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    Results: 1 to 50 of 227

    1.

    Knockout rats via embryo microinjection of zinc-finger nucleases.

    Geurts AM, Cost GJ, Freyvert Y, Zeitler B, Miller JC, Choi VM, Jenkins SS, Wood A, Cui X, Meng X, Vincent A, Lam S, Michalkiewicz M, Schilling R, Foeckler J, Kalloway S, Weiler H, Ménoret S, Anegon I, Davis GD, Zhang L, Rebar EJ, Gregory PD, Urnov FD, Jacob HJ, Buelow R.

    Science. 2009 Jul 24;325(5939):433.PMID: 19628861 [PubMed - indexed for MEDLINE]Related articles

    2.

    Distinct genetic regulation of progression of diabetes and renal disease in the Goto-Kakizaki rat.

    Nobrega MA, Woods LC, Fleming S, Jacob HJ.

    Physiol Genomics. 2009 Sep 9;39(1):38-46. Epub 2009 Jul 7.PMID: 19584172 [PubMed - in process]Related articles

    3.

    Microalterations of inherently unstable genomic regions in rat mammary carcinomas as revealed by long oligonucleotide array-based comparative genomic hybridization.

    Adamovic T, McAllister D, Guryev V, Wang X, Andrae JW, Cuppen E, Jacob HJ, Sugg SL.

    Cancer Res. 2009 Jun 15;69(12):5159-67. Epub 2009 Jun 9.PMID: 19509235 [PubMed - indexed for MEDLINE]Related articles

    4.

    Rats!

    Iannaccone PM, Jacob HJ.

    Dis Model Mech. 2009 May-Jun;2(5-6):206-10. No abstract available. PMID: 19407324 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    Congenic strains provide evidence that four mapped loci in chromosomes 2, 4, and 16 influence hypertension in the SHR.

    Aneas I, Rodrigues MV, Pauletti BA, Silva GJ, Carmona R, Cardoso L, Kwitek AE, Jacob HJ, Soler JM, Krieger JE.

    Physiol Genomics. 2009 Mar 3;37(1):52-7. Epub 2009 Jan 6.PMID: 19126752 [PubMed - indexed for MEDLINE]Related articles

    6.

    The Rat Genome Database 2009: variation, ontologies and pathways.

    Dwinell MR, Worthey EA, Shimoyama M, Bakir-Gungor B, DePons J, Laulederkind S, Lowry T, Nigram R, Petri V, Smith J, Stoddard A, Twigger SN, Jacob HJ; RGD Team.

    Nucleic Acids Res. 2009 Jan;37(Database issue):D744-9. Epub 2008 Nov 7.PMID: 18996890 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    Genetically hypertensive Brown Norway congenic rat strains suggest intermediate traits underlying genetic hypertension.

    Bilusić M, Moreno C, Barreto NE, Tschannen MR, Harris EL, Porteous WK, Thompson CM, Grigor MR, Weder A, Boerwinkle E, Hunt SC, Curb JD, Jacob HJ, Kwitek AE.

    Croat Med J. 2008 Oct;49(5):586-99.PMID: 18925692 [PubMed - indexed for MEDLINE]Related articlesFree article

    8.

    Transfer of the CYP4A region of chromosome 5 from Lewis to Dahl S rats attenuates renal injury.

    Williams JM, Sarkis A, Hoagland KM, Fredrich K, Ryan RP, Moreno C, Lopez B, Lazar J, Fenoy FJ, Sharma M, Garrett MR, Jacob HJ, Roman RJ.

    Am J Physiol Renal Physiol. 2008 Dec;295(6):F1764-77. Epub 2008 Oct 8.PMID: 18842817 [PubMed - indexed for MEDLINE]Related articles

    9.

    Genetic mapping of mammary tumor traits to rat chromosome 10 using a novel panel of consomic rats.

    Adamovic T, McAllister D, Rowe JJ, Wang T, Jacob HJ, Sugg SL.

    Cancer Genet Cytogenet. 2008 Oct;186(1):41-8.PMID: 18786441 [PubMed - indexed for MEDLINE]Related articles

    10.

    Chromosome substitution reveals the genetic basis of Dahl salt-sensitive hypertension and renal disease.

    Mattson DL, Dwinell MR, Greene AS, Kwitek AE, Roman RJ, Jacob HJ, Cowley AW Jr.

    Am J Physiol Renal Physiol. 2008 Sep;295(3):F837-42. Epub 2008 Jul 23.PMID: 18653478 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    What everybody should know about the rat genome and its online resources.

    Twigger SN, Pruitt KD, Fernández-Suárez XM, Karolchik D, Worley KC, Maglott DR, Brown G, Weinstock G, Gibbs RA, Kent J, Birney E, Jacob HJ.

    Nat Genet. 2008 May;40(5):523-7.PMID: 18443589 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    Progress and prospects in rat genetics: a community view.

    Aitman TJ, Critser JK, Cuppen E, Dominiczak A, Fernandez-Suarez XM, Flint J, Gauguier D, Geurts AM, Gould M, Harris PC, Holmdahl R, Hubner N, Izsvák Z, Jacob HJ, Kuramoto T, Kwitek AE, Marrone A, Mashimo T, Moreno C, Mullins J, Mullins L, Olsson T, Pravenec M, Riley L, Saar K, Serikawa T, Shull JD, Szpirer C, Twigger SN, Voigt B, Worley K.

    Nat Genet. 2008 May;40(5):516-22. Review.PMID: 18443588 [PubMed - indexed for MEDLINE]Related articles

    13.

    Molecular networks in Dahl salt-sensitive hypertension based on transcriptome analysis of a panel of consomic rats.

    Liang M, Lee NH, Wang H, Greene AS, Kwitek AE, Kaldunski ML, Luu TV, Frank BC, Bugenhagen S, Jacob HJ, Cowley AW Jr.

    Physiol Genomics. 2008 Jun 12;34(1):54-64. Epub 2008 Apr 22.PMID: 18430809 [PubMed - indexed for MEDLINE]Related articlesFree article

    14.

    Comparative genomics for detecting human disease genes.

    Moreno C, Lazar J, Jacob HJ, Kwitek AE.

    Adv Genet. 2008;60:655-97. Review.PMID: 18358336 [PubMed - indexed for MEDLINE]Related articles

    15.

    Effects of chromosome 17 on features of the metabolic syndrome in the Lyon hypertensive rat.

    Gilibert S, Kwitek AE, Hubner N, Tschannen M, Jacob HJ, Sassard J, Bataillard A.

    Physiol Genomics. 2008 Apr 22;33(2):212-7. Epub 2008 Feb 19.PMID: 18285521 [PubMed - indexed for MEDLINE]Related articlesFree article

    16.

    Tissue engineering: a new frontier in physiological genomics.

    Petersen MC, Lazar J, Jacob HJ, Wakatsuki T.

    Physiol Genomics. 2007 Dec 19;32(1):28-32. Epub 2007 Oct 23. Review.PMID: 17956999 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    Chromosomal mapping of the genetic basis of hypertension and renal disease in FHH rats.

    Mattson DL, Dwinell MR, Greene AS, Kwitek AE, Roman RJ, Cowley AW Jr, Jacob HJ.

    Am J Physiol Renal Physiol. 2007 Dec;293(6):F1905-14. Epub 2007 Sep 26.PMID: 17898042 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    Multiple blood pressure loci on rat chromosome 13 attenuate development of hypertension in the Dahl S hypertensive rat.

    Moreno C, Kaldunski ML, Wang T, Roman RJ, Greene AS, Lazar J, Jacob HJ, Cowley AW Jr.

    Physiol Genomics. 2007 Oct 22;31(2):228-35. Epub 2007 Jun 12. Erratum in: Physiol Genomics. 2009 Apr;37(2):147. PMID: 17566075 [PubMed - indexed for MEDLINE]Related articlesFree article

    19.

    A locus on chromosome 10 influences C-reactive protein levels in two independent populations.

    Broeckel U, Hengstenberg C, Mayer B, Maresso K, Gaudet D, Seda O, Tremblay J, Holmer S, Erdmann J, Glöckner C, Harrison M, Martin LJ, Williams JT, Schmitz G, Riegger GA, Jacob HJ, Hamet P, Schunkert H.

    Hum Genet. 2007 Aug;122(1):95-102. Epub 2007 May 26.PMID: 17530289 [PubMed - indexed for MEDLINE]Related articles

    20.

    Rat survival to anthrax lethal toxin is likely controlled by a single gene.

    Nye SH, Wittenburg AL, Evans DL, O'Connor JA, Roman RJ, Jacob HJ.

    Pharmacogenomics J. 2008 Feb;8(1):16-22. Epub 2007 Apr 17.PMID: 17440430 [PubMed - indexed for MEDLINE]Related articles

    21.

    Efficient transgenic rat production by a lentiviral vector.

    Michalkiewicz M, Michalkiewicz T, Geurts AM, Roman RJ, Slocum GR, Singer O, Weihrauch D, Greene AS, Kaldunski M, Verma IM, Jacob HJ, Cowley AW Jr.

    Am J Physiol Heart Circ Physiol. 2007 Jul;293(1):H881-94. Epub 2007 Feb 23.PMID: 17322424 [PubMed - indexed for MEDLINE]Related articlesFree article

    22.

    The Rat Genome Database, update 2007--easing the path from disease to data and back again.

    Twigger SN, Shimoyama M, Bromberg S, Kwitek AE, Jacob HJ; RGD Team.

    Nucleic Acids Res. 2007 Jan;35(Database issue):D658-62. Epub 2006 Dec 6.PMID: 17151068 [PubMed - indexed for MEDLINE]Related articlesFree article

    23.

    Comprehensive quality control utilizing the prehybridization third-dye image leads to accurate gene expression measurements by cDNA microarrays.

    Wang X, Jia S, Meyer L, Xiang B, Chen LY, Jiang N, Moreno C, Jacob HJ, Ghosh S, Hessner MJ.

    BMC Bioinformatics. 2006 Aug 14;7:378.PMID: 16907976 [PubMed - indexed for MEDLINE]Related articlesFree article

    24.

    Genetic aspects of the etiology and treatment of asthma.

    Meurer JR, Lustig JV, Jacob HJ.

    Pediatr Clin North Am. 2006 Aug;53(4):715-25. Review.PMID: 16873001 [PubMed - indexed for MEDLINE]Related articles

    25.

    Dickkopf homologs in squamous mucosa of esophagitis patients are overexpressed compared with Barrett's patients and healthy controls.

    Ali I, Rafiee P, Hogan WJ, Jacob HJ, Komorowski RA, Haasler GB, Shaker R.

    Am J Gastroenterol. 2006 Jul;101(7):1437-48.PMID: 16863544 [PubMed - indexed for MEDLINE]Related articles

    26.

    Sequence analysis of the complete mitochondrial DNA in 10 commonly used inbred rat strains.

    Schlick NE, Jensen-Seaman MI, Orlebeke K, Kwitek AE, Jacob HJ, Lazar J.

    Am J Physiol Cell Physiol. 2006 Dec;291(6):C1183-92. Epub 2006 Jul 19.PMID: 16855218 [PubMed - indexed for MEDLINE]Related articlesFree article

    27.
    28.

    Absence of an interaction between the Rf-1 and Rf-5 QTLs influencing susceptibility to renal damage in rats.

    van Dijk SJ, Specht PA, Lazar J, Jacob HJ, Provoost AP.

    Nephron Exp Nephrol. 2006;104(3):e96-e102. Epub 2006 Jul 12.PMID: 16837819 [PubMed - indexed for MEDLINE]Related articles

    29.

    Consomic strategies to localize genomic regions related to vascular reactivity in the Dahl salt-sensitive rat.

    Kunert MP, Drenjancevic-Peric I, Dwinell MR, Lombard JH, Cowley AW Jr, Greene AS, Kwitek AE, Jacob HJ.

    Physiol Genomics. 2006 Aug 16;26(3):218-25. Epub 2006 Jun 13.PMID: 16772359 [PubMed - indexed for MEDLINE]Related articlesFree article

    30.

    Synergistic QTL interactions between Rf-1 and Rf-3 increase renal damage susceptibility in double congenic rats.

    Van Dijk SJ, Specht PA, Lazar J, Jacob HJ, Provoost AP.

    Kidney Int. 2006 Apr;69(8):1369-76.PMID: 16541022 [PubMed - indexed for MEDLINE]Related articles

    31.

    BN phenome: detailed characterization of the cardiovascular, renal, and pulmonary systems of the sequenced rat.

    Kwitek AE, Jacob HJ, Baker JE, Dwinell MR, Forster HV, Greene AS, Kunert MP, Lombard JH, Mattson DL, Pritchard KA Jr, Roman RJ, Tonellato PJ, Cowley AW Jr.

    Physiol Genomics. 2006 Apr 13;25(2):303-13. Epub 2006 Feb 14.PMID: 16478827 [PubMed - indexed for MEDLINE]Related articlesFree article

    32.

    Physiogenomic resources for rat models of heart, lung and blood disorders.

    Malek RL, Wang HY, Kwitek AE, Greene AS, Bhagabati N, Borchardt G, Cahill L, Currier T, Frank B, Fu X, Hasinoff M, Howe E, Letwin N, Luu TV, Saeed A, Sajadi H, Salzberg SL, Sultana R, Thiagarajan M, Tsai J, Veratti K, White J, Quackenbush J, Jacob HJ, Lee NH.

    Nat Genet. 2006 Feb;38(2):234-9. Epub 2006 Jan 15.PMID: 16415889 [PubMed - indexed for MEDLINE]Related articles

    33.

    Characterization of blood pressure and renal function in chromosome 5 congenic strains of Dahl S rats.

    Roman RJ, Hoagland KM, Lopez B, Kwitek AE, Garrett MR, Rapp JP, Lazar J, Jacob HJ, Sarkis A.

    Am J Physiol Renal Physiol. 2006 Jun;290(6):F1463-71. Epub 2006 Jan 5.PMID: 16396943 [PubMed - indexed for MEDLINE]Related articlesFree article

    34.

    Impact of genomics on research in the rat.

    Lazar J, Moreno C, Jacob HJ, Kwitek AE.

    Genome Res. 2005 Dec;15(12):1717-28. Review.PMID: 16339370 [PubMed - indexed for MEDLINE]Related articlesFree article

    35.

    Interaction between Rf-1 and Rf-4 quantitative trait loci increases susceptibility to renal damage in double congenic rats.

    Van Dijk SJ, Specht PA, Lutz MM, Lazar J, Jacob HJ, Provoost AP.

    Kidney Int. 2005 Dec;68(6):2462-72.PMID: 16316323 [PubMed - indexed for MEDLINE]Related articles

    36.

    Identification of a QTL on chromosome 1 for impaired autoregulation of RBF in fawn-hooded hypertensive rats.

    López B, Ryan RP, Moreno C, Sarkis A, Lazar J, Provoost AP, Jacob HJ, Roman RJ.

    Am J Physiol Renal Physiol. 2006 May;290(5):F1213-21. Epub 2005 Nov 22.PMID: 16303858 [PubMed - indexed for MEDLINE]Related articlesFree article

    37.

    Tools and strategies for physiological genomics: the Rat Genome Database.

    Twigger SN, Pasko D, Nie J, Shimoyama M, Bromberg S, Campbell D, Chen J, dela Cruz N, Fan C, Foote C, Harris G, Hickmann B, Ji Y, Jin W, Li D, Mathis J, Nenasheva N, Nigam R, Petri V, Reilly D, Ruotti V, Schauberger E, Seiler K, Slyper R, Smith J, Wang W, Wu W, Zhao L, Zuniga-Meyer A, Tonellato PJ, Kwitek AE, Jacob HJ.

    Physiol Genomics. 2005 Oct 17;23(2):246-56. Epub 2005 Aug 16.PMID: 16106031 [PubMed - indexed for MEDLINE]Related articlesFree article

    38.

    Genome-wide scanning with SSLPs in the rat.

    Moreno C, Kennedy K, Andrae JW, Jacob HJ.

    Methods Mol Med. 2005;108:131-8.PMID: 16028680 [PubMed - indexed for MEDLINE]Related articles

    39.

    Renal damage susceptibility and autoregulation in RF-1 and RF-5 congenic rats.

    Van Dijk SJ, Specht PA, Lazar J, Jacob HJ, Provoost AP.

    Nephron Exp Nephrol. 2005;101(2):e59-66. Epub 2005 Jun 20.PMID: 15976509 [PubMed - indexed for MEDLINE]Related articles

    40.

    Increased resistance to myocardial ischemia in the Brown Norway vs. Dahl S rat: role of nitric oxide synthase and Hsp90.

    Shi Y, Hutchins W, Ogawa H, Chang CC, Pritchard KA Jr, Zhang C, Khampang P, Lazar J, Jacob HJ, Rafiee P, Baker JE.

    J Mol Cell Cardiol. 2005 Apr;38(4):625-35.PMID: 15808839 [PubMed - indexed for MEDLINE]Related articles

    41.

    RF-2 gene modulates proteinuria and albuminuria independently of changes in glomerular permeability in the fawn-hooded hypertensive rat.

    Rangel-Filho A, Sharma M, Datta YH, Moreno C, Roman RJ, Iwamoto Y, Provoost AP, Lazar J, Jacob HJ.

    J Am Soc Nephrol. 2005 Apr;16(4):852-6. Epub 2005 Mar 9. No abstract available. PMID: 15758045 [PubMed - indexed for MEDLINE]Related articlesFree article

    42.

    Distinct heritable patterns of angiographic coronary artery disease in families with myocardial infarction.

    Fischer M, Broeckel U, Holmer S, Baessler A, Hengstenberg C, Mayer B, Erdmann J, Klein G, Riegger G, Jacob HJ, Schunkert H.

    Circulation. 2005 Feb 22;111(7):855-62. Epub 2005 Feb 14.PMID: 15710764 [PubMed - indexed for MEDLINE]Related articlesFree article

    43.

    Genetic determinants on rat chromosome 6 modulate variation in the hypercapnic ventilatory response using consomic strains.

    Dwinell MR, Forster HV, Petersen J, Rider A, Kunert MP, Cowley AW Jr, Jacob HJ.

    J Appl Physiol. 2005 May;98(5):1630-8. Epub 2005 Jan 20.PMID: 15661838 [PubMed - indexed for MEDLINE]Related articlesFree article

    44.

    Substitution of chromosome 1 ameliorates L-NAME hypertension and renal disease in the fawn-hooded hypertensive rat.

    Mattson DL, Kunert MP, Roman RJ, Jacob HJ, Cowley AW Jr.

    Am J Physiol Renal Physiol. 2005 May;288(5):F1015-22. Epub 2005 Jan 11.PMID: 15644486 [PubMed - indexed for MEDLINE]Related articlesFree article

    45.

    Genetic linkage and association of the growth hormone secretagogue receptor (ghrelin receptor) gene in human obesity.

    Baessler A, Hasinoff MJ, Fischer M, Reinhard W, Sonnenberg GE, Olivier M, Erdmann J, Schunkert H, Doering A, Jacob HJ, Comuzzie AG, Kissebah AH, Kwitek AE.

    Diabetes. 2005 Jan;54(1):259-67.PMID: 15616037 [PubMed - indexed for MEDLINE]Related articlesFree article

    46.

    The Collaborative Cross, a community resource for the genetic analysis of complex traits.

    Churchill GA, Airey DC, Allayee H, Angel JM, Attie AD, Beatty J, Beavis WD, Belknap JK, Bennett B, Berrettini W, Bleich A, Bogue M, Broman KW, Buck KJ, Buckler E, Burmeister M, Chesler EJ, Cheverud JM, Clapcote S, Cook MN, Cox RD, Crabbe JC, Crusio WE, Darvasi A, Deschepper CF, Doerge RW, Farber CR, Forejt J, Gaile D, Garlow SJ, Geiger H, Gershenfeld H, Gordon T, Gu J, Gu W, de Haan G, Hayes NL, Heller C, Himmelbauer H, Hitzemann R, Hunter K, Hsu HC, Iraqi FA, Ivandic B, Jacob HJ, Jansen RC, Jepsen KJ, Johnson DK, Johnson TE, Kempermann G, Kendziorski C, Kotb M, Kooy RF, Llamas B, Lammert F, Lassalle JM, Lowenstein PR, Lu L, Lusis A, Manly KF, Marcucio R, Matthews D, Medrano JF, Miller DR, Mittleman G, Mock BA, Mogil JS, Montagutelli X, Morahan G, Morris DG, Mott R, Nadeau JH, Nagase H, Nowakowski RS, O'Hara BF, Osadchuk AV, Page GP, Paigen B, Paigen K, Palmer AA, Pan HJ, Peltonen-Palotie L, Peirce J, Pomp D, Pravenec M, Prows DR, Qi Z, Reeves RH, Roder J, Rosen GD, Schadt EE, Schalkwyk LC, Seltzer Z, Shimomura K, Shou S, Sillanpää MJ, Siracusa LD, Snoeck HW, Spearow JL, Svenson K, Tarantino LM, Threadgill D, Toth LA, Valdar W, de Villena FP, Warden C, Whatley S, Williams RW, Wiltshire T, Yi N, Zhang D, Zhang M, Zou F; Complex Trait Consortium.

    Nat Genet. 2004 Nov;36(11):1133-7.PMID: 15514660 [PubMed - indexed for MEDLINE]Related articles

    47.

    Mapping the genetic determinants of hypertension, metabolic diseases, and related phenotypes in the lyon hypertensive rat.

    Bilusic M, Bataillard A, Tschannen MR, Gao L, Barreto NE, Vincent M, Wang T, Jacob HJ, Sassard J, Kwitek AE.

    Hypertension. 2004 Nov;44(5):695-701. Epub 2004 Sep 27.PMID: 15452030 [PubMed - indexed for MEDLINE]Related articlesFree article

    48.

    Transgenic rescue demonstrates involvement of the Ian5 gene in T cell development in the rat.

    Michalkiewicz M, Michalkiewicz T, Ettinger RA, Rutledge EA, Fuller JM, Moralejo DH, Van Yserloo B, MacMurray AJ, Kwitek AE, Jacob HJ, Lander ES, Lernmark A.

    Physiol Genomics. 2004 Oct 4;19(2):228-32. Epub 2004 Aug 24.PMID: 15328390 [PubMed - indexed for MEDLINE]Related articlesFree article

    49.

    Consomic rat model systems for physiological genomics.

    Cowley AW Jr, Liang M, Roman RJ, Greene AS, Jacob HJ.

    Acta Physiol Scand. 2004 Aug;181(4):585-92. Review.PMID: 15283774 [PubMed - indexed for MEDLINE]Related articles

    50.

    High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence.

    Kwitek AE, Gullings-Handley J, Yu J, Carlos DC, Orlebeke K, Nie J, Eckert J, Lemke A, Andrae JW, Bromberg S, Pasko D, Chen D, Scheetz TE, Casavant TL, Soares MB, Sheffield VC, Tonellato PJ, Jacob HJ.

    Genome Res. 2004 Apr;14(4):750-7.PMID: 15060019 [PubMed - indexed for MEDLINE]Related articlesFree article

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