PubMed

Mechanisms of platelet activation: need for new strategies to protect against platelet-mediated atherothrombosis.

Jennings LK.

Thromb Haemost. 2009 Aug;102(2):248-57. Review.PMID: 19652875 [PubMed - indexed for MEDLINE]Related articles

Variability of platelet aggregate dispersal with glycoprotein IIb-IIIa antagonists eptifibatide and abciximab.

Speich HE, Earhart AD, Hill SN, Cholera S, Kueter TJ, Smith JN, White MM, Jennings LK.

J Thromb Haemost. 2009 Jun;7(6):983-91.PMID: 19548907 [PubMed - indexed for MEDLINE]Related articles

Regulation of CD40L (CD154) and CD62P (p-selectin) Surface Expression upon GPIIb-IIIa Blockade of Platelets from Stable Coronary Artery Disease Patients.

Chandler AB, Earhart AD, Speich HE, Kueter TJ, Hansen J, White MM, Jennings LK.

Thromb Res. 2009 May 30. [Epub ahead of print]PMID: 19487018 [PubMed - as supplied by publisher]Related articles

Proteomic and transcriptomic analyses reveal genes upregulated by cis-dichloroethene in Polaromonas sp. strain JS666.

Jennings LK, Chartrand MM, Lacrampe-Couloume G, Lollar BS, Spain JC, Gossett JM.

Appl Environ Microbiol. 2009 Jun;75(11):3733-44. Epub 2009 Apr 10.PMID: 19363075 [PubMed - indexed for MEDLINE]Related articlesFree article

Safety and tolerability of SCH 530348 in patients undergoing non-urgent percutaneous coronary intervention: a randomised, double-blind, placebo-controlled phase II study.

Becker RC, Moliterno DJ, Jennings LK, Pieper KS, Pei J, Niederman A, Ziada KM, Berman G, Strony J, Joseph D, Mahaffey KW, Van de Werf F, Veltri E, Harrington RA; TRA-PCI Investigators.

Lancet. 2009 Mar 14;373(9667):919-28.PMID: 19286091 [PubMed - indexed for MEDLINE]Related articles

Variability in platelet response to the antiplatelet agents aspirin and clopidogrel: mechanisms, measurement, and clinical relevance.

Jennings LK.

Crit Pathw Cardiol. 2009 Mar;8(1):20-8. Review.PMID: 19258834 [PubMed - indexed for MEDLINE]Related articles

Tetraspanins and vascular functions.

Zhang F, Kotha J, Jennings LK, Zhang XA.

Cardiovasc Res. 2009 Jul 1;83(1):7-15. Epub 2009 Feb 27. Review.PMID: 19251723 [PubMed - indexed for MEDLINE]Related articles

Advances in antiplatelet therapy: agents in clinical development.

Angiolillo DJ, Bhatt DL, Gurbel PA, Jennings LK.

Am J Cardiol. 2009 Feb 2;103(3 Suppl):40A-51A. Review.PMID: 19166712 [PubMed - indexed for MEDLINE]Related articles

Role of platelets in atherothrombosis.

Jennings LK.

Am J Cardiol. 2009 Feb 2;103(3 Suppl):4A-10A. Review.PMID: 19166707 [PubMed - indexed for MEDLINE]Related articles

Functional relevance of tetraspanin CD9 in vascular smooth muscle cell injury phenotypes: a novel target for the prevention of neointimal hyperplasia.

Kotha J, Zhang C, Longhurst CM, Lu Y, Jacobs J, Cheng Y, Jennings LK.

Atherosclerosis. 2009 Apr;203(2):377-86. Epub 2008 Aug 8.PMID: 18799160 [PubMed - indexed for MEDLINE]Related articles

Platelets undergo phosphorylation of Syk at Y525/526 and Y352 in response to pathophysiological shear stress.

Speich HE, Grgurevich S, Kueter TJ, Earhart AD, Slack SM, Jennings LK.

Am J Physiol Cell Physiol. 2008 Oct;295(4):C1045-54. Epub 2008 Aug 20.PMID: 18715989 [PubMed - indexed for MEDLINE]Related articlesFree article

Antiplatelet and anticoagulant agents: key differences in mechanisms of action, clinical application, and therapeutic benefit in patients with non-ST-segment-elevation acute coronary syndromes.

Jennings LK, Saucedo JF.

Curr Opin Cardiol. 2008 Jul;23(4):302-8. Review.PMID: 18520712 [PubMed - indexed for MEDLINE]Related articles

Tetraspanin CD9 regulates beta 1 integrin activation and enhances cell motility to fibronectin via a PI-3 kinase-dependent pathway.

Kotha J, Longhurst C, Appling W, Jennings LK.

Exp Cell Res. 2008 May 1;314(8):1811-22. Epub 2008 Feb 9.PMID: 18358474 [PubMed - indexed for MEDLINE]Related articles

Dosing of clopidogrel for platelet inhibition in infants and young children: primary results of the Platelet Inhibition in Children On cLOpidogrel (PICOLO) trial.

Li JS, Yow E, Berezny KY, Bokesch PM, Takahashi M, Graham TP Jr, Sanders SP, Sidi D, Bonnet D, Ewert P, Jennings LK, Michelson AD; PICOLO Investigators.

Circulation. 2008 Jan 29;117(4):553-9. Epub 2008 Jan 14.PMID: 18195173 [PubMed - indexed for MEDLINE]Related articlesFree article

Preoperative platelet inhibition with eptifibatide during coronary artery bypass grafting with cardiopulmonary bypass.

Dyke CM, Jennings LK, Maier G, Andreou C, Daly R, Tamberella MR 3rd.

J Cardiovasc Pharmacol Ther. 2007 Mar;12(1):54-60.PMID: 17495258 [PubMed - indexed for MEDLINE]Related articles

Association between thrombolysis in myocardial infarction myocardial perfusion grade, biomarkers, and clinical outcomes among patients with moderate- to high-risk acute coronary syndromes: observations from the randomized trial to evaluate the relative PROTECTion against post-PCI microvascular dysfunction and post-PCI ischemia among antiplatelet and antithrombotic agents-Thrombolysis In Myocardial Infarction 30 (PROTECT-TIMI 30).

Gibson CM, Kirtane AJ, Morrow DA, Palabrica TM, Murphy SA, Stone PH, Scirica BM, Jennings LK, Herrmann HC, Cohen DJ, McCabe CH, Braunwald E; TIMI Study Group.

Am Heart J. 2006 Oct;152(4):756-61.PMID: 16996854 [PubMed - indexed for MEDLINE]Related articles

Current strategies with eptifibatide and other antiplatelet agents in percutaneous coronary intervention and acute coronary syndromes.

Jennings LK.

Expert Opin Drug Metab Toxicol. 2005 Dec;1(4):727-37. Review.PMID: 16863436 [PubMed - indexed for MEDLINE]Related articles

A randomized trial to evaluate the relative protection against post-percutaneous coronary intervention microvascular dysfunction, ischemia, and inflammation among antiplatelet and antithrombotic agents: the PROTECT-TIMI-30 trial.

Gibson CM, Morrow DA, Murphy SA, Palabrica TM, Jennings LK, Stone PH, Lui HH, Bulle T, Lakkis N, Kovach R, Cohen DJ, Fish P, McCabe CH, Braunwald E; TIMI Study Group.

J Am Coll Cardiol. 2006 Jun 20;47(12):2364-73.PMID: 16781360 [PubMed - indexed for MEDLINE]Related articles

L-arginine chlorination results in the formation of a nonselective nitric-oxide synthase inhibitor.

Yang J, Ji R, Cheng Y, Sun JZ, Jennings LK, Zhang C.

J Pharmacol Exp Ther. 2006 Sep;318(3):1044-9. Epub 2006 May 22.PMID: 16717106 [PubMed - indexed for MEDLINE]Related articlesFree article

Comparison of effects of bare metal versus drug-eluting stent implantation on biomarker levels following percutaneous coronary intervention for non-ST-elevation acute coronary syndrome.

Gibson CM, Karmpaliotis D, Kosmidou I, Murphy SA, Kirtane AJ, Budiu D, Ray KK, Herrmann HC, Lakkis N, Kovach R, French W, Blankenship J, Lui HH, Palabrica T, Jennings LK, Cohen DJ, Morrow DA; TIMI Study Group.

Am J Cardiol. 2006 May 15;97(10):1473-7. Epub 2006 Mar 29.PMID: 16679086 [PubMed - indexed for MEDLINE]Related articles

Rapamycin-coated expanded polytetrafluoroethylene bypass grafts exhibit decreased anastomotic neointimal hyperplasia in a porcine model.

Cagiannos C, Abul-Khoudoud OR, DeRijk W, Shell DH 4th, Jennings LK, Tolley EA, Handorf CR, Fabian TC.

J Vasc Surg. 2005 Nov;42(5):980-8.PMID: 16275457 [PubMed - indexed for MEDLINE]Related articles

The use of the point of care Helena ICHOR/Plateletworks and the Accumetrics Ultegra RPFA for assessment of platelet function with GPIIB-IIIa antagonists.

White MM, Krishnan R, Kueter TJ, Jacoski MV, Jennings LK.

J Thromb Thrombolysis. 2004 Dec;18(3):163-9.PMID: 15815877 [PubMed - indexed for MEDLINE]Related articles

Comparative pharmacodynamic evaluation of eptifibatide and abciximab in patients with non-ST-segment elevation acute coronary syndromes: the TAM2 study.

Saucedo JF, Lui HK, Garza L, Guerra GJ, Jacoski MV, Jennings LK.

J Thromb Thrombolysis. 2004 Oct;18(2):67-74. Erratum in: J Thromb Thrombolysis. 2005 Apr;19(2):139. Dosage error in published abstract; MEDLINE/PubMed abstract corrected. PMID: 15789173 [PubMed - indexed for MEDLINE]Related articles

The beta3 subunit of the integrin alphaIIbbeta3 regulates alphaIIb-mediated outside-in signaling.

Liu J, Jackson CW, Gruppo RA, Jennings LK, Gartner TK.

Blood. 2005 Jun 1;105(11):4345-52. Epub 2005 Feb 8.PMID: 15701721 [PubMed - indexed for MEDLINE]Related articlesFree article

Tetraspanin CD82 attenuates cellular morphogenesis through down-regulating integrin alpha6-mediated cell adhesion.

He B, Liu L, Cook GA, Grgurevich S, Jennings LK, Zhang XA.

J Biol Chem. 2005 Feb 4;280(5):3346-54. Epub 2004 Nov 19.PMID: 15557282 [PubMed - indexed for MEDLINE]Related articlesFree article

Leukocyte-derived myeloperoxidase amplifies high-glucose--induced endothelial dysfunction through interaction with high-glucose--stimulated, vascular non--leukocyte-derived reactive oxygen species.

Zhang C, Yang J, Jennings LK.

Diabetes. 2004 Nov;53(11):2950-9.PMID: 15504976 [PubMed - indexed for MEDLINE]Related articlesFree article

Association between platelet receptor occupancy after eptifibatide (integrilin) therapy and patency, myocardial perfusion, and ST-segment resolution among patients with ST-segment-elevation myocardial infarction: an INTEGRITI (Integrilin and Tenecteplase in Acute Myocardial Infarction) substudy.

Gibson CM, Jennings LK, Murphy SA, Lorenz DP, Giugliano RP, Harrington RA, Cholera S, Krishnan R, Califf RM, Braunwald E; INTEGRITI Study Group.

Circulation. 2004 Aug 10;110(6):679-84. Epub 2004 Jul 19.PMID: 15262838 [PubMed - indexed for MEDLINE]Related articlesFree article

Comparative pharmacodynamic evaluation of eptifibatide and tirofiban HCl in patients undergoing percutaneous coronary intervention (the TAM1 Study).

Saucedo JF, Garza L, Wolford DC, Cook SL, Ramanathan KB, Matin Z, McGrew FA, Jacoski MV, Jennings LK; Tennessee-Arkansas-Mississippi (TAM) Clinical Research Consortium.

Am J Cardiol. 2004 May 15;93(10):1279-82.PMID: 15135704 [PubMed - indexed for MEDLINE]Related articles

Attenuation of neointima formation through the inhibition of DNA repair enzyme PARP-1 in balloon-injured rat carotid artery.

Zhang C, Yang J, Jennings LK.

Am J Physiol Heart Circ Physiol. 2004 Aug;287(2):H659-66. Epub 2004 Mar 25.PMID: 15044192 [PubMed - indexed for MEDLINE]Related articlesFree article

Interaction of myeloperoxidase with vascular NAD(P)H oxidase-derived reactive oxygen species in vasculature: implications for vascular diseases.

Zhang C, Yang J, Jacobs JD, Jennings LK.

Am J Physiol Heart Circ Physiol. 2003 Dec;285(6):H2563-72.PMID: 14613914 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of in vitro cholesterol depletion in mediating human platelet aggregation.

Grgurevich S, Krishnan R, White MM, Jennings LK.

J Thromb Haemost. 2003 Mar;1(3):576-86.PMID: 12871469 [PubMed - indexed for MEDLINE]Related articles

Comparison of shear stress-induced platelet microparticle formation and phosphatidylserine expression in presence of alphaIIbbeta3 antagonists.

Haga JH, Slack SM, Jennings LK.

J Cardiovasc Pharmacol. 2003 Mar;41(3):363-71.PMID: 12605014 [PubMed - indexed for MEDLINE]Related articles

Inhibition of shear-stress-induced platelet aggregation and phosphotyrosine signaling by GPIIb-IIIa antagonists.

Haga JH, Jennings LK, Slack SM.

Ann Biomed Eng. 2002 Nov-Dec;30(10):1262-72.PMID: 12540202 [PubMed - indexed for MEDLINE]Related articles

Thiol alkylation inhibits the mitogenic effects of platelet-derived growth factor and renders it proapoptotic via activation of STATs and p53 and induction of expression of caspase1 and p21(waf1/cip1).

Bhanoori M, Yellaturu CR, Ghosh SK, Hassid A, Jennings LK, Rao GN.

Oncogene. 2003 Jan 9;22(1):117-30.PMID: 12527914 [PubMed - indexed for MEDLINE]Related articles

Identification of CD9 extracellular domains important in regulation of CHO cell adhesion to fibronectin and fibronectin pericellular matrix assembly.

Cook GA, Longhurst CM, Grgurevich S, Cholera S, Crossno JT Jr, Jennings LK.

Blood. 2002 Dec 15;100(13):4502-11.PMID: 12453879 [PubMed - indexed for MEDLINE]Related articlesFree article

Short-term administration of basic fibroblast growth factor enhances coronary collateral development without exacerbating atherosclerosis and balloon injury-induced vasoproliferation in atherosclerotic rabbits with acute myocardial infarction.

Zhang C, Yang J, Feng J, Jennings LK.

J Lab Clin Med. 2002 Aug;140(2):119-25.PMID: 12228768 [PubMed - indexed for MEDLINE]Related articles

A potential role for nuclear factor of activated T-cells in receptor tyrosine kinase and G-protein-coupled receptor agonist-induced cell proliferation.

Yellaturu CR, Ghosh SK, Rao RK, Jennings LK, Hassid A, Rao GN.

Biochem J. 2002 Nov 15;368(Pt 1):183-90.PMID: 12188924 [PubMed - indexed for MEDLINE]Related articlesFree article

Chinese hamster ovary cell motility to fibronectin is modulated by the second extracellular loop of CD9. Identification of a putative fibronectin binding site.

Longhurst CM, Jacobs JD, White MM, Crossno JT Jr, Fitzgerald DA, Bao J, Fitzgerald TJ, Raghow R, Jennings LK.

J Biol Chem. 2002 Sep 6;277(36):32445-52. Epub 2002 Jun 14.PMID: 12068019 [PubMed - indexed for MEDLINE]Related articlesFree article

The pharmacodynamics of parenteral glycoprotein IIb/IIIa inhibitors.

Jennings LK, Jacoski MV, White MM.

J Interv Cardiol. 2002 Feb;15(1):45-60. Review.PMID: 12053684 [PubMed - indexed for MEDLINE]Related articles

Clinical pharmacology of higher dose eptifibatide in percutaneous coronary intervention (the PRIDE study).

Tcheng JE, Talley JD, O'Shea JC, Gilchrist IC, Kleiman NS, Grines CL, Davidson CJ, Lincoff AM, Califf RM, Jennings LK, Kitt MM, Lorenz TJ.

Am J Cardiol. 2001 Nov 15;88(10):1097-102.PMID: 11703951 [PubMed - indexed for MEDLINE]Related articles

Pharmacodynamics and pharmacokinetics of higher-dose, double-bolus eptifibatide in percutaneous coronary intervention.

Gilchrist IC, O'Shea JC, Kosoglou T, Jennings LK, Lorenz TJ, Kitt MM, Kleiman NS, Talley D, Aguirre F, Davidson C, Runyon J, Tcheng JE.

Circulation. 2001 Jul 24;104(4):406-11.PMID: 11468201 [PubMed - indexed for MEDLINE]Related articlesFree article

Pharmacodynamics and pharmacokinetics of eptifibatide in patients with acute coronary syndromes: prospective analysis from PURSUIT.

Tardiff BE, Jennings LK, Harrington RA, Gretler D, Potthoff RF, Vorchheimer DA, Eisenberg PR, Lincoff AM, Labinaz M, Joseph DM, McDougal MF, Kleiman NS; PERIGEE Investigators.

Circulation. 2001 Jul 24;104(4):399-405.PMID: 11468200 [PubMed - indexed for MEDLINE]Related articlesFree article

Rapid assessment of glycoprotein IIb/IIIa blockade with the platelet function analyzer (PFA-100) during percutaneous coronary intervention.

Madan M, Berkowitz SD, Christie DJ, Jennings LK, Smit AC, Sigmon KN, Glazer S, Tcheng JE.

Am Heart J. 2001 Feb;141(2):226-33.PMID: 11174336 [PubMed - indexed for MEDLINE]Related articles

Differential expression of a ligand induced binding site (LIBS) by GPIIb-IIIa ligand recognition peptides and parenteral antagonists.

Jennings LK, Haga JH, Slack SM.

Thromb Haemost. 2000 Dec;84(6):1095-102.PMID: 11154119 [PubMed - indexed for MEDLINE]Related articles

Active GPIIb-IIIa conformations that link ligand interaction with cytoskeletal reorganization.

Mondoro TH, White MM, Jennings LK.

Blood. 2000 Oct 1;96(7):2487-95.PMID: 11001901 [PubMed - indexed for MEDLINE]Related articlesFree article

First report of an intravenous and oral glycoprotein IIb/IIIa inhibitor (RPR 109891) in patients with recent acute coronary syndromes: results of the TIMI 15A and 15B trials.

Giugliano RP, McCabe CH, Sequeira RF, Frey MJ, Henry TD, Piana RN, Tamby JF, Jensen BK, Nicolas SB, Jennings LK, Wise RJ, Braunwald E.

Am Heart J. 2000 Jul;140(1):81-93.PMID: 10874267 [PubMed - indexed for MEDLINE]Related articles

The tetraspanin CD9 influences the adhesion, spreading, and pericellular fibronectin matrix assembly of Chinese hamster ovary cells on human plasma fibronectin.

Cook GA, Wilkinson DA, Crossno JT Jr, Raghow R, Jennings LK.

Exp Cell Res. 1999 Sep 15;251(2):356-71.PMID: 10471321 [PubMed - indexed for MEDLINE]Related articles

A CD9, alphaIIbbeta3, integrin-associated protein, and GPIb/V/IX complex on the surface of human platelets is influenced by alphaIIbbeta3 conformational states.

Longhurst CM, White MM, Wilkinson DA, Jennings LK.

Eur J Biochem. 1999 Jul;263(1):104-11.PMID: 10429193 [PubMed - indexed for MEDLINE]Related articlesFree article

A Ser162-->Leu mutation within glycoprotein (GP) IIIa (integrin beta3) results in an unstable alphaIIbbeta3 complex that retains partial function in a novel form of type II Glanzmann thrombasthenia.

Jackson DE, White MM, Jennings LK, Newman PJ.

Thromb Haemost. 1998 Jul;80(1):42-8.PMID: 9684783 [PubMed - indexed for MEDLINE]Related articles

Integrin-mediated signal transduction.

Longhurst CM, Jennings LK.

Cell Mol Life Sci. 1998 Jun;54(6):514-26. Review.PMID: 9676571 [PubMed - indexed for MEDLINE]Related articles