PubMed

Low rate of CMV end-organ disease in HIV-infected patients despite low CD4+ cell counts and CMV viremia: results of ACTG protocol A5030.

Wohl DA, Kendall MA, Andersen J, Crumpacker C, Spector SA, Feinberg J, Alston-Smith B, Owens S, Chafey S, Marco M, Maxwell S, Lurain N, Jabs D, Benson C, Keiser P, Jacobson MA; A5030 Study Team.

HIV Clin Trials. 2009 May-Jun;10(3):143-52.PMID: 19632953 [PubMed - indexed for MEDLINE]Related articlesFree article

Dose-dependent effect of CDPPB, the mGluR5 positive allosteric modulator, on recognition memory is associated with GluR1 and CREB phosphorylation in the prefrontal cortex and hippocampus.

Uslaner JM, Parmentier-Batteur S, Flick RB, Surles NO, Lam JS, McNaughton CH, Jacobson MA, Hutson PH.

Neuropharmacology. 2009 Oct-Nov;57(5-6):531-8. Epub 2009 Jul 21.PMID: 19627999 [PubMed - in process]Related articles

Human herpesvirus replication and abnormal CD8+ T cell activation and low CD4+ T cell counts in antiretroviral-suppressed HIV-infected patients.

Jacobson MA, Ditmer DP, Sinclair E, Martin JN, Deeks SG, Hunt P, Mocarski ES, Shiboski C.

PLoS One. 2009;4(4):e5277. Epub 2009 Apr 17.PMID: 19381272 [PubMed - indexed for MEDLINE]Related articlesFree article

Discovery of GlyT1 inhibitors with improved pharmacokinetic properties.

Wolkenberg SE, Zhao Z, Wisnoski DD, Leister WH, O'Brien J, Lemaire W, Williams DL Jr, Jacobson MA, Sur C, Kinney GG, Pettibone DJ, Tiller PR, Smith S, Gibson C, Ma BK, Polsky-Fisher SL, Lindsley CW, Hartman GD.

Bioorg Med Chem Lett. 2009 Mar 1;19(5):1492-5. Epub 2009 Jan 10.PMID: 19181525 [PubMed - indexed for MEDLINE]Related articles

Discovery of N-{[1-(propylsulfonyl)-4-pyridin-2-ylpiperidin-4-yl]methyl}benzamides as novel, selective and potent GlyT1 inhibitors.

Zhao Z, Leister WH, O'Brien JA, Lemaire W, Williams DL Jr, Jacobson MA, Sur C, Kinney GG, Pettibone DJ, Tiller PR, Smith S, Hartman GD, Lindsley CW, Wolkenberg SE.

Bioorg Med Chem Lett. 2009 Mar 1;19(5):1488-91. Epub 2009 Jan 9.PMID: 19179073 [PubMed - indexed for MEDLINE]Related articles

A CMV DNA vaccine primes for memory immune responses to live-attenuated CMV (Towne strain).

Jacobson MA, Adler SP, Sinclair E, Black D, Smith A, Chu A, Moss RB, Wloch MK.

Vaccine. 2009 Mar 4;27(10):1540-8. Epub 2009 Jan 23.PMID: 19168107 [PubMed - indexed for MEDLINE]Related articles

The behavioral and neurochemical effects of a novel D-amino acid oxidase inhibitor compound 8 [4H-thieno [3,2-b]pyrrole-5-carboxylic acid] and D-serine.

Smith SM, Uslaner JM, Yao L, Mullins CM, Surles NO, Huszar SL, McNaughton CH, Pascarella DM, Kandebo M, Hinchliffe RM, Sparey T, Brandon NJ, Jones B, Venkatraman S, Young MB, Sachs N, Jacobson MA, Hutson PH.

J Pharmacol Exp Ther. 2009 Mar;328(3):921-30. Epub 2008 Dec 16.PMID: 19088300 [PubMed - indexed for MEDLINE]Related articles

Decreased behavioral activation following caffeine, amphetamine and darkness in A3 adenosine receptor knock-out mice.

Björklund O, Halldner-Henriksson L, Yang J, Eriksson TM, Jacobson MA, Daré E, Fredholm BB.

Physiol Behav. 2008 Dec 15;95(5):668-76. Epub 2008 Sep 27.PMID: 18930070 [PubMed - indexed for MEDLINE]Related articles

Recurrence of skin and soft tissue infection caused by methicillin-resistant Staphylococcus aureus in a HIV primary care clinic.

Graber CJ, Jacobson MA, Perdreau-Remington F, Chambers HF, Diep BA.

J Acquir Immune Defic Syndr. 2008 Oct 1;49(2):231-3. No abstract available. PMID: 18820536 [PubMed - indexed for MEDLINE]Related articles

Poor predictive value of cytomegalovirus (CMV)-specific T cell assays for the development of CMV retinitis in patients with AIDS.

Jacobson MA, Tan QX, Girling V, Poon C, Van Natta M, Jabs DA, Inokuma M, Maecker HT, Bredt B, Sinclair E; Studies of Ocular Complications of AIDS Research Group.

Clin Infect Dis. 2008 Feb 1;46(3):458-66.PMID: 18173357 [PubMed - indexed for MEDLINE]Related articlesFree article

Papulonecrotic eruption in a 44-year-old-man.

Jacobson MA, Pollack RB, Maize JC Jr.

South Med J. 2007 Dec;100(12):1221-2.PMID: 18090966 [PubMed - indexed for MEDLINE]Related articles

Loss of T cell responses following long-term cryopreservation.

Owen RE, Sinclair E, Emu B, Heitman JW, Hirschkorn DF, Epling CL, Tan QX, Custer B, Harris JM, Jacobson MA, McCune JM, Martin JN, Hecht FM, Deeks SG, Norris PJ.

J Immunol Methods. 2007 Sep 30;326(1-2):93-115. Epub 2007 Aug 8.PMID: 17707394 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of a four-week course of interleukin-10 on cytokine production in a placebo-controlled study of HIV-1-infected subjects.

Pott GB, Sailer CA, Porat R, Peskind RL, Fuchs AC, Angel JB, Skolnik PR, Jacobson MA, Giordano MF, Lebeaut A, Grint PC, Dinarello CA, Shapiro L.

Eur Cytokine Netw. 2007 Jun;18(2):49-58. Epub 2007 Jun 26.PMID: 17594937 [PubMed - indexed for MEDLINE]Related articles

Antibiotic use in the treatment of soft tissue abscesses: a survey of current practice.

Rajendran PM, Young DM, Maurer T, Chambers HF, Jacobson MA, Harris HW.

Surg Infect (Larchmt). 2007 Apr;8(2):237-8. No abstract available. PMID: 17437370 [PubMed - indexed for MEDLINE]Related articles

Do CD4+ T cell functional responses to Epstein-Barr virus provide protective immunity against CNS lymphoma in AIDS?

Jacobson MA.

PLoS Med. 2007 Mar 27;4(3):e110. No abstract available. PMID: 17388670 [PubMed - indexed for MEDLINE]Related articlesFree article

Cardioprotection by ecto-5'-nucleotidase (CD73) and A2B adenosine receptors.

Eckle T, Krahn T, Grenz A, Köhler D, Mittelbronn M, Ledent C, Jacobson MA, Osswald H, Thompson LF, Unertl K, Eltzschig HK.

Circulation. 2007 Mar 27;115(12):1581-90. Epub 2007 Mar 12.PMID: 17353435 [PubMed - indexed for MEDLINE]Related articlesFree article

Challenges in the development of mGluR5 positive allosteric modulators: the discovery of CPPHA.

Zhao Z, Wisnoski DD, O'Brien JA, Lemaire W, Williams DL Jr, Jacobson MA, Wittman M, Ha SN, Schaffhauser H, Sur C, Pettibone DJ, Duggan ME, Conn PJ, Hartman GD, Lindsley CW.

Bioorg Med Chem Lett. 2007 Mar 1;17(5):1386-91. Epub 2006 Dec 3.PMID: 17210250 [PubMed - indexed for MEDLINE]Related articles

Protective immunity to cytomegalovirus (CMV) retinitis in AIDS is associated with CMV-specific T cells that express interferon- gamma and interleukin-2 and have a CD8+ cell early maturational phenotype.

Sinclair E, Tan QX, Sharp M, Girling V, Poon C, Natta MV, Jabs DA, Inokuma M, Maecker HT, Bredt B, Jacobson MA; Studies of Ocular Complications of AIDS Research Group.

J Infect Dis. 2006 Dec 1;194(11):1537-46. Epub 2006 Oct 26.PMID: 17083038 [PubMed - indexed for MEDLINE]Related articles

Synthesis and SAR of GlyT1 inhibitors derived from a series of N-((4-(morpholine-4-carbonyl)-1-(propylsulfonyl)piperidin-4-yl)methyl)benzamides.

Zhao Z, O'Brien JA, Lemaire W, Williams DL Jr, Jacobson MA, Sur C, Pettibone DJ, Tiller PR, Smith S, Hartman GD, Wolkenberg SE, Lindsley CW.

Bioorg Med Chem Lett. 2006 Dec 1;16(23):5968-72. Epub 2006 Sep 20.PMID: 16987662 [PubMed - indexed for MEDLINE]Related articles

Cl-IB-MECA [2-chloro-N6-(3-iodobenzyl)adenosine-5'-N-methylcarboxamide] reduces ischemia/reperfusion injury in mice by activating the A3 adenosine receptor.

Ge ZD, Peart JN, Kreckler LM, Wan TC, Jacobson MA, Gross GJ, Auchampach JA.

J Pharmacol Exp Ther. 2006 Dec;319(3):1200-10. Epub 2006 Sep 19.PMID: 16985166 [PubMed - indexed for MEDLINE]Related articlesFree article

Design, synthesis, and in vivo efficacy of glycine transporter-1 (GlyT1) inhibitors derived from a series of [4-phenyl-1-(propylsulfonyl)piperidin-4-yl]methyl benzamides.

Lindsley CW, Zhao Z, Leister WH, O'Brien J, Lemaire W, Williams DL Jr, Chen TB, Chang RS, Burno M, Jacobson MA, Sur C, Kinney GG, Pettibone DJ, Tiller PR, Smith S, Tsou NN, Duggan ME, Conn PJ, Hartman GD.

ChemMedChem. 2006 Aug;1(8):807-11. No abstract available. PMID: 16902933 [PubMed - indexed for MEDLINE]Related articles

Cutaneous involvement by Burkitt lymphoma.

Jacobson MA, Hutcheson AC, Hurray DH, Metcalf JS, Thiers BH.

J Am Acad Dermatol. 2006 Jun;54(6):1111-3. No abstract available. PMID: 16713488 [PubMed - indexed for MEDLINE]Related articles

Safety and immunogenicity of Towne cytomegalovirus vaccine with or without adjuvant recombinant interleukin-12.

Jacobson MA, Sinclair E, Bredt B, Agrillo L, Black D, Epling CL, Carvidi A, Ho T, Bains R, Girling V, Adler SP.

Vaccine. 2006 Jun 19;24(25):5311-9. Epub 2006 May 2.PMID: 16701925 [PubMed - indexed for MEDLINE]Related articles

Antigen-specific T cell responses induced by Towne cytomegalovirus (CMV) vaccine in CMV-seronegative vaccine recipients.

Jacobson MA, Sinclair E, Bredt B, Agrillo L, Black D, Epling CL, Carvidi A, Ho T, Bains R, Adler SP.

J Clin Virol. 2006 Mar;35(3):332-7. Epub 2006 Jan 18.PMID: 16387547 [PubMed - indexed for MEDLINE]Related articles

Pharmacokinetics of clarithromycin extended-release (ER) tablets in patients with AIDS.

Jacobson MA, Nicolau DP, Sutherland C, Smith A, Aweeka F.

HIV Clin Trials. 2005 Sep-Oct;6(5):246-53.PMID: 16306031 [PubMed - indexed for MEDLINE]Related articlesFree article

The safety of discontinuation of maintenance therapy for cytomegalovirus (CMV) retinitis and incidence of immune recovery uveitis following potent antiretroviral therapy.

Wohl DA, Kendall MA, Owens S, Holland G, Nokta M, Spector SA, Schrier R, Fiscus S, Davis M, Jacobson MA, Currier JS, Squires K, Alston-Smith B, Andersen J, Freeman WR, Higgins M, Torriani FJ; ACTG 379 Study Team.

HIV Clin Trials. 2005 May-Jun;6(3):136-46.PMID: 16192248 [PubMed - indexed for MEDLINE]Related articles

Risk factors for mortality in patients with AIDS in the era of highly active antiretroviral therapy.

Jabs DA, Holbrook JT, Van Natta ML, Clark R, Jacobson MA, Kempen JH, Murphy RL; Studies of Ocular Complications of AIDS Research Group.

Ophthalmology. 2005 May;112(5):771-9.PMID: 15878056 [PubMed - indexed for MEDLINE]Related articles

Editorial comment: failure of HAART to reconstitute CMV-specific protective immunity.

Jacobson MA.

AIDS Read. 2005 Apr;15(4):188. No abstract available. PMID: 15844239 [PubMed - indexed for MEDLINE]Related articles

Lower CD4+ T lymphocyte nadirs may indicate limited immune reconstitution in HIV-1 infected individuals on potent antiretroviral therapy: analysis of immunophenotypic marker results of AACTG 5067.

D'Amico R, Yang Y, Mildvan D, Evans SR, Schnizlein-Bick CT, Hafner R, Webb N, Basar M, Zackin R, Jacobson MA.

J Clin Immunol. 2005 Mar;25(2):106-15.PMID: 15821887 [PubMed - indexed for MEDLINE]Related articles

On the mechanism of THF catalyzed vinylic lithiation of allylamine derivatives: structural studies using 2-D and diffusion-ordered NMR spectroscopy.

Jacobson MA, Keresztes I, Williard PG.

J Am Chem Soc. 2005 Apr 6;127(13):4965-75.PMID: 15796563 [PubMed - indexed for MEDLINE]Related articles

Density functional theory studies on the mechanisms of regioselective allylic and cis-vinylic deprotonation of allyl amides and allylamines.

Haeffner F, Jacobson MA, Keresztes I, Williard PG.

J Am Chem Soc. 2004 Dec 29;126(51):17032-9.PMID: 15612742 [PubMed - indexed for MEDLINE]Related articles

A novel selective positive allosteric modulator of metabotropic glutamate receptor subtype 5 has in vivo activity and antipsychotic-like effects in rat behavioral models.

Kinney GG, O'Brien JA, Lemaire W, Burno M, Bickel DJ, Clements MK, Chen TB, Wisnoski DD, Lindsley CW, Tiller PR, Smith S, Jacobson MA, Sur C, Duggan ME, Pettibone DJ, Conn PJ, Williams DL Jr.

J Pharmacol Exp Ther. 2005 Apr;313(1):199-206. Epub 2004 Dec 17.PMID: 15608073 [PubMed - indexed for MEDLINE]Related articlesFree article

CMV antigen-specific CD4+ and CD8+ T cell IFNgamma expression and proliferation responses in healthy CMV-seropositive individuals.

Sinclair E, Black D, Epling CL, Carvidi A, Josefowicz SZ, Bredt BM, Jacobson MA.

Viral Immunol. 2004;17(3):445-54.PMID: 15357911 [PubMed - indexed for MEDLINE]Related articlesFree article

Abundant expression of granzyme A, but not perforin, in granules of CD8+ T cells in GALT: implications for immune control of HIV-1 infection.

Shacklett BL, Cox CA, Quigley MF, Kreis C, Stollman NH, Jacobson MA, Andersson J, Sandberg JK, Nixon DF.

J Immunol. 2004 Jul 1;173(1):641-8.PMID: 15210827 [PubMed - indexed for MEDLINE]Related articlesFree article

Results of a cytomegalovirus (CMV)-specific CD8+/interferon- gamma+ cytokine flow cytometry assay correlate with clinical evidence of protective immunity in patients with AIDS with CMV retinitis.

Jacobson MA, Maecker HT, Orr PL, D'Amico R, Van Natta M, Li XD, Pollard RB, Bredt BM; Adult AIDS Clinical Trials Group and the Studies of Ocular Complications of AIDS Research Group.

J Infect Dis. 2004 Apr 15;189(8):1362-73. Epub 2004 Mar 31.PMID: 15073672 [PubMed - indexed for MEDLINE]Related articles

Avidity of antibodies to cytomegalovirus in HIV-seropositive patients with and without CMV retinitis.

Marshall BC, Jacobson MA, Adler SP; Studies Of Ocular Complications Of AIDS Research Group.

Viral Immunol. 2004;17(1):101-8.PMID: 15018666 [PubMed - indexed for MEDLINE]Related articles

AIDS-related cytomegalovirus retinitis.

Jacobson MA.

Drugs Today (Barc). 1998 May;34(5):409-13.PMID: 15010704 [PubMed]Related articles

A novel selective allosteric modulator potentiates the activity of native metabotropic glutamate receptor subtype 5 in rat forebrain.

O'Brien JA, Lemaire W, Wittmann M, Jacobson MA, Ha SN, Wisnoski DD, Lindsley CW, Schaffhauser HJ, Rowe B, Sur C, Duggan ME, Pettibone DJ, Conn PJ, Williams DL Jr.

J Pharmacol Exp Ther. 2004 May;309(2):568-77. Epub 2004 Jan 27.PMID: 14747613 [PubMed - indexed for MEDLINE]Related articlesFree article

Difference in mGluR5 interaction between positive allosteric modulators from two structural classes.

Williams DL Jr, O'Brien JA, Lemaire W, Chen TB, Chang RS, Jacobson MA, Ha SN, Wisnoski DD, Lindsley CW, Sur C, Duggan ME, Pettibone DJ, Conn PJ.

Ann N Y Acad Sci. 2003 Nov;1003:481-4. No abstract available. PMID: 14684495 [PubMed - indexed for MEDLINE]Related articles

Granulocyte-macrophage colony-stimulating factor induces modest increases in plasma human immunodeficiency virus (HIV) type 1 RNA levels and CD4+ lymphocyte counts in patients with uncontrolled HIV infection.

Jacobson JM, Lederman MM, Spritzler J, Valdez H, Tebas P, Skowron G, Wang R, Jackson JB, Fox L, Landay A, Gilbert MJ, O'Neil D, Bancroft L, Al-Harthi L, Jacobson MA, Merigan TC Jr, Glesby MJ; National Institute of Allergy and Infectious Diseases AIDS Clinical Trials Group.

J Infect Dis. 2003 Dec 15;188(12):1804-14. Epub 2003 Dec 9.PMID: 14673758 [PubMed - indexed for MEDLINE]Related articles

N-desmethylclozapine, an allosteric agonist at muscarinic 1 receptor, potentiates N-methyl-D-aspartate receptor activity.

Sur C, Mallorga PJ, Wittmann M, Jacobson MA, Pascarella D, Williams JB, Brandish PE, Pettibone DJ, Scolnick EM, Conn PJ.

Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13674-9. Epub 2003 Oct 31.PMID: 14595031 [PubMed - indexed for MEDLINE]Related articlesFree article

A family of highly selective allosteric modulators of the metabotropic glutamate receptor subtype 5.

O'Brien JA, Lemaire W, Chen TB, Chang RS, Jacobson MA, Ha SN, Lindsley CW, Schaffhauser HJ, Sur C, Pettibone DJ, Conn PJ, Williams DL Jr.

Mol Pharmacol. 2003 Sep;64(3):731-40.PMID: 12920211 [PubMed - indexed for MEDLINE]Related articlesFree article

Behavioral characterization of mice lacking the A3 adenosine receptor: sensitivity to hypoxic neurodegeneration.

Fedorova IM, Jacobson MA, Basile A, Jacobson KA.

Cell Mol Neurobiol. 2003 Jun;23(3):431-47.PMID: 12825837 [PubMed - indexed for MEDLINE]Related articles

Activation of murine lung mast cells by the adenosine A3 receptor.

Zhong H, Shlykov SG, Molina JG, Sanborn BM, Jacobson MA, Tilley SL, Blackburn MR.

J Immunol. 2003 Jul 1;171(1):338-45.PMID: 12817016 [PubMed - indexed for MEDLINE]Related articlesFree article

Editorial comment: when to discontinue maintenance therapy for OIs in patients on HAART.

Jacobson MA.

AIDS Read. 1999 Mar-Apr;9(2):124. No abstract available. PMID: 12728895 [PubMed - indexed for MEDLINE]Related articles

Trafficking of human immunodeficiency virus type 1-specific CD8+ T cells to gut-associated lymphoid tissue during chronic infection.

Shacklett BL, Cox CA, Sandberg JK, Stollman NH, Jacobson MA, Nixon DF.

J Virol. 2003 May;77(10):5621-31.PMID: 12719554 [PubMed - indexed for MEDLINE]Related articlesFree article

Absolute or total lymphocyte count as a marker for the CD4 T lymphocyte criterion for initiating antiretroviral therapy.

Jacobson MA, Liu L, Khayam-Bashi H, Deeks SG, Hecht FM, Kahn J.

AIDS. 2003 Apr 11;17(6):917-9. No abstract available. PMID: 12660541 [PubMed - indexed for MEDLINE]Related articles

Adenosine A2A or A3 receptors are required for inhibition of inflammation by methotrexate and its analog MX-68.

Montesinos MC, Desai A, Delano D, Chen JF, Fink JS, Jacobson MA, Cronstein BN.

Arthritis Rheum. 2003 Jan;48(1):240-7.PMID: 12528125 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of long-term highly active antiretroviral therapy in restoring HIV-induced abnormal B-lymphocyte function.

Jacobson MA, Khayam-Bashi H, Martin JN, Black D, Ng V.

J Acquir Immune Defic Syndr. 2002 Dec 15;31(5):472-7.PMID: 12473834 [PubMed - indexed for MEDLINE]Related articles

Association of cytomegalovirus (CMV)-specific CD4+ T lymphocyte reactivity and protective immunity against acquired immunodeficiency syndrome-related CMV retinitis.

Jacobson MA, Bredt BM.

J Infect Dis. 2002 Dec 1;186(11):1701-2; author reply 1702-3. No abstract available. PMID: 12447752 [PubMed - indexed for MEDLINE]Related articles