

Jensen LH, Lindebjerg J, Byriel L, Kolvraa S, Crüger DG.

Colorectal Dis. 2008 Jun;10(5):490-7. Epub 2007 Sep 13.PMID: 17868408 [PubMed - indexed for MEDLINE]Related articles

A mouse model for studying the interaction of bisdioxopiperazines with topoisomerase IIalpha in vivo.

Grauslund M, Thougaard AV, Füchtbauer A, Hofland KF, Hjorth PH, Jensen PB, Sehested M, Füchtbauer EM, Jensen LH.

Mol Pharmacol. 2007 Oct;72(4):1003-14. Epub 2007 Jul 10.PMID: 17622580 [PubMed - indexed for MEDLINE]Related articlesFree article

Predictive value of MSH2 gene expression in colorectal cancer treated with capecitabine.

Jensen LH, Danenberg KD, Danenberg PV, Jakobsen A.

Clin Colorectal Cancer. 2007 Mar;6(6):433-5.PMID: 17531106 [PubMed - indexed for MEDLINE]Related articles

A three-dimensional quantitative structure-activity relationship study of the inhibition of the ATPase activity and the strand passing catalytic activity of topoisomerase IIalpha by substituted purine analogs.

Jensen LH, Liang H, Shoemaker R, Grauslund M, Sehested M, Hasinoff BB.

Mol Pharmacol. 2006 Nov;70(5):1503-13. Epub 2006 Jul 31.PMID: 16880287 [PubMed - indexed for MEDLINE]Related articlesFree article

Laser microdissection and microsatellite analysis of colorectal adenocarcinomas.

Jensen LH, Cruger DG, Lindebjerg J, Byriel L, Bruun-Petersen G, Jakobsen A.

Anticancer Res. 2006 May-Jun;26(3A):2069-74.PMID: 16827146 [PubMed - indexed for MEDLINE]Related articles

Quantitative proteomic analysis of post-translational modifications of human histones.

Beck HC, Nielsen EC, Matthiesen R, Jensen LH, Sehested M, Finn P, Grauslund M, Hansen AM, Jensen ON.

Mol Cell Proteomics. 2006 Jul;5(7):1314-25. Epub 2006 Apr 20.PMID: 16627869 [PubMed - indexed for MEDLINE]Related articlesFree article

Combining etoposide and dexrazoxane synergizes with radiotherapy and improves survival in mice with central nervous system tumors.

Hofland KF, Thougaard AV, Dejligbjerg M, Jensen LH, Kristjansen PE, Rengtved P, Sehested M, Jensen PB.

Clin Cancer Res. 2005 Sep 15;11(18):6722-9.PMID: 16166453 [PubMed - indexed for MEDLINE]Related articlesFree article

Substituted purine analogues define a novel structural class of catalytic topoisomerase II inhibitors.

Jensen LH, Thougaard AV, Grauslund M, Søkilde B, Carstensen EV, Dvinge HK, Scudiero DA, Jensen PB, Shoemaker RH, Sehested M.

Cancer Res. 2005 Aug 15;65(16):7470-7.PMID: 16103101 [PubMed - indexed for MEDLINE]Related articlesFree article

Separation of bisdioxopiperazine- and vanadate resistance in topoisomerase II.

Sorensen TK, Grauslund M, Jensen PB, Sehested M, Jensen LH.

Biochem Biophys Res Commun. 2005 Sep 2;334(3):853-60.PMID: 16053917 [PubMed - indexed for MEDLINE]Related articles

Pharmacokinetic profiles of biphasic insulin aspart 30/70 and 70/30 in patients with Type 1 diabetes: a randomized double-blinded crossover study.

Chen JW, Lauritzen T, Christiansen JJ, Jensen LH, Clausen WH, Christiansen JS.

Diabet Med. 2005 Mar;22(3):273-7.PMID: 15717874 [PubMed - indexed for MEDLINE]Related articles

Stability of the topoisomerase II closed clamp conformation may influence DNA-stimulated ATP hydrolysis.

Vaughn J, Huang S, Wessel I, Sorensen TK, Hsieh T, Jensen LH, Jensen PB, Sehested M, Nitiss JL.

J Biol Chem. 2005 Mar 25;280(12):11920-9. Epub 2005 Jan 12.PMID: 15647268 [PubMed - indexed for MEDLINE]Related articlesFree article

Characterisation of cytotoxicity and DNA damage induced by the topoisomerase II-directed bisdioxopiperazine anti-cancer agent ICRF-187 (dexrazoxane) in yeast and mammalian cells.

Jensen LH, Dejligbjerg M, Hansen LT, Grauslund M, Jensen PB, Sehested M.

BMC Pharmacol. 2004 Dec 2;4:31.PMID: 15575955 [PubMed - indexed for MEDLINE]Related articlesFree article

A mutation in human topoisomerase II alpha whose expression is lethal in DNA repair-deficient yeast cells.

Walker JV, Nitiss KC, Jensen LH, Mayne C, Hu T, Jensen PB, Sehested M, Hsieh T, Nitiss JL.

J Biol Chem. 2004 Jun 18;279(25):25947-54. Epub 2004 Mar 22.PMID: 15037624 [PubMed - indexed for MEDLINE]Related articlesFree article

Analysis of bisdioxopiperazine dexrazoxane binding to human DNA topoisomerase II alpha: decreased binding as a mechanism of drug resistance.

Renodon-Cornière A, Jensen LH, Nitiss JL, Jensen PB, Sehested M.

Biochemistry. 2003 Aug 19;42(32):9749-54.PMID: 12911317 [PubMed - indexed for MEDLINE]Related articles

A dual mechanism of action of the anticancer agent F 11782 on human topoisomerase II alpha.

Jensen LH, Renodon-Cornière A, Nitiss KC, Hill BT, Nitiss JL, Jensen PB, Sehested M.

Biochem Pharmacol. 2003 Aug 15;66(4):623-31.PMID: 12906927 [PubMed - indexed for MEDLINE]Related articles

A comparison of postprandial and preprandial administration of insulin aspart in children and adolescents with type 1 diabetes.

Danne T, Aman J, Schober E, Deiss D, Jacobsen JL, Friberg HH, Jensen LH; ANA 1200 Study Group.

Diabetes Care. 2003 Aug;26(8):2359-64.PMID: 12882862 [PubMed - indexed for MEDLINE]Related articlesFree article

Probing the role of linker substituents in bisdioxopiperazine analogs for activity against wild-type and mutant human topoisomerase II alpha.

Renodon-Cornière A, Sørensen TK, Jensen PB, Nitiss JL, Søkilde B, Sehested M, Jensen LH.

Mol Pharmacol. 2003 May;63(5):1159-68.PMID: 12695544 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic diversity and the phylogeography of parthenogenesis: comparing bisexual and thelytokous populations of Nemasoma varicorne (Diplopoda: Nemasomatidae) in Denmark.

Jensen LH, Enghoff H, Frydenberg J, Parker ED Jr.

Hereditas. 2002;136(3):184-94.PMID: 12471664 [PubMed - indexed for MEDLINE]Related articles

Interaction of human DNA topoisomerase II alpha with DNA: quantification by surface plasmon resonance.

Renodon-Cornière A, Jensen LH, Nitiss JL, Jensen PB, Sehested M.

Biochemistry. 2002 Nov 12;41(45):13395-402.PMID: 12416984 [PubMed - indexed for MEDLINE]Related articles

Linker length in podophyllotoxin-acridine conjugates determines potency in vivo and in vitro as well as specificity against MDR cell lines.

Rothenborg-Jensen L, Hansen HF, Wessel I, Nitiss JL, Schmidt G, Jensen PB, Sehested M, Jensen LH.

Anticancer Drug Des. 2001 Dec;16(6):305-15.PMID: 12375883 [PubMed - indexed for MEDLINE]Related articles

Human small cell lung cancer NYH cells resistant to the bisdioxopiperazine ICRF-187 exhibit a functional dominant Tyr165Ser mutation in the Walker A ATP binding site of topoisomerase II alpha.

Wessel I, Jensen LH, Renodon-Corniere A, Sorensen TK, Nitiss JL, Jensen PB, Sehested M.

FEBS Lett. 2002 Jun 5;520(1-3):161-6.PMID: 12044890 [PubMed - indexed for MEDLINE]Related articles

Maleimide is a potent inhibitor of topoisomerase II in vitro and in vivo: a new mode of catalytic inhibition.

Jensen LH, Renodon-Corniere A, Wessel I, Langer SW, Søkilde B, Carstensen EV, Sehested M, Jensen PB.

Mol Pharmacol. 2002 May;61(5):1235-43.PMID: 11961142 [PubMed - indexed for MEDLINE]Related articlesFree article

N-terminal and core-domain random mutations in human topoisomerase II alpha conferring bisdioxopiperazine resistance.

Jensen LH, Wessel I, Møller M, Nitiss JL, Sehested M, Jensen PB.

FEBS Lett. 2000 Sep 1;480(2-3):201-7.PMID: 11034329 [PubMed - indexed for MEDLINE]Related articles

A novel mechanism of cell killing by anti-topoisomerase II bisdioxopiperazines.

Jensen LH, Nitiss KC, Rose A, Dong J, Zhou J, Hu T, Osheroff N, Jensen PB, Sehested M, Nitiss JL.

J Biol Chem. 2000 Jan 21;275(3):2137-46.PMID: 10636919 [PubMed - indexed for MEDLINE]Related articlesFree article

Human small cell lung cancer NYH cells selected for resistance to the bisdioxopiperazine topoisomerase II catalytic inhibitor ICRF-187 demonstrate a functional R162Q mutation in the Walker A consensus ATP binding domain of the alpha isoform.

Wessel I, Jensen LH, Jensen PB, Falck J, Rose A, Roerth M, Nitiss JL, Sehested M.

Cancer Res. 1999 Jul 15;59(14):3442-50.PMID: 10416608 [PubMed - indexed for MEDLINE]Related articlesFree article

Neuroprotection by a novel compound, NS521.

Grønborg M, Johansen TE, Peters D, Ahring PK, Drejer J, Møller A, Jensen LH.

J Pharmacol Exp Ther. 1999 Jul;290(1):348-53.PMID: 10381798 [PubMed - indexed for MEDLINE]Related articlesFree article

SPD 502: a water-soluble and in vivo long-lasting AMPA antagonist with neuroprotective activity.

Nielsen EO, Varming T, Mathiesen C, Jensen LH, Moller A, Gouliaev AH, Wätjen F, Drejer J.

J Pharmacol Exp Ther. 1999 Jun;289(3):1492-501.PMID: 10336544 [PubMed - indexed for MEDLINE]Related articlesFree article

Ligands for the benzodiazepine binding site--a survey.

Teuber L, Wätjens F, Jensen LH.

Curr Pharm Des. 1999 May;5(5):317-43. Review.PMID: 10213798 [PubMed - indexed for MEDLINE]Related articles

MPTP-induced Parkinsonism in minipigs: A behavioral, biochemical, and histological study.

Mikkelsen M, Møller A, Jensen LH, Pedersen A, Harajehi JB, Pakkenberg H.

Neurotoxicol Teratol. 1999 Mar-Apr;21(2):169-75.PMID: 10192277 [PubMed - indexed for MEDLINE]Related articles

In vivo and in vitro evaluation of AMPA receptor antagonists in rat hippocampal neurones and cultured mouse cortical neurones.

Mathiesen C, Varming T, Jensen LH.

Eur J Pharmacol. 1998 Jul 24;353(2-3):159-67.PMID: 9726646 [PubMed - indexed for MEDLINE]Related articles

Chinese hamster ovary cells resistant to the topoisomerase II catalytic inhibitor ICRF-159: a Tyr49Phe mutation confers high-level resistance to bisdioxopiperazines.

Sehested M, Wessel I, Jensen LH, Holm B, Oliveri RS, Kenwrick S, Creighton AM, Nitiss JL, Jensen PB.

Cancer Res. 1998 Apr 1;58(7):1460-8.PMID: 9537249 [PubMed - indexed for MEDLINE]Related articlesFree article

Refinement and reliability of macromolecular models based on X-ray diffraction data.

Jensen LH.

Methods Enzymol. 1997;277:353-66. No abstract available. PMID: 18488317 [PubMed]Related articles

Cognitive theory applied to the treatment of delusions of schizophrenia.

Jensen LH, Kane CF.

Arch Psychiatr Nurs. 1996 Dec;10(6):335-41. Review.PMID: 8987203 [PubMed - indexed for MEDLINE]Related articles

Total number of neurons in the ventro-lateral/posterior thalamic nuclei in a genetic petit mal-like rat strain.

Mouritzen-Dam A, Møller A, Scheel-Krüger J, Jensen LH, Marescaux C, Vergnes M.

Epilepsy Res Suppl. 1996;12:303-7. No abstract available. PMID: 9302529 [PubMed - indexed for MEDLINE]Related articles

Pharmacological profile and anti-ischemic properties of the Ca(2+)-channel blocker NS-638.

Møller A, Christophersen P, Drejer J, Axelsson O, Peters D, Jensen LH, Nielsen EO.

Neurol Res. 1995 Oct;17(5):353-60.PMID: 8584126 [PubMed - indexed for MEDLINE]Related articles

[Patterns of tuberculosis manifestation in the county of Roskilde]

Holm EA, Seibaek MB, Jensen LH.

Ugeskr Laeger. 1994 Sep 12;156(37):5272-5. Danish. PMID: 7941063 [PubMed - indexed for MEDLINE]Related articles

Relation of spatial learning of rats in the Morris water maze task to the number of viable CA1 neurons following four-vessel occlusion.

Olsen GM, Scheel-Krüger J, Møller A, Jensen LH.

Behav Neurosci. 1994 Aug;108(4):681-90.PMID: 7986362 [PubMed - indexed for MEDLINE]Related articles

Does neuronal damage of CA1 relate to spatial memory performance of rats subjected to transient forebrain ischemia?

Olsen GM, Scheel-Krüger J, Møller A, Jensen LH.

Acta Neurol Scand. 1994 Mar;89(3):204-9.PMID: 8030402 [PubMed - indexed for MEDLINE]Related articles

Microdialysis of interstitial amino acids during spreading depression and anoxic depolarization in rat neocortex.

Fabricius M, Jensen LH, Lauritzen M.

Brain Res. 1993 May 28;612(1-2):61-9.PMID: 8330214 [PubMed - indexed for MEDLINE]Related articles

Time- and temperature-dependent forebrain ischemic damage in Mongolian gerbils.

Jensen LH, Møller A.

Acta Neurol Scand. 1992 Mar;85(3):187-90.PMID: 1575001 [PubMed - indexed for MEDLINE]Related articles

The structure of water in protein crystals.

Jensen LH.

Dev Biol Stand. 1992;74:53-61.PMID: 1592185 [PubMed - indexed for MEDLINE]Related articles