PubMed

Changes in gene expression and morphology of mouse embryonic stem cells on differentiation into insulin-producing cells in vitro and in vivo.

Naujok O, Francini F, Picton S, Bailey CJ, Lenzen S, Jörns A.

Diabetes Metab Res Rev. 2009 Jul;25(5):464-76.PMID: 19425055 [PubMed - indexed for MEDLINE]Related articles

Prevention of spontaneous immune-mediated diabetes development in the LEW.1AR1-iddm rat by selective CD8+ T cell transfer is associated with a cytokine shift in the pancreas-draining lymph nodes.

Arndt T, Wedekind D, Weiss H, Tiedge M, Lenzen S, Hedrich HJ, Jörns A.

Diabetologia. 2009 Jul;52(7):1381-90. Epub 2009 Apr 15.PMID: 19367386 [PubMed - indexed for MEDLINE]Related articles

Phenotyping of congenic dipeptidyl peptidase 4 (DP4) deficient Dark Agouti (DA) rats suggests involvement of DP4 in neuro-, endocrine, and immune functions.

Frerker N, Raber K, Bode F, Skripuletz T, Nave H, Klemann C, Pabst R, Stephan M, Schade J, Brabant G, Wedekind D, Jacobs R, Jörns A, Forssmann U, Straub RH, Johannes S, Hoffmann T, Wagner L, Demuth HU, von Hörsten S.

Clin Chem Lab Med. 2009;47(3):275-87.PMID: 19327106 [PubMed - indexed for MEDLINE]Related articles

A new experimental protocol for preferential differentiation of mouse embryonic stem cells into insulin-producing cells.

Naujok O, Francini F, Picton S, Jörns A, Bailey CJ, Lenzen S.

Cell Transplant. 2008;17(10-11):1231-42.PMID: 19181217 [PubMed - indexed for MEDLINE]Related articles

An efficient experimental strategy for mouse embryonic stem cell differentiation and separation of a cytokeratin-19-positive population of insulin-producing cells.

Naujok O, Francini F, Jörns A, Lenzen S.

Cell Prolif. 2008 Aug;41(4):607-24. Epub 2008 Jun 19.PMID: 18616698 [PubMed - indexed for MEDLINE]Related articles

Prevention of insulin resistance and beta-cell loss by abrogating PKCepsilon-induced serine phosphorylation of muscle IRS-1 in Psammomys obesus.

Mack E, Ziv E, Reuveni H, Kalman R, Niv MY, Jörns A, Lenzen S, Shafrir E.

Diabetes Metab Res Rev. 2008 Oct;24(7):577-84.PMID: 18613220 [PubMed - indexed for MEDLINE]Related articles

The mutation of the LEW.1AR1-iddm rat maps to the telomeric end of rat chromosome 1.

Weiss H, Arndt T, Jörns A, Lenzen S, Cuppen E, Hedrich HJ, Tiedge M, Wedekind D.

Mamm Genome. 2008 Apr;19(4):292-7. Epub 2008 Mar 21.PMID: 18357488 [PubMed - indexed for MEDLINE]Related articles

Diabetes therapy by lentiviral hepatic insulin gene expression without transformation of liver.

Elsner M, Jörns A, Lenzen S.

Diabetologia. 2008 Apr;51(4):694-5; author reply 696. Epub 2008 Feb 1. No abstract available. PMID: 18239907 [PubMed - indexed for MEDLINE]Related articles

Induction of heme oxygenase-1 improves the survival of pancreas grafts by prevention of pancreatitis after transplantation.

Becker T, Zu Vilsendorf AM, Terbish T, Klempnauer J, Jörns A.

Transplantation. 2007 Dec 27;84(12):1644-55.PMID: 18165777 [PubMed - indexed for MEDLINE]Related articles

Impaired glucose-stimulated insulin secretion is coupled with exocrine pancreatic lesions in the Cohen diabetic rat.

Weksler-Zangen S, Raz I, Lenzen S, Jörns A, Ehrenfeld S, Amir G, Oprescu A, Yagil Y, Yagil C, Zangen DH, Kaiser N.

Diabetes. 2008 Feb;57(2):279-87. Epub 2007 Oct 31.PMID: 17977959 [PubMed - indexed for MEDLINE]Related articlesFree article

Triiodothyronine (T3)-mediated toxicity and induction of apoptosis in insulin-producing INS-1 cells.

Ximenes HM, Lortz S, Jörns A, Lenzen S.

Life Sci. 2007 May 8;80(22):2045-50. Epub 2007 Mar 12.PMID: 17408701 [PubMed - indexed for MEDLINE]Related articles

Beta cell death in hyperglycaemic Psammomys obesus is not cytokine-mediated.

Jörns A, Rath KJ, Bock O, Lenzen S.

Diabetologia. 2006 Nov;49(11):2704-12. Epub 2006 Sep 20.PMID: 17047921 [PubMed - indexed for MEDLINE]Related articles

MIN6 beta-cell-beta-cell interactions influence insulin secretory responses to nutrients and non-nutrients.

Luther MJ, Hauge-Evans A, Souza KL, Jörns A, Lenzen S, Persaud SJ, Jones PM.

Biochem Biophys Res Commun. 2006 Apr 28;343(1):99-104. Epub 2006 Feb 10.PMID: 16529716 [PubMed - indexed for MEDLINE]Related articles

Mechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes: many differences, few similarities.

Cnop M, Welsh N, Jonas JC, Jörns A, Lenzen S, Eizirik DL.

Diabetes. 2005 Dec;54 Suppl 2:S97-107. Review.PMID: 16306347 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of polyinosinic-polycytidylic acid and adoptive transfer of immune cells in the Lew.1AR1-iddm rat and in its coisogenic LEW.1AR1 background strain.

Wedekind D, Weiss H, Jörns A, Lenzen S, Tiedge M, Hedrich HJ.

Autoimmunity. 2005 Jun;38(4):265-75.PMID: 16206509 [PubMed - indexed for MEDLINE]Related articles

Prevention of nutritionally induced diabetes by rosiglitazone in the gerbil Psammomys obesus.

Hefetz S, Ziv E, Jörns A, Lenzen S, Shafrir E.

Diabetes Metab Res Rev. 2006 Mar-Apr;22(2):139-45.PMID: 16088969 [PubMed - indexed for MEDLINE]Related articles

Genetic analysis of the LEW.1AR1-iddm rat: an animal model for spontaneous diabetes mellitus.

Weiss H, Bleich A, Hedrich HJ, Kölsch B, Elsner M, Jörns A, Lenzen S, Tiedge M, Wedekind D.

Mamm Genome. 2005 Jun;16(6):432-41.PMID: 16075370 [PubMed - indexed for MEDLINE]Related articles

Immune cell infiltration, cytokine expression, and beta-cell apoptosis during the development of type 1 diabetes in the spontaneously diabetic LEW.1AR1/Ztm-iddm rat.

Jörns A, Günther A, Hedrich HJ, Wedekind D, Tiedge M, Lenzen S.

Diabetes. 2005 Jul;54(7):2041-52.PMID: 15983205 [PubMed - indexed for MEDLINE]Related articlesFree article

Desensitization of insulin secretion by depolarizing insulin secretagogues.

Rustenbeck I, Wienbergen A, Bleck C, Jörns A.

Diabetes. 2004 Dec;53 Suppl 3:S140-50. Review.PMID: 15561902 [PubMed - indexed for MEDLINE]Related articlesFree article

Mitochondrial catalase overexpression protects insulin-producing cells against toxicity of reactive oxygen species and proinflammatory cytokines.

Gurgul E, Lortz S, Tiedge M, Jörns A, Lenzen S.

Diabetes. 2004 Sep;53(9):2271-80.PMID: 15331536 [PubMed - indexed for MEDLINE]Related articlesFree article

Beta-cell toxicity of ATP-sensitive K+ channel-blocking insulin secretagogues.

Rustenbeck I, Krautheim A, Jörns A, Steinfelder HJ.

Biochem Pharmacol. 2004 May 1;67(9):1733-41.PMID: 15081872 [PubMed - indexed for MEDLINE]Related articles

Pathology of the pancreas and other organs in the diabetic LEW.1AR1/Ztm- iddm rat, a new model of spontaneous insulin-dependent diabetes mellitus.

Jörns A, Kubat B, Tiedge M, Wedekind D, Hedrich HJ, Klöppel G, Lenzen S.

Virchows Arch. 2004 Feb;444(2):183-9. Epub 2004 Jan 20.PMID: 14735361 [PubMed - indexed for MEDLINE]Related articles

Time frame of pancreas allograft rejection: an immunogenetic analysis in MHC-disparate, presensitized inbred rat strains.

Litmathe J, Bektas H, Jörns A, Klempnauer J.

Transplant Proc. 2003 Dec;35(8):3147-52.PMID: 14698000 [PubMed - indexed for MEDLINE]Related articles

Thyroxine induces pancreatic beta cell apoptosis in rats.

Jörns A, Tiedge M, Lenzen S.

Diabetologia. 2002 Jun;45(6):851-5. Epub 2002 May 17.PMID: 12107729 [PubMed - indexed for MEDLINE]Related articles

Gradual loss of pancreatic beta-cell insulin, glucokinase and GLUT2 glucose transporter immunoreactivities during the time course of nutritionally induced type-2 diabetes in Psammomys obesus (sand rat).

Jörns A, Tiedge M, Ziv E, Shafrir E, Lenzen S.

Virchows Arch. 2002 Jan;440(1):63-9.PMID: 11942578 [PubMed - indexed for MEDLINE]Related articles

Desensitization of insulin secretory response to imidazolines, tolbutamide, and quinine. I. Secretory and morphological studies.

Rustenbeck I, Winkler M, Jörns A.

Biochem Pharmacol. 2001 Dec 15;62(12):1685-94.PMID: 11755122 [PubMed - indexed for MEDLINE]Related articles

The LEW.1AR1/Ztm-iddm rat: a new model of spontaneous insulin-dependent diabetes mellitus.

Lenzen S, Tiedge M, Elsner M, Lortz S, Weiss H, Jörns A, Klöppel G, Wedekind D, Prokop CM, Hedrich HJ.

Diabetologia. 2001 Sep;44(9):1189-96.PMID: 11596676 [PubMed - indexed for MEDLINE]Related articles

Recovery of pancreatic beta cells in response to long-term normoglycemia after pancreas or islet transplantation in severely streptozotocin diabetic adult rats.

Jörns A, Klempnauer J, Tiedge M, Lenzen S.

Pancreas. 2001 Aug;23(2):186-96.PMID: 11484921 [PubMed - indexed for MEDLINE]Related articles

Preconditioning with the prostacyclin analog epoprostenol and cobra venom factor prevents reperfusion injury and hyperacute rejection in discordant liver xenotransplantation.

Meyer zu Vilsendorf A, Link C, Jörns A, Nagel E, Köhl J.

Xenotransplantation. 2001 Feb;8(1):41-7.PMID: 11208190 [PubMed - indexed for MEDLINE]Related articles

Prolonged survival of guinea-pig-to-rat heart xenografts following complement depletion and B-cell-directed immunosuppression by malononitrilamide.

Meyer zu Vilsendorf A, Nagel E, Link C, Jörns A, Köhl J.

Transplant Proc. 2000 Aug;32(5):864-5. No abstract available. PMID: 10936248 [PubMed - indexed for MEDLINE]Related articles

Effect of superoxide dismutase, catalase, chelating agents, and free radical scavengers on the toxicity of alloxan to isolated pancreatic islets in vitro.

Jörns A, Tiedge M, Lenzen S, Munday R.

Free Radic Biol Med. 1999 May;26(9-10):1300-4.PMID: 10381203 [PubMed - indexed for MEDLINE]Related articles

Nutrient-dependent distribution of insulin and glucokinase immunoreactivities in rat pancreatic beta cells.

Jörns A, Tiedge M, Lenzen S.

Virchows Arch. 1999 Jan;434(1):75-82.PMID: 10071239 [PubMed - indexed for MEDLINE]Related articles

Comparative toxicity of alloxan, N-alkylalloxans and ninhydrin to isolated pancreatic islets in vitro.

Jörns A, Munday R, Tiedge M, Lenzen S.

J Endocrinol. 1997 Nov;155(2):283-93.PMID: 9415063 [PubMed - indexed for MEDLINE]Related articlesFree article

Changes of antigenicity and loss of immunogenicity in long-standing class I MHC disparate pancreas allografts.

Klempnauer J, Jörns A, Frericks BB, Bektas H.

Transplant Proc. 1997 Feb-Mar;29(1-2):1151. No abstract available. PMID: 9123244 [PubMed - indexed for MEDLINE]Related articles

Differential effect of donor-specific blood transfusions after kidney, heart, pancreas, and skin transplantation in major histocompatibility complex-incompatible rats.

Bektas H, Jörns A, Klempnauer J.

Transfusion. 1997 Feb;37(2):226-30.PMID: 9051101 [PubMed - indexed for MEDLINE]Related articles

Loss of GLUT2 glucose transporter expression in pancreatic beta cells from diabetic Chinese hamsters.

Jörns A, Tiedge M, Sickel E, Lenzen S.

Virchows Arch. 1996 Jun;428(3):177-85.PMID: 8688972 [PubMed - indexed for MEDLINE]Related articles

Insulin cells in rat whole-pancreas isografts display heterogeneous immunoreactivities and ultrastructure.

Jörns A, Klempnauer J, Steiniger B.

Pancreas. 1995 Apr;10(3):314-24.PMID: 7624306 [PubMed - indexed for MEDLINE]Related articles

Insulin and GLUT2 glucose transporter immunoreactivity in B-cells of whole pancreas isografts and allografts in the streptozotocin-diabetic rat.

Jörns A, Klempnauer J.

Exp Clin Endocrinol Diabetes. 1995;103 Suppl 2:103-6.PMID: 8839264 [PubMed - indexed for MEDLINE]Related articles

Immunocytochemical and ultrastructural heterogeneities of normal and glibenclamide stimulated pancreatic beta cells in the rat.

Jörns A.

Virchows Arch. 1994;425(3):305-13.PMID: 7812517 [PubMed - indexed for MEDLINE]Related articles

Differences in immunologic unresponsiveness after MHC-incompatible heart transplantation induced by donor-specific blood transfusion.

Bektas H, Klempnauer J, Jörns A.

Transplant Proc. 1993 Oct;25(5):2870-1. No abstract available. PMID: 8212269 [PubMed - indexed for MEDLINE]Related articles

Chromostatin, a chromogranin A-derived bioactive peptide, is present in human pancreatic insulin (beta) cells.

Cetin Y, Aunis D, Bader MF, Galindo E, Jörns A, Bargsten G, Grube D.

Proc Natl Acad Sci U S A. 1993 Mar 15;90(6):2360-4.PMID: 8096340 [PubMed - indexed for MEDLINE]Related articlesFree article

The microanatomy of canine islets of Langerhans: implications for intra-islet regulation.

Redecker P, Seipelt A, Jörns A, Bargsten G, Grube D.

Anat Embryol (Berl). 1992;185(2):131-41.PMID: 1536446 [PubMed - indexed for MEDLINE]Related articles

The endocrine pancreas of glucagon- and somatostatin-immunized rabbits. II. Electron microscopy.

Jörns A, Grube D.

Cell Tissue Res. 1991 Aug;265(2):261-73.PMID: 1682052 [PubMed - indexed for MEDLINE]Related articles

The endocrine pancreas of glucagon-and somatostatin-immunized rabbits. I. Light microscopy and immunohistochemistry.

Grube D, Jörns A.

Cell Tissue Res. 1991 Aug;265(2):251-60.PMID: 1682051 [PubMed - indexed for MEDLINE]Related articles

Synaptophysin immunoreactivity in the mammalian endocrine pancreas.

Redecker P, Jörns A, Jahn R, Grube D.

Cell Tissue Res. 1991 Jun;264(3):461-7.PMID: 1907886 [PubMed - indexed for MEDLINE]Related articles

[Chromogranins in endocrine cells of the digestive system]

Grube D, Bargsten G, Cetin Y, Jörns A, Yoshie S.

Acta Histochem Suppl. 1990;38:81-5. Review. German. No abstract available. PMID: 1981942 [PubMed - indexed for MEDLINE]Related articles

Cellular distribution and amount of chromogranin A in bovine endocrine pancreas.

Ehrhart M, Jörns A, Grube D, Gratzl M.

J Histochem Cytochem. 1988 May;36(5):467-72.PMID: 3282005 [PubMed - indexed for MEDLINE]Related articlesFree article

Heterogeneities of the islets in the rabbit pancreas and the problem of "paracrine" regulation of islet cells.

Jörns A, Barklage E, Grube D.

Anat Embryol (Berl). 1988;178(4):297-307.PMID: 2902814 [PubMed - indexed for MEDLINE]Related articles

Chromogranin A (CGA) in the gastro-entero-pancreatic (GEP) endocrine system. I. CGA in the mammalian endocrine pancreas.

Grube D, Aunis D, Bader F, Cetin Y, Jörns A, Yoshie S.

Histochemistry. 1986;85(6):441-52.PMID: 2877960 [PubMed - indexed for MEDLINE]Related articles