PubMed

Organ dysfunction is associated with hyperglycemia in critically ill children.

Kyle UG, Coss Bu JA, Kennedy CE, Jefferson LS.

Intensive Care Med. 2009 Oct 31. [Epub ahead of print]PMID: 19882139 [PubMed - as supplied by publisher]Related articles

Glucagon acts in a dominant manner to repress insulin-induced mammalian target of rapamycin complex 1 signaling in perfused rat liver.

Baum JI, Kimball SR, Jefferson LS.

Am J Physiol Endocrinol Metab. 2009 Aug;297(2):E410-5. Epub 2009 Jun 9.PMID: 19509187 [PubMed - indexed for MEDLINE]Related articles

eIF2{alpha} kinases GCN2 and PERK modulate transcription and translation of distinct sets of mRNAs in mouse liver.

Dang Do AN, Kimball SR, Cavener DR, Jefferson LS.

Physiol Genomics. 2009 Aug 7;38(3):328-41. Epub 2009 Jun 9.PMID: 19509078 [PubMed - in process]Related articles

Elevated corticosterone associated with food deprivation upregulates expression in rat skeletal muscle of the mTORC1 repressor, REDD1.

McGhee NK, Jefferson LS, Kimball SR.

J Nutr. 2009 May;139(5):828-34. Epub 2009 Mar 18.PMID: 19297425 [PubMed - indexed for MEDLINE]Related articles

Hydrogen peroxide impairs insulin-stimulated assembly of mTORC1.

Zhang L, Kimball SR, Jefferson LS, Shenberger JS.

Free Radic Biol Med. 2009 Jun 1;46(11):1500-9. Epub 2009 Mar 10.PMID: 19281842 [PubMed - in process]Related articles

Automated external defibrillators and simulated in-hospital cardiac arrests.

Rossano JW, Jefferson LS, Smith EO, Ward MA, Mott AR.

J Pediatr. 2009 May;154(5):672-6. Epub 2009 Jan 23.PMID: 19167721 [PubMed - indexed for MEDLINE]Related articles

ATF4 is necessary and sufficient for ER stress-induced upregulation of REDD1 expression.

Whitney ML, Jefferson LS, Kimball SR.

Biochem Biophys Res Commun. 2009 Feb 6;379(2):451-5. Epub 2008 Dec 27.PMID: 19114033 [PubMed - indexed for MEDLINE]Related articles

Reduced eukaryotic initiation factor 2Bepsilon-subunit expression suppresses the transformed phenotype of cells overexpressing the protein.

Gallagher JW, Kubica N, Kimball SR, Jefferson LS.

Cancer Res. 2008 Nov 1;68(21):8752-60.PMID: 18974117 [PubMed - indexed for MEDLINE]Related articlesFree article

Fed-state clamp stimulates cellular mechanisms of muscle protein anabolism and modulates glucose disposal in normal men.

Adegoke OA, Chevalier S, Morais JA, Gougeon R, Kimball SR, Jefferson LS, Wing SS, Marliss EB.

Am J Physiol Endocrinol Metab. 2009 Jan;296(1):E105-13. Epub 2008 Oct 28.PMID: 18957614 [PubMed - indexed for MEDLINE]Related articles

Portal infusion of amino acids is more efficient than peripheral infusion in stimulating liver protein synthesis at the same hepatic amino acid load in dogs.

Dardevet D, Kimball SR, Jefferson LS, Cherrington AD, Rémond D, DiCostanzo CA, Moore MC.

Am J Clin Nutr. 2008 Oct;88(4):986-96.PMID: 18842785 [PubMed - indexed for MEDLINE]Related articlesFree article

Post hoc analysis of calfactant use in immunocompromised children with acute lung injury: Impact and feasibility of further clinical trials.

Tamburro RF, Thomas NJ, Pon S, Jacobs BR, Dicarlo JV, Markovitz BP, Jefferson LS, Willson DF; Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network.

Pediatr Crit Care Med. 2008 Sep;9(5):459-64.PMID: 18679142 [PubMed - indexed for MEDLINE]Related articles

AMPK represses TOP mRNA translation but not global protein synthesis in liver.

Reiter AK, Bolster DR, Crozier SJ, Kimball SR, Jefferson LS.

Biochem Biophys Res Commun. 2008 Sep 19;374(2):345-50. Epub 2008 Jul 16.PMID: 18638456 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin signaling in skeletal muscle and liver of neonatal pigs during endotoxemia.

Orellana RA, Suryawan A, Kimball SR, Wu G, Nguyen HV, Jefferson LS, Davis TA.

Pediatr Res. 2008 Nov;64(5):505-10.PMID: 18596577 [PubMed - indexed for MEDLINE]Related articlesFree article

Activation of the mammalian target of rapamycin complex 1 is both necessary and sufficient to stimulate eukaryotic initiation factor 2Bvarepsilon mRNA translation and protein synthesis.

Kubica N, Crispino JL, Gallagher JW, Kimball SR, Jefferson LS.

Int J Biochem Cell Biol. 2008;40(11):2522-33. Epub 2008 May 15.PMID: 18556237 [PubMed - indexed for MEDLINE]Related articlesFree article

Melatonin represses oxidative stress-induced activation of the MAP kinase and mTOR signaling pathways in H4IIE hepatoma cells through inhibition of Ras.

Kimball SR, Abbas A, Jefferson LS.

J Pineal Res. 2008 May;44(4):379-86.PMID: 18410586 [PubMed - indexed for MEDLINE]Related articlesFree article

A validated pediatric transport survey: how is your team performing?

McPherson ML, Jefferson LS, Graf JM.

Air Med J. 2008 Jan-Feb;27(1):40-5.PMID: 18191088 [PubMed - indexed for MEDLINE]Related articles

Rapid turnover of the mTOR complex 1 (mTORC1) repressor REDD1 and activation of mTORC1 signaling following inhibition of protein synthesis.

Kimball SR, Do AN, Kutzler L, Cavener DR, Jefferson LS.

J Biol Chem. 2008 Feb 8;283(6):3465-75. Epub 2007 Dec 10.PMID: 18070882 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of alpha-difluoromethylornithine on thrombospondin-1 production by human breast cancer cells.

Manni A, Rager T, Kimball SR, Jefferson LS, Washington S, Hu X, Verderame MF.

Int J Oncol. 2007 Nov;31(5):1187-91.PMID: 17912446 [PubMed - indexed for MEDLINE]Related articles

Family experiences during resuscitation at a children's hospital emergency department.

McGahey-Oakland PR, Lieder HS, Young A, Jefferson LS.

J Pediatr Health Care. 2007 Jul-Aug;21(4):217-25.PMID: 17606158 [PubMed - indexed for MEDLINE]Related articles

Reverse transport of children from a tertiary pediatric hospital.

McPherson ML, Jefferson LS, Smith EO, Sitler GC, Graf JM.

Air Med J. 2007 Jul-Aug;26(4):183-7.PMID: 17603946 [PubMed - indexed for MEDLINE]Related articles

Retrograde nuclear accumulation of cytoplasmic tRNA in rat hepatoma cells in response to amino acid deprivation.

Shaheen HH, Horetsky RL, Kimball SR, Murthi A, Jefferson LS, Hopper AK.

Proc Natl Acad Sci U S A. 2007 May 22;104(21):8845-50. Epub 2007 May 14.PMID: 17502605 [PubMed - indexed for MEDLINE]Related articlesFree article

Institutional policies on determination of medically inappropriate interventions: use in five pediatric patients.

Okhuysen-Cawley R, McPherson ML, Jefferson LS.

Pediatr Crit Care Med. 2007 May;8(3):225-30.PMID: 17417128 [PubMed - indexed for MEDLINE]Related articles

Modified RIFLE criteria in critically ill children with acute kidney injury.

Akcan-Arikan A, Zappitelli M, Loftis LL, Washburn KK, Jefferson LS, Goldstein SL.

Kidney Int. 2007 May;71(10):1028-35. Epub 2007 Mar 28.PMID: 17396113 [PubMed - indexed for MEDLINE]Related articles

Rapamycin blunts nutrient stimulation of eIF4G, but not PKCepsilon phosphorylation, in skeletal muscle.

Vary TC, Anthony JC, Jefferson LS, Kimball SR, Lynch CJ.

Am J Physiol Endocrinol Metab. 2007 Jul;293(1):E188-96. Epub 2007 Mar 27.PMID: 17389711 [PubMed - indexed for MEDLINE]Related articlesFree article

AMP-activated protein kinase agonists increase mRNA content of the muscle-specific ubiquitin ligases MAFbx and MuRF1 in C2C12 cells.

Krawiec BJ, Nystrom GJ, Frost RA, Jefferson LS, Lang CH.

Am J Physiol Endocrinol Metab. 2007 Jun;292(6):E1555-67. Epub 2007 Jan 30.PMID: 17264220 [PubMed - indexed for MEDLINE]Related articlesFree article

Dexamethasone represses signaling through the mammalian target of rapamycin in muscle cells by enhancing expression of REDD1.

Wang H, Kubica N, Ellisen LW, Jefferson LS, Kimball SR.

J Biol Chem. 2006 Dec 22;281(51):39128-34. Epub 2006 Oct 30.PMID: 17074751 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin stimulates muscle protein synthesis in neonates during endotoxemia despite repression of translation initiation.

Orellana RA, Kimball SR, Suryawan A, Escobar J, Nguyen HV, Jefferson LS, Davis TA.

Am J Physiol Endocrinol Metab. 2007 Feb;292(2):E629-36. Epub 2006 Oct 17.PMID: 17047163 [PubMed - indexed for MEDLINE]Related articlesFree article

Endotoxin and cisplatin synergistically stimulate TNF-alpha production by renal epithelial cells.

Ramesh G, Kimball SR, Jefferson LS, Reeves WB.

Am J Physiol Renal Physiol. 2007 Feb;292(2):F812-9. Epub 2006 Oct 10.PMID: 17032936 [PubMed - indexed for MEDLINE]Related articlesFree article

Hormone, cytokine, and nutritional regulation of sepsis-induced increases in atrogin-1 and MuRF1 in skeletal muscle.

Frost RA, Nystrom GJ, Jefferson LS, Lang CH.

Am J Physiol Endocrinol Metab. 2007 Feb;292(2):E501-12. Epub 2006 Sep 26.PMID: 17003238 [PubMed - indexed for MEDLINE]Related articlesFree article

Diabetic retinopathy: seeing beyond glucose-induced microvascular disease.

Antonetti DA, Barber AJ, Bronson SK, Freeman WM, Gardner TW, Jefferson LS, Kester M, Kimball SR, Krady JK, LaNoue KF, Norbury CC, Quinn PG, Sandirasegarane L, Simpson IA; JDRF Diabetic Retinopathy Center Group.

Diabetes. 2006 Sep;55(9):2401-11.PMID: 16936187 [PubMed - indexed for MEDLINE]Related articlesFree article

Eukaryotic initiation factor 2B and its role in alterations in mRNA translation that occur under a number of pathophysiological and physiological conditions.

Kubica N, Jefferson LS, Kimball SR.

Prog Nucleic Acid Res Mol Biol. 2006;81:271-96. Review. No abstract available. PMID: 16891174 [PubMed - indexed for MEDLINE]Related articles

Time course changes in signaling pathways and protein synthesis in C2C12 myotubes following AMPK activation by AICAR.

Williamson DL, Bolster DR, Kimball SR, Jefferson LS.

Am J Physiol Endocrinol Metab. 2006 Jul;291(1):E80-9.PMID: 16760336 [PubMed - indexed for MEDLINE]Related articlesFree article

Activation of signaling pathways and regulatory mechanisms of mRNA translation following myocardial ischemia-reperfusion.

Crozier SJ, Zhang X, Wang J, Cheung J, Kimball SR, Jefferson LS.

J Appl Physiol. 2006 Aug;101(2):576-82. Epub 2006 May 11.PMID: 16690784 [PubMed - indexed for MEDLINE]Related articlesFree article

Exercise-induced alterations in extracellular signal-regulated kinase 1/2 and mammalian target of rapamycin (mTOR) signalling to regulatory mechanisms of mRNA translation in mouse muscle.

Williamson DL, Kubica N, Kimball SR, Jefferson LS.

J Physiol. 2006 Jun 1;573(Pt 2):497-510. Epub 2006 Mar 16.PMID: 16543272 [PubMed - indexed for MEDLINE]Related articlesFree article

New functions for amino acids: effects on gene transcription and translation.

Kimball SR, Jefferson LS.

Am J Clin Nutr. 2006 Feb;83(2):500S-507S. Review.PMID: 16470021 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of mammalian translation initiation by volatile anesthetics.

Palmer LK, Rannels SL, Kimball SR, Jefferson LS, Keil RL.

Am J Physiol Endocrinol Metab. 2006 Jun;290(6):E1267-75. Epub 2006 Jan 24.PMID: 16434554 [PubMed - indexed for MEDLINE]Related articlesFree article

Signaling pathways and molecular mechanisms through which branched-chain amino acids mediate translational control of protein synthesis.

Kimball SR, Jefferson LS.

J Nutr. 2006 Jan;136(1 Suppl):227S-31S. Review.PMID: 16365087 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucosamine-induced phosphorylation of the alpha-subunit of eukaryotic initiation factor 2 is mediated by the protein kinase R-like endoplasmic-reticulum associated kinase.

Kline CL, Schrufer TL, Jefferson LS, Kimball SR.

Int J Biochem Cell Biol. 2006;38(5-6):1004-14. Epub 2005 Nov 16.PMID: 16324875 [PubMed - indexed for MEDLINE]Related articles

Regulation of cardiac and skeletal muscle protein synthesis by individual branched-chain amino acids in neonatal pigs.

Escobar J, Frank JW, Suryawan A, Nguyen HV, Kimball SR, Jefferson LS, Davis TA.

Am J Physiol Endocrinol Metab. 2006 Apr;290(4):E612-21. Epub 2005 Nov 8.PMID: 16278252 [PubMed - indexed for MEDLINE]Related articlesFree article

Dietary protein and lactose increase translation initiation factor activation and tissue protein synthesis in neonatal pigs.

Frank JW, Escobar J, Suryawan A, Nguyen HV, Kimball SR, Jefferson LS, Davis TA.

Am J Physiol Endocrinol Metab. 2006 Feb;290(2):E225-33. Epub 2005 Sep 6.PMID: 16144813 [PubMed - indexed for MEDLINE]Related articlesFree article

Hindlimb casting decreases muscle mass in part by proteasome-dependent proteolysis but independent of protein synthesis.

Krawiec BJ, Frost RA, Vary TC, Jefferson LS, Lang CH.

Am J Physiol Endocrinol Metab. 2005 Dec;289(6):E969-80. Epub 2005 Jul 26.PMID: 16046454 [PubMed - indexed for MEDLINE]Related articlesFree article

Protein synthesis and translation initiation factor activation in neonatal pigs fed increasing levels of dietary protein.

Frank JW, Escobar J, Suryawan A, Kimball SR, Nguyen HV, Jefferson LS, Davis TA.

J Nutr. 2005 Jun;135(6):1374-81.PMID: 15930440 [PubMed - indexed for MEDLINE]Related articlesFree article

Cellular energy status modulates translational control mechanisms in ischemic-reperfused rat hearts.

Crozier SJ, Vary TC, Kimball SR, Jefferson LS.

Am J Physiol Heart Circ Physiol. 2005 Sep;289(3):H1242-50. Epub 2005 May 13.PMID: 15894572 [PubMed - indexed for MEDLINE]Related articlesFree article

Risk factors associated with pressure ulcers in the pediatric intensive care unit.

McCord S, McElvain V, Sachdeva R, Schwartz P, Jefferson LS.

J Wound Ostomy Continence Nurs. 2004 Jul-Aug;31(4):179-83.PMID: 15851859 [PubMed - indexed for MEDLINE]Related articles

The 2003 national pediatric pressure ulcer and skin breakdown prevalence survey: a multisite study.

McLane KM, Bookout K, McCord S, McCain J, Jefferson LS.

J Wound Ostomy Continence Nurs. 2004 Jul-Aug;31(4):168-78.PMID: 15851858 [PubMed - indexed for MEDLINE]Related articles

Oral leucine administration stimulates protein synthesis in rat skeletal muscle.

Crozier SJ, Kimball SR, Emmert SW, Anthony JC, Jefferson LS.

J Nutr. 2005 Mar;135(3):376-82.PMID: 15735066 [PubMed - indexed for MEDLINE]Related articlesFree article

Meal feeding alters translational control of gene expression in rat liver.

Reiter AK, Crozier SJ, Kimball SR, Jefferson LS.

J Nutr. 2005 Mar;135(3):367-75.PMID: 15735065 [PubMed - indexed for MEDLINE]Related articlesFree article

Acute treatment with TNF-alpha attenuates insulin-stimulated protein synthesis in cultures of C2C12 myotubes through a MEK1-sensitive mechanism.

Williamson DL, Kimball SR, Jefferson LS.

Am J Physiol Endocrinol Metab. 2005 Jul;289(1):E95-104. Epub 2005 Feb 8.PMID: 15701678 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of exogenous surfactant (calfactant) in pediatric acute lung injury: a randomized controlled trial.

Willson DF, Thomas NJ, Markovitz BP, Bauman LA, DiCarlo JV, Pon S, Jacobs BR, Jefferson LS, Conaway MR, Egan EA; Pediatric Acute Lung Injury and Sepsis Investigators.

JAMA. 2005 Jan 26;293(4):470-6. Erratum in: JAMA. 2005 Aug 24;294(8):900. PMID: 15671432 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of amino acids in the translational control of protein synthesis in mammals.

Kimball SR, Jefferson LS.

Semin Cell Dev Biol. 2005 Feb;16(1):21-7. Epub 2004 Dec 10. Review.PMID: 15659336 [PubMed - indexed for MEDLINE]Related articles