PubMed

Pharmacokinetics and Pharmacodynamics of a Chimeric/Humanized Anti-CD3 Monoclonal Antibody, Otelixizumab (TRX4), in Subjects With Psoriasis and With Type 1 Diabetes Mellitus.

Wiczling P, Rosenzweig M, Vaickus L, Jusko WJ.

J Clin Pharmacol. 2009 Nov 23. [Epub ahead of print]PMID: 19934031 [PubMed - as supplied by publisher]

D-optimal designs for parameter estimation for indirect pharmacodynamic response models.

Khinkis LA, Krzyzanski W, Jusko WJ, Greco WR.

J Pharmacokinet Pharmacodyn. 2009 Nov 11. [Epub ahead of print]PMID: 19904585 [PubMed - as supplied by publisher]Related articles

Methods of utilizing baseline values for indirect response models.

Woo S, Pawaskar D, Jusko WJ.

J Pharmacokinet Pharmacodyn. 2009 Oct;36(5):381-405. Epub 2009 Aug 21.PMID: 19697107 [PubMed - in process]Related articles

Pharmacokinetic and pharmacodynamic modeling of a copper-selective chelator (TETA) in healthy adults.

Cho HY, Blum RA, Sunderland T, Cooper GJ, Jusko WJ.

J Clin Pharmacol. 2009 Aug;49(8):916-28.PMID: 19602718 [PubMed - indexed for MEDLINE]Related articles

Identification of global transcriptional dynamics.

Yang EH, Almon RR, Dubois DC, Jusko WJ, Androulakis IP.

PLoS One. 2009 Jul 10;4(7):e5992.PMID: 19593450 [PubMed - indexed for MEDLINE]Related articlesFree article

Scaling pharmacodynamics from in vitro and preclinical animal studies to humans.

Mager DE, Woo S, Jusko WJ.

Drug Metab Pharmacokinet. 2009;24(1):16-24. Review.PMID: 19252333 [PubMed - indexed for MEDLINE]Related articlesFree article

Pharmacodynamics of glucose regulation by methylprednisolone. I. Adrenalectomized rats.

Jin JY, Jusko WJ.

Biopharm Drug Dispos. 2009 Jan;30(1):21-34.PMID: 19156931 [PubMed - indexed for MEDLINE]Related articles

Pharmacodynamics of glucose regulation by methylprednisolone. II. normal rats.

Jin JY, Jusko WJ.

Biopharm Drug Dispos. 2009 Jan;30(1):35-48.PMID: 19156669 [PubMed - indexed for MEDLINE]Related articles

Gene expression analysis of hepatic roles in cause and development of diabetes in Goto-Kakizaki rats.

Almon RR, DuBois DC, Lai W, Xue B, Nie J, Jusko WJ.

J Endocrinol. 2009 Mar;200(3):331-46. Epub 2008 Dec 12.PMID: 19074471 [PubMed - indexed for MEDLINE]Related articles

Mechanism-based modeling of nutritional and leptin influences on growth in normal and type 2 diabetic rats.

Landersdorfer CB, DuBois DC, Almon RR, Jusko WJ.

J Pharmacol Exp Ther. 2009 Feb;328(2):644-51. Epub 2008 Oct 29.PMID: 18971370 [PubMed - indexed for MEDLINE]Related articles

Model-based development of a PPARgamma agonist, rivoglitazone, to aid dose selection and optimize clinical trial designs.

Rohatagi S, Carrothers TJ, Jin J, Jusko WJ, Khariton T, Walker J, Truitt K, Salazar DE.

J Clin Pharmacol. 2008 Dec;48(12):1420-9. Epub 2008 Oct 20.PMID: 18936283 [PubMed - indexed for MEDLINE]Related articles

Development and qualification of a pharmacodynamic model for the pronounced inoculum effect of ceftazidime against Pseudomonas aeruginosa.

Bulitta JB, Ly NS, Yang JC, Forrest A, Jusko WJ, Tsuji BT.

Antimicrob Agents Chemother. 2009 Jan;53(1):46-56. Epub 2008 Oct 13.PMID: 18852268 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanistic population pharmacokinetics of total and unbound paclitaxel for a new nanodroplet formulation versus Taxol in cancer patients.

Bulitta JB, Zhao P, Arnold RD, Kessler DR, Daifuku R, Pratt J, Luciano G, Hanauske AR, Gelderblom H, Awada A, Jusko WJ.

Cancer Chemother Pharmacol. 2009 May;63(6):1049-63. Epub 2008 Sep 13.PMID: 18791718 [PubMed - indexed for MEDLINE]Related articles

Multiple-pool cell lifespan models for neutropenia to assess the population pharmacodynamics of unbound paclitaxel from two formulations in cancer patients.

Bulitta JB, Zhao P, Arnold RD, Kessler DR, Daifuku R, Pratt J, Luciano G, Hanauske AR, Gelderblom H, Awada A, Jusko WJ.

Cancer Chemother Pharmacol. 2009 May;63(6):1035-48. Epub 2008 Sep 13.PMID: 18791717 [PubMed - indexed for MEDLINE]Related articles

Quantitative dynamic models of arthritis progression in the rat.

Earp JC, Dubois DC, Almon RR, Jusko WJ.

Pharm Res. 2009 Jan;26(1):196-203. Epub 2008 Aug 30.PMID: 18758921 [PubMed - indexed for MEDLINE]Related articles

Relationships between circadian rhythms and modulation of gene expression by glucocorticoids in skeletal muscle.

Almon RR, Yang E, Lai W, Androulakis IP, Ghimbovschi S, Hoffman EP, Jusko WJ, Dubois DC.

Am J Physiol Regul Integr Comp Physiol. 2008 Oct;295(4):R1031-47. Epub 2008 Jul 30.PMID: 18667713 [PubMed - indexed for MEDLINE]Related articlesFree article

Pharmacokinetics of dexamethasone in a rat model of rheumatoid arthritis.

Earp JC, Pyszczynski NA, Molano DS, Jusko WJ.

Biopharm Drug Dispos. 2008 Sep;29(6):366-72.PMID: 18613033 [PubMed - indexed for MEDLINE]Related articles

Pharmacokinetic/pharmacodynamic modelling in diabetes mellitus.

Landersdorfer CB, Jusko WJ.

Clin Pharmacokinet. 2008;47(7):417-48. Review.PMID: 18563953 [PubMed - indexed for MEDLINE]Related articles

Circadian variations in rat liver gene expression: relationships to drug actions.

Almon RR, Yang E, Lai W, Androulakis IP, DuBois DC, Jusko WJ.

J Pharmacol Exp Ther. 2008 Sep;326(3):700-16. Epub 2008 Jun 18.PMID: 18562560 [PubMed - indexed for MEDLINE]Related articlesFree article

Modeling corticosteroid effects in a rat model of rheumatoid arthritis I: mechanistic disease progression model for the time course of collagen-induced arthritis in Lewis rats.

Earp JC, Dubois DC, Molano DS, Pyszczynski NA, Keller CE, Almon RR, Jusko WJ.

J Pharmacol Exp Ther. 2008 Aug;326(2):532-45. Epub 2008 Apr 30.PMID: 18448865 [PubMed - indexed for MEDLINE]Related articlesFree article

Modeling corticosteroid effects in a rat model of rheumatoid arthritis II: mechanistic pharmacodynamic model for dexamethasone effects in Lewis rats with collagen-induced arthritis.

Earp JC, Dubois DC, Molano DS, Pyszczynski NA, Almon RR, Jusko WJ.

J Pharmacol Exp Ther. 2008 Aug;326(2):546-54. Epub 2008 Apr 30.PMID: 18448864 [PubMed - indexed for MEDLINE]Related articlesFree article

Development of translational pharmacokinetic-pharmacodynamic models.

Mager DE, Jusko WJ.

Clin Pharmacol Ther. 2008 Jun;83(6):909-12. Epub 2008 Mar 26. Review.PMID: 18388873 [PubMed - indexed for MEDLINE]Related articlesFree article

Mathematical modeling of corticosteroid pharmacogenomics in rat muscle following acute and chronic methylprednisolone dosing.

Yao Z, Hoffman EP, Ghimbovschi S, Dubois DC, Almon RR, Jusko WJ.

Mol Pharm. 2008 Mar-Apr;5(2):328-39. Epub 2008 Feb 14.PMID: 18271548 [PubMed - indexed for MEDLINE]Related articles

Pharmacodynamic/Pharmacogenomic modeling of insulin resistance genes in rat muscle after methylprednisolone treatment: exploring regulatory signaling cascades.

Yao Z, Hoffman EP, Ghimbovschi S, Dubois DC, Almon RR, Jusko WJ.

Gene Regul Syst Bio. 2008 Apr 23;2:141-61.PMID: 19787081 [PubMed - in process]Related articlesFree article

Pharmacodynamic modeling of acute and chronic effects of methylprednisolone on hepatic urea cycle genes in rats.

Hazra A, Dubois DC, Almon RR, Snyder GH, Jusko WJ.

Gene Regul Syst Bio. 2008 Feb 14;2:1-19.PMID: 19787073 [PubMed - in process]Related articlesFree article

Extracting global system dynamics of corticosteroid genomic effects in rat liver.

Yang E, Almon RR, Dubois DC, Jusko WJ, Androulakis IP.

J Pharmacol Exp Ther. 2008 Mar;324(3):1243-54. Epub 2007 Dec 17.PMID: 18086872 [PubMed - indexed for MEDLINE]Related articlesFree article

Population pharmacokinetics and pharmacodynamics of peptidic erythropoiesis receptor agonist (ERA) in healthy volunteers.

Woo S, Krzyzanski W, Duliege AM, Stead RB, Jusko WJ.

J Clin Pharmacol. 2008 Jan;48(1):43-52. Epub 2007 Nov 19.PMID: 18025524 [PubMed - indexed for MEDLINE]Related articles

Target-mediated pharmacokinetic and pharmacodynamic model of recombinant human erythropoietin (rHuEPO).

Woo S, Krzyzanski W, Jusko WJ.

J Pharmacokinet Pharmacodyn. 2007 Dec;34(6):849-68. Epub 2007 Oct 18.PMID: 17943422 [PubMed - indexed for MEDLINE]Related articles

Pharmacodynamic model for chemotherapy-induced anemia in rats.

Woo S, Krzyzanski W, Jusko WJ.

Cancer Chemother Pharmacol. 2008 Jun;62(1):123-33. Epub 2007 Sep 22.PMID: 17891399 [PubMed - indexed for MEDLINE]Related articlesFree article

Pharmacokinetic/pharmacodynamic modeling of corticosterone suppression and lymphocytopenia by methylprednisolone in rats.

Yao Z, DuBois DC, Almon RR, Jusko WJ.

J Pharm Sci. 2008 Jul;97(7):2820-32.PMID: 17828751 [PubMed - indexed for MEDLINE]Related articles

Modeling of corticosteroid effects on hepatic low-density lipoprotein receptors and plasma lipid dynamics in rats.

Hazra A, Pyszczynski NA, DuBois DC, Almon RR, Jusko WJ.

Pharm Res. 2008 Apr;25(4):769-80. Epub 2007 Aug 3.PMID: 17674160 [PubMed - indexed for MEDLINE]Related articles

Modeling receptor/gene-mediated effects of corticosteroids on hepatic tyrosine aminotransferase dynamics in rats: dual regulation by endogenous and exogenous corticosteroids.

Hazra A, Pyszczynski N, DuBois DC, Almon RR, Jusko WJ.

J Pharmacokinet Pharmacodyn. 2007 Oct;34(5):643-67. Epub 2007 Jun 26.PMID: 17593325 [PubMed - indexed for MEDLINE]Related articles

Interspecies comparisons of pharmacokinetics and pharmacodynamics of recombinant human erythropoietin.

Woo S, Jusko WJ.

Drug Metab Dispos. 2007 Sep;35(9):1672-8. Epub 2007 Jun 18.PMID: 17576810 [PubMed - indexed for MEDLINE]Related articlesFree article

Pharmacokinetics of methylprednisolone after intravenous and intramuscular administration in rats.

Hazra A, Pyszczynski N, DuBois DC, Almon RR, Jusko WJ.

Biopharm Drug Dispos. 2007 Sep;28(6):263-73.PMID: 17569107 [PubMed - indexed for MEDLINE]Related articles

Microarray analysis of the temporal response of skeletal muscle to methylprednisolone: comparative analysis of two dosing regimens.

Almon RR, DuBois DC, Yao Z, Hoffman EP, Ghimbovschi S, Jusko WJ.

Physiol Genomics. 2007 Aug 20;30(3):282-99. Epub 2007 May 1.PMID: 17473217 [PubMed - indexed for MEDLINE]Related articlesFree article

Changes in Journal Editors.

Jusko WJ.

J Pharmacokinet Pharmacodyn. 2007 Mar 13. [Epub ahead of print] No abstract available. PMID: 17431752 [PubMed - as supplied by publisher]Related articles

Synergism between arsenic trioxide and heat shock protein 90 inhibitors on signal transducer and activator of transcription protein 3 activity--pharmacodynamic drug-drug interaction modeling.

Wetzler M, Earp JC, Brady MT, Keng MK, Jusko WJ.

Clin Cancer Res. 2007 Apr 1;13(7):2261-70.PMID: 17404111 [PubMed - indexed for MEDLINE]Related articlesFree article

Quantification of dexamethasone and corticosterone in rat biofluids and fetal tissue using highly sensitive analytical methods: assay validation and application to a pharmacokinetic study.

Samtani MN, Jusko WJ.

Biomed Chromatogr. 2007 Jun;21(6):585-97.PMID: 17385808 [PubMed - indexed for MEDLINE]Related articles

Population pharmacokinetic/pharmacodynamic modeling of systemic corticosteroid inhibition of whole blood lymphocytes: modeling interoccasion pharmacodynamic variability.

Hong Y, Mager DE, Blum RA, Jusko WJ.

Pharm Res. 2007 Jun;24(6):1088-97. Epub 2007 Mar 24.PMID: 17385022 [PubMed - indexed for MEDLINE]Related articles

Context specific transcription factor prediction.

Yang E, Simcha D, Almon RR, Dubois DC, Jusko WJ, Androulakis IP.

Ann Biomed Eng. 2007 Jun;35(6):1053-67. Epub 2007 Mar 22.PMID: 17377845 [PubMed - indexed for MEDLINE]Related articles

Application of scaling factors in simultaneous modeling of microarray data from diverse chips.

Yao Z, Zhao B, Hoffman EP, Ghimbovschi S, DuBois DC, Almon RR, Jusko WJ.

Pharm Res. 2007 Apr;24(4):643-9. Epub 2007 Feb 21.PMID: 17318415 [PubMed - indexed for MEDLINE]Related articles

A microarray analysis of the temporal response of liver to methylprednisolone: a comparative analysis of two dosing regimens.

Almon RR, DuBois DC, Jusko WJ.

Endocrinology. 2007 May;148(5):2209-25. Epub 2007 Feb 15.PMID: 17303664 [PubMed - indexed for MEDLINE]Related articlesFree article

Assessing the dynamics of nuclear glucocorticoid-receptor complex: adding flexibility to gene expression modeling.

Hazra A, DuBois DC, Almon RR, Jusko WJ.

J Pharmacokinet Pharmacodyn. 2007 Jun;34(3):333-54. Epub 2007 Feb 7.PMID: 17285360 [PubMed - indexed for MEDLINE]Related articles

Mathematical assessment of properties of precursor-dependent indirect pharmacodynamic response models.

Hazra A, Krzyzanski W, Jusko WJ.

J Pharmacokinet Pharmacodyn. 2006 Dec;33(6):683-717. Epub 2006 Oct 12.PMID: 17053985 [PubMed - indexed for MEDLINE]Related articles

Pharmacokinetic and pharmacodynamic modeling of recombinant human erythropoietin after intravenous and subcutaneous administration in rats.

Woo S, Krzyzanski W, Jusko WJ.

J Pharmacol Exp Ther. 2006 Dec;319(3):1297-306. Epub 2006 Sep 14.PMID: 16973883 [PubMed - indexed for MEDLINE]Related articlesFree article

Kinetics of betamethasone and fetal cardiovascular adverse effects in pregnant sheep after different doses.

Schwab M, Coksaygan T, Samtani MN, Jusko WJ, Nathanielsz PW.

Obstet Gynecol. 2006 Sep;108(3 Pt 1):617-25.PMID: 16946223 [PubMed - indexed for MEDLINE]Related articles

Assessment of dosing impact on intra-individual variability in estimation of parameters for basic indirect response models.

Krzyzanski W, Dmochowski J, Matsushima N, Jusko WJ.

J Pharmacokinet Pharmacodyn. 2006 Oct;33(5):635-55. Epub 2006 Aug 29.PMID: 16941234 [PubMed - indexed for MEDLINE]Related articles

Utility of cleavable isotope-coded affinity-tagged reagents for quantification of low-copy proteins induced by methylprednisolone using liquid chromatography/tandem mass spectrometry.

Qu J, Jusko WJ, Straubinger RM.

Anal Chem. 2006 Jul 1;78(13):4543-52.PMID: 16808464 [PubMed - indexed for MEDLINE]Related articlesFree article

Physiologically based pharmacokinetic modeling of FTY720 (2-amino-2[2-(-4-octylphenyl)ethyl]propane-1,3-diol hydrochloride) in rats after oral and intravenous doses.

Meno-Tetang GM, Li H, Mis S, Pyszczynski N, Heining P, Lowe P, Jusko WJ.

Drug Metab Dispos. 2006 Sep;34(9):1480-7. Epub 2006 Jun 2.PMID: 16751263 [PubMed - indexed for MEDLINE]Related articlesFree article

Modeling circadian rhythms of glucocorticoid receptor and glutamine synthetase expression in rat skeletal muscle.

Yao Z, DuBois DC, Almon RR, Jusko WJ.

Pharm Res. 2006 Apr;23(4):670-9. Epub 2006 Feb 2.PMID: 16673181 [PubMed - indexed for MEDLINE]Related articles